Elevation of High-Mobility Group Protein Box-1 in Serum Correlates with Severity of Acute Intracerebral Hemorrhage by Yu Zhou, Kun-Lin Xiong, Sen Lin, Qi Zhong, Feng-Lin Lu, Hong Liang, Jing-Cheng Li, Jing-Zhou Wang, Qing-Wu Yang

“…Our findings suggest that HMGB1 may play an essential role in the ICH-caused inflammatory injury.…”
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Return to Play Assessment After Lateral Ankle Sprains – German Male Elite Youth Football (Soccer) Academy Baseline Data by Zacharias Flore, Götz Welsch, Hendrik Bloch

“…# Background Lateral ankle sprain (LAS) is one of the most common types of injury in football (soccer). Normative baseline data of performance tests for Return to Play (RTP) decision are still lacking…”
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Resveratrol Induces Differentiation of Human Umbilical Cord Mesenchymal Stem Cells into Neuron-Like Cells by Li Guo, Liang Wang, Li Wang, Shi Yun-peng, Jing-jing Zhou, Zongmao Zhao, De-Pei Li

“…The natural polyphenol resveratrol benefits patients with many diseases including ischemic brain injury. We hypothesize that resveratrol induces differentiation of hUC-MSCs into neuron-like cells. …”
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Does the AO/OTA fracture classification dictate the anesthesia modality for the surgical management of unstable distal radius fractures? A retrospective cohort study in 127 patient... by Sascha Halvachizadeh, Merav Dreifuss, Thomas Rauer, Anne Kaiser, Dirk Ubmann, Hans-Christoph Pape, Florin Allemann

“…Conclusion Solely classifying distal radius fractures does not dictate anesthesia choice. Complexity of injury, anticipated surgery duration, less use of tourniquet, and rehabilitation duration may guide regional anesthesia utilization over GA in distal radius fracture fixation.…”
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Ankle Arthrodesis: Epidemiology, Etiology, and Complications in Diabetic vs Nondiabetic Patients Using US Nationwide Inpatient Sample Data by Assil Mahamid MD, David Maman MD, Summer Sofer, Mykhail Pavlenko MD, Amr Mansour MD, Marah Hodruj MD, Yaron Berkovich MD, Eyal Behrbalk MD

“…Multivariate logistic regression revealed that diabetes mellitus (DM) was significantly associated with increased risks of blood loss (odds ratio [OR] 1.59, 95% CI 1.23-2.05, P = .004), infection (OR 3.12, 95% CI 2.55-3.82, P < .001), heart failure (OR 1.35, 95% CI 1.06-1.73, P = .01), and acute kidney injury (OR 2.42, 95% CI 1.57-3.75, P = .001). No significant association was observed between DM and pneumonia (OR 2.27, 95% CI 1.645-4.605, P = .20). …”
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Sex differences in the time trends of sepsis biomarkers following polytrauma by Cédric Niggli, Philipp Vetter, Jan Hambrecht, Hans-Christoph Pape, Ladislav Mica

“…This retrospective cohort study at University Hospital Zurich included polytrauma patients aged ≥ 16 years with an Injury Severity Score (ISS) ≥ 16 who developed sepsis within 31 days of admission. …”
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Osteoblastic Differentiation and Mitigation of the Inflammatory Response in Titanium Alloys Decorated with Oligopeptides by Aroa Álvarez-López, Raquel Tabraue-Rubio, Rafael Daza, Luis Colchero, Gustavo V. Guinea, Martine Cohen-Solal, José Pérez-Rigueiro, Daniel González-Nieto

“…However, this regenerative capacity can be compromised by various factors, most importantly related with the extent of the injury. Critical-sized defects, exceeding the body’s natural healing ability, demand the use of temporary or permanent devices like artificial joints or bone substitutes. …”
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Comparative Efficacy and Safety of Cardio-Renoprotective Pharmacological Interventions in Chronic Kidney Disease: An Umbrella Review of Network Meta-Analyses and a Multicriteria De... by Ioannis Bellos, Smaragdi Marinaki, Pagona Lagiou, Vassiliki Benetou

“…Compared to placebo, SGLT2i were associated with reduced risks of cardiovascular events [Hazard ratio (HR): 0.776, 95% confidence intervals (CI): 0.727–0.998], kidney disease progression (HR: 0.679, 95% CI: 0.629–0.733), acute kidney injury (HR: 0.873, 95% CI: 0.773–0.907), and serious adverse events (HR: 0.881, 95% CI: 0.847–0.916). …”
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Shared Genes and Pathways in Ulcerative Colitis and Ankylosing Spondylitis: Functional Validation and Implications for Diagnosis by Li L, An G, Li F, Zhang D, Zhu X, Liang C, Zhao Y, Xie K, Zhou P, Zhu H, Jin X, Du L

“…Lin Li,&ast; Guangqi An,&ast; Fuzhen Li,&ast; Donghui Zhang, Xinyue Zhu, Chunyu Liang, Yu Zhao, Kunpeng Xie, Pengyi Zhou, Haiyan Zhu, Xuemin Jin,&ast; Liping Du&ast; Department of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, Henan Province Eye Hospital, Henan International Joint Research Laboratory for Ocular Immunology and Retinal Injury Repair, Zhengzhou, Henan, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Xuemin Jin; Liping Du, Department of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe East Road, Zhengzhou, 450000, People’s Republic of China, Tel +8613603983193 ; +8613838191481, Email jinxuemin@zzu.edu.cn; dulplab@live.cnBackground: Associations between ulcerative colitis (UC) and ankylosing spondylitis (AS) have been reported in multiple studies, but the common etiologies of UC and AS remain unknown. …”
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LR12 Promotes Liver Repair by Improving the Resolution of Inflammation and Liver Regeneration in Mice with Thioacetamide- (TAA-) Induced Acute Liver Failure by Yongjuan Wang, Xiaoli Xie, Hongqun Liu, Huimin Liu, Huiqing Jiang

