NRF2 Antioxidant Response and Interferon‐Stimulated Genes Are Differentially Expressed in SARS‐CoV‐2‐Positive Young Subjects by Walter Toscanelli, Matteo Fracella, Marta De Angelis, Carolina Scagnolari, Leonardo Sorrentino, Elena Piselli, Maria Elena Marcocci, Fabio Midulla, Enrica Mancino, Raffaella Nenna, Laura Petrarca, Anna Teresa Palamara, Guido Antonelli, Alessandra Pierangeli, Lucia Nencioni

“…NRF2 has also been reported to regulate the innate immune response through the inhibition of the interferon (IFN) pathway. …”
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Antibodies to the RBD of SARS-CoV-2 spike mediate productive infection of primary human macrophages by Suzanne Pickering, Harry Wilson, Enrico Bravo, Marianne R. Perera, Jeffrey Seow, Carl Graham, Nathalia Almeida, Lazaros Fotopoulos, Thomas Williams, Atlanta Moitra, Helena Winstone, Tinne A. D. Nissen, Rui Pedro Galão, Luke B. Snell, Katie J. Doores, Michael H. Malim, Stuart J. D. Neil

“…Addition of ruxolitinib significantly increased infection, indicating restraint of infection through innate immune mechanisms rather than entry. High-level production of pro-inflammatory cytokines directly correlated with macrophage infection levels. …”
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Airway β-Defensin-1 Protein Is Elevated in COPD and Severe Asthma by Katherine J. Baines, Thomas K. Wright, Jodie L. Simpson, Vanessa M. McDonald, Lisa G. Wood, Kristy S. Parsons, Peter A. Wark, Peter G. Gibson

“…Background. Innate immune antimicrobial peptides, including β-defensin-1, promote the chemotaxis and activation of several immune cells. …”
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Characterization and functional analysis of chicken hnRNP protein by Ke Wang, Manzi Huang, Qinghua Zeng, Huansheng Wu

“…While the role of hnRNP proteins in modulating interferon signaling and virus replication in mammals has been extensively studied, the impact of chicken hnRNPs on innate immune response and Infectious Bursal Disease Virus (IBDV) replication remains largely unexplored. …”
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FAM210B activates STAT1/IRF9/IFIT3 axis by upregulating IFN-α/β expression to impede the progression of lung adenocarcinoma by Xuejuan Gao, Donglan Huang, Ying Liu, Gui Zhang, Xiaofen Zheng, Baiye Guan, Aiwen Chen, Jiayao Wu, Shi-Ming Luo, Zonghua Liu, Luxuan Chen, Xiaohui Liu, Jingjie Jin, Xingfeng Yin, Zhenghua Sun, Yunfang Zhang, Meizhi Lu, Gong Zhang, Wanting Liu, Langxia Liu

“…RNA-seq analysis further indicated that FAM210B plays a role in regulating innate immune-related signaling pathways in LUAD cells, particularly involving the production of type I interferon (IFN-α/β). …”
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UDP-Induced Phagocytosis and ATP-Stimulated Chemotactic Migration Are Impaired in STIM1−/− Microglia In Vitro and In Vivo by Hye Min Lim, Heo Woon, Jung Woo Han, Yoshihiro Baba, Tomohiro Kurosaki, Min Goo Lee, Joo Young Kim

“…STIM1 function in immune cell calcium signalling has been studied extensively; however, its role in microglia, innate immune cells in brain, has not been fully understood. …”
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Elotuzumab Enhances CD16-Independent NK Cell-Mediated Cytotoxicity against Myeloma Cells by Upregulating Several NK Cell-Enhancing Genes by Yan-Hua Wang, Shotaro Hagiwara, Hiroshi Kazama, Yuki Iizuka, Norina Tanaka, Junji Tanaka

“…Combination therapy using antibodies and natural killer (NK) effectors, which are innate immune cells with safe and potent antitumor activity, is a promising approach for cancer immunotherapy and can enhance antitumor effects. …”
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Significant abundance of bacterial flagellin and expression of its surface localized receptor toll-like receptor 5 and cytokine interleukin-22 in South African infants with poor or... by Nontlantla J. Haindongo, Mapaseka Seheri, Cliff A. Magwira

“…Abstract Bacterial flagellin, a potent intestinal innate immune activator, prevents murine rotavirus (RV) infection independent of adaptive immunity and interferons. …”
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Dynamics of REL, RELA and IRF1 transcription factor expression in U937 macrophages after dioxin exposure by E. V. Kashina, D. Y. Oshchepkov, E. V. Antontseva, M. Y. Shamanina, D. P. Furman, V. A. Mordvinov

“…Macrophages are key regulators of the innate immune response, as well as one of the first types of cells which respond to chemical stress, so the study of the action of TCDD on these cells is important. …”
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A Novel Immune-Related Three-Gene Signature and Immune Infiltration Insights in Psoriasis and Chronic Kidney Disease by Yin T, Zhang T, Ma L

“…Through further functional analysis, these genes were found to be primarily involved in the activation of inflammation and innate immune responses. Subsequently, six hub genes were determined using five topological algorithms. …”
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The role of inflammasomes in hepatocellular carcinoma: Mechanisms and therapeutic insights by Valentina Arrè, Roberto Negro, Gianluigi Giannelli

