Importance of Lipopolysaccharide and Cyclic β-1,2-Glucans in Brucella-Mammalian Infections by Andreas F. Haag, Kamila K. Myka, Markus F. F. Arnold, Paola Caro-Hernández, Gail P. Ferguson

“…Brucella lipopolysaccharide (LPS), unlike Escherichia coli LPS, does not trigger the host's innate immune system. Brucella produces cyclic β-1,2-glucans, which are important for targeting them to their replicative niche in the endoplasmic reticulum within the host cell. …”
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Heat Shock Proteins in Tendinopathy: Novel Molecular Regulators by Neal L. Millar, George A. C. Murrell

“…Heat shock proteins, also called damage-associated molecular patterns (DAMPs), are rapidly released following nonprogrammed cell death, are key effectors of the innate immune system, and critically restore homeostasis by promoting the reconstruction of the effected tissue. …”
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Terminal Complement Pathway Deficiency in an Adult Patient with Meningococcal Sepsis by F. Staels, W. Meersseman, P. Stordeur, K. Willekens, S. Van Loo, A. Corveleyn, I. Meyts, G. Meyfroidt, R. Schrijvers

“…The complement system is an essential part of our innate immune system. Three enzymatic activation pathways are described, all converging into a common terminal pathway which causes lysis of the target cell. …”
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Genetic Diversity of Toll-Like Receptors and Immunity to M. leprae Infection by Bryan E. Hart, Richard I. Tapping

“…Toll-like receptors (TLRs) have emerged as an essential family of innate immune pattern recognition receptors which play a pivotal role in host defense against microbes, including pathogenic strains of mycobacteria. …”
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Evidence for a Potential Role of Metallothioneins in Inflammatory Bowel Diseases by Anouk Waeytens, Martine De Vos, Debby Laukens

“…Recent studies underscore the importance of the damaged epithelial barrier and the dysregulated innate immune system in their pathogenesis. …”
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Ubiquitination of CD47 Regulates Innate Anti‐Tumor Immune Response by Qian Gou, Bingjun Yan, Yalan Duan, Yilei Guo, Jing Qian, Juanjuan Shi, Yongzhong Hou

“…Abstract In addition to adaptive immune checkpoint of PD‐1/PD‐L1, the innate immune checkpoint SIRPα/CD47 plays an important role in regulation of tumor immune escape. …”
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Targeting Toll-Like Receptors for Treatment of SLE by Christopher G. Horton, Zi-jian Pan, A. Darise Farris

“…Toll-like receptors (TLRs) are important innate immune receptors for the identification and clearance of invading pathogens. …”
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Does Hsp60 Provide a Link between Mitochondrial Stress and Inflammation in Diabetes Mellitus? by Joshua Juwono, Ryan D. Martinus

“…We will examine the links between Hsp60 and cellular anti- and proinflammatory processes and specifically address how Hsp60 appears to affect immune inflammation by at least two different mechanisms: as a ligand for innate immune receptors and as an antigen recognised by adaptive immune receptors. …”
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Is the Gut Microbiota a New Factor Contributing to Obesity and Its Metabolic Disorders? by Kristina Harris, Amira Kassis, Geneviève Major, Chieh J. Chou

“…The mechanisms by which the gut microbiota affects metabolic diseases are by two major routes: (1) the innate immune response to the structural components of bacteria (e.g., lipopolysaccharide) resulting in inflammation and (2) bacterial metabolites of dietary compounds (e.g., SCFA from fiber), which have biological activities that regulate host functions. …”
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Host Cell Autophagy in Immune Response to Zoonotic Infections by Panagiotis Skendros, Ioannis Mitroulis

“…The induction of the autophagic machinery by innate immune receptors signaling, such as TLRs, NOD1/2, and p62/SQSTM1 in antigen-presenting cells results in inhibition of survival and elimination of invading pathogens. …”
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Mycobacterium ulcerans and Mycobacterium marinum: Pathogenesis, Diagnosis and Treatment by Loh Teng-Hern Tan, Pendru Raghunath, Long Chiau Ming, Jodi Woan-Fei Law

