Autologous haematopoiesis stem cell transplantation (AHSCT) for treatment-refractory autoimmune diseases in children by Jasmin Beate Kuemmerle-Deschner, Susanne Benseler, Joerg C Henes, Özlem Satirer, Michaela Döring, Till Lesk

“…Safety: Three experienced infections, including HHV6, Candida and Ralstonia sepsis; one developed a systemic inflammatory response syndrome; two new onset secondary autoimmune diseases including autoimmune haemolytic anaemia, Graves’ disease and one was found to have a breast fibroadenoma. …”
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Analysis of Toll-Like Receptors in Human Milk: Detection of Membrane-Bound and Soluble Forms by Chiara Cattaneo, Alice Caramaschi, Elena Uga, Michela Braghin, Gianluca Cosi, Chiara Peila, Maria C. Strozzi, Miriam Sabatini, Diego Gazzolo, Marcello Manfredi, Maria Cavaletto

“…Preterm babies are more susceptible to infections and may succumb to necrotizing enterocolitis (NEC), a gastrointestinal disease which is exacerbated by an excessive inflammatory response after TLR activation. Here, we investigated the presence of Toll-like receptors TLR1/2/4/6 in colostrum and mature milk of women who delivered before (preterm) or after (term) 37 weeks of gestational age, integrating classical immune-related techniques with proteomic LC-MS/MS analysis. …”
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Evaluation of Hepatoprotective Effect of Curcumin on Liver Cirrhosis Using a Combination of Biochemical Analysis and Magnetic Resonance-Based Electrical Conductivity Imaging by Eun Jung Kyung, Hyun Bum Kim, Eun Sang Hwang, Seok Lee, Bup Kyung Choi, Jin Woong Kim, Hyung Joong Kim, Sang Moo Lim, Oh In Kwon, Eung Je Woo

“…Histological staining and immunohistochemical examination showed significant levels of attenuated fibrosis and decreased inflammatory response after both curcumin and lactulose treatments compared with damaged liver tissues by DMN. …”
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Synergistic Stimulation with Different TLR7 Ligands Modulates Gene Expression Patterns in the Human Plasmacytoid Dendritic Cell Line CAL-1 by Tobias Hilbert, Folkert Steinhagen, Christina Weisheit, Georg Baumgarten, Andreas Hoeft, Sven Klaschik

“…Structurally different TLR7 ligands act synergistically on gene expression patterns and on the resulting inflammatory response. These data could impact future strategies optimizing TLR7-targeted drug design.…”
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Monocyte/Lymphocyte Ratio and Cardiovascular Disease Mortality in Peritoneal Dialysis Patients by Yueqiang Wen, Xiaojiang Zhan, Niansong Wang, FenFen Peng, Xiaoran Feng, Xianfeng Wu

“…The monocyte-to-lymphocyte ratio (MLR), as a new marker of the systemic inflammatory response, is associated with cardiovascular disease (CVD) mortality in the general population and hemodialysis patients. …”
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RNAseq of peripheral blood mononucleated cells exposed to platelet-rich fibrin and enamel matrix derivatives by Layla Panahipour, Zahra Kargarpour, Michael Mildner, Hannes Kühtreiber, Reinhard Gruber

“…Our findings suggest that PRF provokes an inflammatory response, while EMD dampens IgE signaling in peripheral mononucleated blood cells.…”
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The Iron-Klotho-VDR Axis Is a Major Determinant of Proximal Convoluted Tubule Injury in Haptoglobin 2-2 Genotype Diabetic Nephropathy Patients and Mice by Inbal Dahan, Nadia Thawho, Evgeny Farber, Nakhoul Nakhoul, Rabea Asleh, Andrew P. Levy, Yan Chun Li, Ofer Ben-Izhak, Farid Nakhoul

“…In the kidney, 1,25(OH)2D3 suppresses the inflammatory response to renal tubular injury and requires normal renal expression of the α-klotho protein. …”
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Visceral Adipose Tissue Inflammation and Vascular Complications in a Rat Model with Severe Dyslipidemia: Sex Differences and PAI-1 Tissue Involvement by Irena Markova, Martina Hüttl, Natalie Gayova, Denisa Miklankova, Kristyna Cerna, Martina Kavanova, Petra Skaroupkova, Sona Cacanyiova, Hana Malinska

“…We investigated the sex-dependent effects of inflammatory responses in visceral adipose tissue (VAT) and perivascular adipose tissue (PVAT), as well as hematological status, in relation to cardiovascular disorders associated with prediabetes. …”
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Bothrops asper snake venom and its metalloproteinase BaP–1 activate the complement system. Role in leucocyte recruitment by Sandra H. P. Farsky, Luís Roberto C. Gonçalves, José M. Gutiérrez, Adriana P. Correa, Alexandra Rucavado, Philippe Gasque, Denise V. Tambourgi

“…The venom of the snake Bothrops asper, the most important poisonous snake in Central America, evokes an inflammatory response, the mechanisms of which are not well characterized. …”
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Exercise induces dynamic changes in intra-articular metabolism and inflammation associated with remodeling of the infrapatellar fat pad in mice by Timothy M. Griffin, Ravi K. Komaravolu, Erika Barboza Prado Lopes, Padmaja Mehta-D’souza, Taylor Conner, Tessa Kovats, Susan Kovats, Madeline Allen, Peyton Harris, Mary Beth Humphrey, Hope D. Welhaven, Priyanka Brahmachary, Ronald K. June

