Therapeutic effects of traditional Chinese medicine Hua-Feng-Dan in a rat model of ischemic stroke involve renormalization of gut microbiota by Xiaoxia He, Xiaofeng Yuan, Qilin Shu, Yayang Gao, Youli Chen, Yao Liu, Yao Liu, Yao Liu, Jian Xu, Jian Xu, Jian Xu, Yongping Zhang, Yongping Zhang, Yongping Zhang, Guoqiong Cao, Guoqiong Cao, Guoqiong Cao

“…Our results suggest that Hua-Feng-Dan may mitigate ischemic stroke injury by renormalizing gut microbiota and restoring gut barrier function, gut metabolism, thereby helping to alleviate inflammatory, neurological damage, and brain metabolic disorders.…”
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Green biosynthetic silver nanoparticles from Ageratum conyzoides as multifunctional hemostatic agents: Combining hemostasis, antibacterial, and anti-inflammatory properties for eff... by Yang Li, Yinfeng Tan, Huange Zhao, Shiting Chen, Azadeh Nilghaz, Rong Cao, Songlin Zhou

“…Furthermore, the hemostatic efficacy of AC-AgNPs is demonstrated in mouse models of tail amputation and liver injury, where AC-AgNPs significantly reduce the amount of blood loss and the bleeding time. …”
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Local Recurrence of Rectal Cancer After Transanal Total Mesorectal Excision and Risk Factors: A Nationwide Multicenter Cohort Study in Japan by Takeru Matsuda, MD, PhD, Ichiro Takemasa, MD, PhD, Hideki Endo, MD, MPH, Shinichiro Mori, MD, PhD, Suguru Hasegawa, MD, PhD, Koya Hida, MD, PhD, Takuya Tokunaga, MD, PhD, Keitaro Tanaka, MD, PhD, Toshiki Mukai, MD, PhD, Jun Watanabe, MD, PhD, Junichiro Kawamura, MD, PhD, Kei Kimura, MD, PhD, Yoshihiro Kakeji, MD, PhD, Masahiko Watanabe, MD, PhD, Seiichiro Yamamoto, MD, PhD, Takeshi Naitoh, MD, PhD, Ta-Ta-Mi study group collaboratives in Japan Society of Laparoscopic Colorectal Surgery

“…There was 1 urethral injury (0.1%). A positive resection margin (R1) was seen in 42 patients (5.9%). …”
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FAM134B-mediated endoplasmic reticulum autophagy protects against cisplatin-induced spiral ganglion neuron damage by Fan Wang, Yue Xu, Yajie Wang, Qian Liu, Yanan Li, Weiwei Zhang, Huiming Nong, Junhong Zhang, Hao Zhao, Huaqian Yang, Lingchuan Guo, Jianfeng Li, Jianfeng Li, Hong Li, Qianqian Yang

“…What’s more, knockdown the expression of FAM134B in SGNs made SGNs more vulnerable to cisplatin-induced injury.DiscussionThe present study revealed the expression pattern of FAM134B in C57BL/6 murine SGNs for the first time. …”
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PCSK9 affects vascular senescence through the SIRT1 pathway by Yuqin Wang, Shaoqing Cao, Zhangyu Wang, Chengsi Li, Jiangping Ye, Yehong Liu, Tianhui Jin, Yuting Zhou, Wentao Su, Gangjun Zong

“…However, the mechanism underlying vascular injury is not fully understood. In the present study, the effect of proprotein convertase subtilin-type kexin 9 (PCSK9) inhibitors on the senescent state of human umbilical vein endothelial cells (HUVECs) and on senescent mice and lipopolysaccharides (LPS) were assessed. …”
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Intranasal delivery of hMSC-derived supernatant for treatment of ischemic stroke by inhibiting the pro-inflammatory polarization of neutrophils by Yixiang Jiang, Ning Wang, Jingyi Liu, Haoran Ren, Wenkang Jiang, Yanting Lei, Xidan Fu, Miao Hao, Xiujuan Lang, Yumei Liu, Xijun Liu, Rui Li, Hulun Li

“…Conclusions Intranasal delivery of hMSC-L and hMSC-M effectively ameliorates cerebral ischemic injury in mice, comparable to traditional administration routes like intravenous delivery. …”
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Effects of prolonged NaHCO3 exposure on the serum immune function, antioxidant capacity, intestinal tight junctions, microbiota, mitochondria, and autophagy in crucian carp (Carass... by Jia Liu, Faye Zhang, Zihao Yan, Zhengyao Guo, Yuqian Lu, Baolan Yao, Yuehong Li, Wenfa Lv

