Inhibition of Matrix Metalloproteinase with BB-94 Protects against Caerulein-Induced Pancreatitis via Modulating Neutrophil and Macrophage Activation by Zengkai Wu, Tunike Mulatibieke, Mengya Niu, Bin Li, Juanjuan Dai, Xin Ye, Yan He, Congying Chen, Li Wen, Guoyong Hu

“…Our results showed that inhibition of MMP with BB-94 protected against pancreatic inflammatory responses in caerulein-induced pancreatitis via modulating neutrophil and macrophage activation.…”
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Genetic Polymorphisms of Toll-like receptors 2 and 9 as Susceptibility Factors for the Development of Ankylosing Spondylitis and Psoriatic Arthritis by Camila F. Oliveira-Toré, Amarilis G. Moraes, Gabriela F. Martinez, Janisleya S. F. Neves, Luciana C. Macedo, Marco A. Rocha-Loures, Marília G. Quirino, Hugo V. Alves, Ana M. Sell, Jeane E. L. Visentainer

“…Toll-like receptors (TLRs) have an important role in the mechanism of innate immunity and may influence inflammatory responses. Polymorphisms in TLR genes that lead to changes in these receptors or that interfere with the transcription rates of mRNA TLR may be involved in the chronic inflammatory immune response observed in SpA. …”
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Investigating the antioxidant and anti-inflammatory potential of Nypa fruticans: a multifaceted approach to skin protection and aging by Seul Ki Kim, Sang-Back Kim, Seul Bi Lee, Kang sub Kim, So-Ri Son, En Jin Choi, Byung Chul Park, Eunyoung Hong, You Ah Kim, Byoung Seok Moon, Sullim Lee

“…Abstract Reactive oxygen species (ROS) produced in the mitochondria of skin cells play a significant role in the degradation of the extracellular matrix and induction of inflammatory responses, both of which are major contributors to skin aging. …”
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Postoperative Tongqi Formula ameliorates postoperative ileus via p38 MAPK signaling pathway and metabolic disorder by Mengmeng Yang, Yuxuan Lu, Shufan Jin, Wanqiu Liu, Miaoshi Yao, Zhiwei Jiang, Yachun Shu

“…In vitro, PTQF effectively inhibited inflammatory responses in RAW264.7 cells. Results from the spleen index and charcoal powder propulsion rate indicated that PTQF alleviated the inflammatory phase of POI in rats by mitigating systemic and intestinal inflammation. …”
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Adipose tissue may not be a major player in the inflammatory pathogenesis of Autism Spectrum Disorder by Baojiang Wang, Yueyuan Qin, Yong Chen, Xiujie Zheng, Yanjuan Chen, Juan Zhao, Feng Zhang, Shan Duan

“…The present study aimed to clarify the role of adipose tissue in inducing inflammatory responses associated with ASD. Methods: A total of 36 children with ASD and 18 unrelated healthy controls, aged 2–14.5 years, were enrolled in the study. …”
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Immunogenicity and protective efficacy of a multi-antigenic adenovirus-based vaccine candidate against Mycobacterium tuberculosis by Jin-Seung Yun, Jin-Seung Yun, Eunkyung Shin, Young-Ran Lee, Jung-Ah Lee, Hyeokjin Lee, Jong-Seok Kim, Sung Jae Shin, Sang-Jun Ha, Sang-Won Lee, Dokeun Kim, Jung-Sik Yoo, Hye-Sook Jeong

“…RNA sequencing of the whole blood of rAd-TB4-vaccinated mice collected pre- and, 1 and 4 weeks post-infection, identified differentially expressed genes associated with immune and inflammatory responses, especially those in the Wnt signaling pathway.ConclusionOur results indicate that rAd-TB4 immunization enhances the immune response to the vaccine boosting antigens in BCG-primed mice, making it a potential adult pulmonary TB vaccine candidate.…”
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Efficacy and safety of anemoside B4 in canine pneumonia treatment: a prospective, randomized controlled trial by Jinzhao Ji, Jinzhao Ji, Xiaoqing Ding, Xiaoqing Ding, Chuanli Liu, Chuanli Liu, Lingling Dai, Lingling Dai, Junting Yu, Junting Yu, Linghao Li, Linghao Li, Shaobing Wan, Shaobing Wan, Yangyang Song, Junqing Zhao, Zhetong Su, Kun Jia, Kun Jia, Shoujun Li, Shoujun Li

“…Anemoside B4 (AB4), derived from the traditional Chinese medicine Pulsatilla, has shown promise in preclinical studies for modulating inflammatory responses and improving clinical symptoms of pneumonia. …”
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Deciphering the role of metal ion transport-related genes in T2D pathogenesis and immune cell infiltration via scRNA-seq and machine learning by Zuhui Pu, Zuhui Pu, Tony Bowei Wang, Ying Lu, Ying Lu, Zijing Wu, Zijing Wu, Yuxian Chen, Ziqi Luo, Xinyu Wang, Lisha Mou, Lisha Mou

“…Cell-cell communication analysis highlighted 16 active signaling pathways, with CXCL, MIF, and COMPLEMENT linked to immune and inflammatory responses, and WNT, KIT, LIFR, and HGF pathways uniquely activated in T2D.ConclusionOur analysis identified genes crucial for T2D, emphasizing ion transport, signaling, and immune cell interactions. …”
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What is the relationship between exposure to environmental pollutants and severe mental disorders? A systematic review on shared biological pathways by Pierluigi Catapano, Mario Luciano, Salvatore Cipolla, Daniela D'Amico, Alessandra Cirino, Maria Chiara Della Corte, Gaia Sampogna, Andrea Fiorillo

