Episiotomies and obstetric anal sphincter injuries following a restrictive episiotomy policy in France: An analysis of the 2010, 2016, and 2021 National Perinatal Surveys. by Raphaele Houlbracq, Camille Le Ray, Béatrice Blondel, Nathalie Lelong, Anne Alice Chantry, Thomas Desplanches, ENP2021 Study Group

“…We aimed to assess variations in the prevalence of both episiotomy and obstetric anal sphincter injury (OASI) from the 2010, 2016, and 2021 National Perinatal Surveys.…”
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Adalimumab (TNFα Inhibitor) Therapy Exacerbates IgA Glomerulonephritis Acute Renal Injury and Induces Lupus Autoantibodies in a Psoriasis Patient by S. S. Wei, R. Sinniah

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Acute Kidney Injury Complicating Critical Forms of COVID-19: risk Factors and Prognostic Impact [version 3; peer review: 2 approved] by Ghadhoune Hatem, Yosra Yahia, Olfa Hammami, Hend Allouche, Insaf Trabelsi, Jihene Guissouma, Hana Ben Ali

Subjects: “…acute kidney injury…”
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A high fraction of inspired oxygen does not mitigate atelectasis-induced lung tissue hypoxia or injury in experimental acute respiratory distress syndrome by Kentaro Tojo, Takuya Yazawa

“…Moreover, changes in FIO2 did not significantly affect lung injury or inflammation. In contrast, hypoxemia observed in the low FIO2 group caused injury to organs other than the lungs. …”
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ROS-ERK Pathway as Dual Mediators of Cellular Injury and Autophagy-Associated Adaptive Response in Urinary Protein-Irritated Renal Tubular Epithelial Cells by Jian-kun Deng, Xueqin Zhang, Hong-luan Wu, Yu Gan, Ling Ye, Huijuan Zheng, Zebing Zhu, Wei Jing Liu, Hua-feng Liu

“…What is more, ERK inhibitor U0126 could decrease the release of neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), and the number of apoptotic cells induced by urinary proteins, indicating the damaging effects of ERK pathway in mediating cellular injury and apoptosis in HK-2 cells. …”
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Effects of N-Acetylcysteine and N-Acetylcysteine Amide on Erythrocyte Deformability and Oxidative Stress in a Rat Model of Lower Extremity Ischemia-Reperfusion Injury by Gokhan Erol, Hakan Kartal, Faruk M. Comu, Erdem Cetin, Ertan Demirdas, Huseyin Sicim, Celal S. Unal, Celalettin Gunay, Bilgehan S. Oz, Cengiz Bolcal

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Transplanted Adult Neural Stem Cells Express Sonic Hedgehog In Vivo and Suppress White Matter Neuroinflammation after Experimental Traumatic Brain Injury by Genevieve M. Sullivan, Regina C. Armstrong

“…Neural stem cells (NSCs) delivered intraventricularly may be therapeutic for diffuse white matter pathology after traumatic brain injury (TBI). To test this concept, NSCs isolated from adult mouse subventricular zone (SVZ) were transplanted into the lateral ventricle of adult mice at two weeks post-TBI followed by analysis at four weeks post-TBI. …”
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Neurocognitive and Neuromuscular Rehabilitation Techniques after ACL Injury, Part 1: Optimizing Recovery in the Acute Post-Operative Phase- A Clinical Commentary by Kevin E. Wilk, Morgan Ivey, Zachary M. Thomas, Lewis Lupowitz

“…Anterior cruciate ligament (ACL) injury rates are on the rise, despite improved surgical techniques and prevention programs. …”
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Hypothermia regulates mitophagy and apoptosis via PINK1/Parkin-VDAC 3 signaling pathway during oxygen-glucose deprivation/recovery injury by Luying Zhang, Song Yang, Hao Cui, Chenchen Hang, Xingsheng Wang, Le An, Zhenyu Shan, Zhen Liang, Rui Shao, Ziren Tang

Subjects: “…Post-cardiac arrest brain injury…”
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NF-κB Inhibition after Cecal Ligation and Puncture Reduces Sepsis-Associated Lung Injury without Altering Bacterial Host Defense by Hui Li, Wei Han, Vasilly Polosukhin, Fiona E. Yull, Brahm H. Segal, Can-Mao Xie, Timothy S. Blackwell

“…In addition, mice treated with CLP+BMS had minimal histological evidence of lung injury and normal wet-dry ratios, indicating protection from acute lung injury. …”
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Exploring therapeutic mechanisms of Chuan Huang Fang-II in the treatment of acute kidney injury on chronic kidney disease patients from the perspective of lipidomics by Ling Chen, Qian Wang, Tonglu Li, Lejia Li, Chen Wang, Bing Xu, Xuezhong Gong

