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121
Role of Complement in Multiorgan Failure
Published 2012-01-01“…The underlying immune response is highly complex and involves activation of the complement system as a crucial entity of innate immunity. Uncontrolled activation of the complement system during sepsis and SIRS with in excessive generation of complement activation products contributes to an ensuing dysfunction of various organ systems. …”
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122
Identification of signaling networks associated with lactate modulation of macrophages and dendritic cells
Published 2025-02-01“…This study identifies key biochemical pathways in innate immune cells that are impacted by lactate, which advances our understanding of the interplay between the tumor microenvironment and innate immunity.…”
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Roitt's essential immunology /
Published 2017Table of Contents: “…Innate immunity -- Specific acquired immunity -- Antibodies -- Membrane receptors for antigen -- Antigen-specific recognition -- Immunological methods and applications [JS2] -- The anatomy of the immune response -- Lymphocyte activation -- The production of effectors -- The regulation of the immune response -- Development and evolution of the immune response -- Adversarial strategies during infection -- Vaccines -- Immunodeficiency -- Allergy and other hypersensitivities -- Transplantation -- Tumor immunology -- Autoimmune diseases.…”
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125
Role of Neutrophils in Psoriasis
Published 2020-01-01“…The abnormalities of innate immunity play crucial roles in the pathogenesis of psoriasis. …”
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126
Mycobacterium bovis Bacillus Calmette-Guérin-Induced Macrophage Cytotoxicity against Bladder Cancer Cells
Published 2010-01-01“…Macrophages play pivotal roles in the host innate immunity and serve as a first line of defense in mycobacterial infection. …”
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127
The Toll of Vascular Insufficiency: Implications for the Management of Peripheral Arterial Disease
Published 2016-01-01“…While a body of literature continues to grow describing the role of danger signaling and innate immunity in cardiac biology, the role of these pathways in the ischemic myopathy associated with PAD has not been extensively studied. …”
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Dysbiosis in the Pathogenesis of Pediatric Inflammatory Bowel Diseases
Published 2012-01-01“…The fundamentals of IBD pathogenesis are considered a defective innate immunity and bacterial killing with overaggressive adaptive immune response. …”
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130
Small Non-coding Transfer RNA-Derived RNA Fragments (tRFs): Their Biogenesis, Function and Implication in Human Diseases
Published 2015-12-01“…They play regulatory roles in several biological contexts such as cancer, innate immunity, stress responses, and neurological disorders. …”
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131
Dissection of the Interplay between Class I PI3Ks and Rac Signaling in Phagocytic Functions
Published 2010-01-01“…This function resides at the core of innate immunity and requires a series of concerted events that lead first to migration to the infected tissue and then to the killing of the invading pathogens. …”
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132
Role of T Lymphocytes in Type 2 Diabetes and Diabetes-Associated Inflammation
Published 2017-01-01“…Inflammatory regulation has been focused on innate immunity especially macrophage for a long time, while increasing evidence suggests T cells are crucial for the development of metabolic inflammation and insulin resistance since 2009. …”
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133
NK-DC Crosstalk in Immunity to Microbial Infection
Published 2016-01-01“…The interaction between natural killer (NK) cell and dendritic cell (DC), two important cellular components of innate immunity, started to be elucidated in the last years. …”
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134
Pathogenesis of Chronic Urticaria: An Overview
Published 2014-01-01“…An increasing recognition of chronic urticaria as an immune mediated inflammatory disorder related to altered cytokine-chemokine network consequent to immune dysregulation resulting from disturbed innate immunity is emerging as yet another pathogenic explanation. …”
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135
Role of Adaptive Immunity in Alcoholic Liver Disease
Published 2012-01-01“…Stimulation of innate immunity is increasingly recognized to play an important role in the pathogenesis of alcoholic liver disease (ALD), while the contribution of adaptive immunity has received less attention. …”
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136
Cellular Immunity of Patients with Tuberculosis Combined with Diabetes
Published 2022-01-01“…By reviewing the related articles on tuberculosis complicated with diabetes published in recent years, this paper expounds on the effect of hyperglycemia on innate immunity and adaptive immunity of patients with TB. …”
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137
Coleopteran Antimicrobial Peptides: Prospects for Clinical Applications
Published 2012-01-01“…Initial research reports, however, indicate that coleopterans possess unique immune response mechanisms, and studies of these novel mechanisms may help to further elucidate innate immunity. Recently, the complete genome sequence of Tribolium was published, boosting research on coleopteran immunity and leading to the identification of Tribolium AMPs that are shared by Drosophila and mammals, as well as other AMPs that are unique. …”
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138
A Novel Type of Non-coding RNA, nc886, Implicated in Tumor Sensing and Suppression
Published 2015-06-01“…Thus, the significance of the nc886:PKR pathway in cancer is to sense and eliminate pre-malignant cells, which is analogous to PKR's role in cellular innate immunity. Beyond this tumor sensing role, nc886 plays a putative tumor suppressor role as supported by experimental evidence. …”
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139
Functional Role of Milk Fat Globule-Epidermal Growth Factor VIII in Macrophage-Mediated Inflammatory Responses and Inflammatory/Autoimmune Diseases
Published 2016-01-01“…Inflammation involves a series of complex biological processes mediated by innate immunity for host defense against pathogen infection. …”
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140
Immunopathogenesis of spondyloarthropathies – Concept of major histocompatibility locus-I-opathy
Published 2021-01-01“…The term “MHC-I-opathy” encompasses of a group of diseases which exhibit interaction between tissue-specific factors and innate immune cells. Further studies are needed for understanding of its therapeutic implication in such diseases.…”
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