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141
Tag7 (PGLYRP1) Can Induce an Emergence of the CD3+CD4+CD25+CD127+ Cells with Antitumor Activity
Published 2018-01-01“…We have shown that in the human peripheral blood cells, the innate immunity protein Tag7 can activate a subpopulation of CD3+CD4+CD25+ cells, which have antitumor activity. …”
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142
Attempts to identify the molecular cause of autoinflammatory recurrent fever
Published 2024-11-01“…Systemic autoinflammatory diseases caused by dysregulation of the innate immunity are a known cause of recurrent fevers. …”
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143
The Interplay of Renin-Angiotensin System and Toll-Like Receptor 4 in the Inflammation of Diabetic Nephropathy
Published 2020-01-01“…The underlying mechanisms of DN are complex and required to be further investigated. Both innate immunity and renin-angiotensin system (RAS) play critical roles in the pathogenesis of DN. …”
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144
Tissue Factor, Blood Coagulation, and Beyond: An Overview
Published 2011-01-01“…TF overexpression/hypercoagulability often observed in many clinical conditions certainly expands its role in proinflammation, diabetes, obesity, cardiovascular diseases, angiogenesis, tumor metastasis, wound repairs, embryonic development, cell adhesion/migration, innate immunity, infection, pregnancy loss, and many others. …”
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145
cGAS/STING signaling pathway in gynecological malignancies: From molecular mechanisms to therapeutic values
Published 2025-01-01“…The cGAS/STING signaling pathway, a pivotal mechanism in innate immunity, detects cytosolic DNA from pathogens or cellular damage, triggering immune responses via type I interferons and inflammatory cytokines. …”
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146
Cytokine Immunopathogenesis of Enterovirus 71 Brain Stem Encephalitis
Published 2012-01-01“…Cytokines, as a part of innate immunity, favor the development of antiviral and Th1 immune responses. …”
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147
The Response of Macrophages and Neutrophils to Hypoxia in the Context of Cancer and Other Inflammatory Diseases
Published 2016-01-01“…Macrophages and neutrophils, the chief cellular components of innate immunity, display distinct properties when exposed to hypoxic conditions. …”
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148
Recent Advances of the NLRP3 Inflammasome in Central Nervous System Disorders
Published 2016-01-01“…These cytokines play a critical role in mediating inflammation and innate immunity response. Among various inflammasome complexes, the NLRP3 inflammasome is the best characterized, which has been demonstrated as a crucial role in various diseases. …”
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149
The Impact of Farnesoid X Receptor Activation on Intestinal Permeability in Inflammatory Bowel Disease
Published 2012-01-01“…The development and investigation of FXR agonists provide strong support for the regulatory role of FXR in mucosal innate immunity. Activation of FXR in the intestinal tract decreases the production of proinflammatory cytokines such as interleukin (IL) 1-beta, IL-2, IL-6, tumour necrosis factor-alpha and interferon-gamma, thus contributing to a reduction in inflammation and epithelial permeability. …”
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150
microRNAs as a New Mechanism Regulating Adipose Tissue Inflammation in Obesity and as a Novel Therapeutic Strategy in the Metabolic Syndrome
Published 2014-01-01“…Recently, a growing body of evidence supports the role of miRNAs as a new important inflammatory mediator by regulating both the adaptive and innate immunity. This review will focus on the implication of miRNAs in white AT inflammation in obesity, and will also highlight the potential of miRNAs as targets for therapeutic intervention in MS as well as the challenges lying in miRNA-targeting therapeutics.…”
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151
Role of Toll-Like Receptors and Their Downstream Molecules in the Development of Nonalcoholic Fatty Liver Disease
Published 2010-01-01“…Activation of innate immunity is associated with the development of liver disease, including non-alcoholic fatty liver disease (NAFLD). …”
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152
NK Cell Subtypes as Regulators of Autoimmune Liver Disease
Published 2016-01-01“…As major components of innate immunity, NK cells not only exert cell-mediated cytotoxicity to destroy tumors or infected cells, but also act to regulate the functions of other cells in the immune system by secreting cytokines and chemokines. …”
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153
Selected Mechanisms of Action of Bacteriophages in Bacterial Infections in Animals
Published 2025-01-01“…Due to their complex protein structure, phages can also directly or indirectly modulate immune processes, including innate immunity, by modulating phagocytosis and cytokine reactions, as well as acquired immunity, by producing antibodies and activating effector cells. …”
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154
Essential Role of Zinc and Zinc Transporters in Myeloid Cell Function and Host Defense against Infection
Published 2018-01-01“…In this review, we will discuss the most recent developments regarding zinc’s role in innate immunity and protection against pathogen invasion.…”
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155
IL-17A and Th17 Cells in Lung Inflammation: An Update on the Role of Th17 Cell Differentiation and IL-17R Signaling in Host Defense against Infection
Published 2013-01-01“…IL-17A acts on nonimmune cells in infected tissues to strengthen innate immunity by inducing the expression of antimicrobial proteins, cytokines, and chemokines. …”
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156
Fagonia indica Repairs Hepatic Damage through Expression Regulation of Toll-Like Receptors in a Liver Injury Model
Published 2018-01-01“…Furthermore, a significant expression regulation of innate immunity components such as toll-like receptors 4 and 9 and MyD-88 was observed suggesting an immune regulatory role of the plant in curing liver injury. …”
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157
Peptidylarginine Deiminase 2 in Murine Antiviral and Autoimmune Antibody Responses
Published 2022-01-01“…The peptidylarginine deiminases (PADs) and the citrullinated proteins that they generate have key roles in innate immunity and rheumatoid arthritis, an inflammatory arthritis with antibodies that target citrullinated proteins. …”
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158
Human Herpesviridae Methods of Natural Killer Cell Evasion
Published 2012-01-01“…As evidence emerges about the role of innate immunity and natural killer (NK) cells in the control of herpesvirus infection, evidence of viral methods of innate immune evasion grows as well. …”
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159
Leukocyte Production of Inflammatory Mediators Is Inhibited by the Antioxidants Phloretin, Silymarin, Hesperetin, and Resveratrol
Published 2014-01-01“…Recognition of conserved pathogen-associated molecular patterns is a crucial component of innate immunity to Gram-negative bacteria such as Escherichia coli, as well as the periodontal pathogen Aggregatibacter actinomycetemcomitans. …”
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160
The Four Pillars for Successful Regenerative Therapy in Endodontics: Stem Cells, Biomaterials, Growth Factors, and Their Synergistic Interactions
Published 2022-01-01“…The regenerated dental pulp will recover the protective mechanisms including innate immunity, tertiary dentin formation, and pain sensitivity. …”
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