The Impact of Farnesoid X Receptor Activation on Intestinal Permeability in Inflammatory Bowel Disease by Maja Stojancevic, Karmen Stankov, Momir Mikov

“…The development and investigation of FXR agonists provide strong support for the regulatory role of FXR in mucosal innate immunity. Activation of FXR in the intestinal tract decreases the production of proinflammatory cytokines such as interleukin (IL) 1-beta, IL-2, IL-6, tumour necrosis factor-alpha and interferon-gamma, thus contributing to a reduction in inflammation and epithelial permeability. …”
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microRNAs as a New Mechanism Regulating Adipose Tissue Inflammation in Obesity and as a Novel Therapeutic Strategy in the Metabolic Syndrome by Qian Ge, Sonia Brichard, Xu Yi, QiFu Li

“…Recently, a growing body of evidence supports the role of miRNAs as a new important inflammatory mediator by regulating both the adaptive and innate immunity. This review will focus on the implication of miRNAs in white AT inflammation in obesity, and will also highlight the potential of miRNAs as targets for therapeutic intervention in MS as well as the challenges lying in miRNA-targeting therapeutics.…”
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Role of Toll-Like Receptors and Their Downstream Molecules in the Development of Nonalcoholic Fatty Liver Disease by Kouichi Miura, Ekihiro Seki, Hirohide Ohnishi, David A. Brenner

“…Activation of innate immunity is associated with the development of liver disease, including non-alcoholic fatty liver disease (NAFLD). …”
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NK Cell Subtypes as Regulators of Autoimmune Liver Disease by Guohui Jiao, Bangmao Wang

“…As major components of innate immunity, NK cells not only exert cell-mediated cytotoxicity to destroy tumors or infected cells, but also act to regulate the functions of other cells in the immune system by secreting cytokines and chemokines. …”
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Selected Mechanisms of Action of Bacteriophages in Bacterial Infections in Animals by Renata Urban-Chmiel, Ewelina Pyzik

“…Due to their complex protein structure, phages can also directly or indirectly modulate immune processes, including innate immunity, by modulating phagocytosis and cytokine reactions, as well as acquired immunity, by producing antibodies and activating effector cells. …”
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Essential Role of Zinc and Zinc Transporters in Myeloid Cell Function and Host Defense against Infection by Muna Sapkota, Daren L. Knoell

“…In this review, we will discuss the most recent developments regarding zinc’s role in innate immunity and protection against pathogen invasion.…”
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IL-17A and Th17 Cells in Lung Inflammation: An Update on the Role of Th17 Cell Differentiation and IL-17R Signaling in Host Defense against Infection by Hsing-Chuan Tsai, Sharlene Velichko, Li-Yin Hung, Reen Wu

“…IL-17A acts on nonimmune cells in infected tissues to strengthen innate immunity by inducing the expression of antimicrobial proteins, cytokines, and chemokines. …”
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Fagonia indica Repairs Hepatic Damage through Expression Regulation of Toll-Like Receptors in a Liver Injury Model by Fareeha Azam, Nadeem Sheikh, Gibran Ali, Asima Tayyeb

“…Furthermore, a significant expression regulation of innate immunity components such as toll-like receptors 4 and 9 and MyD-88 was observed suggesting an immune regulatory role of the plant in curing liver injury. …”
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Mechanisms of allorecognition and xenorecognition in transplantation by Il Hee Yun, Jaeseok Yang

“…Advances in our understanding of the recognition mechanisms of adaptive and innate immunity against allogeneic and xenogeneic antigens may improve our understanding of graft rejection.…”
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Peptidylarginine Deiminase 2 in Murine Antiviral and Autoimmune Antibody Responses by Aisha M. Mergaert, Michael F. Denny, Brock Kingstad-Bakke, Mandar Bawadekar, S. Janna Bashar, Thomas F. Warner, Marulasiddappa Suresh, Miriam A. Shelef

“…The peptidylarginine deiminases (PADs) and the citrullinated proteins that they generate have key roles in innate immunity and rheumatoid arthritis, an inflammatory arthritis with antibodies that target citrullinated proteins. …”
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Fine-tuning SLE treatment: the potential of selective TYK2 inhibition by Yoshiya Tanaka, Shingo Nakayamada, Yurie Satoh-Kanda

“…In systemic lupus erythematosus (SLE), adaptive immunity is activated by the stimulation of innate immunity, leading to the development of autoreactive T cells and activation and differentiation of B cells. …”
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Human Herpesviridae Methods of Natural Killer Cell Evasion by Carl I. Odom, David C. Gaston, James M. Markert, Kevin A. Cassady

“…As evidence emerges about the role of innate immunity and natural killer (NK) cells in the control of herpesvirus infection, evidence of viral methods of innate immune evasion grows as well. …”
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Leukocyte Production of Inflammatory Mediators Is Inhibited by the Antioxidants Phloretin, Silymarin, Hesperetin, and Resveratrol by Jezrom B. Fordham, Afsar Raza Naqvi, Salvador Nares

“…Recognition of conserved pathogen-associated molecular patterns is a crucial component of innate immunity to Gram-negative bacteria such as Escherichia coli, as well as the periodontal pathogen Aggregatibacter actinomycetemcomitans. …”
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The Four Pillars for Successful Regenerative Therapy in Endodontics: Stem Cells, Biomaterials, Growth Factors, and Their Synergistic Interactions by C. Brizuela, George T.-J. Huang, A. Diogenes, T. Botero, M. Khoury

“…The regenerated dental pulp will recover the protective mechanisms including innate immunity, tertiary dentin formation, and pain sensitivity. …”
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Macrophages, Inflammation, and Tumor Suppressors: ARF, a New Player in the Game by Paqui G. Través, Alfonso Luque, Sonsoles Hortelano

“…The interaction between tumor progression and innate immune system has been well established in the last years. …”
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Hib Vaccines: Past, Present, and Future Perspectives by Adi Essam Zarei, Hussein A. Almehdar, Elrashdy M. Redwan

“…While earlier developments of adjuvants created effective products, there is still a need to create new generations, rationally designed based on recent discoveries in immunology, mainly in innate immunity. Many factors may play a role in the immunogenicity of Hib conjugate vaccines, such as the polysaccharides and proteins carrier used in vaccine construction, as well as the method of conjugation. …”
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Deciphering the Multifaceted Relationship between Oncolytic Viruses and Natural Killer Cells by Christopher A. Alvarez-Breckenridge, Jianhua Yu, Balveen Kaur, Michael A. Caligiuri, E. Antonio Chiocca

“…NK cells are a key component of innate immunity that mediates antiviral immunity while also coordinating tumor clearance. …”
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Nonprofessional Phagocytosis Can Facilitate Herpesvirus Entry into Ocular Cells by Vaibhav Tiwari, Deepak Shukla

“…Phagocytosis is a major mechanism by which the mediators of innate immunity thwart microbial infections. Here we demonstrate that human herpesviruses may have evolved a common mechanism to exploit a phagocytosis-like entrapment to gain entry into ocular cells. …”
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Inborn errors of immunity (primary immunodeficiencies) by Vy H. D. Kim, Julia E. M. Upton, Beata Derfalvi, Kyla J. Hildebrand, Christine McCusker

“…., combined or humoral immunodeficiencies) or of innate immunity (e.g., phagocyte and complement disorders). …”
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Toll-Like Receptors in Natural Killer Cells and Their Application for Immunotherapy by Ji-Yoon Noh, Suk Ran Yoon, Tae-Don Kim, Inpyo Choi, Haiyoung Jung

“…Innate immunity represents the first barrier for host defense against microbial infection. …”
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