Autoimmune Hepatitis: Progress from Global Immunosuppression to Personalised Regulatory T Cell Therapy by Nwe Ni Than, Hannah C. Jeffery, Ye H. Oo

“…Autoimmune hepatitis (AIH) is an immune mediated liver injury. The precise aetiology of AIH is still unknown but current evidence suggests both genetic and environmental factors are involved. …”
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The Temporal Pattern of a Lesion Modulates the Functional Network Topology of Remote Brain Regions by W. De Baene, G. J. M. Rutten, M. M. Sitskoorn

“…These results underline the utility of a network perspective in evaluating effects of focal brain injury.…”
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Quadriceps Activation After Anterior Cruciate Ligament Reconstruction: The Early Bird Gets the Worm! by Ayrton MOIROUX--SAHRAOUI, Florian FORELLI, Jean MAZEAS, Alexandre JM RAMBAUD, Andreas BJERREGAARD, Jérôme RIERA

“…Arthrogenic Muscle Inhibition (AMI) is a phenomenon observed in individuals with joint injury or pathology, characterized by a reflexive inhibition of surrounding musculature, altered neuromuscular control, and compromised functional performance. …”
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Concurrent Stenoocclusive Disease of Intracranial and Extracranial Arteries in a Patient with Polycythemia Vera by Le H. Hua, Robert L. Dodd, Neil E. Schwartz

“…The pathophysiology may be due to a prothrombotic state leading to repeated endothelial injury, resultant intimal hyperplasia, and progressive steno-occlusion.…”
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Dietary Solid-state-fermentation product of Bacillus velezensis T23 alleviate hepatic steatosis, oxidative stress, gut barrier damage, and microbiota dysbiosis in juvenile genetica... by Qiang Hao, Rolf Erik Olsen, Einar Ringø, Qianwen Ding, Tsegay Teame, Yuanyuan Yao, Chao Ran, Yalin Yang, Zhen Zhang, Zhigang Zhou

“…The purpose of this study was to evaluate the effects of solid-state fermentation product of autochthonous Bacillus velezensis T23 on improving hepatic steatosis, liver antioxidation capacity, gut injury and gut microbiota profile of genetically improved farmed tilapia (GIFT, Oreochromis niloticus). …”
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Clinical Outcomes of Transcatheter Aortic Valve Replacement in Nonagenarians: A Systematic Review and Meta-Analysis by Yan Liu, Yu Du, Mingjie Fu, Yue Ma, Deguang Wang, Jinglin Zhang, Wei Liu, Yingxin Zhao, Yujie Zhou

“…There were no significant differences in the rate of myocardial infarction, stage 2 or 3 acute kidney injury, new pacemaker implantation, or conversion to surgical aortic valve replacement. …”
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Project-based management to reduce skin damage associated with acupressure medical adhesives in patients undergoing acupoint application for chronic gastritis (基于项目化管理降低慢性胃炎患者穴位贴敷医... by WANG Qian (王倩), WANG Jiehong (王捷虹), SHA Zhihui (沙志惠)

“…Objective To evaluate the project-based management in reducing acupressure medical adhesive-associated skin injury in patients with chronic gastritis, and provide a reliable basis for clinical practice. …”
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3D-printed constructs deliver bioactive cargos to expedite cartilage regeneration by Rong Jiao, Xia Lin, Jingchao Wang, Chunyan Zhu, Jiang Hu, Huali Gao, Kun Zhang

“…Cartilage is solid connective tissue that recovers slowly from injury, and pain and dysfunction from cartilage damage affect many people. …”
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Transcriptomic and proteomic analysis of the jejunum revealed the effects and mechanism of protocatechuic acid on alleviating Salmonella typhimurium infection in chickens by Sheng Zhang, Qin Wang, Xiangtian Yao, Jingjing Dong, Guanhuo Li, Yingan Zang, Shouqun Jiang, Yibing Wang

“…Protocatechuic acid has anti-inflammatory, immunoregulatory and anti-pathogenic effects, and is expected to be an effective choice for alleviating Salmonella infection and intestinal injury. A total of 180 1-d female, yellow-feathered chickens were randomly allocated into 3 treatment groups, the controls (Ctr), the Salmonella-challenged treatment (Sal) and the protocatechuic acid treatment (PA). …”
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Role of hepatocyte RIPK1 in maintaining liver homeostasis during metabolic challenges by Weigao Zhang, Hu Liu, Danyang Zhang, Yuguo Yi, Liang Tao, Yunfeng Zhu, Shuxian Huang, Xunan Zhao, Qianchao Shao, Peiqi Li, Yiwen Weng, Wei Lu, Jianfa Zhang, Haibing Zhang, Yuxin Chen, Dan Weng

