hnRNPA2/B1 Ameliorates LPS-Induced Endothelial Injury through NF-κB Pathway and VE-Cadherin/β-Catenin Signaling Modulation In Vitro by Yi Chen, Dan Tang, Linjie Zhu, Tianjie Yuan, Yingfu Jiao, Hexin Yan, Weifeng Yu

“…Overexpression of hnRNPA2/B1 can reduce the permeability and inflammatory response of HUVEC stimulated by LPS in vitro, while increasing the expression of VE-Cadherin and β-catenin. …”
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Exploring the Underlying Mechanism of Weiling Decoction Alleviates Cold-Dampness Diarrhea Based on Network Pharmacology, Transcriptomics, Molecular Docking and Experimental Validat... by Yannan Zhang, Shuai Zhang, Yimeng Fan, Sijuan Huang, Shimin Wang, Zhihui Hao, Jianzhong Shen

“…WLD treatment significantly alleviated the symptoms of CDD, reduced intestinal damage, and diminished the inflammatory response. Additionally, WLD influenced key genes in immune-related pathways. …”
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Exploring and Verifying the Mechanism and Targets of Shenqi Pill in the Treatment of Nonalcoholic Steatohepatitis via Network Pharmacology and Experiments by Beihui He, Zheng Chen, Yunmeng Nie, Minmin Luo, Sumei Xu, Junbin Yan, Zhiyun Chen

“…Network pharmacology analysis and bioinformatics analysis showed that PTGS2, JUN, MYC, and CDKN1A might be crucial target genes in the primary mechanism of SQP in treating NASH and improving the inflammatory response. The UPLC–MS/MS results confirmed that the hub active compound, quercetin, screened out through the TCMSP database, is indeed present in SQP. …”
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The Gut Microbiota and Its Relevance to Peripheral Lymphocyte Subpopulations and Cytokines in Patients with Rheumatoid Arthritis by Yuan Li, Sheng-Xiao Zhang, Xu-Fang Yin, Ming-Xing Zhang, Jun Qiao, Xiao-Hong Xin, Min-Jing Chang, Chong Gao, Ya-Feng Li, Xiao-Feng Li

“…Growing experimental and clinical evidence suggests that a chronic inflammatory response induced by gut microbiome critically contribute to the development of rheumatoid arthritis (RA). …”
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Evidence and perspectives on miRNA, circRNA, and lncRNA in myocardial ischemia-reperfusion injury: a bibliometric study by Xiaowen Bo, Qiuyu Li, Siyuan Chen, Tian Zhou, Ning Yin, Wenpeng Song, Donghui Zhao, Jinghua Liu, Qian Fan

“…Among these, circular RNA, therapy target, inflammatory response, and cardiomyocyte ferroptosis are likely to emerge as emerging trends in this field. …”
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Exploring the Anti-depression Mechanism of Polygonatum ordoratum Based on GEO Database Combined with Network Pharmacology and Molecular Docking Technology by Zhenxu JIANG, Chaoxing WANG, Yuliang WANG, Hong ZHAO, Yu SHEN, Shiqing SUN, Yongzhe MA, Mingming SONG, Yu ZHANG

“…Conclusion: Yuzhu may exert its antidepressant effects through inflammatory response, oxidative stress, and prostaglandin synthesis pathways.…”
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Effects of <i>Cordyceps cicadae</i> Polysaccharide on Gut Microbiota, the Intestinal Mucosal Barrier, and Inflammation in Diabetic Mice by Lijia Sun, Huaibo Yuan, Huiqing Ma, Yani Wang

“…The TLR4/NF-κB signaling pathway, as a therapeutic target for diabetic intestinal diseases, plays a role in regulating the inflammatory response and protecting the intestinal barrier function. …”
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Short-term effects of follicle-stimulating hormone on immune function, lipid, and vitamin metabolism in transiently castrated men by Jéssica Guedes, Indira Pla, Aniel Sanchez, Gyorgy Marko-Varga, Gilberto Barbosa Domont, K Barbara Sahlin, Berk Hazir, Aleksander Giwercman, Fábio César Sousa Nogueira, Johan Malm, Yvonne Lundberg Giwercman

“…Results: FSH significantly upregulates key proteins involved in the modulation of inflammatory response and innate immune system (P ≤ 0.03) and dysregulates lipid metabolism, evidenced by downregulation of multiple apolipoproteins (P ≤ 0.04) and increased levels of cholesterol and glycerophospholipids (P ≤ 0.03). …”
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Association of neutrophil-to-lymphocyte ratio with severe abdominal aortic calcification: new evidence from the United States by Hao Deng, Mengmeng Sun, Zhentong Zhao, Kun Fan, Zizhang Zhao, Yifan Chi, Wei Sheng

“…The neutrophil-to-lymphocyte ratio (NLR) measured in the peripheral blood typically reflects the body's inflammatory response by combining laboratory markers of innate and adaptive immunity. …”
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Efficacy of double filtration plasmapheresis in hyperlipidemia acute pancreatitis: a retrospective observational study by Rong Qin, Yibei Liu, Rui Ding, Minhui Yang, Yun Huang, Xujia Chen, Feng Zhang, Yanting Liu, Hongping Jia, Yiyao Duan, Lifang Zhou, Hui Wang

“…In terms of complications, the rate of systemic inflammatory response syndrome (SIRS) differed significantly between the groups (P < 0.05). …”
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Transcriptional Profiling Underscores the Role of Preprocurement Allograft Metabolism and Innate Immune Status on Outcomes in Human Liver Transplantation by Joohyun Kim, MD, PhD, Michael T. Zimmermann, PhD, Angela J. Mathison, PhD, Gwen Lomberk, PhD, Raul Urrutia, MD, Johnny C. Hong, MD

