Cryo-thermal therapy reshaped the tumor immune microenvironment to enhance the efficacy of adoptive T cell therapy by Shicheng Wang, Peng Peng, Junjun Wang, Zelu Zhang, Ping Liu, Lisa X. Xu

“…Cryo-thermal therapy (CTT) can induce an acute inflammatory response and remold the immune environment, providing an appropriate environment for the activation of adaptive immunity. …”
Get full text

Structural and Functional Characterization of Recombinant Interleukin-10 from Indian Major Carp Labeo rohita by Sweta Karan, Pujarini Dash, Himani Kaushik, Pramoda K. Sahoo, Lalit C. Garg, Aparna Dixit

“…The data indicate that the dimeric alpha helical structure and function of IL-10 of L. rohita as a key regulator of anti-inflammatory response have remained conserved during evolution.…”
Get full text

Andrographolide Protects against HG-Induced Inflammation, Apoptosis, Migration, and Impairment of Angiogenesis via PI3K/AKT-eNOS Signalling in HUVECs by Ming-Xia Duan, Heng Zhou, Qing-Qing Wu, Chen Liu, Yang Xiao, Wei Deng, Qi-Zhu Tang

“…We discovered that Andr inhibited the inflammatory response (IL-1β, IL-6, and TNFα), decreased the apoptosis ratio and cell migration, and promoted tube formation in response to HG stimulation. …”
Get full text

Adenosine A2A Receptors Modulate Acute Injury and Neuroinflammation in Brain Ischemia by Felicita Pedata, Anna Maria Pugliese, Elisabetta Coppi, Ilaria Dettori, Giovanna Maraula, Lucrezia Cellai, Alessia Melani

“…Proinflammatory cytokines, which upregulate cell adhesion molecules, exert an important role in promoting recruitment of leukocytes that in turn promote expansion of the inflammatory response in ischemic tissue. Protracted neuroinflammation is now recognized as the predominant mechanism of secondary brain injury progression. …”
Get full text

Expression Profile of Brain Aging and Metabolic Function are Altered by Resveratrol or α-Ketoglutarate Supplementation in Rats Fed a High-Fat Diet by Paulina Szczurek-Janicka, Katarzyna Ropka-Molik, Maria Oczkowicz, Sylwia Orczewska-Dudek, Mariusz Pietras, Marek Pieszka

“…Moreover, 32% of the 84 analyzed genes correlated with aging were differentially expressed compared to the control group, with the largest functional class being related to inflammatory response. Dietary RESV ameliorated the changes in plasma glucose, total cholesterol, and triiodothyronine concentrations induced by HFD feeding and significantly downregulated 60% of the surveyed genes compared to the control group, resulting in a major molecular shift compared to HFD alone. …”
Get full text

Lung-Derived Mediators Induce Cytokine Production in Downstream Organs via an NF-κB-Dependent Mechanism by E. K. Patterson, L. J. Yao, N. Ramic, J. F. Lewis, G. Cepinskas, L. McCaig, R. A. W. Veldhuizen, C. M. Yamashita

“…Previous studies have demonstrated that injured, mechanically ventilated lungs represent the origin of the host inflammatory response; however, mechanisms which perpetuate systemic inflammation remain uncharacterized. …”
Get full text

Crosstalk between MicroRNAs and Peroxisome Proliferator-Activated Receptors and Their Emerging Regulatory Roles in Cardiovascular Pathophysiology by Yin-Feng Zhang, Hai-Ming Xu, Fei Yu, Man Wang, Meng-Yang Li, Tao Xu, Yan-Yan Gao, Jian-Xun Wang, Pei-Feng Li

“…Peroxisome proliferator-activated receptors (PPARs) play vital roles in cardiovascular pathophysiology, such as energy balance, cell proliferation/apoptosis, inflammatory response, and adipocyte differentiation. These vital roles make PPARs potential targets for therapeutic prevention of cardiovascular diseases (CVDs). …”
Get full text

EGCG Maintains Th1/Th2 Balance and Mitigates Ulcerative Colitis Induced by Dextran Sulfate Sodium through TLR4/MyD88/NF-κB Signaling Pathway in Rats by Xue Bing, Liu Xuelei, Dong Wanwei, Liang Linlang, Chen Keyan

“…EGCG can inhibit the intestinal inflammatory response by reducing the severity of ulcerative colitis and maintaining the Th1/Th2 balance through the TLR4/MyD88/NF-κB signaling pathway.…”
Get full text

Understanding Autoimmune Mechanisms in Multiple Sclerosis Using Gene Expression Microarrays: Treatment Effect and Cytokine-related Pathways by A. Achiron, M. Gurevich, D. Magalashvili, I. Kishner, M. Dolev, M. Mandel

“…Multiple sclerosis (MS) is a central nervous system disease in which activated autoreactive T-cells invade the blood brain barrier and initiate an inflammatory response that leads to myelin destruction and axonal loss. …”
Get full text

Discovering the anti-parasitic activity of melatonin loaded lecithin/chitosan nanoparticles against giardiasis and cryptosporidiosis in Balb/c infected mice by Mohamed Nasser, Mona B. Abd El-atif, Habiba Alaa, Mariam Abdelaziz, Mariam Mustafa, Mustafa Masour, Salma Magdy, Salma Mohsen, Yomna El Karamany, Alyaa Farid

