Upregulation of Cardiac IL-10 and Downregulation of IFN-γ in Balb/c IL-4−/− in Acute Chagasic Myocarditis due to Colombian Strain of Trypanosoma cruzi by Marcos Vinicius da Silva, Vera Lúcia de Almeida, Wendyson Duarte de Oliveira, Natália Carasek Matos Cascudo, Pollyana Guimarães de Oliveira, Crislaine Aparecida da Silva, Aline Cristina Souza da Silva, Maria Luíza Gonçalves dos Reis Monteiro, Rosana Rosa Miranda Correa, Milton Adriano Pelli Oliveira, Ruy de Sousa Lino-Júnior, Mara Rúbia Nunes Celes, Juliana Reis Machado

“…Inflammatory response in Chagas disease is related to parasite and host factors. …”
Get full text

Identification of potential corticosteroid binding sites on the SARS CoV-2 main protease Mpro — in silico docking study by Н. В. Хміль, А. В. Шестопалова, В. Г. Колесніков, А. О. Боєчко-Немовча

“…Pathogenetic therapy is carried out with systemic corticosteroids, which suppress the cytokine storm by mitigating the SARS-CoV-2-induced systemic inflammatory response and inhibit SARS-CoV-2 main protease Mpro, a key component of viral replication. …”
Get full text

The ABC transporter A7 modulates neuroinflammation via NLRP3 inflammasome in Alzheimer’s disease mice by Irene Santos-García, Pablo Bascuñana, Mirjam Brackhan, María Villa, Ivan Eiriz, Thomas Brüning, Jens Pahnke

“…This regulation implicates ABCA7 as a key driver ultimately involved in the persistence of the inflammatory response observed in AD.…”
Get full text

Effects of fermented Artemisia annua on the intestinal microbiota and metabolites of Hu lambs with naturally infected with Eimeria spp. by Shuaiqi Liu, Shuaiqi Liu, Shuaiqi Liu, Shiheng Li, Shiheng Li, Shiheng Li, Shunli Lu, Shunli Lu, Shunli Lu, Mingfan Yang, Manyu Liu, Manyu Liu, Manyu Liu, Juanfeng Li, Juanfeng Li, Juanfeng Li, Senyang Li, Senyang Li, Senyang Li, Fuchun Jian, Fuchun Jian, Fuchun Jian

“…Chinese herbal medicines are investigated as alternative methods for controlling coccidian infections.MethodsIn this study, the effect of fermented Artemisia annua (FA) on oocysts per gram (OPG), average daily gain (ADG), and expression of inflammatory factors were investigated in lambs that were naturally infected with coccidia.ResultsThe results showed that the FA had similar anti-coccidiosis effect to the original drug, while the FA demonstrated a more significant effect on weight gain, and a better ability to reduce the inflammatory response compared to the unfermented drug during the treatment period (P < 0.05). …”
Get full text

hBMSC-EVs alleviate weightlessness-induced skeletal muscle atrophy by suppressing oxidative stress and inflammation by Mengyuan Chang, Ruiqi Liu, Bingqian Chen, Jin Xu, Wei Wang, Yanan Ji, Zihui Gao, Boya Liu, Xinlei Yao, Hualin Sun, Feng Xu, Yuntian Shen

“…They demonstrate the ability to inhibit protein degradation mediated by UPS and autophagy lysosome pathway, along with the suppression of oxidative stress and inflammatory responses. Furthermore, hBMSC-EVs impede the transition of slow muscle fibers to fast muscle fibers via upregulation of Sirt1 and PGC-1α protein levels. …”
Get full text

Association between red blood cell distribution width-to-albumin ratio and prognosis in post-cardiac arrest patients: data from the MIMIC-IV database by Yinhe Cai, Yinhe Cai, Yao Zhang, Yao Zhang, Ningzhi Zhou, Ningzhi Zhou, Yong Tang, Yong Tang, Haixia Zheng, Haixia Zheng, Hong Liu, Hong Liu, Jiahua Liang, Ruixiang Zeng, Shengqing Song, Yu Xia, Yu Xia

“…BackgroundCardiac arrest (CA) triggers a systemic inflammatory response, resulting in brain and cardiovascular dysfunction. …”
Get full text

Multi-trace elements-enriched functional drink accelerates gastric ulcer repair via the HGF/c-Met/STAT3 pathway by Yongnan Piao, Nuoya Wang, Mingji Jin, Jianyu Piao, Mingfeng Han, Zifei Wang, Chunhua Quan, Jishan Yin, Zhonggao Gao, Wenxiang Cui, Shuangqing Wang, Xiuquan Quan

