Sarcopenia is a risk factor for postoperative delirium in geriatric hip fracture patients: a retrospective study by Yi-Ming Qi, Hao-Tao Li, Shi-Min Chang, Sun-Jun Hu, Shou-Chao Du, Chen-Dong Liu, Yong-Qian Chu, Yun-Feng Rui, Yun-Feng Rui

“…The aim of this study was to explore the prevalence of POD and sarcopenia in geriatric patients undergoing hip fracture surgeries and to investigate the correlation between preoperative sarcopenia and POD.MethodsAfter applying specific inclusion and exclusion criteria, the information of 234 patients were retrospectively collected. …”
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Obtaining patient phenotypes in SARS-CoV-2 pneumonia, and their association with clinical severity and mortality by Fernando García-García, Dae-Jin Lee, Mónica Nieves-Ermecheo, Olaia Bronte, Pedro Pablo España, José María Quintana, Rosario Menéndez, Antoni Torres, Luis Alberto Ruiz Iturriaga, Isabel Urrutia, COVID-19 & Air Pollution Working Group

“…Our clustering algorithm identified k=3 distinct phenotypes and 18 strongly informative variables: Phenotype A (788 cases [50.9% prevalence] – age $$\sim$$ ∼ 57, Charlson comorbidity $$\sim$$ ∼ 1, pneumonia CURB-65 score $$\sim$$ ∼ 0 to 1, respiratory rate at admission $$\sim$$ ∼ 18 min-1, FiO2 $$\sim$$ ∼ 21%, C-reactive protein CRP $$\sim$$ ∼ 49.5 mg/dL [median within cluster]); phenotype B (620 cases [40.0%] – age $$\sim$$ ∼ 75, Charlson $$\sim$$ ∼ 5, CURB-65 $$\sim$$ ∼ 1 to 2, respiration $$\sim$$ ∼ 20 min-1, FiO2 $$\sim$$ ∼ 21%, CRP $$\sim$$ ∼ 101.5 mg/dL); and phenotype C (140 cases [9.0%] – age $$\sim$$ ∼ 71, Charlson $$\sim$$ ∼ 4, CURB-65 $$\sim$$ ∼ 0 to 2, respiration $$\sim$$ ∼ 30 min-1, FiO2 $$\sim$$ ∼ 38%, CRP $$\sim$$ ∼ 152.3 mg/dL). …”
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Heart failure with mildly reduced ejection fraction: retrospective study of ejection fraction trajectory risk by Robert J.H. Miller, Majid Nabipoor, Erik Youngson, Gynter Kotrri, Nowell M. Fine, Jonathan G. Howlett, Ian D. Paterson, Justin Ezekowitz, Finlay A. McAlister

“…Categorizing HFmrEF patients based on LVEF trajectory provides meaningful clinical information and may assist clinicians with management decisions.…”
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Second-line treatment patterns and outcomes in advanced HCC after progression on atezolizumab/bevacizumab by Meng Wu, Claudia A.M. Fulgenzi, Antonio D’Alessio, Alessio Cortellini, Ciro Celsa, Giulia F. Manfredi, Bernardo Stefanini, Y. Linda Wu, Yi-Hsiang Huang, Anwaar Saeed, Angelo Pirozzi, Tiziana Pressiani, Lorenza Rimassa, Martin Schoenlein, Kornelius Schulze, Johann von Felden, Yehia Mohamed, Ahmed O. Kaseb, Arndt Vogel, Natascha Roehlen, Marianna Silletta, Naoshi Nishida, Masatoshi Kudo, Caterina Vivaldi, Lorenz Balcar, Bernhard Scheiner, Matthias Pinter, Amit G. Singal, Joshua Glover, Susanna Ulahannan, Fredrich Foerster, Arndt Weinmann, Peter R. Galle, Neehar D. Parikh, Wei-Fan Hsu, Alessandro Parisi, Hong Jae Chon, David J. Pinato, Celina Ang

