Lipid mediators in post-mortem brain samples from patients with Alzheimer's disease: A systematic review by Aidan D. Tyrrell, Giulia Cisbani, Mackenzie E. Smith, Chuck T. Chen, Yue-Tong Chen, Raphael Chouinard-Watkins, Kathryn E. Hopperton, Ameer Y. Taha, Richard P. Bazinet

“…A proposed contributor to Alzheimer's disease (AD) pathology is the induction of neuroinflammation due to tau and beta-amyloid protein accumulation causing neuronal injury and dysfunction. Dysregulation of lipid mediators derived from polyunsaturated fatty acids may contribute to this inflammatory response in the brain of patients with AD, yet the literature has not yet been systematically reviewed. …”
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Incomplete remyelination via therapeutically enhanced oligodendrogenesis is sufficient to recover visual cortical function by Gustavo Della-Flora Nunes, Lindsay A. Osso, Johana A. Haynes, Lauren Conant, Michael A. Thornton, Michael E. Stockton, Katherine A. Brassell, Amanda Morris, Yessenia I. Mancha Corchado, John A. Gaynes, Anthony R. Chavez, Michaelanne B. Woerner, Deidre A. MacKenna, Aryan Alavi, Anne Danks, Alon Poleg-Polsky, Rohan Gandhi, Jeffrey A. Vivian, Daniel J. Denman, Ethan G. Hughes

“…Abstract Myelin loss induces neural dysfunction and contributes to the pathophysiology of neurodegenerative diseases, injury conditions, and aging. Because remyelination is often incomplete, better understanding endogenous remyelination and developing remyelination therapies that restore neural function are clinical imperatives. …”
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Gap junction intercellular communications regulates activation of SARM1 and protects against axonal degeneration by Wen Jie Zhu, Jun Liu, Wan Hua Li, Zhi Ying Zhao, Chongquan Huang, Jian Yuan Yang, Hon Cheung Lee, Yong Juan Zhao

“…Our results demonstrate a novel intercellular regulation mechanism of SARM1 and reveal a protective role of healthy tissue against AxD induced by injury or neuroinflammation.…”
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The immunoregulatory effects of scoparone on immune-mediated inflammatory diseases by Feifei Qiu, Jingru Lin, Xiaofei Huang, Bin Yang, Weihui Lu, Weihui Lu, Zhenhua Dai, Zhenhua Dai

“…Therefore, this review not only summarizes the immunomodulatory and therapeutic effects of SCO on immune-based inflammatory diseases (IMIDs), such as inflammatory bowel disease, osteoarthritis, allergic rhinitis, acute lung injury, type 1 diabetes and neuroinflammatory diseases etc., but also provides a comprehensive summary of its therapeutic effects on hepatic diseases, including non-alcoholic steatohepatitis, fulminant hepatic failure and hepatic fibrosis. …”
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Predictors of direct oral anticoagulant concentrations in the trauma population by Laura Adams, Alan M Smith, Louis Perkins, Dmitri Lerner, Jarrett Santorelli, Leslie Kobayashi

“…The population was 53% woman, with median age of 78 years, and median Injury Severity Score of 5. In total, 39% of patients had therapeutic and 20% had supratherapeutic anti-Xa levels. …”
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Patients with chronic heart failure and predominant left atrial versus left ventricular myopathy by Xuanyi Jin, Wan Ting Tay, Dinna Soon, David Sim, Seet Yoong Loh, Sheldon Lee, Fazlur Jaufeerally, Lieng Hsi Ling, A. Mark Richards, Adriaan A. Voors, Carolyn S. P. Lam, Joost P. van Melle

“…Conclusion While most patients with HF have balanced LA/LV myopathy, those with predominant LA myopathy are characterized by older age, more AF, more diabetes, higher circulating biomarkers of cardiac stress and injury, and worse outcomes.…”
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The role of homogenization cycles and Poloxamer 188 on the quality of mitochondria isolated for use in mitochondrial transplantation therapy by Ryosuke Takegawa, Kei Hayashida, Atsushi Murao, Yusuke Endo, Cyrus E. Kuschner, Jacob Kazmi, Eriko Nakamura, Ping Wang, Lance B. Becker