“…Although having common ancestry and highly similar in genetic makeup, M. ulcerans and M. marinum have differential impacts on the host innate immune system. In term pathogenesis, prolonged cell exposure to exotoxin mycolactone produced by M. ulcerans could lead to Buruli ulcer. …”
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Alphaherpesvirus in Pets and Livestock by Shu-Hui Duan, Ze-Min Li, Xue-Jie Yu, Dan Li

“…During infection, herpesviruses not only stimulate innate immune responses in host cells but also interfere with signaling pathways through specific proteins to achieve immune evasion. …”
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Interleukin-1 as a Common Denominator from Autoinflammatory to Autoimmune Disorders: Premises, Perils, and Perspectives by Giuseppe Lopalco, Luca Cantarini, Antonio Vitale, Florenzo Iannone, Maria Grazia Anelli, Laura Andreozzi, Giovanni Lapadula, Mauro Galeazzi, Donato Rigante

“…A complex web of dynamic relationships between innate and adaptive immunity is now evident for many autoinflammatory and autoimmune disorders, the first deriving from abnormal activation of innate immune system without any conventional danger triggers and the latter from self-/non-self-discrimination loss of tolerance, and systemic inflammation. …”
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Agonistic anti-NKG2D antibody structure reveals unique stoichiometry and epitope compared to natural ligands by Daniel Fallon, Ching-Shin Huang, Jingya Ma, Christopher Morgan, Zhaohui Sunny Zhou

“…Natural killer (NK) cells are effector cells of the innate immune system that distinguish between healthy and abnormal cells through activating and inhibitory receptor signaling. …”
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The Metabolic Features of Tumor-Associated Macrophages: Opportunities for Immunotherapy? by Sonja S. Mojsilovic, Slavko Mojsilovic, Victor H. Villar, Juan F. Santibanez

“…Tumor-associated macrophages (TAMs) are the most abundant innate immune cells in the tumor microenvironment (TME). …”
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Vitamin D Potentiates the Inhibitory Effect of MicroRNA-130a in Hepatitis C Virus Replication Independent of Type I Interferon Signaling Pathway by Xiaoqiong Duan, Yujuan Guan, Yujia Li, Shan Chen, Shilin Li, Limin Chen

“…Our previous study established that miR-130a inhibits HCV replication by restoring the host innate immune response. We aimed to determine whether there is additive inhibitory effect of calcitriol and miR-130a on HCV replication. …”
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Far beyond Phagocytosis: Phagocyte-Derived Extracellular Traps Act Efficiently against Protozoan Parasites In Vitro and In Vivo by Liliana M. R. Silva, Tamara Muñoz-Caro, Rafael A. Burgos, Maria A. Hidalgo, Anja Taubert, Carlos Hermosilla

“…The formation of extracellular traps (ETs) by activated mononuclear phagocytes is meanwhile well accepted as an effector mechanism of the early host innate immune response acting against microbial infections. …”
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Characteristics of Plasmacytoid Dendritic Cell and CD4+ T Cell in HIV Elite Controllers by Jean-Philippe Herbeuval, Nikaïa Smith, Jacques Thèze

“…Controllers represent a heterogeneous population; we describe in this paper some common characteristics concerning innate immune response and CD4+ T cells of HIV controllers.…”
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Signaling Pathway of Nucleotide-Binding Oligomerization Domain-Containing Protein 1 and Potential Therapeutic Targets for Regulating the Gut Microbiota of Individuals with Gallston... by Sanjana Murali, Nandini Krishnamurthy, R. B. Devi Krishna, Shanthi Vijayaraghavan, S. Rajesh Kumar, Andrea Mary Francis

“…The essential receptor through which the innate immune system detects bacterial components and controls inflammation, namely, nucleotide-binding oligomerization domain-containing protein 1 (NOD1), is a major participant in the interaction. …”
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The Effect of Immunosuppressive Drugs on MDSCs in Transplantation by Fan Yang, Yang Li, Qian Zhang, Liang Tan, Longkai Peng, Yong Zhao

“…Myeloid-derived suppressor cells (MDSCs) are a group of innate immune cells that regulates both innate and adaptive immune responses. …”
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