Outcome of dual implantation in distal end femur fractures among patients attending a tertiary care hospital in Karnataka by Kumar SVA, Vishnuprasad SH, Vittal V, Diwakar P, Zai SAK

“…Patient demographics, medical histories, fracture characteristics (laterality, type, knee status, injury mode, and associated injuries), and clinical outcomes after follow-up were extracted from records and through clinical observation. …”
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Long-term correction of hemophilia A via integration of a functionally enhanced FVIII gene into the AAVS1 locus by nickase in patient-derived iPSCs by Do-Hun Kim, Sang-Hwi Choi, Jin Jea Sung, Sieun Kim, Hanui Yi, Sanghyun Park, Chan Wook Park, Young Woo Oh, Jungil Lee, Dae-Sung Kim, Jong-Hoon Kim, Chul-Yong Park, Dong-Wook Kim

“…Compared with mice transplanted with wild-type BDD-FVIII-containing ECs, immunocompetent HA mice intravenously transplanted with FE-KI ECs presented a 2.12-fold increase in FVIII activity in the blood and an approximately 20% greater survival rate after hemorrhagic tail injury. For sustained efficacy, FE-KI ECs were subcutaneously transplanted into immunodeficient HA mice, resulting in amelioration of the hemophilia phenotype for more than 3 months. …”
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In Acute IgA Nephropathy, Proteinuria and Creatinine Are in the Spot, but Podocyturia Operates in Silence: Any Place for Amiloride? by H. Trimarchi, M. Paulero, R. Canzonieri, A. Schiel, A. Iotti, C. Costales-Collaguazo, A. Stern, M. Forrester, F. Lombi, V. Pomeranz, R. Iriarte, T. Rengel, I. Gonzalez-Hoyos, A. Muryan, E. Zotta

“…In this report, we present a case of acute renal injury with proteinuria and microscopic hematuria in a young male. …”
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American Orthopaedic Foot and Ankle Society (AOFAS) Ankle-Hindfoot Score: a study protocol for the translation and validation of the Dutch language version by Cornelis H Van der Vlies, Esther M M van Lieshout, Michael H J Verhofstad, Duncan E Meuffels, A Siebe de Boer, Wim E Tuinebreijer, P Ted Den Hoed

“…Introduction The American Orthopaedic Foot and Ankle Society (AOFAS) Ankle-Hindfoot Score is among the most commonly used instruments for measuring the outcome of treatment in patients who sustained a complex ankle or hindfoot injury. It combines a clinician-reported and a patient-reported part. …”
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Development and in vitro evaluation of biomimetic injectable hydrogels from decellularized human nerves for central nervous system regeneration by Gopal Agarwal, Kennedy Moes, Christine E. Schmidt

“…Injuries to the central nervous system (CNS) often lead to persistent inflammation and limited regeneration. …”
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CD300E+ macrophages facilitate liver regeneration after splenectomy in decompensated cirrhotic patients by Tao Yang, Yuan Zhang, Chujun Duan, Hui Liu, Dong Wang, Qingshan Liang, Xiao Chen, Jingchang Ma, Kun Cheng, Yong Chen, Ran Zhuang, Jikai Yin

“…Thus, understanding liver regeneration processes during cirrhotic injury is highly important. This study explored the role of macrophage heterogeneity in liver regeneration following splenectomy. …”
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A Clinical Prospective Observational Cohort Study on the Prevalence and Primary Diagnostic Accuracy of Occult Vertebral Fractures in Aged Women with Acute Lower Back Pain Using Mag... by Atsushi Terakado, Sumihisa Orita, Kazuhide Inage, Go Kubota, Tomohiro Kanzaki, Hiroshi Mori, Yuji Shinohara, Junichi Nakamura, Yusuke Matsuura, Yasuchika Aoki, Takeo Furuya, Masao Koda, Seiji Ohtori

“…Acute LBP patients may suffer vertebral injury with almost no morphologic change in X-ray, which can be detected using MRI.…”
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Comprehensive Medical and Psychological Rehabilitation in War Trauma (clinical case) by O.A. Panchenko, A.V. Kabantseva, O.O. Zhogina, I.A. Serdyuk

“…., 65 years old, sustained a mine-blast injury (MBI) to the right upper limb extremity during shelling. …”
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Heart-Kidney Biomarkers in Patients Undergoing Cardiac Stress Testing by Mikko Haapio, Andrew A. House, Massimo de Cal, Dinna N. Cruz, Paolo Lentini, Davide Giavarina, Antonio Fortunato, Luigi Menghetti, Matteo Salgarello, Andrea Lupi, Giuliano Soffiati, Alessandro Fontanelli, Pierluigi Zanco, Claudio Ronco

“…We examined association of inducible myocardial perfusion defects with cardiorenal biomarkers, and of diminished left ventricular ejection fraction (LVEF) with kidney injury marker plasma neutrophil gelatinase-associated lipocalin (NGAL). …”
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The Impact of Physical Activities on Male Fertility: A Systematic Review by Albert Kapla, Alicja Černohorská, Daria Bednarczyk, Julia Białeta, Karolina Siembab, Katarzyna Rowińska, Michalina Jurkiewicz, Wiktor Garbarczyk, Wiktoria Pysiewicz, Agnieszka Napieralska

“…However, moderation in training load is necessary, as excessive training volume can lead to hormonal regulation issues or simply result in injury in the groin area. …”
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Feasibility of transpedicular screw placement through the posterior arch of C1: A CT study in the Emirati population by Ivan James Prithishkumar, Dineshwary Suresh, Nerissa Naidoo, Rashid AlSharhan, Usama Al Bastaki, Jeyaseelan Lakshmanan, Baylis Vivek Joseph