“…Abstract Mitochondrial transplantation (MTx) offers a promising therapeutic approach to mitigate mitochondrial dysfunction in conditions such as ischemia–reperfusion (IR) injury. The quality and viability of donor mitochondria are critical to MTx success, necessitating the optimization of isolation protocols. …”
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Emergency interventions for cardiogenic shock due to decompensated aortic stenosis: a systematic review and meta-analysis by Mauro Chiarito, Dario Bongiovanni, Evaldas Girdauskas, Bastian Wein, Eva Harmel, Tamer Owais, Stephanie Gladys Kühne, Andrea Patrignani, Sebastien Elvinger, Damyan Penev, Philip W Raake

“…Secondary endpoints were in-hospital mortality, 1-year mortality, bleeding, major vascular complications, myocardial infarction, stroke, incidence of pacemaker implantation, acute kidney injury and aortic regurgitation.Results Seventeen studies were included, totalling 2811 patients. …”
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Markers of Inflammation and Fibrosis in Alcoholic Hepatitis and Viral Hepatitis C by Manuela G. Neuman, Hemda Schmilovitz-Weiss, Nir Hilzenrat, Marc Bourliere, Patrick Marcellin, Cristhian Trepo, Tony Mazulli, George Moussa, Ankit Patel, Asad A. Baig, Lawrence Cohen

“…Proinflammatory cytokines’ responses to viral and/or toxic injury differed with the severity of liver inflammation. …”
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Effect of eHealth-delivered exercise programmes on balance in people aged 65 years and over living in the community: a systematic review and meta-analysis of randomised controlled... by Corneel Vandelanotte, Anne Tiedemann, Kim Delbaere, Stephanie Alley, Meghan Ambrens, Juliana S Oliveira, Quyen To

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Solo Sonographically Guided PCNL under Spinal Anesthesia: Defining Predictors of Success by Akbar Nouralizadeh, Hamid Pakmanesh, Abbas Basiri, Mohammad Aayanifard, Mohammad Hossein Soltani, Ali Tabibi, Farzaneh Sharifiaghdas, Seyed Amir Mohsen Ziaee, Naser Shakhssalim, Reza Valipour, Behzad Narouie, Mohammad Hadi Radfar

“…There was no cases of organ injury or death. Conclusion. Solo ultrasonographically guided PCNL under spinal anesthesia is feasible with an acceptable stone-free rate and complication rate.…”
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Gradual Increase of High Mobility Group Protein B1 in the Lungs after the Onset of Acute Exacerbation of Idiopathic Pulmonary Fibrosis by Masahito Ebina, Hiroyuki Taniguchi, Taku Miyasho, Shingo Yamada, Naoko Shibata, Hiromitsu Ohta, Shu Hisata, Shinya Ohkouchi, Tsutomu Tamada, Hidekazu Nishimura, Akitoshi Ishizaka, Ikuro Maruyama, Yoshinori Okada, Kondo Takashi, Toshihiro Nukiwa

“…To evaluate the roles of inflammatory mediators in acute exacerbation, the concentrations of high mobility group protein B1 (HMGB1), a chief mediator of acute lung injury, and 18 inflammatory cytokines were measured in the bronchoalveolar lavage fluid, serially sampled from seven IPF patients after the onset of acute exacerbation. …”
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A persona-based exploration of rabies post-exposure prophylaxis seeking behavior and its implication for communication strategic planning: Evidence from Thailand by Jitjayang Yamabhai, Patoo Cusripituck, Teerawan Mingbualuang, Nareerat Sangkachai, Wimwiga Sakchainanon, Chanatda Tungwongjulaniam, Onphirul Yurachai, Ratana Theerawat, Anuwat Wiratsudakul

“…Meanwhile, individuals who have a neutral inclination are more likely to contemplate getting vaccinated following a dog bite, particularly if the injury is substantial. Those with a negative trend demonstrate a notable lack of attention or concern toward preventing rabies. …”
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Neutrophil-to-Lymphocyte Ratio, Monocyte-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, and Mean Platelet Volume-to-Platelet Count Ratio as Biomarkers in Critically Ill and Inj... by Dragan Djordjevic, Goran Rondovic, Maja Surbatovic, Ivan Stanojevic, Ivo Udovicic, Tamara Andjelic, Snjezana Zeba, Snezana Milosavljevic, Nikola Stankovic, Dzihan Abazovic, Jasna Jevdjic, Danilo Vojvodic

