Anticancer Role of PPARγ Agonists in Hematological Malignancies Found in the Vasculature, Marrow, and Eyes by P. J. Simpson-Haidaris, S. J. Pollock, S. Ramon, N. Guo, C. F. Woeller, S. E. Feldon, R. P. Phipps

“…Because peroxisome proliferator-activated receptor (PPAR)-γ agonists are potent mediators of anti-inflammatory responses, it was a logical extension to examine the role of PPARγ agonists in the treatment and prevention of cancer. …”
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Helicobacter pylori and the microbiome in gastric cancer development and treatment: A year in review by P. Vieira, M. Barbedo-Tavares, C. Figueiredo

“…In the microbial world, Helicobacter pylori infection is the major risk factor that initiates a cascade of inflammatory responses and genetic alterations that drive gastric cancer development. …”
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Permeability of blood-tear barrier to fluorescein and albumin after application of platelet-activating factor to the eye of the guinea pig by J. L. Van Delft, F. Meijer, J. A. Van Best, N. J. Van Haeringen

“…One of the inflammatory responses of the eye to local application of platelet-activating factor (PAF) is oedema of the conjunctiva, caused by extravasation of plasma. …”
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Pinitol Improves Diabetic Foot Ulcers in Streptozotocin-Induced Diabetes Rats Through Upregulation of Nrf2/HO-1 Signaling by Jinsick Kim, Min Young Go, Chae Young Jeon, Jung Un Shin, Mujun Kim, Hye Won Lim, Dong Wook Shin

“…Our findings indicated that pinitol enhanced cell migration, proliferation, and wound healing by activating Nrf2, thereby mitigating oxidative stress and inflammatory responses at the wound site. Additionally, pinitol restored mitochondrial energy metabolism, decreased matrix metalloproteinase (MMP) activity, and increased collagen deposition. …”
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TREM1—Microglia crosstalk: Neurocognitive disorders by Huashan Li, Wanqiu Yu, Xue Zheng, Zhaoqiong Zhu

“…Triggering receptor expressed on myeloid cells 1 (TREM1), a pattern-recognition receptor on microglia, becomes upregulated in response to injury and synergistically amplifies inflammatory responses mediated by other pattern-recognition receptors, leading to uncontrolled inflammation. …”
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Chitooligosaccharides promote diabetic wound healing by mediating fibroblast proliferation and migration by Zihan Li, Chuwei Zhang, Lei Wang, Qingrong Zhang, Yipeng Dong, Xinyu Sha, Bolin Wang, Zhihan Zhu, Wenmiao Wang, Yongjun Wang, Youlang Zhou, Yi Zhang

“…The COS also mitigated inflammatory responses by controlling leukocyte infiltration and bacterial infection. …”
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Oxidative stress and reactive oxygen species in otorhinolaryngological diseases: insights from pathophysiology to targeted antioxidant therapies by Linghui Meng, Shengyang Liu, Jinfeng Luo, Yanyi Tu, Tao Li, Ping Li, Jinzhuang Yu, Li Shi

“…Mitochondrial dysfunction exacerbates ROS generation, leading to cellular damage and inflammatory responses. In otorhinolaryngological diseases, oxidative stress is strongly associated with conditions such as hearing loss, allergic rhinitis, and chronic sinusitis, where oxidative damage and tissue inflammation are key pathological features. …”
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Interkingdom signaling between gastrointestinal hormones and the gut microbiome by Xinyu Zhao, Ye Qiu, Lanfan Liang, Xiangsheng Fu

“…As a vital component of the intestinal microecosystem, the gut microbiota influences the synthesis and release of many gastrointestinal hormones through mechanisms such as modulating the intestinal environment, producing metabolites, impacting mucosal barriers, generating immune and inflammatory responses, and releasing neurotransmitters. Conversely, gastrointestinal hormones exert feedback regulation on the gut microbiota by modulating the intestinal environment, nutrient absorption and utilization, and the bacterial biological behavior and composition. …”
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Mirtazapine Treatment of a Severe Depressive Episode and Resolution of Elevated Inflammatory Markers by Shahzad M. Alikhan, Jessica A. Lee, Luiz Dratcu

“…This observation adds to the evidence that changes in inflammatory responses may be implicated in the mode of action of antidepressants. …”
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Stachyose modulates gut microbiota and alleviates DSS-induced ulcerative colitis in mice by Chen Wang, Junying Bai, Botao Wang, Leilei Yu, Fengwei Tian, Jianxin Zhao, Hao Zhang, Huayi Suo, Wei Chen, Qixiao Zhai

