Biological Functions and Clinical Significance of the ABCG1 Transporter by Stanislav Kotlyarov, Anna Kotlyarova

“…Cholesterol transport is the mechanism that links metabolism and the innate immune system. Due to its lipid transport function, ABCG1 may contribute to the prevention of atherosclerosis and is involved in the functioning of the lung, pancreas, and other organs and systems. …”
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Peptide with Dual Roles in Immune and Metabolic Regulation: Liver-Expressed Antimicrobial Peptide-2 (LEAP-2) by Yitong Li, Ying Liu, Meng Gou

“…Liver-expressed antimicrobial peptide 2 (LEAP-2) was originally discovered as an antimicrobial peptide that plays a vital role in the host innate immune system of various vertebrates. Recent research discovered LEAP-2 as an endogenous antagonist and inverse agonist of the GHSR1a receptor. …”
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Inflammasome in Intestinal Inflammation and Cancer by Tiago Nunes, Heitor S. de Souza

“…The caspase-1 pathway leads to the upregulation of important cytokines from the interleukin (IL)-1 family, IL-1β, and IL-18, with subsequent activation of the innate immune response. In this review, we discuss the molecular structure, the mechanisms behind the inflammasome activation, and its possible role in the pathogenesis of inflammatory bowel diseases and intestinal cancer. …”
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Discussion of irritable bowel syndrome issue and functional constipations in reports of the 21st United European Gastroenterological Week (Berlin, 2013) by A. A. Sheptulin, M. A. Vizye-Khripunova

“…Of etiological and pathogenic factors of IBS the major attention is given now to hereditary factors, past intestinal infections, bile acids absorbtion disorders, changes of innate immune system. Differential diagnostics of IBS with other diseases (celiac sprue, chronic inflammatory bowel diseases, et al.), that may progress under a mask of the functional intestinal disorders is required. …”
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Type 2 Diabetes, PUFAs, and Vitamin D: Their Relation to Inflammation by Ana L. Guadarrama-López, Roxana Valdés-Ramos, Beatríz E. Martínez-Carrillo

“…Recently, the study of the innate immune system has offered an explanation model of the pathogenesis of T2DM. …”
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Stimulation of Innate and Adaptive Immunity by Using Filamentous Bacteriophage fd Targeted to DEC-205 by Luciana D’Apice, Valerio Costa, Rossella Sartorius, Maria Trovato, Marianna Aprile, Piergiuseppe De Berardinis

“…RNA-Seq data analysis indicates that the bacteriophage fd virions are sensed as a pathogen by dendritic cells; they activate the danger receptors that trigger an innate immune response and thus confer a strong adjuvanticity that is needed to obtain a long-lasting adaptive immune response.…”
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Arachidonic Acid Derivatives and Their Role in Peripheral Nerve Degeneration and Regeneration by Carlos Rodrigo Camara-Lemarroy, Emmanuel Irineo Gonzalez-Moreno, Francisco Javier Guzman-de la Garza, Nancy Esthela Fernandez-Garza

“…Part of this neuroimmune signaling is mediated by the innate immune system, including arachidonic acid (AA) derivatives such as prostaglandins and leukotrienes. …”
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The Role of CARD9 Deficiency in Neutrophils by Ruanmei Sheng, Xiaoming Zhong, Zhiwen Yang, Xuemin Wang

“…Neutrophils play a critical role in innate immune defense and directly contribute to infectious and autoimmune ailments. …”
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Association of Toll-Like Receptor Signaling and Reactive Oxygen Species: A Potential Therapeutic Target for Posttrauma Acute Lung Injury by Meng Xiang, Janet Fan, Jie Fan

“…Hemorrhagic shock (HS) that results from major trauma promotes the development of SIRS and ALI by priming the innate immune system for an exaggerated inflammatory response. …”
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Modulation of Toll-Like Receptor Activity by Leukocyte Ig-Like Receptors and Their Effects during Bacterial Infection by Louise E. Pilsbury, Rachel L. Allen, Martin Vordermeier