“…C1 bears a complicated relationship with adjacent neurovascular structures such as the vertebral artery and cervical spinal cord, which are at risk of injury in a misplaced screw. The objective of this study was to look at the feasibility of transpedicular screw placement into the C1 lateral mass with entry through the posterior arch. …”
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Rapid Detection of microRNA-122 in Serum and Finger Blood Using a Lateral Flow Nucleic Acid Biosensor by Min Zhang, Meijing Ma, Jiahui Wang, Yurui Zhou, Xueji Zhang, Guodong Liu

“…MicroRNA122 (miR-122) is a microRNA that is highly expressed in hepatocytes and has been identified as a prospective therapeutic target and biomarker for liver injury. An expanding body of research has demonstrated that miR-122 is a critical regulator in both the initiation and progression of a wide range of liver diseases. …”
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Emergency Medical Services Provider-Perceived Alzheimer’s Disease and Related Dementias in the Prehospital Setting by Esmeralda Melgoza, Valeria Cardenas, Hiram Beltrán-Sánchez

“…Among cases with EMS provider-perceived ADRD, the most common primary impressions were mental disorders (17.1%), weakness (17.0%), injury (15.7%), and pain (13.1%). Increasing age was associated with higher odds of EMS provider-perceived ADRD among both sexes. …”
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Chimonanthus nitens Oliv. leaves flavonoids alleviate hyperuricemia by regulating uric acid metabolism and intestinal homeostasis in mice by Wenya Meng, Lingli Chen, Kehui Ouyang, Suyun Lin, Yang Zhang, Jing He, Wenjun Wang

“…In addition, CLF repaired renal injury by significantly down-regulating mRNA and protein expressions of renal UA reabsorption-related proteins and up-regulating the mRNA and protein expressions of UA secretory-related proteins. …”
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Maresin 1 Mitigates Inflammatory Response and Protects Mice from Sepsis by Ruidong Li, Yaxin Wang, Zhijun Ma, Muyuan Ma, Di Wang, Gengchen Xie, Yuping Yin, Peng Zhang, Kaixiong Tao

“…Moreover, Mar1 attenuated lung injury and decreased level of alanine transaminase (ALT), aspartate transaminase (AST), creatinine (Cre), and blood urea nitrogen (BUN) in serum in mice after CLP surgery. …”
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Innate Immune Effectors Play Essential Roles in Acute Respiratory Infection Caused by Klebsiella pneumoniae by Dong Liu, Zhifu Chen, Yue Yuan, Haiming Jing, Jintao Zou, Xiaoli Zhang, Xi Zeng, Weijun Zhang, Quanming Zou, Jinyong Zhang

“…In the current study, we established an acute pneumonia model of K. pneumoniae respiratory infection in mice and confirmed that the injury was most severe 48 h post infection. Flow cytometric assay demonstrated that alveolar macrophages were the predominant cells in BALF before infection, and neutrophils were quickly recruited after infection, and this was in consistent with the kinetics of chemokine expression. …”
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Comparison of Platelet-Rich Plasma-Impregnated Suture Material with Low and High Platelet Concentration to Improve Colonic Anastomotic Wound Healing in Rats by Mehmet Akif Aydin, Eray Metin Guler, Ahu Senem Demiroz, Muhammet Fatih Aydin, Gulcan Saglam

“…Rats were sacrificed on the postoperative 7th day for analysis of colonic anastomosis region including macroscopic observation, measurement of anastomotic bursting pressure (ABP), and the hydroxyproline levels and histopathological findings in colon tissue samples. Results. Total injury scores were significantly lower in the L-PRP and H-PRP groups than those in the control group (median (range) 13.00 (7.00) and 11.50 (6.00) vs. 15.50 (4.00), p<0.05 and p<0.01, respectively). …”
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Protein Kinase A Is Involved in Neuropathic Pain by Activating the p38MAPK Pathway to Mediate Spinal Cord Cell Apoptosis by Yajun Deng, Liang Yang, Qiqi Xie, Fengbiao Yang, Guoqiang Li, Guangzhi Zhang, Shaoping Li, Zuolong Wu, Jing Wang, Xuewen Kang

“…A neuropathic pain-related gene expression dataset was downloaded from Gene Expression Omnibus, and differentially expressed genes were screened using the R software. cytoHubba was used to screen for hub genes. A spared nerve injury (SNI) rat model was established, and the paw withdrawal threshold was determined using von Frey filaments. …”
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Impact of Coronary Artery Disease and Percutaneous Coronary Intervention on Transcatheter Aortic Valve Implantation by Anthony G. Matta, Thibault Lhermusier, Francisco Campelo Parada, Frederic Bouisset, Ronan Canitrot, Vanessa Nader, Stéphanie Blanco, Meyer Elbaz, Jerome Roncalli, Didier Carrié

“…The overall prevalence of in-hospital death, stroke, major or life-threatening bleeding, minor bleeding, major vascular complications, minor vascular complications, pacemaker implantation, and acute kidney injury was 2.7%, 2.4%, 2.8%, 3.6%, 3.9%, 7.5%, 12.5%, and 2.7%, respectively. …”
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Multiple-Wearable-Sensor-Based Gait Classification and Analysis in Patients with Neurological Disorders by Wei-Chun Hsu, Tommy Sugiarto, Yi-Jia Lin, Fu-Chi Yang, Zheng-Yi Lin, Chi-Tien Sun, Chun-Lung Hsu, Kuan-Nien Chou

“…The 20 subjects selected to participate in this study were separated into two groups: stroke patients (11) and patients with neurological disorders other than stroke (brain concussion, spinal injury, or brain hemorrhage) (9). The temporal parameters of gait were calculated using a wearable device, and various features and sensor configurations were examined to establish the ideal accuracy for classifying different groups. …”
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