The MAPK MEK1/2-ERK1/2 Pathway and Its Implication in Hepatocyte Cell Cycle Control by Jean-Philippe Guégan, Christophe Frémin, Georges Baffet

“…The models mimic the physiological process of hepatic regeneration after liver injury or partial hepatectomy. Many reports suggest that the mitogen-activated protein kinase (MAPK) ERK1/2 can support hepatocyte proliferation in vitro and in vivo and the MEK/ERK cascade acts as an essential element in hepatocyte responses induced by the EGF. …”
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Demographics, aetiology and outcome of paediatric acute liver failure in Singapore by Fang Kuan Chiou, Veena Logarajah, Christopher Wen Wei Ho, Lynette Suk-Hui Goh, Sivaramakrishnan Venkatesh Karthik, Marion Margaret Aw, Kong Boo Phua

“…PALF was defined by: absence of chronic liver disease; biochemical evidence of acute liver injury; and coagulopathy, non-correctible by vitamin K, defined as prothrombin time (PT) ≥20 seconds or international normalised ratio (INR) ≥2.0 regardless of hepatic encephalopathy (HE) or PT ≥15 seconds or INR ≥1.5 in the presence of HE. …”
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Assessing changing baleen whale distributions and reported incidents relative to vessel activity in the Northwest Atlantic. by Hannah Solway, Boris Worm, Tonya Wimmer, Derek P Tittensor

“…Adverse interactions, notably vessel strikes and fishing gear entanglement, often result in distress, injury, or death for these animals. In Atlantic Canadian waters, such negative interactions or 'incidents' are consistently reported to marine animal response organizations but have not yet been analyzed relative to the spatial distribution of whales and vessels. …”
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Immunohistochemical Analysis of Postburn Scars following Treatment Using Dermal Substitutes by Mi Young Lee, Hyunchul Kim, In Suk Kwak, Youngchul Jang, Younghee Choi

“…Samples of unburned, normal skin and deep 2nd or 3rd degree burns were obtained from patients who experienced a burn injury in the past to at least 6 months before biopsy, which was performed between 2011 and 2012. …”
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Evaluating the Factors Affecting COVID-19 Patients’ Mortality in Arak in 2020 by Hossein Mazaherpour, Masoumeh Soofian, Elham Farahani, Ahmad Saebbian, Mostafa Etebari, Sakineh Mazaherpour, Fatemeh Ashrafian, Amitis Ramezani

“…There was a significant relationship in terms of blood pressure, age, oxygen saturation, tachycardia, tachypnea, the interval between the onset of symptoms and hospitalization, diabetes mellitus, lung disease, cardiovascular disease, history of opium abuse, C-reactive protein, white blood cell, lymphocytes, hemoglobin, creatinine elevation, elevated liver enzyme, creatine phosphokinase, lactate dehydrogenase, ferritin, D-dimer, troponin, prothrombin time, international normalized ratio, intensive care unit admission days, arrhythmia, sepsis, acute respiratory distress syndrome, acute kidney injury (AKI), and the type of antiviral and antibiotic therapy between the two groups of patients. …”
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Cost-Effectiveness Analysis of Transanal Irrigation for Managing Neurogenic Bowel Dysfunction in Japan by Atsushi Sengoku, Shinichi Noto, Masashi Nomi, Anton Emmanuel, Tatsunori Murata, Toshiki Mimura

“…**Background:** Neurogenic bowel dysfunction (NBD) is a common sequela in Spinal Cord Injury (SCI) patients. Bowel dysfunction symptoms have a significant negative impact on quality of life (QOL) and are often socially disabling. …”
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Ligament-Derived Stem Cells: Identification, Characterisation, and Therapeutic Application by Katie Joanna Lee, Peter David Clegg, Eithne Josephine Comerford, Elizabeth Gail Canty-Laird

“…Ligament is prone to injury and degeneration and has poor healing potential and, with currently ineffective treatment strategies, stem cell therapies may provide an exciting new treatment option. …”
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Real-world pharmacovigilance analysis unveils the toxicity profile of amivantamab targeting EGFR exon 20 insertion mutations in non-small cell lung cancer by Jing Zhang, Wenjie Li

“…Results A significant proportion of adverse events (AEs) was attributable to injury, poisoning, and procedural complications, cutaneous disorders, respiratory ailments, infections, as well as vascular and lymphatic system disturbances. …”
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The Potential of Neonatal Organ Donation in Central Sweden by Emil Bluhme, Ewa Henckel, Boubou Hallberg, Carl Jorns

