Immune-checkpoint-inhibitor therapy directed against PD-L1 is tolerated in the heart without manifestation of cardiac inflammation in a preclinical reversible melanoma mouse model by Caroline Schoenherr, Caroline Schoenherr, Stefan Pietzsch, Stefan Pietzsch, Cristina Barca, Franziska E. Müller, Frauke S. Bahr, Martina Kasten, Andre Zeug, Sergej Erschow, Christine S. Falk, Evgeni Ponimaskin, James T. Thackeray, Denise Hilfiker-Kleiner, Denise Hilfiker-Kleiner, Melanie Ricke-Hoch

“…Without a second hit that triggers the inflammatory response, anti-PD-L1 treatment appears to be safe for the heart in the preclinical melanoma mouse model.…”
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Is Intra-articular Platelet-rich Plasma Injection Safe and Effective in Osteoarthritis Knee? A Prospective Study: A Case Series by R Sahaya Jose, N Kattu Bava, M Syed Moosa

“…The release of platelet-derived factors directly at the site of cartilage disease, particularly with interest to knee OA, may stimulate the natural regenerative signaling cascade and enhance tissue healing with further mediation of the anti-inflammatory response. Suppression of mediators, such as interleukin-1 interaction with nociceptors, brings inflammatory and analgesic effects. …”
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Hyssopus cuspidatus volatile oil: a potential treatment for steroid-resistant asthma via inhibition of neutrophil extracellular traps by Xu Wang, Hui-Ming Peng, Meng-Ru Zhang, Jing-Jing Li, Chuan-Peng Zhao, Ya-Li Zhang, Si-Yu Wang, Si-Ying Zhu, Jian-Kang Lu, Hai-Long Yin, Qiang Yin, Jin-Bo Fang

“…Abstract Background Steroid-resistant asthma (SRA) is a form of asthma resistant to corticosteroid therapy, which is characterized by the presence of neutrophil-predominant inflammatory response and neutrophil extracellular traps (NETs) formation. …”
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Elucidation of the mechanism of berberine against gastric mucosa injury in a rat model with chronic atrophic gastritis based on a combined strategy of multi-omics and molecular bio... by Lisheng Chen, Lisheng Chen, Xin Wang, Xin Wang, Jianyu Li, Lijuan Zhang, Wenbin Wu, Shizhang Wei, Wenjun Zou, Yanling Zhao, Yanling Zhao

“…Network pharmacology showed that the treatment of CAG by BBR mainly involved in inflammatory response, apoptosis, angiogenesis and metabolic processes. …”
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Interleukin-1 Receptor-Associated Kinase-3 Aggravates Neuroinflammatory Injury After Intracerebral Hemorrhage via Activation NF-κB/IL-17A Pathway in Mice by Wang J, Li Y, Tan C, Shao J, Tang W, Kong Q, Sheng W, Ding Z, Li F, Piao J, Lv D, Hu L, Wang Q, Jiang X

“…Recombinant IL-17A exacerbated the inflammatory response in vivo and in vitro; however, IRAK3 knockdown reversed this process.Conclusion: IRAK3 aggravates neuroinflammation by activating the NF-κB/IL-17A signaling pathway, thereby exacerbating neurological deficits following ICH. …”
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Airway microbiota dysbiosis and metabolic disorder in ozone and PM2.5 co-exposure induced lung inflammatory injury in mice by Lin Yang, Fei Xu, Shuaiqi Zhao, Yuling Zeng, Qiong Wu, Ling Zhang, Saige Shi, Fengquan Zhang, Juan Li, Zhen An, Huijun Li, Hui Wu, Jie Song, Weidong Wu

“…The results demonstrated that co-exposure to O3 and PM2.5 exacerbated the pathological changes and inflammatory response induced by O3 or PM2.5. Further studies revealed that co-exposure to O3 and PM2.5 increased the abundance of Prevotella in the airways and caused more severe metabolic disorders compared to O3 or PM2.5 exposure. …”
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Prognostic significance of albumin corrected anion gap in patients with acute pancreatitis: a novel perspective by Jianjun Wang, Pei Yang, Xintao Zeng, Sirui Chen, Xi Chen, Lan Deng, Ruizi Shi, Chuan Qin, Huiwen Luo, Jianping Gong, Hua Luo, Decai Wang

