C5a-C5aR1 axis mediates lung inflammation and fibrosis induced by single-walled carbon nanotubes via promoting neutrophils recruitment by Jiaojiao Zhu, Xiang Zhang, Lanlan Li, Hongxu Yang, Hang Liu, Danyang Wu, Zikai Liu, Bin Liu, Tong Shen

“…In conclusion, our study provides novel insights into the underlying biological mechanism that C5a-C5aR1 axis regulates neutrophils recruitment-mediated lung injury induced by SWCNT, may help to develop therapeutic strategies for SWCNT-provoked lung injury.…”
Get full text

Protective mechanism of quercetin compounds against acrylamide-induced hepatotoxicity by Linzi Li, Xueying Lei, Lin Chen, Ya Ma, Jun Luo, Xuebo Liu, Xinglian Xu, Guanghong Zhou, Xianchao Feng

“…Long-term exposure to acrylamide (AA) can cause liver injury and endanger human health. However, whether quercetin compounds can attenuate AA-induced liver injury and the specific mechanism are not clear. …”
Get full text

Scaphoid Waist Nonunion in an 8-Year-Old: A Rare Occurrence by T. M. Gause, T. E. Moran, J. B. Carr, D. N. Deal

“…Injury patterns have evolved as children are more commonly presenting with adult-type fracture patterns. …”
Get full text

A Case of Chronic Ethylene Glycol Intoxication Presenting without Classic Metabolic Derangements by Stephanie M. Toth-Manikowski, Hanni Menn-Josephy, Jasvinder Bhatia

“…We present a case of chronic ethylene glycol ingestion in a patient who presented with acute kidney injury and repeated denials of an exposure history. …”
Get full text

Movement System Dysfunction Applied to Youth and Young Adult Throwing Athletes by Ashley E. Disantis, RobRoy Martin

“…Shoulder and elbow injuries in overhead athletes, especially baseball pitchers, have become more common and result in limited participation. …”
Get full text

Fracture of the Atlas through a Synchondrosis of Anterior Arch by Gamze Turk, Ismail M. Kabakus, Erhan Akpinar

“…Greater elasticity of intervertebral ligaments and also the spinal vertebrae explains why cervical fractures in paediatric ages are rare. The injury usually results from a symmetric or asymmetric axial loading. …”
Get full text

Use of Methadone for Neuropathic Pain by Dwight Moulin

“…Chronic neuropathic pain is often considered to be a common complication of injury to the central or peripheral nervous system and the pain itself is usually assumed to be intractable. …”
Get full text

Workup and Management of Persistent Neuralgia following Nerve Block by Paul David Weyker, Christopher Allen-John Webb, Thoha M. Pham

“…Workup with electrodiagnostic studies and magnetic resonance neurography revealed injury to both the femoral and sciatic nerves. Diagnostic studies and potential mechanisms for nerve injury are discussed.…”
Get full text

PEEP or No PEEP: That Is Not the Question by Jesús Villar, Arthur S Slutsky

“…Generally, positive end-expiratory pressure (PEEP) is applied to improve oxygenation, and has been shown to improve gas exchange and lung compliance in acute lung injury, but it is not without risk. To date, no controlled outcome studies have been published to demonstrate the best method of choosing the level of PEEP. …”
Get full text

Bortezomib-Induced Pulmonary Toxicity: A Case Report and Review of Literature by Prakash Kharel, Deekchha Uprety, Abhinav B. Chandra, Yirui Hu, Anuradha Avinash Belur, Ajay Dhakal

“…Bortezomib-induced lung injury, although not appreciated during the introductory time of the medication, has now been highlighted in multiple case reports. …”
Get full text

Prognostic and Diagnostic Value of Endocan in Kidney Diseases by Elisabeth Samouilidou, Virginia Athanasiadou, Eirini Grapsa

“…Endocan could additionally improve the early diagnostic evaluation of acute kidney disease, chronic renal allograft injury, and acute rejection after kidney transplantation, thus contributing to endothelial cell injury monitoring in a timely manner.…”
Get full text

Cranio-Caudal Identification and Preservation of Spinal Accessory Nerve during Modified Radical Neck Dissection by Pushkar P. Waknis, Ravina Dharamsi, Mrinal Gawali, Divya Palanisami

“…Introduction: The spinal accessory nerve (SAN) is encountered during neck dissection surgeries and is at the highest risk for iatrogenic injury, which may lead to shoulder syndrome. This functional deformity can be avoided by preservation of SAN in modified radical neck dissection (MRND). …”
Get full text

Fractalkine and Other Chemokines in Primary Biliary Cirrhosis by Shinji Shimoda, Carlo Selmi, M. Eric Gershwin

“…We submit the hypothesis that BEC are in fact the innocent victims of the autoimmune injury and that the adaptive immune response is critical in PBC.…”
Get full text

Antioxidants and the Integrity of Ocular Tissues by Marcela P. Cabrera, Ricardo H. Chihuailaf

“…These radicals can interact with various cellular components and induce cell injury. When free radicals exceed the antioxidant capacity, cell injury causes diverse pathologic changes in the organs. …”
Get full text

Leukocytes: The Double-Edged Sword in Fibrosis by Jakub Kryczka, Joanna Boncela

“…Scaring is strongly associated with inflammation and wound healing to regain tissue integrity in response to skin tissue injury. However, increased and uncontrolled inflammation, repetitive injury, and individual predisposition might lead to fibrosis, a severe disorder resulting in the formation of dense and stiff tissue that loses the physical properties and physiological functions of normal tissue. …”
Get full text

Forsaken Foregut: Case Report of Simultaneous Black Esophagus and Ischemic Cholangiopathy by Paul A. Cameron, Franzjosef Schweiger

“…Other contributing factors may include corrosive injury from gastric contents and diminished mucosal repair mechanisms. …”
Get full text

Repair of Acute Patellar Tendon Rupture Using an Internal Brace Technique by Aki Fukuda, Shigeto Nakazora, Akinobu Nishimura, Ko Kato

“…Acute patellar tendon rupture is a serious injury, resulting in the disruption of the knee extensor mechanism. …”
Get full text

Hepatocyte growth factor stimulates neutrophil degranulation but not respiratory burst by I. C. Kowanko, A. Ferrante, T. Nakamura

“…Hepatocyte growth factor (HGF) is a cytokine produced during injury to the liver and other organs. Neutrophils are numerous in such tissue injury sites and may be influenced by HGF. …”
Get full text

Pharmacotherapy of Posttraumatic Cognitive Impairments by David B. Arciniegas, Jonathan M. Silver

“…This article reviews first the neurobiological consequences of traumatic brain injury with a particular emphasis on acute and long-term posttraumatic neurochemical disturbances. …”
Get full text

Upper Gastrointestinal Bleeding Secondary to Sodium Polystyrene Sulfonate Use: A Rare Adverse Effect of Commonly Prescribed Treatment by Hamzah Shariff, Shiva Naidoo, Ghazal Ghafari, Hongjie Li, Manisha Devi, Kishore Kumar

“…He was found to have severe hyperkalemia, acute kidney injury, and rhabdomyolysis. The hyperkalemia was treated with sodium polystyrene sulfonate (SPS). …”
Get full text