“…In total, 16 neonates had a catastrophic neurological injury in combination with lack of brainstem reflexes, indicating plausibility of donation after brain death. …”
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Estimating Kidney Function in the Critically Ill Patients by Gemma Seller-Pérez, Manuel E. Herrera-Gutiérrez, Javier Maynar-Moliner, José A. Sánchez-Izquierdo-Riera, Anibal Marinho, José Luis do Pico

“…Efforts directed to stratify the risk of acute kidney injury (AKI) have crystallized in the RIFLE or AKIN systems, based in sequential changes in Crs or urine flow. …”
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Metformin and Fibrosis: A Review of Existing Evidence and Mechanisms by Maoyan Wu, Huiwen Xu, Jingyu Liu, Xiaozhen Tan, Shengrong Wan, Man Guo, Yang Long, Yong Xu

“…Fibrosis is a physiological response to organ injury and is characterized by the excessive deposition of connective tissue components in an organ, which results in the disruption of physiological architecture and organ remodeling, ultimately leading to organ failure and death. …”
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Acute Popliteal Artery Occlusion after Revision Total Knee Arthroplasty by Ryu Tsujimoto, Tomoyuki Matsumoto, Koji Takayama, Yohei Kawakami, Masato Kamimura, Takehiko Matsushita, Ryosuke Kuroda, Masahiro Kurosaka

“…In this case, it was possible that the arterial disease that accompanied the vascular endothelium injury such as pseudoaneurysm had existed since the previous surgery at another hospital and was destroyed by the surgical procedure, which led to the formation of thrombosis and arterial occlusion. …”
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Nonsurgical Management of Adductor-related groin pain with Ultrasound-Guided Platelet-Rich Plasma Injection and Physical Therapy in a Competitive Soccer Player: A Case Report by Giorgio Zeppieri, Micheal S Smith, Ryan P. Roach

“…# Introduction Adductor-related groin pain involves an injury to the common aponeurosis connecting the rectus abdominus and adductor longus to the pubis. …”
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The Study on the Shock Wave Propagation Rule of a Gas Explosion in a Gas Compartment by Shu-Chao Lin, Qing-Zhao Hou, Anna Derlatka, Shan Gao, Jin-Jun Kang, Xiao-Lei Dong

“…The basic procedure for predicting the peak pressure of the blast wave is provided by considering the initial conditions and the gas compartment, and the corresponding injury effect of the explosion wave on the living beings is assessed. …”
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Paediatric one-day admission: why and is it necessary? by Jing Zhan Lock, Zi Xean Khoo, Jen Heng Pek

“…Upper respiratory tract infection (62, 12.9%), gastroenteritis (60, 12.5%) and head injury (52, 10.8%) were the three most common conditions. …”
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The Functional Movement Screen: Exploring Interrater Reliability between Raters in the Updated Version by Ricky Morgan, Steven LeMire, Lindsey Knoll, Emily Schuster, Cooper Tietz, Austin Weisz, Gary Schindler

“…The updated FMS™ may be reliably used to assess risk for future injury. # Level of Evidence 3…”
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Alpha-actinin-4-mediated FSGS: an inherited kidney disease caused by an aggregated and rapidly degraded cytoskeletal protein. by June Yao, Tu Cam Le, Claudine H Kos, Joel M Henderson, Phillip G Allen, Bradley M Denker, Martin R Pollak

“…Focal segmental glomerulosclerosis (FSGS) is a common pattern of renal injury, seen as both a primary disorder and as a consequence of underlying insults such as diabetes, HIV infection, and hypertension. …”
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Technique of sacrectomy at the combined operations for locally advanced rectal cancer by P. V. Tsarkov, S. K. Efetov, I. A. Tulina, L. V. Sidorova

“…To describe the surgical maneuvers allowing to decrease the degree of blood loss, duration of procedure and degree of surgical injury. To develop method for sacrectomy border location for the correct intraoperative navigation. …”
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α 2-Adrenoceptors: Challenges and Opportunities—Enlightenment from the Kidney by William A. Pettinger, Edwin K. Jackson

“…Now α2-ARs lurk on the horizon involving hypertension causality, renal denervation for hypertension, injury from falling in the elderly and prazosin’s mechanism of action in anxiety states such as posttraumatic stress disorder (PTSD). …”
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A Single Bout of Fasting (24 h) Reduces Basal Cytokine Expression and Minimally Impacts the Sterile Inflammatory Response in the White Adipose Tissue of Normal Weight F344 Rats by Kristin J. Speaker, Madeline M. Paton, Stewart S. Cox, Monika Fleshner

“…Sterile inflammation occurs when inflammatory proteins are increased in blood and tissues by nonpathogenic states and is a double-edged sword depending on its cause (stress, injury, or disease), duration (transient versus chronic), and inflammatory milieu. …”
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