“…These results can help inform clinicians of possible treatment options for patients who progress after frontline atezolizumab plus bevacizumab while we await maturing data from randomized-controlled trials.…”
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Prevalence and factors associated with childhood malaria and anaemia in Osun state, Nigeria: a baseline household malariometric study by Olusola Ajibaye, Semiu Adebayo Rahman, Oluwagbemiga Olanrewaju Aina, Chinazo Ujuju, Chimere Obiora Agomo, Samuel Akindele, Olakiigbe Abiodun, Tolulope Victoria Uzoka, Nnenna Ogbulafor, Olufemi Oroge, Rufai-Ahmed Garba, Michael Ekholuenetale, Kolawole Maxwell, Ridwan Akorede Awosanya, Mary Abosede Adekola, Benjamin Bukky Ilesanmi, Adekemi Ajayi, Olusola Oresanya, James K. Tibenderana, Adeola Yetunde Olukosi

“…These findings would inform the positioning of PMC intervention touch-points to reduce malaria burden in young children.…”
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The triglyceride-glucose index trajectories are associated with cardiovascular diseases in people living with HIV: evidence from a prospective cohort study in China, 2005–2022 by Yinsong Luo, Liqin Sun, Yun He, Fang Zhao, Duo Shan, Fan Bu, Lingyun Ge, Xiaorui Li, Yiyao Hu, Xi Xiao, Hongzhou Lu, Jiaye Liu

“…Incorporating TyG index monitoring into routine clinical assessments could enhance risk stratification and inform tailored prevention strategies. Further studies are needed to validate these findings in other cohorts and to explore their applicability in women.…”
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gp91phox, a Novel Biomarker Evaluating Oxidative Stress, Is Elevated in Subclinical Hypothyroidism by Xiaochun Ma, Furong Wang, Xiaowen Zhen, Lifang Zhao, Li Fang, Zhenfang Dong, Wenbin Chen, Xiaoming Zhou

“…All the patients were newly diagnosed and did not take any medication. The information of lipid profile and thyroid function was extracted, and the concentrations of gp91phox were obtained with ELISA. …”
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Implementing a nurse-enabled, integrated, shared-care model involving specialists and general practitioners in early breast cancer post-treatment follow-up (EMINENT): a single-cent... by Raymond J. Chan, Fiona Crawford-Williams, Chad Yixian Han, Lee Jones, Alexandre Chan, Daniel McKavanagh, Marissa Ryan, Christine Carrington, Rebecca L. Packer, Megan Crichton, Nicolas H. Hart, Emma McKinnell, Melissa Gosper, Juanita Ryan, Bethany Crowe, Ria Joseph, Carolyn Ee, Jane Lee, Steven M. McPhail, Katharine Cuff, Laisa Teleni, Jon Emery

“…GPs can meet the survivorship care needs identified breast cancer survivors. This trial can inform a large, pragmatic, hybrid effectiveness-implementation trial. …”
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Beneficial and harmful effects of duloxetine versus placebo, ‘active placebo’ or no intervention for adults with major depressive disorder: a systematic review with meta-analysis a... by Christian Gluud, Marija Barbateskovic, Joanna Moncrieff, Faiza Siddiqui, Janus C Jakobsen, Mathias Maagaard, Sophie Juul, Johanne Juul Petersen, Caroline Barkholt Kamp, Mark Abie Horowitz, Kiran Kumar Katakam

“…Trial sequential analysis showed that we did not have enough information to assess the effects of duloxetine on serious adverse events (SAEs) (OR 0.67, 95% CI 0.44 to 1.02; I2=0.0%; 19 trials) or suicide or suicide attempts (OR 1.08, 95% CI 0.37 to 3.16; six trials). …”
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Carriage of Extended-Spectrum-β-Lactamase- and AmpC-β-Lactamase-Producing Enterobacteriaceae (ESBL-PE) in Healthy Community and Outpatient Department (OPD) Patients in Nepal by Dipendra Kumar Mandal, Shiv Kumar Sah, Shyam Kumar Mishra, Sangita Sharma, Hari Prasad Kattel, Sanjeet Pandit, Pranav Kumar Yadav, Ujjwal Laghu, Rajani Lama, Niranjan Prasad Sah, Jeevan Bahadur Sherchand, Keshav Parajuli, Anup Bastola, Sher Bahadur Pun, Basista Prasad Rijal, Bharat Mani Pokharel

“…Extended-spectrum β-lactamase (ESBL)- and AmpC-β-lactamase-producing Enterobacteriaceae have recently emerged as a public threat in the treatment of nosocomial as well as community-acquired infections. Very little information is currently available about its existence in Nepal. …”
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A human visual cognitive mechanism based network for surface defect detection(基于人类视觉认知机制的表面缺陷检测) by 崔丽莎(CUI Lisha), 代润鹏(DAI Runpeng), 姜晓恒(JIANG Xiaoheng), 李飞蝶(LI Feidie), 陈恩庆(CHEN Enqing), 徐明亮(XU Mingliang)