“…Besides, the metabolome result of serum samples showed that stachyose treatment significantly altered serum metabolites against inflammatory responses in colitis mice. Also, a significant correlation can be found between 23 metabolite biomarkers and 18 differential genera. …”
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PCSK9-antibodies fail to block PCSK9-induced inflammation in macrophages and cannot recapitulate protective effects of PCSK9-deficiency in experimental myocardial infarction by Simon Rauterberg, Simon Rauterberg, Carmen Härdtner, Jennifer Hein, Paola Schrepf, Remi Peyronnet, Christoph Koentges, Tamara A. Vico, Carolin Ehlert, Bianca Dufner, Diana Lindner, Constantin von zur Mühlen, Dennis Wolf, Dirk Westermann, Ingo Hilgendorf, Alexander von Ehr

“…In vitro, PCSK9 induced significant inflammatory responses in macrophages, which were not mitigated by Alirocumab.ConclusionPCSK9 accumulation in the heart post-MI contributes to adverse cardiac remodeling and inflammation. …”
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RETRACTED: Long non‐coding RNA Sox2OT promotes coronary microembolization‐induced myocardial injury by mediating pyroptosis by Liying Xuan, Danni Fu, Dong Zhen, Dongsong Bai, Lijun Yu, Guohua Gong

“…Results Rat CME disrupted the cardiac functions and induced inflammatory responses and oxidative stress, and activated the nuclear factor‐kappa B (NF‐κB) pathway and pyroptosis (all P < 0.05). …”
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Periodontal Diseases: Major Exacerbators of Pulmonary Diseases? by Bakey Kouanda, Zeeshan Sattar, Patrick Geraghty

“…However, changes in the normal microflora due to oral disease, old age, lifestyle habits, or dental intervention may contribute to altered aspiration of oral periodontopathic bacteria into the lungs and changing inflammatory responses. Equally, periodontal diseases are associated with the longitudinal decline in spirometry lung volume. …”
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Tissue Factor, Blood Coagulation, and Beyond: An Overview by Arthur J. Chu

“…Biochemically, extracellular TF signaling interfaced through protease-activated receptors (PARs) elicits cellular activation and inflammatory responses. TF diverse biological roles are associated with either coagulation-dependent or noncoagulation-mediated actions. …”
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The effects of the ketone body ?-hydroxybutyrate on the neuronal transcriptome by Zayn Cheema, Megan Chen, Dana Poon, Taara Reddy, John Vergis, Sinead O'Donovan

“…We identified significantly altered (p<0.05) pathways associated with inflammation and immunity such as “regulation of proinflammatory cytokine production” and “modulation of inflammatory responses.” We did not identify significant modulation of energy metabolism-related pathways in response to BHB administration. …”
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AM3, an Oral BRM: Protective Agent against Iatrogenic Bone-Marrow and Liver Damage in Breast Cancer Patients under Conventional Adjuvant Radiochemotherapy by Vicente G Villarrubia, Paula Marquez, Jose Cobo, Guillermo J Sada

“…Finally, studies on acute-phase reactants, such as C-reactive protein, IgA. and factors B, C'3, and C'5 of the complement system, suggest that a modulation of hepatic inflammatory responses by AM3 appears to be essential for clinical effects described.…”
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Ocular neuroinflammatory response secondary to SARS-CoV-2 infection-a review by Yun Zhao, Ying Tang, Qi Yao Wang, Jia Li

“…SARS-CoV-2 infection has been shown to have neurotropism and therefore to lead to not only peripheral inflammatory responses but also neuroinflammation. Because the receptor for SARS-CoV-2, angiotensin-converting enzyme 2 (ACE2), can be found in many intraocular tissues, coronavirus disease 2019 (COVID-19) may also contribute to persistent intraocular neuroinflammation, microcirculation dysfunction and ocular symptoms. …”
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Cytokine Immunopathogenesis of Enterovirus 71 Brain Stem Encephalitis by Shih-Min Wang, Huan-Yao Lei, Ching-Chuan Liu

“…Both the CNS and the systemic inflammatory responses to infection play important, but distinctly different, roles in the pathogenesis of EV71 pulmonary edema. …”
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Lactobacillus rhamnosus: An emerging probiotic with therapeutic potential for depression by Jing Feng, Qiuyu Cen, Yanru Cui, Xiaomin Hu, Min Li, Linjie Wang, Juanfang Wei, Nianyi Sun, Junyu Wang, Anren Zhang

“…This review preliminarily explores the clinical significance of Lactobacillus rhamnosus in the treatment of depression and summarizes the potential mechanisms by which Lactobacillus rhamnosus treats depression, including its regulation of gut microbiota, alterations in gene expression, improvement of intestinal barrier function, maintenance of neurotransmitter balance, suppression of inflammatory responses, modulation of the immune system, coping with oxidative stress, and optimization of metabolic processes. …”
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The Host Genetic Diversity in Malaria Infection by Vitor R. R. de Mendonça, Marilda Souza Goncalves, Manoel Barral-Netto

“…The clinical manifestation of malaria results primarily from the lysis of infected erythrocytes and subsequent immune and inflammatory responses. Herein, we review the genetic alterations associated with erythrocytes or mediators of the immune system, which might influence malaria outcome. …”
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