“…Inflammasomes, the multiprotein complexes that launch the innate immune response, emerge as important mediators in the pathogenesis of HCC. …”
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Transcription factor KLF2 is associated with the dysfunctional status of NK cells and the prognosis of pediatric B-ALL patients by Fang Wu, Huimin Xu, Benshan Zhang

“…BackgroundNatural killer cells, an important component of the innate immune system, can directly recognize and lyse virally infected or transformed cells. …”
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Wild-type bone marrow cells repopulate tissue resident macrophages and reverse the impacts of homozygous CSF1R mutation. by Dylan Carter-Cusack, Stephen Huang, Sahar Keshvari, Omkar Patkar, Anuj Sehgal, Rachel Allavena, Robert A J Byrne, B Paul Morgan, Stephen J Bush, Kim M Summers, Katharine M Irvine, David A Hume

“…These studies provide a model for the pathology and treatment of CSF1R mutations in humans and the innate immune deficiency associated with prematurity.…”
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High expression of nucleotide-binding oligomerization domain protein 1 correlates with poor prognosis and immune cell infiltration in Glioblastoma Multiforme patients by Hongyang Zhao, Beiwu Lan, Zenghui Zhao, Peining Zhu, Chong Wang, Yufei Gao

“…Abstract Nucleotide-binding oligomerization domain protein 1 (NOD1) is one of the innate immune receptors that has been associated with tumorigenesis and abnormally expressed in various cancers. …”
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Analysis of whole transcriptome reveals the immune response to porcine reproductive and respiratory syndrome virus infection and tylvalosin tartrate treatment in the porcine alveol... by Kun Du, Yu Xia, Qian Wu, Miao Yin, Hong Zhao, Xi-wen Chen

“…The miRNA-seq revealed that tylvalosin tartrates-enhanced miRNAs might play roles in regulating angiogenesis and innate immune-related functions, and it rescued the expression of three anti-inflammation miRNAs (ssc-miR-30a-5p, ssc-miR-218-5p, and ssc-miR-218) that were downregulated due to PRRSV infection. …”
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Mesothelial cell responses to acute appendicitis or small bowel obstruction reactive ascites: Insights into immunoregulation of abdominal adhesion. by Melissa A Hausburg, Kaysie L Banton, Christopher D Cassidy, Robert M Madayag, Carlos H Palacio, Jason S Williams, Raphael Bar-Or, Rebecca J Ryznar, David Bar-Or

“…Between groups, 26 analytes were differentially abundant including innate immune response, wound healing, and mucosal defense proteins. …”
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RAB3GAP2 dysregulation in adult T-cell leukemia/lymphoma (ATLL) compared to acute lymphoblastic leukemia (ALL): a molecular perspective by Samira Pourrezaei, Arash Letafati, Ghazale Molaverdi, Mehdi Norouzi, Sayed-Hamidreza Mozhgani

“…The principal aim of this study was to investigate cellular processes related to innate immune response, intracellular protein transport, and translational initiation regulation in individuals afflicted with ATLL and Acute lymphoblastic leukemia (ALL). …”
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Invariant Natural Killer T Cells as Key Players in Host Resistance against Paracoccidioides brasiliensis by Joes Nogueira-Neto, Flavio V. Loures, Alessandra S. Schanoski, David A. G. Andrade, Michelangelo B. Gonzatti, Tania A. Costa, Bruno C. Vivanco, Patrícia Xander, Daniela S. Rosa, Vera L. G. Calich, Alexandre C. Keller

“…To determine whether iNKT cells contribute in vivo to host resistance against P. brasiliensis infection, we infected intratracheally wild-type and Jα18-/- C57BL/6 mouse strains with the virulent Pb18 isolate. iNKT cell deficiency impaired the airway acute inflammatory response, resulting in decreased airway neutrophilia and reduced IFN-γ, KC, and nitric oxide (NO) production. The deficient innate immune response of Jα18-/- mice to Pb18 infection resulted in increased fungal burden in the lungs and spleen. …”
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Promoting ER stress in a plasmacytoid dendritic cell line drives fibroblast activation by Beatriz H. Ferreira, Inês S. Silva, Andreia Mendes, Fátima Leite-Pinheiro, Adrienne W. Paton, James C. Paton, Iola F. Duarte, Philippe Pierre, Catarina R. Almeida

“…Plasmacytoid dendritic cells (pDCs) are innate immune cells that play a key role in the development of fibrosis in SSc patients, through still poorly defined mechanisms. …”
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Ultrasound May Suppress Tumor Growth, Inhibit Inflammation, and Establish Tolerogenesis by Remodeling Innatome via Pathways of ROS, Immune Checkpoints, Cytokines, and Trained Immun... by Qian Yang, Ruijing Zhang, Peng Tang, Yu Sun, Candice Johnson, Jason Saredy, Susu Wu, Jiwei Wang, Yifan Lu, Fatma Saaoud, Ying Shao, Charles Drummer, Keman Xu, Daohai Yu, Rongshan Li, Shuping Ge, Xiaohua Jiang, Hong Wang, Xiaofeng Yang

“…We used microarray datasets from the NCBI GEO DataSet repository and conducted comprehensive data-mining analyses, where we examined the gene expression of 1376 innate immune regulators (innatome genes (IGs) in cells treated with LIUS. …”
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