Melatonin as an Anti-Inflammatory Agent Modulating Inflammasome Activation by Gaia Favero, Lorenzo Franceschetti, Francesca Bonomini, Luigi Fabrizio Rodella, Rita Rezzani

“…Inflammation may be defined as the innate response to harmful stimuli such as pathogens, injury, and metabolic stress; its ultimate function is to restore the physiological homeostatic state. …”
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Role of ginsenoside Rg1 as a PPAR-γ activator in protecting against manganese-induced hepatotoxicity: Insights into the TLR4/MyD88/MAPK signaling pathway by Mengjing Zhao, Min Zhang, Shoudong Ni

“…Rg1, a principal bioactive compound of ginseng, significantly alleviates Mn-induced liver injury. Rg1 markedly enhances the activities of SOD, GSH, and CAT, while reducing levels of MDA and ROS, indicating an improvement in antioxidant defense capacity. …”
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THE ROLE OF PLATELET-RICH FIBRIN FACILITATES THE HEALING OF GASTROCNEMIUS MUSCLE DEFECT: A PRELIMINARY STUDY ON ANIMAL MODEL by Dwikora Novembri Utomo, Kukuh Dwiputra Hernugrahanto

“…Conclusion: The use of PRF facilitates the healing of muscle injury. This study will be used as a fondation for further study on PRF.…”
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Thermal Changes in Guidewires Used During Endoscopic Retrograde Cholangiopancreatography During Electrical Conductance: An Ex-Vivo Safety Experiment by Rahul Karna, Nicholas Michael McDonald, Jacob Weiner, Théodon I. Netoff, Stuart K Amateau

“…In our ex-vivo study, minimal heat was generated via electrical conductivity despite direct current suggesting negligible risk of thermal injury during sphincterotomy. …”
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Correlation between Traits of Emotion-Based Impulsivity and Intrinsic Default-Mode Network Activity by Jizheng Zhao, Dardo Tomasi, Corinde E. Wiers, Ehsan Shokri-Kojori, Şükrü B. Demiral, Yi Zhang, Nora D. Volkow, Gene-Jack Wang

“…Negative urgency (NU) and positive urgency (PU) are implicated in several high-risk behaviors, such as eating disorders, substance use disorders, and nonsuicidal self-injury behavior. The current study aimed to explore the possible link between trait of urgency and brain activity at rest. …”
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Alpiniae oxyphyllae Fructus ameliorates renal lipid accumulation in diabetic kidney disease via activating PPARα by Zi-Jie Yan, Lin Zhang, Xin-Yao Han, Yu Kang, Shu-Man Liu, Tian-Peng Ma, Man Xiao, Yi-Qiang Xie

“…AOF lowered blood glucose, improved dyslipidemia, and attenuated renal injury in DKD mice. AOF-containing serum accentuated high glucose-induced decrease in cell viability and ameliorated lipid accumulation. …”
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Inhibition of Murine Pulmonary Microvascular Endothelial Cell Apoptosis Promotes Recovery of Barrier Function under Septic Conditions by Lefeng Wang, Sanjay Mehta, Michael Brock, Sean E. Gill

“…Sepsis is characterized by injury of the pulmonary microvasculature and the pulmonary microvascular endothelial cells (PMVEC), leading to barrier dysfunction and acute respiratory distress syndrome (ARDS). …”
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The Role of Mannose-Binding Lectin in Severe Sepsis and Septic Shock by Gennaro De Pascale, Salvatore Lucio Cutuli, Mariano Alberto Pennisi, Massimo Antonelli

“…However an excess of MBL activation might be also harmful due to the possibility of an unbalanced proinflammatory response and an additional host injury. Strategies of replacement therapies in critically ill patients with severe infections are under investigation but still far to be applied in clinical practice.…”
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Induction of stigma-like structures in saffron (Crocus sativus L.): Exploring factors and metabolite analysis. by Parvaneh Mahmoudi, Ahmad Moieni, Mojtaba Khayam Nekouei, Mohsen Mardi, Ghasem Hosseini Salekdeh

“…Furthermore, intact, and injury ovary explants were found to be the most effective explant types for inducing SLSs. …”
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Therapeutic Improvement of Scarring: Mechanisms of Scarless and Scar-Forming Healing and Approaches to the Discovery of New Treatments by Nick L. Occleston, Anthony D. Metcalfe, Adam Boanas, Nicholas J. Burgoyne, Kerry Nield, Sharon O'Kane, Mark W. J. Ferguson

“…Scarring in the skin after trauma, surgery, burn or sports injury is a major medical problem, often resulting in loss of function, restriction of tissue movement and adverse psychological effects. …”
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Synthetic embryology of the human heart by Maria Belen Paredes-Espinosa, Janet L. Paluh