“…Expression levels of hallmark inflammatory response genes were higher transitioning from CI to ER and decreased from ER to LR. …”
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Evaluation of the protective role of resveratrol on LPS-induced septic intestinal barrier function via TLR4/MyD88/NF-κB signaling pathways by Zhongliang Shi, Yanna Jiao, Zhizhen Lai, Juan Liu, Bo Yang, Mahong Hu, Jianbiao Meng

“…Resveratrol has been shown to reduce the expression of intestinal apoptotic proteins, enhance the expression of intestinal tight junction proteins, and inhibit the inflammatory response mediated by the TLR4/MyD88/NF-κB signaling pathway, thereby alleviating LPS-induced septic intestinal injury.…”
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Alpha-1 Antitrypsin as a Regulatory Protease Inhibitor Modulating Inflammation and Shaping the Tumor Microenvironment in Cancer by Siyu Xiang, Liu Yang, Yun He, Feng Ding, Shuangying Qiao, Zonghua Su, Zheng Chen, Aiping Lu, Fangfei Li

“…Therefore, in this review, we have elucidated the pivotal roles of AAT in inflammation and the tumor microenvironment, including the structure and molecular properties of AAT, its molecular functions in the regulation of the inflammatory response and tumor microenvironment, and its clinical implications in cancer including its diagnosis, prognosis, and therapeutic intervention. …”
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Sex differences in the neuroinflammatory signaling pathway: effect of miRNAs on fatty acid synthesis in microglia by Haolin Zheng, Akiko Mizokami, Sergio Romera-Giner, Jaime Llera-Oyola, Yosuke Yamawaki, Tomomi Sano, Eijiro Jimi, Francisco García-García, Takashi Kanematsu

“…Following testosterone treatment, miRNA, gene, and protein expression levels were investigated. An inflammatory response was induced using lipopolysaccharide (LPS) stimulation, and subsequent p65 phosphorylation was assessed. …”
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Isotype diversity of antibodies specific for component allergens in the context of allergic diseases: eosinophilic esophagitis (EoE), asthma, and the alpha-gal syndrome (AGS) by Thomas A. E. Platts-Mills, Matthew H. MacCallum, Jeffrey M. Wilson, Lisa J. Workman, Elizabeth A. Erwin

“…Furthermore, it is not clear whether the IgG isotypes, particularly IgG1 and IgG3, play a role in the inflammatory response to the oligosaccharide. Overall, it is clear that current and future investigation of allergic diseases requires careful assessment of allergen specific antibodies of diverse isotypes in addition to IgE.…”
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TAK-242 improves sepsis-associated acute kidney injury in rats by inhibiting the TLR4/NF-κB signaling pathway by Yan-mei Xia, Yu-qian Guan, Ji-fang Liang, Wei-dong Wu

“…Above indicators after TAK-242 treatment were close to those of the Sham group.Conclusion TAK-242 can improve oxidative stress, mitochondrial dysfunction, and inflammatory response by inhibiting the activity of TLR4/NF-κB signaling pathway, thereby preventing rats from SA-AKI.…”
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Selected Biomarkers Correlate with the Origin and Severity of Sepsis by Michal Holub, Olga Džupová, Michaela Růžková, Alžběta Stráníková, Eva Bartáková, Jan Máca, Jiří Beneš, Heiko Herwald, Ondřej Beran

“…The microbial etiology and source of sepsis influence the inflammatory response. Therefore, the plasma levels of cytokines (IL-6, IL-8, and IL-10), chemokines (CCL2/MCP-1, MIP-1β), heparin-binding protein (HBP), soluble CD14 (sCD14), and cortisol were analyzed in blood from septic patients obtained during the first 96 hours of intensive care unit hospitalization. …”
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Thyroid hormone receptor- and stage-dependent transcriptome changes affect the initial period of Xenopus tropicalis tail regeneration by Shouhong Wang, Liezhen Fu, Bin Wang, Yanmei Cai, Jianping Jiang, Yun-Bo Shi

“…Results We discovered that GO (gene ontology) terms related to inflammatory response, metabolic process, cell apoptosis, and epithelial cell migration were highly enriched among commonly regulated genes during wound healing at either stage 56 or 61 or with either wild type (WT) or TRDKO tadpoles, consistent with the morphological changes associated with wound healing occurring in both regenerative (WT stage 56, TRDKO stage 56, TRDKO stage 61) and nonregenerative (WT stage 61) animals. …”
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Proinflammatory Tear Cytokines in Human Adenoviral Keratoconjunctivitis and Clinical Eye Severity by Santacruz Valdés C, Ponce-Rosas ER, Jimenez-Martinez MC

“…In the less severely affected eyes, inflammatory response, conjunctival hyperemia, and conjunctival hemorrhages were significantly correlated with IL-12 and TNF-a, and ocular discharge was significantly correlated with all tear cytokines. …”
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PPAR-γ agonist mitigates intestinal barrier dysfunction and inflammation induced by Clostridioides difficile SlpA in vitro by Maryam Noori, Masoumeh Azimirad, Mahsa Ghorbaninejad, Anna Meyfour, Mohammad Reza Zali, Abbas Yadegar

“…SlpA can attenuate PPAR-γ expression, trigger TJ disruption, and stimulate inflammatory response in host cells. Notably, these events could be reversed by pretreatment of cells with PPAR-γ agonist. …”
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