“…The results of this study have characterized the molecular mechanisms of intestinal injury in crucian carp caused by NaHCO3 stress, and thus provide empirical support for aquaculture in saline-alkali waters.…”
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Efficacy and Safety of a Novel Low-Dose Water-Dispersible Turmeric Extract in the Management of Knee Osteoarthritis: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial by Thanawala S, Shah R, Alluri KV, Bhupathiraju K, Prasad N, Agarwal Y

“…Study endpoints included assessment of changes from baseline to day 90 in pain intensity (visual analog scale [VAS], knee injury and osteoarthritis outcome score [KOOS]), inflammatory biomarkers, and safety profile. …”
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The development of a food-group, tree classification method and its use in exploring dietary associations with metabolic dysfunction-associated Steatotic liver disease (MASLD) and... by Amina A. Alawadi, Amrita Vijay, Jane I. Grove, Moira A. Taylor, Guruprasad P. Aithal

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Assessing the feasibility of measuring residents’ quality of life in English care homes and the construct validity and internal consistency of measures completed by staff proxy: a... by Claire Goodman, Julienne Meyer, Karen Spilsbury, Barbara Hanratty, Rachael Carroll, Adam L Gordon, Gizdem Akdur, Anne Killett, Jennifer Burton, Ann-Marie Towers, Stacey Rand, Nick Smith, Sinead Palmer, Stephen Allan, Lucy Anne Webster

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Cholangiocyte organoids for disease, cancer, and regenerative medicine by Munemasa Nagao, Akihisa Fukuda, Hirotaka Kashima, Sho Matsuyama, Kei Iimori, Shinnosuke Nakayama, Kenta Mizukoshi, Munenori Kawai, Go Yamakawa, Mayuki Omatsu, Mio Namikawa, Tomonori Masuda, Yukiko Hiramatsu, Yu Muta, Takahisa Maruno, Yuki Nakanishi, Tatsuaki Tsuruyama, Hiroshi Seno

“…Biliary duct disorders include cholangitis, neoplasms, and injury. However, the underlying mechanisms are not fully understood. …”
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Cardiac repair using regenerating neonatal heart tissue-derived extracellular vesicles by Hanjing Li, Yining Liu, Yuqing Lin, Sijia Li, Chenlu Liu, Ao Cai, Wei Li, Wanyu Zhang, Xinlu Gao, Zhongyu Ren, Haoyu Ji, Yang Yu, Xiuxiu Wang, Wenya Ma, Ning Wang, Dan Zhao, Tianlong Li, Yu Liu, Benzhi Cai

“…Abstract Neonatal mammalian hearts are capable of regenerating by inducing cardiomyocyte proliferation after injury. However, this regenerative capability in adult mammalian hearts almost disappears. …”
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improving Pain mAnagement for childreN and young people attendeD by Ambulance (PANDA): protocol for a realist review. [version 3; peer review: 2 approved, 1 approved with reservati... by Paul Leighton, Georgette Eaton, Georgie Nicholls, Kacper Sumera, Marishona Ortega, Jessica Hodgson, Michael Baliousis, Aloysius Niroshan Siriwardena, Despina Laparidou, Bill Lord, Sarah Redsell, Gregory Adam Whitley, Tatiana Bujor

“…Approximately 20% of these suffer acute pain caused by illness or injury. Pain is a highly complex sensory and emotional experience. …”
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4-Octyl itaconate inhibits synovitis in the mouse model of post-traumatic osteoarthritis and alleviates pain by Yu-Zhen Tang, Wan Chen, Bao-Yun Xu, Gang He, Xiu-Cheng Fan, Kang-Lai Tang

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Effectiveness of advanced cardiovascular life support in hyperkalemic cardiac arrest: A randomized experimental study in pigs by Najmiddin Mamadjonov, Wan Young Heo, Kyung Woon Jeung, Yong Hun Jung, Hyoung Youn Lee, Seok Jin Ryu, Byung Kook Lee, Yong Soo Cho, Tag Heo

“…The remaining 20 animals had no internal organ injury due to cardiopulmonary resuscitation and were included in the study. …”
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Neutrophil elastase inhibitor (Sivelestat) in the treatment of acute respiratory distress syndrome induced by COVID-19: a multicenter retrospective cohort study by Yuting Li, Jianjun Zhao, Jiahui Wei, Yanhong Zhang, Haitao Zhang, Ying Li, Ting Liao, Yang Hu, Bo Yuan, Xinmei Zhang, Wanyan Liu, Changgang Liu, Qingsong Cui, Shunzi Wu, Hongmei Jiang, Wenge Liu, Weiheng Liu, Hongguang Xu, Gang Li, Yuyan Cai, Liting Chen, Bingwei Chen, Dong Zhang

