Shedding new light on atherosclerosis therapeutics: Nanomedicines targeting atherosclerotic immune microenvironment by Zhiyue Wang, Jie Sheng, Guangming Lu, Longjiang Zhang

“…Moreover, we elaborated on nanomaterials that regulate innate immune responses, adaptive immune responses, and aberrant immunometabolism to achieve AIME modulation. …”
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Cardiac-Restricted IGF-1Ea Overexpression Reduces the Early Accumulation of Inflammatory Myeloid Cells and Mediates Expression of Extracellular Matrix Remodelling Genes after Myoca... by Enrique Gallego-Colon, Robert D. Sampson, Susanne Sattler, Michael D. Schneider, Nadia Rosenthal, Joanne Tonkin

“…Taken together, these results indicate that the IGF-1Ea transgene shifts the balance of innate immune cell populations early after infarction, favouring a reduction in inflammatory myeloid cells. …”
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Antigen Gene Transfer to Human Plasmacytoid Dendritic Cells Using Recombinant Adenovirus and Vaccinia Virus Vectors by Hetty J. Bontkes, Janneke J. Ruizendaal, Marco W. J. Schreurs, Duco Kramer, Chris J. L. M. Meijer, Erik Hooijberg

“…Plasmacytoid dendritic cells (PDC) play a role in the innate immune response to viral infections through the secretion of IFNα but may also play a role in specific T-cell induction. …”
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Evaluation of Human β-defensin-3 Diagnostic Role in a Group of Iraqi Patients with Osteoporosis by Zahraa S. Hassan, Layla O. Farhan

“…Human β-defensin (HBD-3) is ananti-inflammatory peptide andcrucial part of the human innate immune system. Giving early therapeutic intervention for OP requires an early diagnosis. …”
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Role of High-Density Lipoprotein Cholesterol (HDL-C) as a Clinical Predictor of Decompensation in Patients with Chronic Liver Disease (CLD) by Harshavardhan Rao B, Priya Nair, Anoop K. Koshy, S. Krishnapriya, C. R. Greeshma, Rama P. Venu

“…High-density lipoprotein cholesterol (HDL-C) has a significant role in innate immune response to LPS in the circulation and could therefore increase the risk for decompensation in patients with CLD. …”
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TRIM25: A Global Player of Cell Death Pathways and Promising Target of Tumor-Sensitizing Therapies by Wolfgang Eberhardt, Usman Nasrullah, Josef Pfeilschifter

“…In addition to its originally described function in antiviral innate immune response, TRIM25 can play critical yet context-dependent roles in apoptotic- and non-apoptotic-regulated cell death pathways, including pyroposis, necroptosis, ferroptosis, and autophagy. …”
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TLR7 Polymorphism (rs179008 and rs179009) in HIV-Infected Individual Naïve to ART by HariOm Singh, Dharmesh Samani, Sumit Aggarwal

“…Toll-like receptors (TLRs) play an important role in the innate immune response to HIV infection. Single nucleotide polymorphism (SNP) in TLR7 (Gln11Leu) gene has been associated with a rapid decline of CD4T cell count. …”
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Effect of Dietary Administration of Green Macroalgae (Ulva intestinalis) on Mucosal and Systemic Immune Parameters, Antioxidant Defence, and Related Gene Expression in Zebrafish (D... by Elaheh Rouhani, Roghieh Safari, Mohammad Reza Imanpour, Seyed Hossein Hoseinifar, Metin Yazici, Ehab El-Haroun

“…This study investigated the effects of adding green macroalgae gutweed (Ulva intestinalis) powder to zebrafish (Danio rerio) feed at different levels on innate immune responses, antioxidant defence, and gene expression. …”
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Modifying non-coding regions of linear DNA vaccines to explore the interplay of expression and inflammation in immunogenicity by David C. Stirling, Maria de Miguel Ferrer, Sungwon Kim, Madina Wane, Daniel Kysh, Lisa J. Caproni, John S. Tregoning

“…The interplay between antigen expression and the innate immune response impacts the overall immune response to DNA vaccines. …”
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12,13-diHOME Promotes Inflammatory Macrophages and Epigenetically Modifies Their Capacity to Respond to Microbes and Allergens by Din L. Lin, Kevin M. Magnaye, Cara E. Porsche, Sophia R. Levan, Elze Rackaityte, Mustafa Özçam, Susan V. Lynch

“…These observations offer plausible mechanisms by which this lipid promotes early-life pathogenic microbiome development and innate immune dysfunction associated with childhood allergic sensitization.…”
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Early neutrophil activation and NETs release in the pristane-induced lupus mice model. by Solange Carrasco, Bernadete L Liphaus, Tatiana Vasconcelos Peixoto, Thais Martins Lima, Sueli Kunimi Kubo Ariga, Zelita Aparecida Jesus Queiroz, Thays de Matos Lobo, Sergio Catanozi, Letícia Gomes Rodrigues, Antônio Santos Filho, Walcy Rosolia Teodoro, Ana Paula Pereira Velosa, Débora Levy, Francisco Garcia Soriano, Cláudia Goldenstein-Schainberg

