Small Non-coding Transfer RNA-Derived RNA Fragments (tRFs): Their Biogenesis, Function and Implication in Human Diseases by Yu Fu, Inhan Lee, Yong Sun Lee, Xiaoyong Bao

“…They play regulatory roles in several biological contexts such as cancer, innate immunity, stress responses, and neurological disorders. …”
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Dissection of the Interplay between Class I PI3Ks and Rac Signaling in Phagocytic Functions by Carlotta Costa, Giulia Germena, Emilio Hirsch

“…This function resides at the core of innate immunity and requires a series of concerted events that lead first to migration to the infected tissue and then to the killing of the invading pathogens. …”
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Role of T Lymphocytes in Type 2 Diabetes and Diabetes-Associated Inflammation by Chang Xia, Xiaoquan Rao, Jixin Zhong

“…Inflammatory regulation has been focused on innate immunity especially macrophage for a long time, while increasing evidence suggests T cells are crucial for the development of metabolic inflammation and insulin resistance since 2009. …”
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NK-DC Crosstalk in Immunity to Microbial Infection by Rony Thomas, Xi Yang

“…The interaction between natural killer (NK) cell and dendritic cell (DC), two important cellular components of innate immunity, started to be elucidated in the last years. …”
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Pathogenesis of Chronic Urticaria: An Overview by Sanjiv Jain

“…An increasing recognition of chronic urticaria as an immune mediated inflammatory disorder related to altered cytokine-chemokine network consequent to immune dysregulation resulting from disturbed innate immunity is emerging as yet another pathogenic explanation. …”
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Role of Adaptive Immunity in Alcoholic Liver Disease by Emanuele Albano

“…Stimulation of innate immunity is increasingly recognized to play an important role in the pathogenesis of alcoholic liver disease (ALD), while the contribution of adaptive immunity has received less attention. …”
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Cellular Immunity of Patients with Tuberculosis Combined with Diabetes by Peng Cheng, Liang Wang, Wenping Gong

“…By reviewing the related articles on tuberculosis complicated with diabetes published in recent years, this paper expounds on the effect of hyperglycemia on innate immunity and adaptive immunity of patients with TB. …”
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Coleopteran Antimicrobial Peptides: Prospects for Clinical Applications by Monde Ntwasa, Akira Goto, Shoichiro Kurata

“…Initial research reports, however, indicate that coleopterans possess unique immune response mechanisms, and studies of these novel mechanisms may help to further elucidate innate immunity. Recently, the complete genome sequence of Tribolium was published, boosting research on coleopteran immunity and leading to the identification of Tribolium AMPs that are shared by Drosophila and mammals, as well as other AMPs that are unique. …”
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A Novel Type of Non-coding RNA, nc886, Implicated in Tumor Sensing and Suppression by Yong Sun Lee

“…Thus, the significance of the nc886:PKR pathway in cancer is to sense and eliminate pre-malignant cells, which is analogous to PKR's role in cellular innate immunity. Beyond this tumor sensing role, nc886 plays a putative tumor suppressor role as supported by experimental evidence. …”
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Functional Role of Milk Fat Globule-Epidermal Growth Factor VIII in Macrophage-Mediated Inflammatory Responses and Inflammatory/Autoimmune Diseases by Young-Su Yi

“…Inflammation involves a series of complex biological processes mediated by innate immunity for host defense against pathogen infection. …”
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Immunopathogenesis of spondyloarthropathies – Concept of major histocompatibility locus-I-opathy by Amlan Kusum Datta, Uddalak Chakraborty, Swati Kumar, Atanu Chandra

“…The term “MHC-I-opathy” encompasses of a group of diseases which exhibit interaction between tissue-specific factors and innate immune cells. Further studies are needed for understanding of its therapeutic implication in such diseases.…”
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Tag7 (PGLYRP1) Can Induce an Emergence of the CD3+CD4+CD25+CD127+ Cells with Antitumor Activity by T. N. Sharapova, E. A. Romanova, L. P. Sashchenko, D. V. Yashin

“…We have shown that in the human peripheral blood cells, the innate immunity protein Tag7 can activate a subpopulation of CD3+CD4+CD25+ cells, which have antitumor activity. …”
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Attempts to identify the molecular cause of autoinflammatory recurrent fever by Oksana Boyarchuk, Diana Savkiv

“…Systemic autoinflammatory diseases caused by dysregulation of the innate immunity are a known cause of recurrent fevers. …”
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The Interplay of Renin-Angiotensin System and Toll-Like Receptor 4 in the Inflammation of Diabetic Nephropathy by Qi Feng, Dongwei Liu, Yanfang Lu, Zhangsuo Liu

“…The underlying mechanisms of DN are complex and required to be further investigated. Both innate immunity and renin-angiotensin system (RAS) play critical roles in the pathogenesis of DN. …”
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Tissue Factor, Blood Coagulation, and Beyond: An Overview by Arthur J. Chu

“…TF overexpression/hypercoagulability often observed in many clinical conditions certainly expands its role in proinflammation, diabetes, obesity, cardiovascular diseases, angiogenesis, tumor metastasis, wound repairs, embryonic development, cell adhesion/migration, innate immunity, infection, pregnancy loss, and many others. …”
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cGAS/STING signaling pathway in gynecological malignancies: From molecular mechanisms to therapeutic values by Danyang Zhang, Bingxue Zhang

“…The cGAS/STING signaling pathway, a pivotal mechanism in innate immunity, detects cytosolic DNA from pathogens or cellular damage, triggering immune responses via type I interferons and inflammatory cytokines. …”
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Cytokine Immunopathogenesis of Enterovirus 71 Brain Stem Encephalitis by Shih-Min Wang, Huan-Yao Lei, Ching-Chuan Liu

“…Cytokines, as a part of innate immunity, favor the development of antiviral and Th1 immune responses. …”
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The Response of Macrophages and Neutrophils to Hypoxia in the Context of Cancer and Other Inflammatory Diseases by Antje Egners, Merve Erdem, Thorsten Cramer

“…Macrophages and neutrophils, the chief cellular components of innate immunity, display distinct properties when exposed to hypoxic conditions. …”
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Recent Advances of the NLRP3 Inflammasome in Central Nervous System Disorders by Keren Zhou, Ligen Shi, Yan Wang, Sheng Chen, Jianmin Zhang

“…These cytokines play a critical role in mediating inflammation and innate immunity response. Among various inflammasome complexes, the NLRP3 inflammasome is the best characterized, which has been demonstrated as a crucial role in various diseases. …”
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Unlocking the potential of antimicrobial peptides: Beta-defensins and the future of cancer diagnostics by Saranya Velmurugan, Gowtham Kumar Subbaraj

“…Beta-defensins, a group of antimicrobial peptides crucial for innate immunity, have been linked to oral cancer development. …”
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