“…In 158 patients matched on the propensity for treatment, receipt of sivelestat was associated with improved oxygenation, decreased Murray lung injury score, increased non-mechanical ventilation time within 28 days, increased alive and ICU-free days within 28 days (HR, 1.85; 95% CI 1.29 to 2.64; log-rank p < 0.001), shortened ICU stay and ultimately improved survival (HR, 2.78; 95% CI 1.32 to 5.88; log-rank p = 0.0074). …”
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Risk factors associated with degenerative glenohumeral osteoarthritis by Ravi Prakash, Nitin B Jain, Ziyi Chen, Folefac D Atem, Michael S Khazzam, Rashmi Pathak, Daniel Tai, Ursa BezanPetric, Estefanie Garduno Rapp

“…In univariate analysis, significant associations with GH OA were found for increasing age (&gt;40 to ≤50: OR 3.29, 95% CI 2.44 to 4.45; &gt;50 to ≤60: OR 5.90, 95% CI 4.49 to 7.77; &gt;60 to ≤70: OR 12.18, 95% CI 9.22 to 16.08 and &gt;70: OR 16.54, 95% CI 12.47 to 21.94), higher BMI (≤19: OR 1.44, 95% CI 1.01 to 2.04; &gt;25 to ≤30: OR 1.57, 95% CI 1.32 to 1.86; &gt;30 to ≤35: OR 1.85, 95% CI 1.54 to 2.22 and &gt;35: OR 1.77, 95% CI 1.28 to 2.45), prior shoulder injury (OR 1.30; 95% CI 1.12 to 1.50), shoulder surgery history (OR 0.71; 95% CI 0.57 to 0.87), shoulder pain at night (OR 1.35; 95% CI 1.07 to 1.70) and hypertension (OR 0.70; 95% CI 0.60 to 0.81). …”
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The prevalence of hand pathology in regional orthopaedic hospitals in KwaZulu-Natal: A cross-sectional study by S Thabit, M O'Connor, W Parker, T Mashishi, K Moodley, A Peer, K Matanzima, A J de Villiers, O Adewusi, R Aboobaker, A Rocher

“…Distal radius (DR) fractures were the most common hand injury (46%, 188/406) and a large proportion of trauma to the bony elements of the hand were open injuries (23%, 93/406). …”
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An atlas of neuropathic pain-associated molecular pathological characteristics in the mouse spinal cord by Fu-Lu Dong, Lina Yu, Pei-Da Feng, Jin-Xuan Ren, Xue-Hui Bai, Jia-Qi Lin, De-Li Cao, Yu-Tao Deng, Yan Zhang, Hui-Hui Shen, Hao Gong, Wen-Xing Sun, Dong-Qiu Chi, Yixiao Mei, Longfei Ma, Ming-Zhe Yin, Meng-Na Li, Peng-Fei Zhang, Nan Hu, Bing-Lin Zhou, Ying Liu, Xuan-Jie Zheng, Yi-Fan Chen, Da Zhong, Yuan-Xiang Tao, Min Yan, Bao-Chun Jiang

“…Abstract Peripheral nerve injury (PNI)-induced neuropathic pain (NP) is a severe disease with high prevalence in clinics. …”
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Emergency volunteering willingness and participation: a cross-sectional survey of residents in northern China by Hong Sun, Chaojie Liu, Wei Xu, Ye Li, Qunhong Wu, Lijun Gao, Zheng Kang, Yanhua Hao, Ning Ning, Mingli Jiao, Libo Liang, Yu Cui, Mengli Shi, Chao Liang, Xiaowen Zhao, Jie Fei, Qiuyu Wei, Ming Yi

“…Higher levels of willingness to volunteer and participation in volunteering were found in those who resided in rural areas (OR=1.308 (1.064 to 1.608) for willingness; OR=1.518 (1.208 to 1.908) for participation), had stronger community attachment (OR=1.720 (1.429 to 2.069) for willingness; OR=1.547 (1.266 to 1.890) for participation), had higher recognition of responsibility (OR=1.981 (1.498 to 2.619) for willingness; OR=1.517 (1.177 to 1.955) for participation), demonstrated preparedness behaviour (OR=1.714 (1.424 to 2.064) for willingness; OR=1.391 (1.151 to 1.681) for participation) and were covered by injury insurance (OR=1.335 (1.102 to 1.619) for willingness; OR=1.822 (1.500 to 2.214) for participation). …”
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