“…Leukocyte and platelet counts were recorded upon fulfilling Sepsis-3 criteria and for traumatized Injury Severity Score > 25 points. Patients were divided into four subgroups: peritonitis, pancreatitis, trauma with sepsis, and trauma without sepsis. …”
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Diagnosis and Treatment of Sepsis in a Fourteen-year-old Patient: A case study of pulmonary inflammatory discharge without typical features of respiratory tract infection by Bartłomiej Żaczek, Jakub Kozłowski, Alicja Kamińska, Wojciech Kupczak, Kinga Bujak, Aleksandra Kocjan, Ismael Alsoubie, Natalie Papachristoforou, Wojciech Kaźmierski, Mateusz Ziomek, Paulina Lis, Marta Czubaj-Kowal

“…This article presents the case of a 14-year-old patient who was admitted to the Paediatric Unit due to a high fever (up to 42 degrees Celsius) lasting from five days and severe pain in the area of the lower ribs on the left side, at the site of an injury that occurred two weeks earlier. Conclusion. …”
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Assembly of Genetically Engineered Ionizable Protein Nanocage-based Nanozymes for Intracellular Superoxide Scavenging by Qiqi Liu, Zhanxia Gao, Xiangyun Zhang, Qiannan Duan, Yue Zhang, Adam C. Midgley, Li Jiao, Ruming Liu, Mingsheng Zhu, Deling Kong, Jie Zhuang, Xinglu Huang

“…The in vivo protective effects of these ionizable cascade nanozymes against cardiac oxidative injury are demonstrated in female mouse models of cardiac ischemia-reperfusion (IR). …”
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Gas-phase fractionation DDA promotes in-depth DIA phosphoproteome analysis by Zhiwei Tu, Yabin Li, Shuhui Ji, Shanshan Wang, Rui Zhou, Gertjan Kramer, Yu Cui, Fei Xie

“…We used GPF-DDA hybrid DIA phosphoproteomics to characterize lung tissue upon direct (smoke induced) and indirect (sepsis induced) acute lung injury (ALI) in mice. The differentially expressed phosphosites (DEPsites) in direct ALI were found in proteins related to mRNA processing and RNA. …”
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Jack Surgery: Reconstructing Collapsed Femoral Head in Association Research Circulation Osseous Stage III Osteonecrosis: A Series of 13 Cases by Ying Zhong, Yichen Gong, Shuaijie Lv, Wenxi Du, Xun Liu, Jianhua Zhang, Peijian Tong

“…No deep infection, fracture, osteotomy nonunion, nerve injury, deep vein thrombosis, pulmonary embolism, or other complications occurred. …”
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Tripterygium Glycosides Tablet Ameliorates Renal Tubulointerstitial Fibrosis via the Toll-Like Receptor 4/Nuclear Factor Kappa B Signaling Pathway in High-Fat Diet Fed and Streptoz... by Ze-jun Ma, Xiao-na Zhang, Li Li, Wei Yang, Shan-shan Wang, Xin Guo, Pei Sun, Li-ming Chen

“…Tripterygium glycosides tablet (TGT) is a Chinese traditional medicine that has been shown to protect podocytes from injury and reduce the proteinuria. The aim of this study was to assess the effect of TGT on renal tubulointerstitial fibrosis and its potential mechanism in high-fat diet fed and STZ-induced diabetic rats. …”
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Esophageal Endoscopic Submucosal Dissection Assisted by an Overtube with a Traction Forceps: An Animal Study by Ken Ohata, Kuangi Fu, Eiji Sakai, Kouichi Nonaka, Tomoaki Tashima, Yohei Minato, Akiko Ohno, Takafumi Ito, Yosuke Tsuji, Hideyuki Chiba, Makoto Yamawaki, Hideyuki Hemmi, Teruo Nakaya, Junichi Fukushima, Nobuyuki Matsuhashi

“…Histologically, muscular injury was more common among the C-ESD procedures (80% versus 13%, P=0.009). …”
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