“…<h4>Conclusions</h4>We demonstrated early changes in the innate immune response such as an increased number of activated neutrophils and LDGs and mainly increased NETosis in the pristane-induced mice model which may be considered as the primary event triggering lupus development.…”
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A minimal mathematical model for the initial molecular interactions of death receptor signalling by Christian Winkel, Simon Neumann, Christina Surulescu, Peter Scheurich

“…TNF itself is a strong proinflammatory regulator of the innate immune system, but has been also recognized as a major factor in progression of autoimmune diseases. …”
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Withaferin A Inhibits Nuclear Factor-κB-Dependent Pro-Inflammatory and Stress Response Pathways in the Astrocytes by Francesca Martorana, Giulia Guidotti, Liliana Brambilla, Daniela Rossi

“…Since the steroid lactone Withaferin A was described to inhibit NF-κB activity in different cell types, we next determined the impact of this natural compound towards the identified astrocytic signalling pathway. Innate immune activation was induced by stimulation of the LPS/TLR4 axis in spinal cord astrocytes. …”
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Reevaluating the Concept of Treating Experimental Tumors with a Mixed Bacterial Vaccine: Coley’s Toxin by C. Maletzki, U. Klier, W. Obst, B. Kreikemeyer, M. Linnebacher

“…Antitumoral effects following local therapy were primarily accompanied by stimulation of innate immune mechanisms. Data presented herein prove that the historical approach of using killed bacteria as active immunotherapeutic agents still holds promise, and further careful preclinical analyses may pave the way back into clinical applications.…”
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Spontaneous tumor regression following COVID-19 vaccination by Hui Dai, Renata Ferrarotto, Myrna Godoy, Diana Bell, Shiaw-Yih Lin, Daniel J McGrail, Luana Guimaraes de Sousa, Kaiyi Li, Mario L Marques-Piubelli, Cipriano Gonzalez, Sammy Ferri-Borgogno, Jared Burks

“…Systemic reactogenicity, a manifestation of the innate immune response to vaccines, occurs in up to 69% of patients following vaccination with RNA-based COVID-19 vaccines. …”
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Mycobacterium tuberculosis Multidrug-Resistant Strain M Induces Low IL-8 and Inhibits TNF-α Secretion by Bronchial Epithelial Cells Altering Neutrophil Effector Functions by Denise Kviatcovsky, Leonardo Rivadeneyra, Luciana Balboa, Noemí Yokobori, Beatriz López, Viviana Ritacco, Mirta Schattner, María del Carmen Sasiain, Silvia de la Barrera

“…M strain, the most prevalent multidrug-resistant strain of Mycobacterium tuberculosis (Mtb) in Argentina, has mounted mechanisms to evade innate immune response. The role of human bronchial epithelium in Mtb infection remains unknown as well as its crosstalk with neutrophils (PMN). …”
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Proteome differences of dental stem cells between permanent and deciduous teeth by data-independent acquisition proteomics by Zhang Suping, Liu Yuqing, Dong Jin, Jiao Min, Gu Yongchun, Chen Liling, Yuan Na, Wang Jianrong, Yang Dezhao, Meng Fanwen

“…These proteins are known to be involved in critical cellular processes such as mitochondrial energy metabolism, mTOR-related autophagy pathway, and innate immune response. Conversely, SHED displayed elevated expression of AKR1B family, which participated in glycerolipid metabolism and adipogenic differentiation, PRKG1, MGLL and UQCRB proteins associated with thermogenesis. …”
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Bioceramic Surface Topography Regulating Immune Osteogenesis by Jianxin Hao, Lin Du, Yuening He, Chengtie Wu

“…After the implantation of bioceramics, innate immune response that occurs at the interface of materials can deeply influence the subsequent inflammation and bone regeneration progress. …”
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The effect of cannabis-derived terpenes on alveolar macrophage function by Patrick M. Greiss, Patrick M. Greiss, Patrick M. Greiss, Jacquelyn D. Rich, Jacquelyn D. Rich, Jacquelyn D. Rich, Geoffrey A. McKay, Dao Nguyen, Dao Nguyen, Dao Nguyen, Dao Nguyen, Mark G. Lefsrud, David H. Eidelman, David H. Eidelman, David H. Eidelman, Carolyn J. Baglole, Carolyn J. Baglole, Carolyn J. Baglole, Carolyn J. Baglole, Carolyn J. Baglole

“…However, it is not known whether terpenes derived from cannabis alone or in combination with the cannabinoid ∆9-THC impacts the function of alveolar macrophages, a specialized pulmonary innate immune cell that is important in host defense against pathogens. …”
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Caspase-11 Modulates Inflammation and Attenuates Toxoplasma gondii Pathogenesis by Sheryl L. Coutermarsh-Ott, John T. Doran, Caroline Campbell, Tere M. Williams, David S. Lindsay, Irving C. Allen

“…Our data indicates that caspase-11 modulates the innate immune response to T. gondii through a mechanism which is distinct from that currently described for the canonical inflammasome. …”
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