Exploring the associations of gut microbiota with inflammatory and the early hematoma expansion in intracerebral hemorrhage: from change to potential therapeutic objectives by Haixiao Jiang, Wei Zeng, Fei Zhu, Xiaoli Zhang, Demao Cao, Aijun Peng, Hongsheng Wang

“…We deduced that emICH could rapidly trigger the dysbiosis of intestinal flora, and the disturbed microbiota could, in turn, exacerbate inflammatory response and increase the risk of hematoma expansion. …”
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Synergistic anti-oxidative/anti-inflammatory treatment for acute lung injury with selenium based chlorogenic acid nanoparticles through modulating Mapk8ip1/MAPK and Itga2b/PI3k-AKT... by Huizhen Xing, Xinwei Bai, Xiaoying Pei, Yuqi Zhang, Xueying Zhang, Shujun Chen, Dan Li, Bin Lv, Xiaoying Wang, Xiaoli Wu

“…Abstract Oxidative stress and inflammatory dysregulation play crucial roles in pathogenesis of acute lung injury (ALI), and their cyclic synergy drives excessive inflammatory responses and further exacerbates ALI. Therefore, new effective strategies to treat ALI are urgently needed. …”
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MiR-155-Mediated Deregulation of GPER1 Plays an Important Role in the Gender Differences Related to Inflammatory Bowel Disease by Xiaojuan Shao, Jintao Li, Fumin Xu, Dongfeng Chen, Kaijun Liu

“…MiR-155 was upregulated and showed proinflammatory activity, whereas GPER1 showed an anti-inflammatory response during the pathogenesis of IBD. The results demonstrated that more proinflammatory cytokines and reduced GPER1 levels were observed in the male IBD patients. …”
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Scent of COVID-19: Whole-Genome Sequencing Analysis Reveals the Role of <i>ACE2</i>, <i>IFI44</i>, and <i>NDUFAF4</i> in Long-Lasting Olfactory Dysfunction by Beatrice Spedicati, Alessandro Pecori, Maria Pina Concas, Aurora Santin, Romina Ruberto, Giuseppe Giovanni Nardone, Andrea D’Alessandro, Giancarlo Tirelli, Paolo Boscolo-Rizzo, Giorgia Girotto

“…Conversely, an increased gene score in <i>IFI44</i> and <i>NDUFAF4</i> might be associated with a decreased inflammatory response, thus correlating with a better olfactory performance. …”
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Metagenomic Sequencing Combined with Metabolomics to Explore Gut Microbiota and Metabolic Changes in Mice with Acute Myocardial Infarction and the Potential Mechanism of Allicin by Gao Y, Qin G, Liang S, Yin J, Wang B, Jiang H, Liu M, Luo F, Li X

“…Mechanistically, NP and in vivo experiments indicated that allicin might suppress pyroptosis and reduce inflammatory response via blocked activation of the NF-κB-mediated NLRP3/Caspase-1/GSDMD pathway. …”
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The effect of meningococcal vaccines on new generation of systemic inflammatory markers in children by Omer Okuyan, Neval Elgormus, Seyma Dumur, Ugurcan Sayili, Hafize Uzun

“…However, further studies involving larger patient cohorts as well as detailed laboratory data on specific markers of inflammation are needed to draw comprehensive conclusions regarding the inflammatory response following vaccination.…”
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Role of Astrocytic Dysfunction in the Pathogenesis of Parkinson’s Disease Animal Models from a Molecular Signaling Perspective by Lucas Udovin, Cecilia Quarracino, María I. Herrera, Francisco Capani, Matilde Otero-Losada, Santiago Perez-Lloret

“…Activation of astrocyte TRPV1 receptors by noxious stimuli results in reduced inflammatory response and increased ciliary neurotrophic factor (CNTF) synthesis, which enhances neuronal survival and differentiation. …”
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IL-33 Deficiency Attenuates Lung Inflammation by Inducing Th17 Response and Impacting the Th17/Treg Balance in LPS-Induced ARDS Mice via Dendritic Cells by Li Cheng, Yang Jiao, Wei Jiang, Xin Zhang, Liping Zhang, Gongwei Jia

“…The characteristic pathophysiological feature of acute respiratory distress syndrome (ARDS) is a dysregulated inflammatory response. T helper 17 (Th17) cells in the lung are inflammatory cells that contribute to pulmonary inflammatory cascades. …”
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Lipid mediators in post-mortem brain samples from patients with Alzheimer's disease: A systematic review by Aidan D. Tyrrell, Giulia Cisbani, Mackenzie E. Smith, Chuck T. Chen, Yue-Tong Chen, Raphael Chouinard-Watkins, Kathryn E. Hopperton, Ameer Y. Taha, Richard P. Bazinet

