Dietary Conjugated Linoleic Acid and Hepatic Steatosis: Species-Specific Effects on Liver and Adipose Lipid Metabolism and Gene Expression by Diwakar Vyas, Anil Kumar G. Kadegowda, Richard A. Erdman

“…The potential role of liver FA composition, insulin secretion and sensitivity, adipokine, and inflammatory responses are discussed as potential mechanisms behind CLA-induced hepatic steatosis.…”
Get full text

The limited immunomodulatory effects of escharectomy on the kinetics of endotoxin, cytokines, and adhesion molecules in major burns by Tae-Hyung Han, Soo-Yeon Lee, Jung-Eun Kwon, In-Suk Kwak, Kwang-Min Kim

“…Escharectomy appeared to have a limited immunomodulatory effect on the inflammatory mediators in systemic inflammatory responses induced by major burns. This is probably related to the timing and extent of surgery, and the complex nature of burn-related inflammation.…”
Get full text

The Role of Noncoding RNA in Airway Allergic Diseases through Regulation of T Cell Subsets by Shenghao Cheng, Qingping Tang, Shaobing Xie, Sihui Wen, Hua Zhang, Zhihai Xie, Weihong Jiang

“…The human body is frequently exposed to allergens and environmental irritants that trigger immune and inflammatory responses, resulting in altered gene expression. …”
Get full text

Unlocking nature’s pharmacy: an in-depth exploration of phytochemicals as potential sources of anti-cancer and anti-inflammatory molecules by Shifana C. Sadiq, Maria Pellissery Joy, Sreekumar U. Aiswarya, Abhishek Ajmani, Chenicheri K. Keerthana, Tennyson P. Rayginia, Noah Isakov, Ruby John Anto

“…This review is an attempt to elucidate and correlate the regulatory role of phytochemicals on cellular signaling pathways implicated in oncogenesis and inflammatory responses, highlighting the significance and potential of phytochemical-based therapies for cancer prevention and treatment, as well as for managing inflammatory conditions. …”
Get full text

Vitamin D on the susceptibility of gestational diabetes mellitus: a mini-review by Ting Zhang, Ting Zhang, Lan Yang, Shuman Yang, Song Gao

“…Vitamin D can regulate the course of gestational diabetes, which may be related to regulation of insulin gene transcription, insulin secretion, intracellular and cytosolic calcium balance, inhibition of oxidative stress and inflammatory responses and alteration of glucose metabolism. …”
Get full text

Synergistic enhancement of spinal fusion in preclinical models using low-dose rhBMP-2 and stromal vascular fraction in an injectable hydrogel composite by Hye Yeong Lee, Seong Bae An, Sae Yeon Hwang, Gwang Yong Hwang, Hye-Lan Lee, Hyun Jung Park, Joongkyum Shin, Keung Nyun Kim, Sung Won Wee, Sol Lip Yoon, Yoon Ha

“…Through a series of in vitro studies and preclinical models involving rats and minipigs, we demonstrated that the hydrogel system enables the sustained release of rhBMP-2, resulting in significantly improved bone density and integration, alongside reduced inflammatory responses. The combination of rhBMP-2 and SVF in this injectable formulation yielded superior spinal fusion outcomes, with enhanced mechanical properties and increased bone mass in both small and large animal models. …”
Get full text

Microglial C/EBPβ-Fcgr1 regulatory axis blocking inhibits microglial pyroptosis and improves neurological recovery by Jing Li, Yubing Yang, Chenguang Zhao, Jinghao Zhao, Xiaohui Wang, Shengshou Ye, Dong Wang, Chengdong Zhou, Jie Li, Shuang Wang, Ke Li, Chunmiao Liu, Xijing He, Jie Qin

“…Abstract CAAT/Enhancer Binding Protein β (C/EBPβ) is associated with inflammatory responses in neurodegenerative pathologies, particularly in the brain. …”
Get full text

Immunomodulatory effect of efferocytosis at the maternal–fetal interface by Hui Tao, Ruilin Ma, Jianjian Cui, Zejun Yang, Wencong He, Yanan Li, Yin Zhao

“…Abstract Efferocytosis is a mechanism by which phagocytes efficiently clear apoptotic cells, averting their secondary necrosis and the subsequent release of potentially immunogenic or cytotoxic substances that can trigger strong immune and inflammatory responses. During efferocytosis, the metabolic pathways of phagocytes are transformed, which, along with the catabolism of apoptotic cargo, can affect their function and inflammatory state. …”
Get full text

Molecular Mechanisms Underlying Anti-Inflammatory Actions of 6-(Methylsulfinyl)hexyl Isothiocyanate Derived from Wasabi (Wasabia japonica) by Takuhiro Uto, De-Xing Hou, Osamu Morinaga, Yukihiro Shoyama

“…In this paper, we review the anti-inflammatory properties of 6-MSITC and discuss potential molecular mechanisms focusing on inflammatory responses by macrophages.…”
Get full text

The micro(nano)plastics perspective: exploring cancer development and therapy by Xiangying Deng, Yajun Gui, Lin Zhao

“…Microplastics are capable of triggering cytotoxicity and chronic inflammation, and may promote cancer through mechanisms such as pro-inflammatory responses, oxidative stress and endocrine disruption. …”
Get full text