“…One family of immunoregulatory proteins which can provide a balancing effect on TLR activity are the Leukocyte Ig-like receptors (LILRs), which act as innate immune receptors for self-proteins. Here we describe the LILR family, their inhibitory effect on TLR activity in cells of the monocytic lineage, their signalling pathway, and their antimicrobial effects during bacterial infection. …”
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TIRAP, TRAM, and Toll-Like Receptors: The Untold Story by Valérie Lannoy, Anthony Côté-Biron, Claude Asselin, Nathalie Rivard

“…They act as microbial sensors, playing major roles in the regulation of the innate immune system. TLRs mediate their cellular functions through the activation of MyD88-dependent or MyD88-independent signaling pathways. …”
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Neonatal Sepsis due to Coagulase-Negative Staphylococci by Elizabeth A. Marchant, Guilaine K. Boyce, Manish Sadarangani, Pascal M. Lavoie

“…Multiple factors, including prematurity, invasive life-saving medical interventions, and immaturity of the innate immune system, put these infants at greater risk of developing infection. …”
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Identification of an immunological signature of long COVID syndrome by Gisella Guerrera, Manolo Sambucci, Eleonora Timperi, Mario Picozza, Andrea Misiti, Andrea Misiti, Roberta Placido, Silvia Corbisiero, Silvia D’Orso, Andrea Termine, Carlo Fabrizio, Francesca Gargano, Sharon Eleuteri, Luisa Marchioni, Veronica Bordoni, Luigi Coppola, Marco Iannetta, Chiara Agrati, Giovanna Borsellino, Luca Battistini

“…While LC patients displayed recovery in innate immune profiles comparable to healthy and Recovered individuals, deficits in T cell and memory B cell populations were evident, differentiating LC from full recovery. …”
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Reverse transcriptase inhibitors diminish systemic proinflammatory responses to bacterial pathogens by Karthik Hullahalli, Katherine G. Dailey, Ryan Acbay, Masataka Suzuki, George I. Balazs, Matthew K. Waldor

“…Understanding how innate immune responses are controlled during infection is important for developing new approaches to dampen excessive inflammation. …”
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Evaluation of the Expression of Infection-Related Long Noncoding RNAs among COVID-19 Patients: A Case-Control Study by Zahra Firoozi, Elham Mohammadisoleimani, Farzaneh Bagheri, Atefeh Taheri, Babak Pezeshki, Mohammad Mehdi Naghizadeh, Abdolreza Daraei, Jalal Karimi, Yousef Gholampour, Yaser Mansoori, Zahra Montaseri

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a worldwide pandemic, activates signaling cascades and leads to innate immune responses and secretion of multiple chemokines and cytokines. …”
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Inflammasomes in neurodegenerative diseases by Qianchen Wang, Songwei Yang, Xuan Zhang, Shanshan Zhang, Liping Chen, Wanxue Wang, Naihong Chen, Jiaqing Yan

“…Abstract Inflammasomes represent a crucial component of the innate immune system, which respond to threats by recognizing different molecules. …”
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Toll-Like Receptors in Hepatic Ischemia/Reperfusion and Transplantation by John Evankovich, Timothy Billiar, Allan Tsung

“…The TLRs play central roles in sensing tissue damage and activating the innate immune system following I/R. Engagement of TLRs by endogenous DAMPs activates proinflammatory signaling pathways leading to the production of cytokines, chemokines and further release of endogenous danger signals. …”
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Neutrophils in Tuberculosis: Heterogeneity Shapes the Way? by Irina V. Lyadova

“…The outcome of the infection depends on host ability to mount effective protection and balance inflammatory responses. Neutrophils are innate immune cells implicated in both processes. Accordingly, during M. tuberculosis infection, they play a dual role. …”
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(1 →3)- β -D-Glucan and endotoxin modulate immune response to inhaled allergen by R. Rylander, P. G. Holt

“…The results demonstrate a complex interaction between adaptive and innate immune mechanisms in the lung, determined by exposure to common contaminants in airborne dust.…”
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Macrophage-derived extracellular vesicles as new players in chronic non-communicable diseases by Fengjuan Lin, Huiyu Luo, Jiexian Wang, Qing Li, Longying Zha

“…Macrophages are innate immune cells present in all tissues and play an important role in almost all aspects of the biology of living organisms. …”
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