“…Then, we evaluated effectiveness of melatonin (Mel) and melatonin loaded lecithin/chitosan nanoparticles (Mel-LCNPs) against giardiasis and cryptosporidiosis in mice models using parasitological and inflammatory response examination. Results The number of positive samples for Cryptosporidium was higher than that for Giardia with percentage of 46.67% and 40.0%, respectively. …”
Get full text

Enhanced precise therapy of ROS-sensitive dual-layer shell nanoparticles loading quercetin on DSS-induced ulcerative colitis mice by Yang Bai, Danling Jiang, Boda Wu, Jiao Peng, Ji Wang, Yuhui Chen, Xi Li

“…Ulcerative colitis (UC) is an intestinal condition, involving inflammatory response, apoptosis, and associated processes. …”
Get full text

Complex Inflammation mRNA-Related Response in ALS Is Region Dependent by Sara Berjaoui, Mónica Povedano, Paula Garcia-Esparcia, Margarita Carmona, Ester Aso, Isidre Ferrer

“…The present observations show a complex participation of cytokines and mediators of the inflammatory response in ALS consistent with increased proinflammatory cytokines and sequestration of anti-inflammatory IL-10 in affected neurons.…”
Get full text

Protective Effect of Thalidomide on 2,4,6-Trinitrobenzenesulfonic Acid-Induced Experimental Colitis in Rats via the Inhibition of T Helper 17 Cells by Ying Xie, Dandan Li, Xiaoshuang Luan, Shuang Jin, Bo Yan, Feng Tian

“…The underlying mechanism may be a reduction in the expression levels of IL-6, IL-17, IL-23, and RORγt in colonic tissue and then subsequent inhibition of the differentiation and function of Th17 cells, thus further alleviating the intestinal inflammatory response.…”
Get full text

Hepatoprotective Role of 4-Octyl Itaconate in Concanavalin A-Induced Autoimmune Hepatitis by Wenchang Yang, Yaxin Wang, Peng Zhang, Tao Wang, Chengguo Li, Xin Tong, Xiangyu Zeng, Yuping Yin, Kaixiong Tao, Ruidong Li

“…In conclusion, our study indicated that OI alleviated Con A-induced hepatic damage by reducing inflammatory response, oxidative stress, and apoptosis.…”
Get full text

Enterococcus faecium NCIMB 10415 Modulates Epithelial Integrity, Heat Shock Protein, and Proinflammatory Cytokine Response in Intestinal Cells by Shanti Klingspor, Angelika Bondzio, Holger Martens, Jörg R. Aschenbach, Katharina Bratz, Karsten Tedin, Ralf Einspanier, Ulrike Lodemann

“…Probiotics have shown positive effects on gastrointestinal diseases; they have barrier-modulating effects and change the inflammatory response towards pathogens in studies in vitro. …”
Get full text

Synthesis, Characterization, and In Vivo Cytokinome Profile of IL-12-Loaded PLGA Nanospheres by Ryan A. Lacinski, Justin E. Markel, Jabeen Noore, Hillary G. Pratt, Brock A. Lindsey

“…Similar trends were observed with IL-1β and CXCL-1, suggesting a decreased likelihood of progression to a systemic inflammatory response syndrome-like state. As IL-12-NS delivers logarithmically lower amounts of IL-12 than previously administered during human clinical trials, our data reflect the importance of IL-12-NS which safely create a systemic immunostimulatory environment.…”
Get full text

Azathioprine Hypersensitivity Syndrome during Treatment of Severe Interstitial Lung Disease with Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis by Eri Nakano, Tomohiko Asakawa, Mea Asou, Eri Nohara, Tomoyuki Seki, Makoto Araki

“…Three exacerbations of the inflammatory response occurred during the subsequent 3 months. …”
Get full text

Effects of spray dried plasma on litter growth performance and oxidative stress and inflammation of sows kept in a hot environment by Hannah M. Bailey, Natalia S. Fanelli, Joy M. Campbell, Hans H. Stein

“…Abstract Background Feeding spray dried plasma (SDP) to weanling pigs improves growth, but there is a lack of research on how SDP impacts oxidative stress and inflammatory response in lactating sows, and performance of their piglets after weaning. …”
Get full text

C4d Deposition in Fetal Vessels of the Placenta in Neonatal Lupus Syndrome by Yuichiro Sato, Tomoko Yamaguchi, Jyunsuke Muraoka, Hajime Taniguchi, Atsushi Kisanuki, Kazunari Maekawa, Atushi Yamashita, Murasaki Aman, Yuki Kodama, Hiroshi Sameshima, Yujiro Asada

“…Our findings suggest that maternal autoantibodies affect the inflammatory response of the fetus through the placenta and that C4d deposition may be useful for diagnosing NLS.…”
Get full text

The Therapeutic Effects and Possible Mechanism of Pranoprofen in Mouse Model of Corneal Alkali Burns by Minting Chen, Abdirahman Abdinasir Gureeye, Yacouba Cissé, Lang Bai

“…Pranoprofen may alleviate inflammatory response by inhibiting the expression levels of NLRP3 and IL-1β at the early stage of corneal alkali injury, lowering the expression of MMP-13 and ultimately reducing corneal epithelial damage.…”
Get full text