“…Dysregulation of lipid mediators derived from polyunsaturated fatty acids may contribute to this inflammatory response in the brain of patients with AD, yet the literature has not yet been systematically reviewed. …”
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Infectious Keratitis: Secreted Bacterial Proteins That Mediate Corneal Damage by Mary E. Marquart, Richard J. O'Callaghan

“…Most, but not all, of these proteins are secreted toxins and enzymes that mediate host cell death, degradation of stromal collagen, cleavage of host cell surface molecules, or induction of a damaging inflammatory response. Studies of these bacterial pathogens have determined the proteins of interest that could be targets for future therapeutic options for decreasing corneal damage.…”
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Update for diagnosis and treatment of syndrome after cardiac injury: a mini-review by Ruihui Lai, Tan Xu, Tan Xu

“…This condition is considered to be an autoimmune-mediated inflammatory response leading to pericarditis as the primary manifestation of the cardiac disease. …”
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Severe Eosinophilic Meningoencephalitis Secondary to Suspected Neuroangiostrongyliasis with a Good Clinical Outcome by Fabian Chiong, Andrew R. Lloyd, Jeffrey J. Post

“…Management of neuroangiostrongyliasis with anthelminthic is controversial as it is thought to cause worsened outcomes through inciting an inflammatory response as a result of parasite killing. We managed to successfully treat our patient using albendazole and prednisolone and achieved a good outcome.…”
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The Role of Leukotriene Receptor Signaling in Inflammation and Cancer by Ramin Massoumi, Anita Sjölander

“…The release of these mediators, by cells recruited to or present at the site of inflammation, modulate/influence the magnitude of the inflammatory response. A better understanding of eicosanoids and how their receptors trigger intracellular signaling during inflammatory conditions is helping to elucidate the well-known connection between chronic inflammatory disease and neoplastic transformation. …”
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Diagnostic and Prognostic Role of Procalcitonin in Infections by Maria Hatzistilianou

“…The problems with sepsis definitions and diagnoses are indications of the need to focus on biochemical mediators capable not only of distinguishing the inflammatory response to infection from other types of inflammation, but also of indicating the severity and prognosis of the disease. …”
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Relationship between Periodontitis and Ischemic Cerebrovascular Disease by Magda Pinilla Pérez, Elisa DBeche Riambau, Miriam Castro Ortega

“…Periodontitis is an immunoinflammatory disorder of microbial etiology caused by unique germs in the oral cavity that can spread through the bloodstream, activate the host's inflammatory response and promote the formation, maturation and exacerbation of atheromatous plaque. …”
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Correlation between the Neutrophil-to-Lymphocyte Ratio and Multiple Sclerosis: Recent Understanding and Potential Application Perspectives by Qingqing Zhou, Rui Jia, Jingxia Dang

“…In this review, we aimed to discuss the inflammatory response in MS, mainly the function of lymphocytes and neutrophils, which can be implemented in the utility of NLR as a diagnostic tool in MS patients. …”
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Dietary Glycaemic Index and Type 2 Diabetes Mellitus: Potential Modulation of Gut Microbiota by Hanusha Durganaudu, Thubasni Kunasegaran, Amutha Ramadas

“…Generally, diet has strong influence on the gut microbiota, which recently have been found to be associated with insulin resistance and the inflammatory response in diabetes. The possible modulation of the gut microbiota with dietary intervention is a topic of emerging interest, with limited evidence among T2DM population. …”
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Conservative Management of an Iatrogenic Esophageal Tear in Kenya by Peter Waweru, David Mwaniki

“…This rare, devastating, mostly iatrogenic, condition can quickly lead to severe complications and death due to an overwhelming inflammatory response to gastric contents in the mediastinum. …”
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Yersiniosis and acute secondary axonal sensorimotor polyneuropathy: a case report by A. Daškevičiūtė, R. Mameniškienė

“…This article presents a case of yersiniosis which presented with febrile fever and severe inflammatory response. At the onset of the disease, Guillain–Barre syndrome was suspected but later acute axonal sensorimotor polyneuropathy was diagnosed. …”
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Multiple sclerosis: overview of orally administrated disease-modifying drugs. Do genetics influence the success of treatment? by A. Ovčinikova, R. Kizlaitienė

“…In MS treatment, disease modifying therapies (DMTs) are essential to reduce disease progression by suppressing the inflammatory response responsible for promoting lesion formation. …”
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