“…In addition, ACAG showed superior performance, with a larger AUC than the anion gap, albumin, and Systemic Inflammatory Response Syndrome score and Sequential Organ Failure Assessment at 3, 7, 10, 14, 28, 90, and 180 days and 1 year. …”
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Circulating Th1 and Th2 Subset Accumulation Kinetics in Septic Patients with Distinct Infection Sites: Pulmonary versus Nonpulmonary by Ming Xue, Yuying Tang, Xu Liu, Mingyuan Gu, Jianfeng Xie, Ling Liu, Yingzi Huang, Fengmei Guo, Yi Yang, Haibo Qiu

“…Circulating Th1 and Th2 populations were evaluated by flow cytometry, and clinical data related to disease severity and inflammatory response were collected. The associations of circulating Th1 and Th2 subset accumulations with distinct infection sites or outcomes within subgroups were explored. …”
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Metasilicate-based alkaline mineral water improves the growth performance of weaned piglets by maintaining gut-liver axis homeostasis through microbiota-mediated secondary bile aci... by Jian Chen, Kanwar K. Malhi, Xiaowei Li, Xiangwen Xu, Jianxun Kang, Bichen Zhao, Yaru Xu, Xuenan Li, Jinlong Li

“…Our results indicated that metasilicate-based AMW effectively alleviated weaning-induced colonic or liver morphological injury and inflammatory response, as well as liver cholesterol metabolism disorders. …”
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Evaluation of Inflammatory Markers and Clinical Outcomes in COVID-19 Patients with Concurrent <i>Clostridioides difficile</i> Infection: A Comparative Cohort Analysis by Flavia Ignuta, Adrian Vlad, Teodor Cerbulescu, Stana Loredana, Felix Bratosin, Ovidiu Rosca, Lavinia Stelea, Daciana Nistor

“…Conclusions: <i>C. difficile</i> co-infection in COVID-19 patients is associated with an intensified inflammatory response and worse clinical outcomes. Among the evaluated markers, CAR and PNI emerged as robust predictors of severe disease. …”
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Serum NLR combined with CA125 and HE4 improves the diagnostic and prognostic efficiency in patients with ovarian cancer by Yun Tian, Yun Tian, Xiabing Li, Xiabing Li, Hongjian Zhang, Hongjian Zhang, Yaping Wang, Yaping Wang, Hongyu Li, Hongyu Li, Qiaohong Qin, Qiaohong Qin

“…An elevated neutrophil-to-lymphocyte ratio (NLR) serves as an indicator of host inflammatory response and has been linked to poorer overall survival (OS) across various cancer types; however, its examination in OC remains limited. …”
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Screening and identification of host signaling pathways for alleviating influenza-induced production of pro-inflammatory cytokines, IP-10, IL-8, and MCP-1, using a U937 cell-based... by Si Chen, Si Chen, Yang Yu, Yue Su, Xiaoqin Lian, Lefang Jiang, Zhuogang Li, Mingxin Zhang, Yarou Gao, Haonan Zhang, Xingjian Zhu, Jiaxin Ke, Xulin Chen

“…Influenza virus infection initiates an exaggerated inflammatory response, which may culminate in a fatal cytokine storm characterized by the excessive production of pro-inflammatory cytokines. …”
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Mesangial Cells Exhibit Features of Antigen-Presenting Cells and Activate CD4+ T Cell Responses by Hongyu Yu, Shaoyuan Cui, Yan Mei, Qinggang Li, Lingling Wu, Shuwei Duan, Guangyan Cai, Hanyu Zhu, Bo Fu, Li Zhang, Zhe Feng, Xiangmei Chen