“…Finally, FD reduced the severity of gastric mucosal injury caused by invasive factors, improved the morphological structure of gastric mucosal cells, enhanced the ability of oxidative stress, and inhibited excessive inflammatory response. In addition, the combination of OME and FD-L did not significantly affect the therapeutic efficacy of OME, but reduced its adverse effects. …”
Get full text

Correlation of newer inflammatory markers in patients with type 2 diabetes mellitus: A cross-sectional study by Swetha Akkina, Srikanth Akula, Rajeev Gandham, Preethi Batakala, Bhagyalakshmi Atla, Divija Reddy Bonthu, Sunkara Uha Priya

“…Conclusion: The study may conclude that increased levels of NLR, PLR, SII, SIRI, MHR, NHR, and PHR in T2DM and their positive correlation with blood sugar and HbA1c may serve as alternate markers of inflammation and are useful to assess the impact of systemic inflammatory response in T2DM patients.…”
Get full text

Serum IL-18 Is Increased at Early Postburn Period in Moderately Burned Patients

“…<p>A severe systemic inflammatory response is usually seen after burn injury. …”
Get full text

Exploration of the mechanism of Lithospermum erythrorhizon oil in treating atopic dermatitis based on network pharmacology and experimental validation of the PI3K-Akt pathway regul... by Weisheng Hu, Yinlan Wang, Yingjie Zhou, Junbao Shi, Zengyan Li, Xiaoling Jiang, Qinyuan Wu, Changming Zhong, Huilan Weng, Sijie Ouyang, Yuan Jing, Xianxiang Cai, Mingda Ye, Ning Huang

“…GO and KEGG analyses were significant in biological processes like cell migration and inflammatory response regulation, and in pathways such as IL-17 signaling and PI3K-Akt signaling. …”
Get full text

Transcriptomic and proteomic analysis of the jejunum revealed the effects and mechanism of protocatechuic acid on alleviating Salmonella typhimurium infection in chickens by Sheng Zhang, Qin Wang, Xiangtian Yao, Jingjing Dong, Guanhuo Li, Yingan Zang, Shouqun Jiang, Yibing Wang

“…Mechanistically, the transcriptomic results showed that dietary protocatechuic acid inhibited acute inflammatory response and activated the signaling pathways of cytokine-cytokine receptor interaction, complement and coagulation cascades. …”
Get full text

Dry eye syndrome before corneal refractive surgery: the prevalence and pathogenesis-oriented therapy by N.V. Maychuk, I.S. Malyshev, M.R. Obraztsova

“…To relieve the sterile inflammatory response, the patients received a course of steroids as anti-inflammatory agents followed by cyclosporin A. …”
Get full text

Astaxanthin mitigates doxorubicin-induced cardiotoxicity via inhibiting ferroptosis and autophagy: a study based on bioinformatic analysis and in vivo/vitro experiments by Bowen Yin, Jingyi Ren, Xuanyi Liu, Yadong Zhang, Jinshi Zuo, Rui Wen, Huanting Pei, Miaomiao Lu, Siqi Zhu, Zhenao Zhang, Ziyi Wang, Yanyi Zhai, Yuxia Ma

“…The experimental results show that ASX significantly mitigates DOX-induced myocardial tissue damage, inflammatory response, oxidative stress, and damage to H9C2 cells. …”
Get full text

Detection of viral antigen and inflammatory mediators in fatal pediatric dengue: a study on lung immunopathogenesis by Leandro Junqueira Moragas, Laíza Vianna Arruda, Laíza Vianna Arruda, Lucca de Lima Siqueira Oliveira, Felipe de Andrade Vieira Alves, Felipe de Andrade Vieira Alves, Natália Gedeão Salomão, Natália Gedeão Salomão, Jemima Fuentes Ribeiro da Silva, Carlos Alberto Basílio-de-Oliveira, Rodrigo Panno Basílio-de-Oliveira, Ronaldo Mohana-Borges, Caio Gonçalves Azevedo, Gabriela Xavier de Oliveira, Jorge José de Carvalho, Fernando Colonna Rosman, Fernando Colonna Rosman, Marciano Viana Paes, Kíssila Rabelo, Kíssila Rabelo

“…While the characterization of the inflammatory response and cellular expression was done by marking the viral protein, macrophages, lymphocytes and pro-inflammatory cytokines.Results and discussionThe results confirm that vascular dysfunctions such as hemorrhage, vascular congestion and edema associated with a mononuclear infiltrate were observed in all three cases. …”
Get full text

Bioinformatic characterization of STING expression in hematological malignancies reveals association with prognosis and anti-tumor immunity by Xiang-mei Wen, Xiang-mei Wen, Xiang-mei Wen, Zi-jun Xu, Zi-jun Xu, Zi-jun Xu, Ji-chun Ma, Ji-chun Ma, Ji-chun Ma, Min-jie Zhang, Min-jie Zhang, Min-jie Zhang, Ye Jin, Ye Jin, Jiang Lin, Jiang Lin, Jiang Lin, Jun Qian, Jun Qian, Yuan-yuan Fang, Yuan-yuan Fang, Yuan-yuan Fang, Shu-yu Luo, Shu-yu Luo, Shu-yu Luo, Zhen-wei Mao

