Methylcobalamin protects against liver failure via engaging gasdermin E by Wanfeng Xu, Yun Wang, Shuang Cui, Qiuling Zheng, Yanghao Lin, Qingqing Cui, Yuxin Xie, Yuming Zeng, Chuan Zhang, Yujie Li, Xin Jin, Minna Qin, Huiyong Sun, Haiping Hao, Lijuan Cao

“…Abstract Gasdermin E (GSDME) is a pyroptotic cell death effector and a promising target for pyroptotic tissue injury. Here we perform high-throughput screening and demonstrate that methylcobalamin (MeCbl), an endogenous coenzyme form of vitamin B12, is a specific GSDME inhibitor and highly effective against cholestatic liver failure. …”
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Functional Outcome (Short Term) of Modular Cementless Bipolar HemiArthroplasty (Hydroxyapatite-Coated Stem) for Fracture Neck of Femur in the Elderly by Navin K. Shukla, Lata Keshkar, Jayanta Mukherjee, Ratnesh Kumar, Shivendra Singh, Alok C. Agrawal

“…There was no difference in outcome, whether an injury occurred to the dominant or nondominant extremity. …”
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Welfare Implications of Low-Dose Atipamezole Reversal of Tiletamine/Zolazepam/Xylazine Anaesthesia in Pigs by Rachel Layton, David S. Beggs, Andrew Fisher, Peter Mansell, Daniel Layton, Peter A. Durr, Teegan Allen, Grace Taylor, Michael L. Kelly, David T. Williams, Kelly J. Stanger

“…We categorised side effects and behaviours as having either a low or high negative welfare impact based on the potential risk of injury and whether behaviours were displayed before or after return to consciousness. …”
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The impact of uric acid on musculoskeletal diseases: clinical associations and underlying mechanisms by Jing Zhang, Na Sun, Wanhao Zhang, Wenjie Yue, Xiaochen Qu, Xiaochen Qu, Zhonghai Li, Zhonghai Li, Gang Xu, Gang Xu

“…This review discusses the mechanisms linking SU to musculoskeletal disorders, as well as the clinical associations of SU with conditions such as sarcopenia, T2D with sarcopenia, McArdle disease, heart failure, gout, OA, IDD, OP and exercise-induced acute kidney injury (EIAKI), offering valuable insights for improved prevention and treatment strategies. …”
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Alpha Mangostin Inhibits the Proliferation and Activation of Acetaldehyde Induced Hepatic Stellate Cells through TGF-β and ERK 1/2 Pathways by Novriantika Lestari, Melva Louisa, Vivian Soetikno, Averina Geffanie Suwana, Putra Andito Ramadhan, Taufiq Akmal, Wawaimuli Arozal

“…Liver fibrosis is characterized by excessive accumulation of extracellular matrix in chronic liver injury. Alcohol-induced fibrosis may develop into cirrhosis, one of the major causes of liver disease mortality. …”
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Comparing the Scores of The Functional Movement Screen™ in Individuals with Low Back Pain versus Healthy Individuals: A Systematic Review and Meta-Analysis by Khalid M. Alkhathami, Bijad Alqahtani

“…# Background The Functional Movement Screen™ (FMS™) is widely used to assess functional movement patterns and illuminate movement dysfunctions that may have a role in injury risk. However, the association between FMS™ scores and LBP remains uncertain…”
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Functional Properties of Human-Derived Mesenchymal Stem Cell Spheroids: A Meta-Analysis and Systematic Review by Sarah Ezquerra, Amparo Zuleta, Rodrigo Arancibia, José Estay, Francisco Aulestia, Flavio Carrion

“…For instance, research exhibited reduced inflammation, faster wound healing, and closure, functional recovery and tissue repair due to immunomodulatory effects, better MSC engraftment in damaged tissue, higher MSC survival and less apoptosis at the injury. Still, further research and clinical studies with controlled and consistent results are needed to see the real therapeutic efficacy of MSC spheroids.…”
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Comorbidity patterns and mortality in atrial fibrillation: a latent class analysis of the EURopean study of Older Subjects with Atrial Fibrillation (EUROSAF) by Huah Shin Ng, Richard Woodman, Nicola Veronese, Alberto Pilotto, Arduino A. Mangoni

“…The model identified phenotype 1 (hypertensive, other circulatory conditions, metabolic diseases; 33%), phenotype 2 (digestive diseases, infection, injury, non-specific clinical and laboratory abnormalities; 26%), and phenotype 3 (heart failure, respiratory diseases; 41%). …”
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Enhancing trauma triage in low-resource settings using machine learning: a performance comparison with the Kampala Trauma Score by Mike Nsubuga, Timothy Mwanje Kintu, Helen Please, Kelsey Stewart, Sergio M. Navarro

“…Abstract Background Traumatic injuries are a leading cause of morbidity and mortality globally, with a disproportionate impact on populations in low- and middle-income countries (LMICs). …”
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Influence of Methylprednisolone Pulse Therapy on Liver Function in Patients with Graves’ Orbitopathy by Piotr Miśkiewicz, Anna Jankowska, Kinga Brodzińska, Justyna Milczarek-Banach, Urszula Ambroziak