“…Animal models showed the potential impact of pollution on brain functioning through increased inflammatory responses, oxidative stress, HPA axis disruption, hippocampal damage, and neurotransmitters dysregulation. …”
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Microplastics: A threat to Fetoplacental unit and Reproductive systems by Abass Toba Anifowoshe, Md Noor Akhtar, Abisola Majeed, Asem Sanjit Singh, Toyyibah Funmilayo Ismail, Upendra Nongthomba

“…Once in contact with the fetoplacental unit, these particles may trigger inflammatory responses, oxidative stress, and even epigenetic modifications. …”
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FSTL1 aggravates high glucose-induced oxidative stress and transdifferentiation in HK-2 cells by Baoyuan Zhang, Hang Geng, Kai Zhao, Moussa Omorou, Shuang Liu, Zhihui Ye, Fanting Zhang, Haiyan Luan, Xuesong Zhang

“…Abstract Chronic hyperglycemia, a hallmark of diabetes, can trigger inflammatory responses in the kidney, leading to diabetic nephropathy (DN). …”
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Dexmedetomidine pretreatment enhances protective effect efficacy of pericytes agaist acute lung injury in septic mice by LUO Xi, ZHANG Zisen, YANG Ao

“…Both PC cell treatment effectively alleviated the pulmonary vascular endothelial leakage， reduced Evans blue content per unit tissue， improved lung pathological structure， lung function and inflammatory responses， and significantly improved the survival rates in the PC group and the Dex-PC group （P<0.05）. …”
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Effects of ruminal short-chain fatty acid concentration and pH on histology, hematology, and inflammation in cannulated Holstein dairy calves by A.R. Wolfe, M.H.P.M. Narciso, R.R.E. Uwiera, A.H. Laarman

“…Overall, the data demonstrate that stress and inflammatory responses can be affected by changing rumen environments. …”
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The Impact of Chemotherapy and Body Mass Index on Cancer‐Related Fatigue in Colon Cancer Patients: A PROFILES‐Registry Study by Anneke Kastelein, Floortje Mols, Laura Kervezee, Niels H. Chavannes, Hans Gelderblom, Jacques Neefjes, Chris Hinnen

“…As both obesity and chemotherapy promote inflammatory responses, obese cancer patients may be at risk of more severe CRF, especially when receiving chemotherapy. …”
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C5a/C5aR regulates Th1/Th2 imbalance in sepsis-associated lung injury by promoting neutrophil activation to increase PAD4 expression by Zhenbing Lu, Ling Zhu, Changlin Yi, Bi Su, Renying Wang

“…In sepsis-induced lung injury mice, addition of GSK484, a PAD4 inhibitor, effectively alleviated sepsis-induced lung edema and inflammatory responses. GSK484 was found to inhibit C5a/C5aR expression and suppress apoptosis and lung injury. …”
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Circular RNA encoded by PPARG in the peripheral blood and a lipopolysaccharide-induced cardiomyocyte inflammation model is identified as a marker of fulminant myocarditis by Shasha Huang, Shumin He, Fei Xiao, Yang Zhou, Su Lyu

“…Circular RNAs (circRNAs) are highly stable in peripheral blood due to their special closed-loop structure, and reports have described their involvement in regulating inflammatory responses and cell injury in cardiomyocytes. …”
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Puerarin Ameliorates the Ferroptosis in Diabetic Liver Injure Through the JAK2/STAT3 Pathway Inhibition Based on Network Pharmacology and Experimental Validation by Fan X, Liu S, Yu J, Hua J, Feng Y, Wang Z, Shen Y, Lan W, Wang J

“…Puerarin also ameliorated hepatic pathological changes and inflammatory responses, and attenuated oxidative stress and iron overload in KKAy mice. …”
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Trajectories of systemic immune inflammation index and mortality risk in patients with moderate-to-severe traumatic brain injury: a retrospective cohort study by Zhiyong Tang, Zhiyong Tang, Canlin Liao, Zerui Zhuang, Zhennan Xu, Mingfa Liu, Haixiong Xu

“…BackgroundSome studies have shown a strong link between the central nervous system and peripheral immune system, but the prognostic implications of dynamic peripheral immune-inflammatory responses in patients with traumatic brain injury (TBI) remain unclear. …”
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Identification of SETD4 as an Onco‐Immunological Biomarker Encompassing the Tumor Microenvironment, Prognoses, and Therapeutic Responses in Various Human Cancers by Yuyun Zhong, Ruiqi Wang, Zijie Huang, Zhaoting Hu, Bin Peng, Bin Chen, Liyue Sun

“…ABSTRACT Background SET domain‐containing protein 4 (SETD4) is a histone methyltransferase that has been shown to modulate cell proliferation, differentiation, and inflammatory responses by regulating histone H4 trimethylation (H4K20me3). …”
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Clinical and microbiological characteristics and prognosis of invasive infection caused by Klebsiella pneumoniae in the community by Hongkui Sun, Hanlin Zhang, Wenqing Lai, Li Lei, Jianwei Li, Miaolian Chen, Haijun Li, Zhanyuan Zhao

“…No significant differences were found between patients with or without invasive infections, as well as between surviving and non-surviving patients (all p ≥ 0.05).Conclusion Patients with cKp invasive infections exhibit more severe inflammatory responses and a poorer prognosis, necessitating vigilant attention from clinicians. …”
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