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Protective role of vitamin D receptor against mitochondrial calcium overload from PM2.5-Induced injury in renal tubular cells by Mengqiu Lu, Zishun Zhan, Dan Li, Hengbing Chen, Aimei Li, Jing Hu, Zhijun Huang, Bin Yi

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Ethyl Lactate Ameliorates Hepatic Steatosis and Acute‐on‐Chronic Liver Injury in Alcohol‐Associated Liver Disease by Inducing Fibroblast Growth Factor 21 by Yang Jiang, Shuang Wei, Shiming Shen, Yuxiao Liu, Weitong Su, Dong Ding, Zengpeng Zheng, Haokai Yu, Tingting Zhang, Qiuli Yang, Jiuxiang Zhao, Yi Shen, Xia Fang, Liangcai Lin, Dongguang Xiao, Aoyuan Cui, Qin Wan, Yadong Zhang, Yu Li, Cuiying Zhang

“…Importantly, FGF21 deficiency in hepatocytes blocks the downregulation of lipogenesis by ethyl lactate and exacerbates alcoholic steatosis, inflammation and liver injury. The regulatory mechanism is discussed during the pathophysiological conditions and suggests new lines of research into the therapeutic use of a foodborne small molecule ethyl lactate.…”
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Targeting Oxidative Stress Injury after Ischemic Stroke in Conscious Rats: Limited Benefits with Apocynin Highlight the Need to Incorporate Long Term Recovery by Robert M. Weston, Bin Lin, Gregory J. Dusting, Carli L. Roulston

“…This study evaluated the effects of apocynin, a known antioxidant and inhibitor of Nox2 NADPH, on neuronal injury and cell-specific responses to stroke induced in the conscious rat. …”
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Kaempferol protects against high-salt-induced hypertension and vascular endothelial injury by inhibiting ferroptosis through the ATF4/ACSL4 pathway by Qiuer Liang, Minghao Chen, Guangtian Chen, Pengli Xu, Lai Kwan Lam, Pengcheng Xie, Ting Xie, Wanqing Tu, Tianhao Liu, Xiaopeng Peng, Haoyao Yuan, Liguo Chen, Ya Xiao

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Cholinergic Elicitation Prevents Ventricular Remodeling via Alleviations of Myocardial Mitochondrial Injury Linked to Inflammation in Ischemia-Induced Chronic Heart Failure Rats by Yang Zhao, Huaxin Sun, Kai Li, Luxiang Shang, Xiaoyan Liang, Hang Yang, Zhenyu Dong, Jiasuoer Xiaokereti, Shuai Shang, Qina Zhou, Xianhui Zhou, Ling Zhang, Yanmei Lu, Baopeng Tang

“…Cholinergic anti-inflammatory pathway (CAP) is implicated in cardioprotection in chronic heart failure (CHF) by downregulating inflammation response. Mitochondrial injuries play an important role in ventricular remodeling of the CHF process. …”
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Association between normal saline infusion volume in the emergency department and acute kidney injury in heat stroke patients: a multicenter retrospective study by Lan Chen, Junlu Zhao, Liyun Lu, Zhumei Gong, Shuying Xu, Xiaoling Yang, Yuping Zhang, Xiuqin Feng

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Predictive model of acute kidney injury in critically ill patients with acute pancreatitis: a machine learning approach using the MIMIC-IV database by Shengwei Lin, Wenbin Lu, Ting Wang, Ying Wang, Xueqian Leng, Lidan Chi, Peipei Jin, Jinjun Bian

Subjects: “…Acute kidney injury…”
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Traumatic Penetrating Neck Injury with Right Common Carotid Artery Dissection and Stenosis Effectively Managed with Stenting: A Case Report and Review of the Literature by Seidu A. Richard, Chang Wei Zhang, Cong Wu, Wang Ting, Xie Xiaodong

“…Introduction. Penetrating neck injuries (PNI) are common and associated with arterial and other neuronal injuries. …”
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Impact of mechanical ventilation on severe acute kidney injury in critically ill patients with and without COVID-19 – a multicentre propensity matched analysis by Fabian Perschinka, Timo Mayerhöfer, Teresa Engelbrecht, Alexandra Graf, Paul Zajic, Philipp Metnitz, Michael Joannidis

“…Abstract Background Acute kidney injury (AKI) is common in critically ill patients and is associated with increased morbidity and mortality. …”
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