“…Additionally, the fusion branch introduces the feature preserving downsampling (FPD) module that employs patch merging technique, effectively alleviating the issue of minor defect information loss caused by traditional downsampling. …”
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Design, evaluation, and future projections of the NARCliM2.0 CORDEX-CMIP6 Australasia regional climate ensemble by G. Di Virgilio, G. Di Virgilio, J. P. Evans, J. P. Evans, F. Ji, F. Ji, E. Tam, J. Kala, J. Andrys, C. Thomas, D. Choudhury, C. Rocha, S. White, Y. Li, M. El Rafei, R. Goyal, M. L. Riley, J. Lingala

“…NARCliM2.0 is a valuable resource for assessing climate change impacts on societies and natural systems and informing resilience planning by reducing model biases versus earlier NARCliM generations and providing more up-to-date future climate projections utilising CMIP6.…”
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Retrospective analysis of amantadine response and predictive factors in intensive care unit patients with non-traumatic disorders of consciousness by Corinna Blum, Constanze Single, Kornelia Laichinger, Anna Hofmann, Tim W. Rattay, Tim W. Rattay, Kamaldeen Adeyemi, Reimer Riessen, Michael Haap, Helene Häberle, Ulf Ziemann, Annerose Mengel, Katharina Feil

“…Findings from this study informed the design of our ongoing prospective study, which aims to further evaluate the long-term efficacy of amantadine.…”
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Establishment and validation a relapse prediction model for bipolar disorder by Xiaoqian Zhang, Xiaoqian Zhang, Xiaoqian Zhang, Xiaoqian Zhang, Minghao Wu, Daojin Wang, Long Wang, Long Wang, Long Wang, Wen Xie, Wen Xie, Wen Xie

“…Recurrence risk factors for BD were selected using univariate and binary logistic regression analyses based on the clinical data of the patients and other pertinent information. A nomogram model was developed to predict the incidence of BD relapse. …”
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Distribution of Airway Findings in ANCA-Associated Vasculitis: A 20-Year Observational Analysis by Megan M. Sullivan, Maximiliano Diaz Menindez, Hassan Baig, Anushka Irani, Ronald Butendieck, Benjamin Wang, Florentina Berianu, Carolyn Mead-Harvey, Andy Abril, Vikas Majithia

“…Maximum likelihood estimation with 10 repetitions per model ensured robustness in model selection, guided by the Akaike information criterion (AIC). Patient and disease characteristics were summarized and compared across predicted classes. …”
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Integrated analysis of the prevalence and influencing factors of poststroke dysphagia by Xiaopeng Wen, Baochao Fan, Jie Zhan, Hao Wen, Huihui Ban, Yujiao Yang, Chenyang Tao, Cui Li, Kunbin Li, Liming Lu

“…Abstract Objectives Poststroke dysphagia (PSD) is a common complication after stroke but there is limited information on its global prevalence and influencing factors, such as spatial, temporal, demographic characteristics, and stroke-related factors. …”
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Lower incidence of hepatocellular carcinoma with tenofovir alafenamide in chronic hepatitis B: Evidence from a large-scale cohort by Hye-Jin Yoo, Jae-Young Kim, Jeong-Ju Yoo, Hye Won Lee, Sang Gyune Kim, Young Seok Kim

“…From a practical perspective, these findings can guide physicians in prescribing more effective treatments, assist researchers in designing further studies to explore the mechanisms behind the effectiveness of TAF, and inform policymakers to craft healthcare policies that optimize patient outcomes while considering potential limitations, such as the observational nature of the study and residual confounding factors.…”
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Impact of alcohol drinking and tobacco smoking on the drug-resistance of newly diagnosed tuberculosis: a retrospective cohort study in Shandong, China, during 2004–2020 by Yi-Fan Li, Yao Liu, Qi Fu, Wan-mei Song, Jin-yue Liu, Qian-yun Zhang, Ting-ting Xu, Shi-jin Li, Qi-qi An, Si-qi Liu, Huai-chen Li, Ning Ning Tao, Xue-han Zhu, Chun-bao Yu, Jihua Dong