“…Gastruloid synthetic embryology heart models offer new insights into previously hidden processes of development and provide powerful platforms for addressing heart disease that extends beyond cardiomyocytes, such as arrhythmogenic diseases, congenital defects, and systemic injury interactions, as in spinal cord injuries. The holistic view that is emerging will reveal heart development and disease in unprecedented detail to drive transformative state-of-the-art innovative applications for heart health.…”
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Cardiac Implications of COVID-19 in Deceased and Recovered Patients: A Systematic Review by Rajaram Khanal, Shreeyash Raj Bhattarai, Kriti Basnet, Sangam Shah, Roman Dhital, Sanjit Kumar Sah, Sujan Poudel, Odalys Frontela, George Michel, Sima Marzban, Alfonso J. Rodriguez-Morales

“…Cardiac complications such as heart failure, myocardial injury, and arrhythmias are common among patients infected with COVID-19. …”
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Allergic Interstitial Nephritis Manifesting as a Striated Nephrogram by Irfan Moinuddin, Erika Bracamonte, Bijin Thajudeen, Amy Sussman, Machaiah Madhrira, James Costello

“…Allergic interstitial nephritis (AIN) is an underdiagnosed cause of acute kidney injury (AKI). Guidelines suggest that AIN should be suspected in a patient who presents with an elevated serum creatinine and a urinalysis that shows white cells, white cell casts, or eosinophiluria. …”
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A Simple Bone Cyst in Cervical Vertebrae of an Adolescent Patient by Adriana Bruges Boude, Lina González Vásquez, Fernando Alvarado-Gomez, María Constanza Bedoya, Andrés Rodríguez-Múnera, Luis Carlos Morales-Saenz

“…In this case, the proximity of the cyst to the right vertebral artery and the risk of injury were high; however the surgical approach used was successful and no recurrence or instability was evidenced on postoperative MRI.…”
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LOWER LEG DEFORMITY CORRECTION USING ILIZAROV DEVICE IN DR SOETOMO GENERAL HOSPITAL SURABAYA: A CASE SERIES by Jeffry Andrianus, Citra Ahdi Prasetya

“…Benefit of the gradual correction using Ilizarov system are: (1) reduce the risk of neurovascular injury, (2) minimal soft tissue disturbance, (3) multiplanar and multidirectional correction. …”
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Interpreting Intervention Induced Neuroplasticity with fMRI: The Case for Multimodal Imaging Strategies by Lee B. Reid, Roslyn N. Boyd, Ross Cunnington, Stephen E. Rose

“…Direct measurement of recovery from brain injury is an important goal in neurorehabilitation, and requires reliable, objective, and interpretable measures of changes in brain function, referred to generally as “neuroplasticity.” …”
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Fatal Postpartum Hemorrhage in a Patient with Niemann-Pick Disease Type B by Atakan Tanacan, Abdullah Yalcin, Canan Unal, Seda Banu Akinci, Mehmet Sinan Beksac

“…Unfortunately, she had a detrimental course with hypoxic brain injury leading to brain death. Conclusions. In conclusion, physicians should keep in mind that patients with a history of splenectomy and/or uncontrollable hemorrhage must be carefully evaluated for rare diseases like lysosomal storage diseases and that NPD B can cause mortality because of postpartum bleeding. …”
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Investigating the effect of urban governance on urban resilience (Case study: Tehran) by Gholam Reza soroushan, Abdallah hendiani, parvane zivyar pardei, Ali tavakolan

“…In the meantime, the issue of resilience in urban communities means that society is able to withstand severe natural disasters without major damage, injury, production stoppage and reduced quality of life, and also at the superficial level, the goal of resilience as an ideal. …”
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Benefits of surgical obturators in oral maxillofacial rehabilitation. Review of literature by Madelaine Bárbara Jiménez Gutiérrez, José Miguel Robaina Ruiz, Iván Díaz Cal

“…<strong>Introduction:</strong> Fractures due to traumatic injury, surgical resection of tumors and congenital defects expose the maxilla to aggressions, and for rehabilitation there are obturator prostheses that recover some functions such as swallowing and phonation, as well as aesthetics. …”
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Report of Three Cases of AKI Following Weight-Based Gentamicin Prophylaxis for IPP Implantation: Potential Concerns for Patients with Preexisting Conditions by Robert H. Moore, Uzoma A. Anele, Sarah C. Krzastek, Adam P. Klausner, J. Tyler Roseman

“…Therefore, in order to expose potential safety issues, we present three cases of postoperative acute kidney injury following weight-based gentamicin prophylaxis after implantation of inflatable penile prostheses.…”
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