“…Triggering receptor expressed on myeloid cells-1 (TREM-1) controls the mobilization of inflammatory cells in response to injury and consequently enhances liver damage. LR12 is a TREM-1 inhibitory peptide. …”
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Zingiber striolatum phytochemicals ameliorated hyperglycemia symptoms by modulating gut microbial communities in mice with type 2 diabetes mellitus by Tingting Liu, Xiaodong Ge, Lu Song, Huanhuan Wu, Xue Qian, Bowen Jia, Chao Zhao, Yi Zhuang

“…IntroductionProlonged hyperglycemia caused by type 2 diabetes mellitus (T2DM) can lead to liver injury and disrupt the community of the gut microbiota that pose significant risks to human health. …”
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Antitoxic Effects of Chicory Herb Extract Fractions in Rats with Toxic Hepatitis by I. A. Lupanova, O. L. Saybel, E. N. Kurmanova, E. V. Ferubko, I. A. Martynchik, P. G. Mizina

“…The aqueous and butanolic fractions of the chicory herb extract had the highest antitoxic activity in experimental animal toxic liver injury.…”
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Transition to Virtual Care Services during COVID-19 at Canadian Pain Clinics: Survey and Future Recommendations by Victoria Borg Debono, Samuel Neumark, Norman Buckley, Ramesh Zacharias, Eleni Hapidou, Jennifer Anthonypillai, Susy Faria, Carrie-Lynn Meyer, Thomas Carter, Nadia Parker, Brenda Lau, Emmanuel Abreu, Scott Duggan, Etienne Bisson, Josie Pierre, Regina Visca, Patricia Poulin

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The Importance of Sleep in Athletic Performance - A Systematic Review by Julia Białeta, Katarzyna Rowińska, Karolina Siembab, Michalina Jurkiewicz, Agnieszka Napieralska, Wiktor Garbarczyk, Albert Kapla, Alicja Černohorská, Wiktoria Pysiewicz, Daria Bednarczyk

“…Results Research conclusively states that insufficient sleep impairs physical endurance and strength, reduces coordination and increases injury risk2–5. It impacts cognitive processes – decreases focus, diminishes strategic thinking and slows reaction times6. …”
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Strategies to Improve the Quality and Freshness of Human Bone Marrow-Derived Mesenchymal Stem Cells for Neurological Diseases by Da Yeon Lee, Sung Eun Lee, Do Hyeon Kwon, Saraswathy Nithiyanandam, Mi Ha Lee, Ji Su Hwang, Shaherin Basith, Jung Hwan Ahn, Tae Hwan Shin, Gwang Lee

“…Human bone marrow-derived mesenchymal stem cells (hBM-MSCs) have been studied for their application to manage various neurological diseases, owing to their anti-inflammatory, immunomodulatory, paracrine, and antiapoptotic ability, as well as their homing capacity to specific regions of brain injury. Among mesenchymal stem cells, such as BM-MSCs, adipose-derived MSCs, and umbilical cord MSCs, BM-MSCs have many merits as cell therapeutic agents based on their widespread availability and relatively easy attainability and in vitro handling. …”
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Multi-Omics and Network-Based Drug Repurposing for Septic Cardiomyopathy by Pei-Pei Liu, Xin-Yue Yu, Qing-Qing Pan, Jia-Jun Ren, Yu-Xuan Han, Kai Zhang, Yan Wang, Yin Huang, Tao Ban

“…Among them, acetaminophen and pyridoxal phosphate significantly improved cardiac function in SCM moues, as demonstrated by the increased ejection fraction (EF) and fractional shortening (FS), and the reduced levels of cardiac injury biomarkers: B-type natriuretic peptide (BNP) and cardiac troponin I (cTn-I). …”
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α-amanitin induces hepatotoxicity via PPAR-γ inhibition and NLRP3 inflammasome activation by Haowei Wang, Huijie Zhang, Lin Miao, Chan Wang, Hanxin Teng, Xiaodong Li, Xiaoxing Zhang, Genmeng Yang, Shangwen Wang, Xiaofeng Zeng

“…In vivo, α-amanitin induced dose-dependent liver injury in mice, evident by elevated serum ALT and AST, and histological liver damage. …”
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Disparity of serum uric acid threshold for CKD among hypertensive and non-hypertensive individuals by Bowen Zhu, Fang Li, Weidong Zhang, Shuan Zhao, Nana Song, Shi Jin, Ziyan Shen, Yufei Lu, Yang Li, Hong Liu

“…For the hospital-based population, kidney injury was marked by a KIM-1 positive area.Results Our results indicate a higher prevalence of CKD in the community population with hypertension (10.2% vs. 3.9%, p < .001). …”
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Polytrauma in Older Adults Leads to Significantly Increased TIMP-1 Levels in the Early Posttraumatic Period by Mareen Braunstein, Thomas Kusmenkov, Wolf Mutschler, Christian Kammerlander, Wolfgang Böcker, Viktoria Bogner-Flatz

“…Higher rates and intensity of acute inflammation following severe injury suggest that deregulated inflammation may contribute to these higher rates of posttraumatic morbidity and mortality in older adults. …”
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Construction and validation of risk prediction models for renal replacement therapy in patients with acute pancreatitis by Fei Zuo, Lei Zhong, Jie Min, Jinyu Zhang, Longping Yao

“…Results The mean age of the cohort was 59.17 years, with an average Acute Physiology and Chronic Health Evaluation II (APACHE II) score of 17.55. Acute kidney injury (AKI) was observed in 52.43% of patients with AP, and 9.05% required RRT. …”
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