miR-7-5p Promotes Hepatic Stellate Cell Activation by Targeting Fibroblast Growth Factor Receptor 4 by Shuxia Tian, Min Chen, Bing Wang, Yonglong Han, Haonan Shang, Junming Chen

“…Fibroblast growth factor receptor 4 (FGFR4) is a key mediator that protects the liver from chronic injury. MicroRNA-7 (miR-7) is a tumor suppressor and associated with lipid homeostasis in the liver. …”
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ATP Induces Disruption of Tight Junction Proteins via IL-1 Beta-Dependent MMP-9 Activation of Human Blood-Brain Barrier In Vitro by Fuxing Yang, Kai Zhao, Xiufeng Zhang, Jun Zhang, Bainan Xu

“…In conclusion, our study explored the mechanism of ATP/P2X7R signaling in the disruption of BBB following brain trauma/stress injury, especially focusing on the relationship with IL-1β and MMP-9.…”
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Rostral Agranular Insular Cortex Lesion with Motor Cortex Stimulation Enhances Pain Modulation Effect on Neuropathic Pain Model by Hyun Ho Jung, Jaewoo Shin, Jinhyung Kim, Seung-Hee Ahn, Sung Eun Lee, Chin Su Koh, Jae Sung Cho, Chanho Kong, Hyung-Cheul Shin, Sung June Kim, Jin Woo Chang

“…After inducing neuropathic pain (NP) rat models by the spared nerve injury method, we made a lesion on the rostral agranular insular cortex (RAIC) unilaterally and compared behaviorally determined pain threshold and latency in 2 groups: Group A (NP + MCS; n=7) and Group B (NP + RAIC lesion + MCS; n=7). …”
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Topographic and morphometric characterization of the humerii nutrient foramina and their implications for fracture repair and healing by Pedzisai Mazengenya, Palesa Mokoena, Brendon Kurt Billings, Arthur Tsalani Manjatika

“…Abstract Fractures of the humerus are common on the midshaft of the bone, often causing injury to the nutrient artery. Successful fracture repair and healing requires preservation of the blood supply to the long bones which is conveyed through the nutrient foramina (NF). …”
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Current Approach of Functioning Head and Neck Paragangliomas: Case Report of a Young Patient with Multiple Asynchronous Tumors by Alejandro Terrones-Lozano, Alan Hernández-Hernández, Edgar Nathal Vera, Gerardo Yoshiaki Guinto-Nishimura, Jorge Luis Balderrama-Bañares, Claudia Ramírez-Rentería, Judith de la Serna-Soto, Alfredo Adolfo Reza-Albarran, Lesly Portocarrero-Ortiz

“…A 33-year-old man with a past medical history of resection of an abdominal PGL at the age of eleven underwent a CT scan after a mild traumatic brain injury revealing an incidental brain tumor. The diagnosis of a functioning PGL was made, and further testing was undertaken with a PET-CT with 68Ga-DOTATATE, SPECT-CT 131-MIBG, and genetic testing. …”
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Neurologic Complications Associated with Sjögren’s Disease: Case Reports and Modern Pathogenic Dilemma by Michele Colaci, Giulia Cassone, Andreina Manfredi, Marco Sebastiani, Dilia Giuggioli, Clodoveo Ferri

“…Conclusions. Cranial nerve injury is a harmful complication of SS, even if less commonly recorded compared to peripheral neuropathy. …”
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Sensorimotor Dysfunction Following Anterior Cruciate Ligament Reconstruction- an Afferent Perspective: A Scoping Review by Thilina N Vitharana, Enda King, Kieran Moran

“…# Background Sensorimotor dysfunction is thought to occur following anterior cruciate ligament (ACL) injury which may have implications on future reinjury risk. …”
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Bronchoscopic lung lavage and exogenous surfactant successfully reverse respiratory failure after severe chlorine exposure: A pediatric case report by Paola Papoff, Benedetto D'Agostino, Roberto Cicchetti, Antonella Bitti, Valentina Pennetta, Elena Caresta

“…Given the underlying pathophysiology of chlorine lung injury characterized by surfactant dysfunction, the boy was treated with repeated bronchoscopic lung lavages followed by exogenous surfactant (Curosurf 30 mg/kg total), 1 h after intubation and subsequently after 6 and 12 h, when he achieved a significant and stable reduction in ventilatory requirements. …”
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Protective Effect of Thalidomide on 2,4,6-Trinitrobenzenesulfonic Acid-Induced Experimental Colitis in Rats via the Inhibition of T Helper 17 Cells by Ying Xie, Dandan Li, Xiaoshuang Luan, Shuang Jin, Bo Yan, Feng Tian

“…Thalidomide effectively alleviated the symptoms and intestinal inflammatory injury induced by TNBS in rats, the effect of which was dose-dependent. …”
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Clinical application of oral Chinese Patent Medicines in ophthalmology: a scoping review protocol by Wei Zhou, Kai Xu, Ziyang Huang, Xiaoyu Li, Xing Liao, Lina Liang, Yamin Li, Qianqian Zuo