TGF-β1/Smads and miR-21 in Renal Fibrosis and Inflammation by Agnieszka Loboda, Mateusz Sobczak, Alicja Jozkowicz, Jozef Dulak

“…Recent findings indicate the prominent role of microRNAs, small noncoding RNA molecules that inhibit gene expression through the posttranscriptional repression of their target mRNAs, in different pathologic conditions, including renal pathophysiology. miR-21 was also shown to play a dynamic role in inflammatory responses and in accelerating injury responses to promote organ failure and fibrosis. …”
Get full text

A multi-omics spatial framework for host-microbiome dissection within the intestinal tissue microenvironment by Bokai Zhu, Yunhao Bai, Yao Yu Yeo, Xiaowei Lu, Xavier Rovira-Clavé, Han Chen, Jason Yeung, Dingani Nkosi, Jonathan Glickman, Antonio Delgado-Gonzalez, Georg K. Gerber, Mike Angelo, Alex K. Shalek, Garry P. Nolan, Sizun Jiang

“…Our findings reveal a global but systematic transformation in tissue immune responses, encompassing tissue-level remodeling in response to host immune and epithelial cell state perturbations, bacterial population shifts, localized inflammatory responses, and metabolic process alterations during colitis. …”
Get full text

Ferroptosis: A New Pathway in the Interaction between Gut Microbiota and Multiple Sclerosis by Junjie Jian, Jun Wei

“…Concurrently, the gut microbiota, known to affect systemic immunity and neurological health, emerges as an important regulator of iron homeostasis and inflammatory responses, thereby influencing ferroptotic pathways. …”
Get full text

Mechanisms of inflammatory microenvironment formation in cardiometabolic diseases: molecular and cellular perspectives by Menghua Liu, Rumeng Chen, Zhiwei Zheng, Shuling Xu, Chunyan Hou, Yining Ding, Mengling Zhang, Meihua Bao, Binsheng He, Sen Li

“…In diabetic cardiomyopathy, a high-glucose environment leads to the accumulation of advanced glycation end products (AGEs), activating the Receptor for Advanced Glycation Endproducts (RAGE) and triggering inflammatory responses that further damage cardiac and microvascular function. …”
Get full text

Metformin delays the decline in thermogenic function of brown adipose tissue in a mouse model of Hutchinson-Gilford progeria syndrome by Xin Xiang, Yuyue Feng, Hongcheng Li, Wenbo Li, Jia Li, Zhu Xia, Hua Pang, Zhengjie Wang

“…Moreover, metformin reduced inflammatory responses around senescent cells, further improving the overall senescent state of the tissue. …”
Get full text

Exploring Host Genetic Polymorphisms Involved in SARS-CoV Infection Outcomes: Implications for Personalized Medicine in COVID-19 by Omar Ramos-Lopez, Lidia Daimiel, Ana Ramírez de Molina, Diego Martínez-Urbistondo, Juan A. Vargas, J. Alfredo Martínez

“…Thus, genes implicated in key pathophysiological processes such as the mechanisms related to the entry of the virus into the cell and the antiviral immune/inflammatory responses were identified. Conclusions. Although caution must be taken, the results of this systematic review suggest that multiple genetic polymorphisms are associated with SARS-CoV infection features by affecting virus pathogenesis and host immune response, which could have important applications for the study and understanding of genetics in SARS-CoV-2/COVID-19 and for personalized translational clinical practice depending on the population studied and associated environments.…”
Get full text

Advances in Knowledge Regarding Arterial Curvature and its Relationship to Ischemic Stroke: A Narrative Review by Lin-Han Zhang, Fei Cao

“…Furthermore, the haemodynamic changes associated with arterial curvature can result in reduced cerebral perfusion pressure, endothelial dysfunction, oxidative stress, and inflammatory responses. These factors contribute to the development of atherosclerosis and the formation of arterial dissections. …”
Get full text

PCSK9: A Potential Therapeutic Target for Sepsis by Yuan Yuan, Wei Wu, Shanshan Sun, Yi Zhang, Zhi Chen

“…Moreover, it might improve cholesterol accumulation and augment toll-like receptor function in macrophages, which supported inflammatory responses. Accordingly, PCSK9 might show detrimental effects on immune host response and survival in sepsis. …”
Get full text

A toolkit for quantifying individual response to herbal extracts in metabolic and inflammatory stress by Soo-yeon Park, Oran Kwon, Tim van den Broek, Jildau Bouwman, Ji Yeon Kim

“…Blood samples were collected, and a machine learning algorithm was used to predict health estimation scores based on metabolic and inflammatory responses. The resulting health space model visually represents individuals’ health status in a 2-D space. …”
Get full text

Overview of Community-Acquired Pneumonia and the Role of Inflammatory Mechanisms in the Immunopathogenesis of Severe Pneumococcal Disease by Helen C. Steel, Riana Cockeran, Ronald Anderson, Charles Feldman

“…Thereafter, the review is focused on the pneumococcus, specifically the major virulence factors of this microbial pathogen and their role in triggering overexuberant inflammatory responses which contribute to the immunopathogenesis of invasive disease. …”
Get full text