PATHOLOGICAL CHANGES IN MICE TREATED WITH CYCLOPHOSPHAMIDE AND EXOGENOUS DNA by E. V. Dolgova, V. P. Nikolin, N. A. Popova, A. S. Proskurina, K. E. Orishchenko, E. A. Alyamkina, Ya. R. Efremov, S. I. Baiborodin, E. R. Chernykh, A. A. Ostanin, S. S. Bogachev, T. S. Gvozdeva, E. M. Malkova, O. S. Taranov, V. A. Rogachev, A. S. Panov, S. N. Zagrebelnyi, M. A. Shurdov

“…Most of the pathological changes observed are consistent with severe inflammatory response. This suggestion is proven by structural equivalents of functional involution of lymphoid organs, such as thymus, spleen, and lymph nodes.We speculate that the death of treated animals resulted from multiple organ dysfunctions caused by accidental involution of lymphoid organs and the systemic inflammatory response syndrome, both associated with injections of fragmented exogenous DNA into experimental animals within the «death window», which corresponds to the final step in the repair of the majority of CP-induced double-strand breaks.…”
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Acute Neuroinflammatory Response in the Substantia Nigra Pars Compacta of Rats after a Local Injection of Lipopolysaccharide by Yazmin M. Flores-Martinez, Manuel A. Fernandez-Parrilla, Jose Ayala-Davila, David Reyes-Corona, Victor M. Blanco-Alvarez, Luis O. Soto-Rojas, Claudia Luna-Herrera, Juan A. Gonzalez-Barrios, Bertha A. Leon-Chavez, Maria E. Gutierrez-Castillo, Irma A. Martínez-Dávila, Daniel Martinez-Fong

“…Models of Parkinson’s disease with neurotoxins have shown that microglial activation does not evoke a typical inflammatory response in the substantia nigra, questioning whether neuroinflammation leads to neurodegeneration. …”
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Choline Phospholipid Metabolites of Human Vascular Endothelial Cells Altered by Cyclooxygenase Inhibition, Growth Factor Depletion, and Paracrine Factors Secreted by Cancer Cells by Noriko Mori, Kshama Natarajan, V. P. Chacko, Dmitri Artemov, Zaver M. Bhujwalla

“…The ability of INDO to alter choline phospholipid metabolism in the presence of growth factor supplements suggests that the inflammatory response pathways of HUVECs may play a role in cancer cell-HUVEC interaction and in the response of HUVECs to growth factors.…”
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Linking Innate and Adaptive Immunity: Human Vγ9Vδ2 T Cells Enhance CD40 Expression and HMGB-1 Secretion by Shirin Kalyan, Anthony W. Chow

“…IPP-primed γδ T cells significantly augment the inflammatory response mediated by monocytes and αβ T cells to TSST-1, the staphylococcal superantigen that is the major causative agent of toxic shock syndrome. …”
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Modulation of the Wound Healing through Noncoding RNA Interplay and GSK-3β/NF-κB Signaling Interaction by Xianyi Wang, Wanqiu Li, Shengdi Lu, Zhongliang Ma

“…The nuclear factor kappa B (NF-κB) signaling pathway, a classical pathway that triggers inflammatory response, is regulated by many regulators, such as glycogen synthase kinase 3 beta (GSK-3β). …”
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Spatial distribution-based progression of spinal cord injury pathology: a key role for neuroimmune cells by Jian Li, Xiaolei Zhai, Chaochun Yu

“…In addition to impairing movement and sensory functions, spinal cord injury (SCI) triggers complex pathophysiological responses, with the spatial dynamics of immune cells playing a key role. The inflammatory response and subsequent healing processes following SCI are profoundly influenced by the spatial distribution and movement of immune cells. …”
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Deubiquitinases: Novel Therapeutic Targets in Immune Surveillance? by Gloria Lopez-Castejon, Mariola J. Edelmann

“…Modulation of DUB activity by small molecules has been proposed as a way to control dysregulation or overactivation of these key players of the inflammatory response. We will also discuss the advances and challenges of a potential use of DUBs as therapeutic targets in inflammatory pathologies.…”
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The Role of Toll-Like Receptor 4 in Infectious and Noninfectious Inflammation by Monica Molteni, Sabrina Gemma, Carlo Rossetti

“…TLR4-mediated inflammation, triggered by exogenous or endogenous ligands, is also involved in several acute and chronic diseases, having a pivotal role as amplifier of the inflammatory response. This review focuses on the research progress about the role of TLR4 activation in infectious and noninfectious (e.g., sterile) inflammation and the effects of TLR4 signaling in some pathological conditions.…”
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Looking for Pyroptosis-Modulating miRNAs as a Therapeutic Target for Improving Myocardium Survival by Seahyoung Lee, Eunhyun Choi, Min-Ji Cha, Ki-Chul Hwang