“…However, comprehensive evidence for using CPMs in ophthalmology is lacking.Aim We will apply the methodology of scoping review to systematically search and sort out the available evidence on oral CPMs for the treatment of eye diseases, identify the distribution of evidence in this field and provide a basis for clinical practice and medical decisions.Methods The scoping review will be implemented in the following seven steps: (1) defining the research question; (2) searching National Essential Medicines List (2018 edition), National Basic Medical Insurance, Work Injury Insurance and Maternity Insurance Drug Catalog (2020 edition) and Chinese Pharmacopoeia (2020 edition) for oral CPMs for the treatment of eye diseases; (3) searching Embase, Web of Science, PubMed, Cochrane Library, Chongqing VIP Chinese Scientific Journals Database, Chinese National Knowledge Infrastructure, Chinese Biomedical Literature Database and Wanfang Database for relevant literature published from inception to December 2021; (4) developing eligibility criteria; (5) screening the studies based on inclusion criteria; (6) extracting relevant data and lastly, (7) collating, summarising and reporting the results.Ethics and dissemination Since the scoping review aims at collecting data from publicly available publications, this study does not require ethical approval. …”
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Item-level and Composite-level Interrater Reliability of Functional Movement Screen™ Scores Following Condensed Training in Novice Raters by Brent A Harper, Stephen M Glass

“…# BACKGROUND The Functional Movement Screen™ (FMS™) is a clinical instrument designed to use movement behaviors to screen individuals for injury risk. Current rater certification programs focus on extensive, individualized training, which may not be appropriate in all screening contexts…”
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Influence of <i>Apis mellifera syriaca</i> Bee Venom on Nociception and Inflammatory Cytokine Profiles in Experimental Hyperalgesia by Mohamad Ayoub, Salma Fayjaloun, Rabih Roufayel, Dany El Obeid, Ziad Fajloun, Mohamad Rima, Marc Karam

“…Hyperalgesia is a condition marked by an abnormal increase in pain sensitivity, often occurring in response to tissue injury, inflammation, or prolonged exposure to certain medications. …”
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Proinflammatory Responses of Heme in Alveolar Macrophages: Repercussion in Lung Hemorrhagic Episodes by Rafael L. Simões, Maria Augusta Arruda, Cláudio Canetti, Carlos H. Serezani, Iolanda M. Fierro, Christina Barja-Fidalgo

“…Taken together, the data support a dual role for heme in the inflammatory response associated with lung hemorrhage, acting as a proinflammatory molecule that can either act as both an adjuvant of the innate immunity and as an amplifier of the inflammatory response, leading tissue injury. The understanding of heme effects on pulmonary inflammatory processes can lead to the development of new strategies to ameliorate tissue damage associated with hemorrhagic episodes.…”
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The mediating role of physical activity and quality of life in the association between knee osteoarthritis-related symptoms and physical function of post-COVID patients in Metro Ma... by Donald Manlapaz, Jon Timothy Rivero, Eliana Caris Cabildo, Jeremy Christian Advincula, Marc Angelo Aquino, Miguel Gabriel De la Paz, Maria Paulina Duldulao, Andrea Amor Maravilla, Cyd Ahnilark Montera, Kent Stefon Tee

“…The Filipino version of the Knee Injury and Osteoarthritis Outcome Score and International Physical Activity Questionnaire-Short Form will be used to assess the mediating variables.Analysis The study will employ descriptive and regression analyses for data analysis and follow the Strengthening the Reporting of Observational Studies in Epidemiology statement for reporting the data.Ethics and dissemination This study has received ethical approval from the Ethics Review Committee of the College of Rehabilitation Sciences. …”
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Pain assessment and management of adult patients in the Swedish EMS: a nationwide registry study by Glenn Larsson, Pär Wennberg, Kristoffer Wibring

“…The study focused on patients who contacted the EMS due to pain, trauma, or injury. Pain intensity was recorded using the Numeric Rating Scale (NRS). …”
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Time-lapse imaging of identified granule cells in the mouse dentate gyrus after entorhinal lesion in vitro reveals heterogeneous cellular responses to denervation by Davide Greco, Alexander Drakew, Nina Rößler, Nina Rößler, Tassilo Jungenitz, Peter Jedlicka, Peter Jedlicka, Thomas Deller

“…Denervation of neurons is a network consequence of brain injury. The effects of denervation on neurons can be readily studied in vitro using organotypic slice cultures of entorhinal cortex and hippocampus. …”
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Professional Baseball Player Type and Geographic Region of Origin Impacts Shoulder External and Internal Rotation Strength by Lori A. Michener, Adam J. Barrack, Bernard Y. Liebeskind, Ryan J. Zerega, Jonathan C. Sum, Ryan L. Crotin, Hillary A. Plummer

“…# Background Shoulder strength deficits are implicated in arm injuries and performance deficits in baseball players…”
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Selective Vulnerability of the Cochlear Basal Turn to Acrylonitrile and Noise by B. Pouyatos, C. A. Gearhart, A. Nelson-Miller, S. Fulton, L. D. Fechter

“…They provide an initial basis for distinguishing the pattern of cochlear injury that results from noise exposure from that which occurs due to the combined effects of noise and a chemical contaminant.…”
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Effects of an 8-week pre-season targeted training on sprinting performance, agility and lower limb muscular asymmetries in elite soccer players by Artur Gołaś, Przemysław Pietraszewski, Robert Roczniok, Artur Terbalyan, Adam Maszczyk, Rafał Opaliński, Adam Zając

“…A comprehensive training approach including speed, agility, and resistance training based on specific movement patterns should be applied by strength and conditioning practitioners in soccer teams to achieve peak physical performance and reduce injury risk due to the partial elimination of muscular asymmetries.…”
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The Efficacy of the Mulligan Concept to Treat Meniscal Pathology: A Systematic Review by Nathan C. Reep, Sydney N. Leverett, Rebecca M. Heywood, Russell T. Baker, Darren L. Barnes, Scott W. Cheatham

“…# Background Meniscal pathologies are common knee injuries and arthroscopic surgery is the current accepted gold standard for treatment. …”
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