“…Exclusive criteria: retreated cases; extrapulmonary tuberculosis; without information on drug susceptibility testing results, smoking or drinking habits; bacteriological identification as non-tuberculous mycobacteria.Primary and secondary outcome measures Patients were classified into four groups including smokers only (G1), drinker only (G2), smoker +drinker (G3), non-smoker +non-drinker group (G0). …”
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Determinants of 5-year survival in patients with advanced NSCLC with PD-L1≥50% treated with first-line pembrolizumab outside of clinical trials: results from the Pembro-real 5Y glo... by Mieke Van Hemelrijck, Salvatore Grisanti, Avinash Aujayeb, Martin Forster, Giannis Mountzios, Andrea Napolitano, Bruno Vincenzi, Joachim G J V Aerts, Marina Garassino, Valter Torri, Solange Peters, Alex Friedlaender, Alfredo Addeo, Giuseppe Lo Russo, Roberto Ferrara, Diego Signorelli, Alessandro Russo, So Yeon Kim, Jarushka Naidoo, Scott Gettinger, Heather Wakelee, Martin Sebastian, Mark Awad, Abdul Rafeh Naqash, Alessio Cortellini, Raffaele Giusti, Michele De Tursi, Federica Zoratto, Marco Russano, Rita Chiari, Biagio Ricciuti, Andrea De Giglio, Alain Gelibter, Giuseppe Tonini, Amin H Nassar, Alessandra Curioni-Fontecedro, Eleni Karapanagiotou, Emilio Bria, Jack Bell, Paolo Bironzo, Joao V Alessi, Alessandro Morabito, David J Pinato, Francesco Passiglia, Carlo Genova, Francesca Mazzoni, Alessandro Inno, Francesco Grossi, Luca Cantini, Lorenza Landi, Luigi Della Gravara, Margarita Majem, Uma Mukherjee, Federica Biello, Alessandro Leonetti, Annalisa Guida, Marianna Macerelli, Gabriele Minuti, Giulio Metro, Thomas Newsom-Davis, Eleni Josephides, Andrea Camerini, Elisa Roca, David O’Reilly, Mingjia Li, Laura Mezquita, Teresa Gorría, Claudia A M Fulgenzi, Lauren Young, Joel W Neal, Javier Baena, Francesco Pantano, Jacobo Rogado, Mary Jo Fidler, Teresa Beninato, Federica Pecci, Alessandro Di Federico, Kazuki Takada, Leonardo Brunetti, Talal El Zarif, Laura Moliner, Alberto Servetto, Sukumar Kalvapudi, Sai Yendamuri, Edoardo Garbo, Giuseppina Rita Di Fazio, Monica Loza, Ritujith Jayakrishnan, Michele Montrone, Nichola O Awosika, Bartlomiej Tomasik, Maximilian Rost, Isabelle Monnet, Francesco Agustoni, Artur Katz, Dwight Hall Owen, Michele Ghidini, Armida D’Incecco, Gianpaolo Spinelli, Monica Verrico, Manuel Dupont, Rafael Di Marco Barros, Diego Luigi Cortinovis, Chiara Bennati, Frank Aboubakar Nana, Anne-Marie Dingemans, Taher Abu Hejleh

“…Hierarchical organization indicates ECOG-PS, age and PD-L1-TPS as the most important predictors of 5-year survival, potentially informing clinical practice.…”
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Validation of formaldehyde products from three satellite retrievals (OMI SAO, OMPS-NPP SAO, and OMI BIRA) in the marine atmosphere with four seasons of Atmospheric Tomography Missi... by J. Liao, J. Liao, G. M. Wolfe, A. E. Kotsakis, A. E. Kotsakis, A. E. Kotsakis, J. M. Nicely, J. M. Nicely, J. M. St. Clair, J. M. St. Clair, T. F. Hanisco, G. González Abad, C. R. Nowlan, Z. Ayazpour, Z. Ayazpour, I. De Smedt, E. C. Apel, R. S. Hornbrook

“…Examination of retrieval components reveals that slant column corrections have a larger impact on the retrievals over remote marine regions, while AMFs play a smaller role. This study informs us that the potential latitude-dependent biases in the retrievals<span id="page2"/> require further investigation for improvement and should be considered when using marine HCHO satellite data, and vertical profiles from in situ instruments are crucial for validating satellite retrievals.…”
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