“…STING expression was positively correlated with immune-related pathways such as IFN-gamma response, IFN-alpha response, and inflammatory response. Cytolytic score and STING expression were positively correlated in some hematological tumors, especially chronic lymphocytic leukemia and mantle cell lymphoma. …”
Get full text

Protective Mechanism of Alisol A 24-Acetate on Brain Microvascular Endothelial Cells in Mice with Cerebral Ischemia-Reperfusion Injury by TRPM2/Akt/GSK3β Pathway by LI Huihong, DENG Yunfei, WEI Wei, ZHAN Zengtu, LIN Libin, XUE Xiehua

“…Compared with the model group, the expression levels of p-NF-κB, IL-1β, TNF-α and TRPM2 of the 24A group significantly decreased, while the expression levels of p-Akt and p-GSK3β significantly increased (<italic>P</italic>&lt;0.05).Conclusion24A can effectively improve the neurological function and cognitive function, reduce inflammatory response and ameliorate BMECs damage of CI/RI mice, which may be related to the regulation of TRPM2/Akt/GSK3β pathway.…”
Get full text

Repeated low-intensity noise exposure exacerbates age-related hearing loss via RAGE signaling pathway by Jianbin Sun, Na Sai, Tong Zhang, Chaoying Tang, Shuhang Fan, Qin Wang, Da Liu, Xianhai Zeng, Juanjuan Li, Weiwei Guo, Shiming Yang, Weiju Han

“…Proteomics analysis revealed an upregulation in the receptor for the advanced glycation end-products (RAGE) signaling pathway, which was associated with an activated inflammatory response, vascular injury, and mitochondrial and synaptic dysfunction. …”
Get full text

Macrophage Dvl2 deficiency promotes NOD1-Driven pyroptosis and exacerbates inflammatory liver injury by Xiaoye Qu, Dongwei Xu, Tao Yang, Yizhu Tian, Christopher T. King, Xiao Wang, Mingwei Sheng, Yuanbang Lin, Xiyun Bian, Changyong Li, Longfeng Jiang, Qiang Xia, Douglas G. Farmer, Bibo Ke

“…Therefore, macrophage Dvl2 deficiency promotes NOD1-mediated pyroptosis and exacerbates IR-induced hepatocellular death by disrupting the YAP-HSF1 axis. eEF2 is crucial for modulating NOD1-driven pyroptosis, inflammatory response, and hepatocyte death. Our findings underscore a novel role of macrophage Dvl2 in modulating liver inflammatory injury and imply the therapeutic potential in organ IRI and transplant recipients.…”
Get full text

Effect of Zhuanggu Jianxi Decoction on Synovitis in Knee Osteoarthritis Rabbits via LXRs/NF-κB Pathway by CHEN Peng, GUO Jiemei, XIAO Yan, WANG Jianhui, SU Youxin

“…Compared with the Zhuanggu Jianxi decoction group, the protein expression of LXRα and N-CoR in both the LXRα and N-CoR inhibitor groups were significantly decreased (<italic>P</italic>&lt;0.05), and the protein expression of P50 and P65 were significantly increased (<italic>P</italic>&lt;0.05).ConclusionZhuanggu Jianxi decoction could improve the pathological manifestations of synovial lining cell hyperplasia and the disorder arrangement, inflammatory cell infiltration and fibrous tissue hyperplasia, reduce the content of inflammatory related indexes in tissues, so as to reduce the inflammatory response of KOA synovial tissue in rabbits, which may be related to the up-regulation of LXRα and N-CoR protein expression in synovial cells via LXRs/NF-κB pathway in synovial tissue, thereby down-regulating P50 and P65 protein to reduce IL-1β, TNF-α, MMP-3 and MMP-13.…”
Get full text

DNA hypomethylation-mediated upregulation of GADD45B facilitates airway inflammation and epithelial cell senescence in COPD by Yuan Zhan, Qian Huang, Zhesong Deng, Shanshan Chen, Ruonan Yang, Jiaheng Zhang, Yating Zhang, Maocuo Peng, Jixing Wu, Yiya Gu, Zhilin Zeng, Jungang Xie

“…Moreover, experiments involving bidirectional modulation of GADD45B expression in HBE cells further substantiated its positive regulatory role in inflammatory response and cellular senescence. Mechanically, GADD45B-facilitated inflammation was directly mediated by p38 phosphorylation, while GADD45B interacted with FOS to promote cellular senescence in a p38 phosphorylation-independent manner. …”
Get full text