“…Interactions between mesangial cells and T cells are essential for sustaining the inflammatory response in a variety of glomerulonephritides. …”
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Phase-dependent iron depletion differentially regulates the niche of intestinal stem cells in experimental colitis via ERK/STAT3 signaling pathway by Shubin Wang, Xiangjun Liu, Lu Xu, Jinyi Lang, Dengqun Liu, Dengqun Liu

“…Signaling pathway and inflammatory infiltration were investigated by immunostaining.ResultsIron depletion within the early stage of DSS treatment significantly inhibited the onset of the inflammatory response, maintained the integrity of the colonic epithelium, and preserved the activity of intestinal stem cells (ISCs) both in vivo and in vitro. …”
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Safety and efficacy of oral edible bird’s nest supplementation: Anti-inflammatory and immunomodulatory benefits for Arabian race stallions during exercise by Khalid Obaid AL-Khaldi, Khalid Hamed Al-Ruzaiqi, Abdul Salam Babji, Seng Joe Lim, Mohammed Babatunde Sadiq, Nurhusien Yimer

“…Experiment 2 showed higher SA levels post-exercise in the EBN group (p < 0.05) compared to Premier E® and control groups, suggesting enhanced anti-inflammatory response. Hematological indices, including mean corpuscular volume, red cell distribution width, and platelet counts, were significantly improved in the EBN group, indicating potential immunomodulatory benefits. …”
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Injectable Nanocomposite Hydrogel for Accelerating Diabetic Wound Healing Through Inflammatory Microenvironment Regulation by Chen Y, Li Y, Song H, Liu X, Zhang H, Jiang J, Liu H, Zhuo R, Cheng G, Fang J, Xu L, Qi Y, Sun D

“…This hydrogel effectively suppresses inflammatory responses, modulates the polarization of macrophages towards the M2 phenotype, and promotes angiogenesis, thus fostering a favorable immune microenvironment for skin regeneration. …”
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Alpha-synuclein pathology enhances peripheral and CNS immune responses to bacterial endotoxins by Anna-Sophia Hartke, Cara S. Schreiber, Kristina Lau, Ivo Wiesweg, Inken Waltl, Ulrich Kalinke, Franziska Richter, Christopher Käufer

“…Increasing evidence points to infectious diseases as contributor to the pathogenesis of neurodegeneration in Parkinson's disease (PD), probably driven by a peripheral and CNS inflammatory response together with alpha-synuclein (aSyn) pathology. …”
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HMGB-1 as a predictor of major bleeding requiring activation of a massive transfusion protocol in severe trauma by Michal Frelich, Marek Bebej, Jan Pavlíček, Filip Burša, Vojtěch Vodička, Zdeněk Švagera, Adéla Kondé, Ondřej Jor, Markéta Bílená, Tereza Romanová, Peter Sklienka

“…., amphoterin) is released into the blood, and its levels correlate with the development of a systemic inflammatory response, traumatic coagulopathy, and fibrinolysis. …”
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Emodin protects against severe acute pancreatitis-associated acute lung injury by activating Nrf2/HO-1/GPX4 signal and inhibiting ferroptosis in vivo and in vitro by Gang Shen, Haiyun Wen, Huijuan Li, Xuetao Zhang, Bowen Lan, Xuanchi Dong, Peng Ge, Yalan Luo, Hailong Chen

“…Results The findings demonstrated that suppressing Nrf2 expression exacerbated the inflammatory response brought on by SAP and the pathological alterations of SAP-ALI. …”
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Proteomics unveil candidate biomarkers and pathogenesis of subacute thyroiditis by Litong Ran, Xiufei Liu, Yongfeng Tian, Jiaran Zhu, Zhengyuan Gong, Qiao Qiao, Xin Jiang, Yuren Wang, Guojun Yang, Hongting Zheng, Yi Zheng, Hua Qu

“…Gene ontology and KEGG enrichment analyses identified that these proteins were enriched in processes involving infection, inflammatory response and cell adhesion and junction, which likely contribute to the pathogenesis. …”
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