“…Exercise transiently increased cytokine and chemokine gene expression in synovium-IFP tissue, resolving within the first 5 days of exercise. The acute inflammatory response was associated with decreased adipocyte size and elevated CD45+Gr1+ myeloid cells, increased collagen content, and oxidized phospholipids. …”
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Immunoregulative coating for scarless healing in anterior cruciate ligament reconstruction by Shuang Wang, Chao Xu, Yuanman Yu, Jie Li, Tianwu Chen, Jing Wang, Changsheng Liu

“…PET's inert surface, lower bioactivity, and mechanical abrasion trigger an M1 macrophage-mediated inflammatory response, leading to excessive, disorganized scar tissue. …”
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Pioglitazone Attenuates Drug-Eluting Stent-Induced Proinflammatory State in Patients by Blocking Ubiquitination of PPAR by Zhongxia Wang, Tao Zhang, Lizhe Sun, Ruifeng Li, Yuanyuan Wei, Xiaojuan Fan, Zuyi Yuan, Junhui Liu, Tao Chen

“…The inflammatory response after polymer-based drug-eluting stent (DES) placement has recently emerged as a major concern. …”
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Spontaneous tumor regression following COVID-19 vaccination by Hui Dai, Renata Ferrarotto, Myrna Godoy, Diana Bell, Shiaw-Yih Lin, Daniel J McGrail, Luana Guimaraes de Sousa, Kaiyi Li, Mario L Marques-Piubelli, Cipriano Gonzalez, Sammy Ferri-Borgogno, Jared Burks

“…Tumor regression can occur following an intense immune-inflammatory response and novel strategies to treat cancer rely on manipulating the host immune system. …”
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Zinc Supplementation Prevented Type 2 Diabetes-Induced Liver Injury Mediated by the Nrf2-MT Antioxidative Pathway by Lechu Yu, Yuanyuan Liu, Yichun Jin, Tinghao Liu, Wenhan Wang, Xuemian Lu, Chi Zhang

“…This induced preventive effects on conditions caused by type 2 diabetes like oxidative stress, apoptosis, the subsequent hepatic inflammatory response, fibrosis, hypertrophy, and hepatic dysfunction. …”
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The Effects of Vitamin D on Gentamicin-Induced Acute Kidney Injury in Experimental Rat Model by Ender Hur, Alev Garip, Asuman Camyar, Sibel Ilgun, Melih Ozisik, Sena Tuna, Murat Olukman, Zehra Narli Ozdemir, Eser Yildirim Sozmen, Sait Sen, Fehmi Akcicek, Soner Duman

“…Vitamin D has proven to be effective on renin expression, inflammatory response, oxidative stress, apoptosis, and atherosclerosis. …”
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Immunological Dynamics Associated with Direct-Acting Antiviral Therapies in Naive and Experimented HCV Chronic-Infected Patients by Grenda Leite Pereira, Andréa Monteiro Tarragô, Walter Luiz Lima Neves, Pedro Vieira da Silva Neto, Priscila Sarmento de Souza, Juliana dos Santos Affonso, Keyla Santos de Sousa, Jéssica Albuquerque da Silva, Allyson Guimarães Costa, Flamir da Silva Victoria, Marilu Barbieri Victoria, Adriana Malheiro

“…Before treatment, correlations in the naive HCV group demonstrated a mix of inflammatory response occurring with moderate correlations between chemokines, inflammatory cytokines, and Th2 profile, with a strong regulation between IL-10 and IL-17A. …”
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RIPK3-Mediated Necroptosis and Neutrophil Infiltration Are Associated with Poor Prognosis in Patients with Alcoholic Cirrhosis by Zhenzhen Zhang, Guomin Xie, Li Liang, Hui Liu, Jing Pan, Hao Cheng, Hua Wang, Aijuan Qu, Yan Wang

“…In conclusion, RIPK3-mediated necroptosis and neutrophil-mediated alcoholic liver inflammatory response are highly correlated with poor prognosis in patients with end-stage alcoholic cirrhosis. …”
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The association of lipid accumulation product with inflammatory parameters and mortality: evidence from a large population-based study by Yi Chi, Yiqing Zhang, Huang Lin, Shanshan Zhou, Genlin Jia, Wei Wen

“…Mediation analysis revealed that Systemic Inflammatory Response Index (SIRI), Monocyte-to-HDL ratio (MHR), and Neutrophil-to-Lymphocyte ratio (NLR) mediated 27.15%, 35.15%, and 16.55%, respectively, of the association between AVI and all-cause mortality.ConclusionAVI is positively associated with all-cause mortality in older adults with hypertension, and this association appears to be partially mediated by inflammatory parameters.…”
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NMO-IgG and AQP4 Peptide Can Induce Aggravation of EAMG and Immune-Mediated Muscle Weakness by Tehila Mizrachi, Livnat Brill, Malcolm Rabie, Yoram Nevo, Yakov Fellig, Mayan Zur, Dimitrios Karussis, Oded Abramsky, Talma Brenner, Adi Vaknin-Dembinsky

“…Thus, our study shows increased disease severity in EAMG mice following immunization with the NMO autoantigen AQP4 or by NMO-Ig, mediated by augmented inflammatory response. This can explain exacerbation or increased susceptibility of patients with one autoimmune disease to develop additional autoimmune syndrome.…”
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B and NK Cells Closely Correlate with the Condition of Patients with Acute Pancreatitis by Xin Wei, Weifeng Yao, Huiping Li, Jingjing Qian, Yaosheng Xie, Zhuo Zhang, Hong Lu, Liang Shi, Xiangyang Lin

“…Pancreatitis can lead to systemic inflammatory response, but the relationship between lymphocyte changes and patients with pancreatitis remains unclear. …”
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