“…Our results demonstrated that hepatocyte-specific deficiency of RIPK1 sensitized the liver to short-term fasting-induced liver injury and hepatocyte apoptosis in both male and female mice. …”
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Soluble and cell-based markers of immune checkpoint inhibitor-associated nephritis by Sandra M Herrmann, Riley Fadden, Ryan J Sullivan, Kerry L Reynolds, Harish Seethapathy, Meghan E Sise, Shruti Gupta, Alexandra-Chloe Villani, Qiyu Wang, Daiana Moreno, Destiny Harden, R Neal Smith, Ivy A Rosales, Robert B Colvin, Sarah Chute, Lynn D Cornell, Nancy J Yang, Sara Barmettler, Sophia Wells, Jocelyn Farmer

“…The downstream impact of T cell activation in the affected kidney was investigated using archived biopsy samples to evaluate the gene expression of IL2RA, IL-2 signaling, and T cell receptor signaling in patients with ICI-nephritis compared with other causes of drug-induced nephritis, acute tubular injury, and histologically normal controls.Results sIL-2R level in peripheral blood was significantly higher in patients with ICI-nephritis (N=24) (median 2.5-fold upper limit of normal (ULN), IQR 1.9–3.3), compared with ICI-treated controls (N=10) (median 0.8-fold ULN, IQR 0.5–0.9, p<0.001) and hemodynamic AKI controls (N=6) (median 0.9-fold-ULN, IQR 0.7–1.1, p=0.008). …”
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The Effects of GABAergic System under Cerebral Ischemia: Spotlight on Cognitive Function by Juan Li, Luting Chen, Feng Guo, Xiaohua Han

“…However, no study has investigated the changes in the system in the hippocampus during cerebral ischemic injury, which results in cognitive impairment, particularly at the chronic ischemic stage and the late phase of ischemia. …”
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Apelin Protects Primary Rat Retinal Pericytes from Chemical Hypoxia-Induced Apoptosis by Li Chen, Yong Tao, Jing Feng, Yan Rong Jiang

“…These results suggest that apelin suppressed hypoxia-induced pericytes injury, which indicated that apelin could be a potential therapeutic target for retinal angiogenic diseases.…”
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A Case of Sevoflurane Use during Pregnancy in the Management of Persistent Status Asthmaticus by Jessica Parrott, Mitch Tener, Katie Dennis, Matthew Sharpe, Cecily Clark-Ganheart

“…Histologic features suggested drug induced hepatic injury. Liver function subsequently normalized. She delivered a term neonate without short-term complications. …”
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Nasal hyperreactivity and inflammation in allergic rhinitis by I. M. Garrelds, C. de Graaf-in't Veld, R. Gerth van Wijk, F. J. Zijlstra

“…These inflammatory cells migrate under the influence of chemotactic agents to the site of injury and induce the process of repair. Several types of inflammatory cells have been implicated in the pathogenesis of allergic rhinitis. …”
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Successful Renal Transplantation after Presumed Cyanide Toxicity Treated with Hydroxocobalamin and Review of the Literature by Ryan J. Hendrix, Paulo N. Martins, Jeffrey S. Stoff, Aaron Ahearn, Adel Bozorgzadeh, Babak Movahedi

“…We report two cases of successful renal transplantation with allografts from donors who suffered anoxic brain injury as the primary cause of death from house fires. …”
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Serum Lactate Dehydrogenase Is a Sensitive Predictor of Systemic Complications of Acute Pancreatitis by Dong-Ni Huang, Hao-Jie Zhong, Ying-Li Cai, Wen-Rui Xie, Xing-Xiang He

“…Acute pancreatitis (AP) is a common and potentially life-threatening inflammatory disease that can cause various complications, including systemic inflammatory response syndrome (SIRS), pleural effusion, ascitic fluid, myocardial infarction, and acute kidney injury (AKI). However, there is still a lack of rapid and effective indicators to assess the disease. …”
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Pectoralis Major Tear with Retracted Tendon: How to Fill the Gap? Reconstruction with Hamstring Autograft and Fixation with an Interference Screw by L. Baverel, K. Messedi, G. Piétu, V. Crenn, F. Gouin

“…Rupture of the pectoralis major tendon is considered an uncommon injury and a significant number of ruptures are missed or diagnosed late, leading to a chronic tear. …”
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The Relevance and Potential Role of Orbital Fat in Inflammatory Orbital Diseases: Implications for Diagnosis and Treatment by Prince Dadson, Peter Ngum, Luis Eduardo Juarez-Orozco, Michael Ntodie, Piotr Loba

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Trapezoid Fracture Associated with Scaphoid Fracture in a Football Goalkeeper by Tetsuya Yamamoto, Takehiko Matsushita, Kenjiro Ito, Shinji Matsushima, Kazuya Yoshida, Ryosuke Kuroda

“…If there is sustained pain in the wrist and hand after punching, combined trapezoid and scaphoid fractures should be considered as the possible injury.…”
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