“…Pyroptosis is the most recently identified type of regulated cell death with inflammatory response and has characteristics distinct from those of apoptosis or necrosis. …”
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Myeloid-Related Protein Activity in Rheumatoid Arthritis by Charles J. Malemud

“…In that regard, MRP-8 and MRP-14 regulate the inflammatory response through their capacity to recruit neutrophils and monocytes to target tissues resulting in attachment to endothelium. …”
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Intra-Abdominal Hypertension and Abdominal Compartment Syndrome in Association with Ruptured Abdominal Aortic Aneurysm in the Endovascular Era: Vigilance Remains Critical by Matthew C. Bozeman, Charles B. Ross

“…Morbidity and mortality due to systemic inflammatory response syndrome (SIRS) and multiple organ failure (MOF) are significant. …”
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Cytokine and Growth Factor Activation In Vivo and In Vitro after Spinal Cord Injury by Elisa Garcia, Jorge Aguilar-Cevallos, Raul Silva-Garcia, Antonio Ibarra

“…These mechanisms include the disruption of the spinal cord blood barrier, edema and ion imbalance, in particular intracellular calcium and sodium concentrations, glutamate excitotoxicity, free radicals, and the inflammatory response contributing to the neurodegenerative process which is characterized by demyelination and apoptosis of neuronal tissue.…”
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Hyperglycemia in Streptozotocin-Induced Diabetes Leads to Persistent Inflammation and Tissue Damage Following Uveitis Due to Reduced Levels of Ciliary Body Heme Oxygenase-1 by Settimio Rossi, Michele D'Amico, Annalisa Capuano, Mary Romano, Pasquale Petronella, Clara Di Filippo

“…Impairment of the stress-sensitive enzyme HO-1 in STZ-hyperglycemic rats increases and prolongs the inflammatory response to EIU.…”
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Possible Involvement of Liver Resident Macrophages (Kupffer Cells) in the Pathogenesis of Both Intrahepatic and Extrahepatic Inflammation by Yuki Kakinuma, Takuya Kimura, Yoshifumi Watanabe

“…These results strongly suggest that KCs are involved in not only intrahepatic inflammatory response but also systemic (especially) chronic inflammation.…”
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Systemic and Local CC Chemokines Production in a Murine Model of Listeria monocytogenes Infection by Marina Bubonja, Branka Wraber, Gordana Brumini, Ivana Gobin, Danijela Veljkovic, Maja Abram

“…The liver-to-serum ratio was more pronounced in the case of macrophage inflammatory protein 1α (MIP-1α), suggesting its role in the inflammatory response in the liver. The ratio of brain-to-serum concentration of monocyte chemoattractant protein 1 (MCP-1) remained the same as in the control animals, while it was lower in the infected mice, both in the case MIP-1α and in the case of regulated on activation, normal T cell expressed and secreted (RANTES). …”
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Progress on long non-coding RNAs in calcific aortic valve disease by Yan Shen, Jiahui Li, Zehao Zhao, Xiaomin Chen

“…Research has shown that lncRNAs participate in the pathological process underlying CAVD by regulating osteogenic differentiation and inflammatory response of valve interstitial cells. Specifically, lncRNAs, such as H19, MALAT1, and TUG1, are closely associated with CAVD. …”
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Higher-Order Chromatin Regulation of Inflammatory Gene Expression by Jin-Wen Xu, Shuang Ling, Jun Liu

“…This article will review emerging evidence on the genome organization hierarchy underlying the inflammatory response.…”
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Tumor necrosis factor-α/interleukin-10 balance in normal and cystic fibrosis children by Galina V. Shmarina, Alexander L. Pukhalsky, Svetlana N. Kokarovtseva, Daria A. Pukhalskaya, Lidia A. Shabalova, Nikolai I. Kapranov, Natalia J. Kashirskaja

“…Exuberant production of TNF-α contributes to overwhelming inflammatory response and tissue damage. But, commonly, increase in TNF-α is counterbalanced by simultaneous synthesis of an anti-inflammatory cytokine IL-10, which suppresses production of many activating and regulatory mediators.…”
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The effect of caloric restriction on genetical pathways by Mustafa Fevzi Karagöz, A. Gülçin Sağdıçoğlu Celep

“…Mitochondrial biogenesis is stimulated, antioxidant capacity increases, and inflammatory response decreases. Adipose tissue and lipid metabolism are regulated by the regulation of fatty acid synthesis and oxidation. …”
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Systemic Inflammation and Acute-on-Chronic Liver Failure: Too Much, Not Enough by Wim Laleman, Joan Claria, Schalk Van der Merwe, Richard Moreau, Jonel Trebicka

“…Dysbalanced immune function is central to its pathogenesis and outcome with an initial excessive systemic inflammatory response that drives organ failure and mortality. …”
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