“…One of the adverse effects of this therapy is liver dysfunction that can be mild (ALT < 100 U/L), moderate (ALT: 100–300 U/L), and severe defined as acute liver injury (ALI) (ALT > 300 U/L). ALI can be irreversible and fatal. …”
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Understanding hospital length of stay in trauma laparotomy patients: a National Trauma Database Study by Jeremy Grushka, Kosar Khwaja, Hayaki Uchino, Evan G Wong

“…Adult trauma patients who underwent trauma laparotomy following blunt or penetrating abdominal injuries were identified using International Classification of Diseases, 10th Revision codes and Abbreviated Injury Scales. …”
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Clinical implications of DNA ploidy, stroma, and nucleotyping in predicting peritoneal metastasis risk for gastric cancer by Jingwen Yuan, Yue Jiang, Fangfang Chen, Tian Li, Zhi Zeng, Shasha Ruan, Junfeng Yan, Jiatong Lu, Qiang Li, Jingping Yuan, Qiang Tong

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Development of a Novel Sensor System Based on Magnetic Microspheres to Detect Cardiac Troponin T by Junrong Zhang, Hongxiang Liu, Baofeng Xu, Sijun Huang, Rui Liu, Jinming Zhu, Yi Guo, Li Xu

“…Acute myocardial infarction (AMI) causes irreversible injury to cardiomyocytes in a short time and may result in various complications, severely threatening patient safety. …”
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Early childhood constraint therapy for sensory/motor impairment in cerebral palsy: a randomised clinical trial protocol by Garey Noritz, Olena Chorna, Jill Heathcock, Alexandra Key, Helen Carey, Ellyn Hamm, Mary Ann Nelin, Micah Murray, Amy Needham, James C Slaughter, Nathalie L Maitre

“…It is a disorder resulting from sensory and motor impairments due to perinatal brain injury, with lifetime consequences that range from poor adaptive and social function to communication and emotional disturbances. …”
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Exploring the Molecular Modalities in the Pathogenesis of Diabetic Kidney Disease with a Focus on the Potential Therapeutic Implications by Lyubomir Gaydarski, Kristina Petrova, Ivan Angushev, Stancho Stanchev, Alexandar Iliev, Nikola Stamenov, Vidin Kirkov, Boycho Landzhov

“…Preclinical studies highlight its dual role in renal protection and injury through anti-inflammatory and antioxidant pathways, while other evidence suggests that it may exacerbate DKD through podocyte damage and angiogenesis. …”
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Applications of Amniotic Membrane and Fluid in Stem Cell Biology and Regenerative Medicine by Kerry Rennie, Andrée Gruslin, Markus Hengstschläger, Duanqing Pei, Jinglei Cai, Toshio Nikaido, Mahmud Bani-Yaghoub

“…While a major focus of research has been the use of amniotic membrane and fluid in tissue engineering and cell replacement, AM- and AF-derived cells may also have capabilities in protecting and stimulating the repair of injured tissues via paracrine actions, and acting as vectors for biodelivery of exogenous factors to treat injury and diseases. Much progress has been made since the discovery of AM and AF cells with stem cell characteristics nearly a decade ago, but there remain a number of problematic issues stemming from the inherent heterogeneity of these cells as well as inconsistencies in isolation and culturing methods which must be addressed to advance the field towards the development of cell-based therapies. …”
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The Therapeutic Effects and Possible Mechanism of Pranoprofen in Mouse Model of Corneal Alkali Burns by Minting Chen, Abdirahman Abdinasir Gureeye, Yacouba Cissé, Lang Bai

“…Pranoprofen may alleviate inflammatory response by inhibiting the expression levels of NLRP3 and IL-1β at the early stage of corneal alkali injury, lowering the expression of MMP-13 and ultimately reducing corneal epithelial damage.…”
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Impact of Hyperoxia and Hypocapnia on Neurological Outcomes in Patients with Aneurysmal Subarachnoid Hemorrhage: A Retrospective Study by Kin Chio Li, Catherine Wing Yan Tam, Hoi-Ping Shum, Wing Wa Yan

“…In recent decades, there is increasing evidence suggesting that hyperoxia and hypocapnia are associated with poor outcomes in critically ill patients with cardiac arrest or traumatic brain injury. Yet, the impact of hyperoxia and hypocapnia on neurological outcome in patients with subarachnoid hemorrhage (SAH) has not been well studied. …”
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Are preschool Kosovar children anxious on the edge? Validating the Preschool Anxiety Scale by Samire BLLACA BALAJ, Merita SHALA, Mimoza SHAHINI, Pranvera JETISHI ÇOLLAKU

“…For the subscales there were no differences in values from Cronbach’s α and McDonald’s Omega ωt: obsessive‐compulsive subscale (.71), social phobia (.78), physical injury fears (.72), and separation anxiety (.79) were in fair range, while it was in poor range for the generalized anxiety (0.55). 16.3% of children were found to have significant anxiety symptoms. …”
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Neuromodulation of Attentional Control in Major Depression: A Pilot DeepTMS Study by Jodie Naim-Feil, John L. Bradshaw, Dianne M. Sheppard, Oded Rosenberg, Yechiel Levkovitz, Pinhas Dannon, Paul B. Fitzgerald, Moshe Isserles, Abraham Zangen

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