Molecular Imaging of Autoimmune Diseases and Inflammation by S. Anna Sargsyan, Joshua M. Thurman

“…Agents that report on molecular disease biomarkers can be used to diagnose and monitor disease. Many inflammatory diseases have molecular signatures within altered tissues. …”
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The Tumor Necrosis Factor Superfamily of Cytokines in the Inflammatory Myopathies: Potential Targets for Therapy by Boel De Paepe, Kim K. Creus, Jan L. De Bleecker

“…For each TNF family member, possibilities for treating inflammatory diseases in general and the IM in particular are explored.…”
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Bacterial Infections, DNA Virus Infections, and RNA Virus Infections Manifest Differently in Neutrophil Receptor Expression by Esa-Matti Lilius, Jari Nuutila

“…The analysis of the expression levels of FcγRI, CR1, and CR3, along with CRP and ESR data, provides a novel application to the diagnosis of infectious and inflammatory diseases. The best clinical benefit will be obtained when the individual variables are combined to generate the CIS point method for a bacterial infection marker, DNAVS point for differentiating between DNA and RNA virus infections, and CRP/CD11b ratio for a marker of Gram-positive sepsis.…”
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Serum levels of TNF-α, sIL-2R, IL-6, and IL-8 are increased and associated with elevated lipid peroxidation in patients with Behçet's disease by Cem Evereklioglu, Hamdi Er, Yusuf Türköz, Mustafa Çekmen

“…Cytokines play a role in immune response and in many inflammatory diseases. The aim of this case-control study is to investigate serum pro-inflammatory cytokine tumour necrosis factor (TNF)-α, interleukin-1beta (IL-1β), soluble IL-2 receptor (sIL-2R), IL-6, and chemokine IL-8 levels in patients with BD. …”
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Interleukin-1, Tumour Necrosis Factor and Treatment of the Septic Shock Syndrome by Charles A Dinarello

“…The IL-1 receptor antagonist, a naturally occurring cytokine, blocks shock and death due to Escherichia coli as well as ameliorates a variety of inflammatory diseases. Soluble TNF and IL-1 surface receptors, which bind their respective cytokines. also ameliorate disease processes. …”
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Curbing Inflammation in Multiple Sclerosis and Endometriosis: Should Mast Cells Be Targeted? by David A. Hart

“…Inflammatory diseases and conditions can arise due to responses to a variety of external and internal stimuli. …”
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MicroRNAs in Postischemic Vascular Repair by Andrea Caporali, Costanza Emanueli

“…In adulthood, angiogenesis is activated as a reparative process during wound healing and following ischemia, and it plays a key role in tumor growth and metastasis as well as in inflammatory diseases and diabetic retinopathy. MicroRNAs (miRNAs) are endogenous, small, noncoding RNAs that negatively control gene expression of target mRNAs. …”
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Abnormal 18F-FDG Uptake Detected with Positron Emission Tomography in a Patient with Breast Cancer: A Case of Sarcoidosis and Review of the Literature by Selmin Ataergin, Nuri Arslan, Ahmet Ozet, Mehmet Ali Ozguven

“…18F-FDG PET is a useful and sensitive imaging method for a variety of malignancies, however, the specificity is low in active infections and inflammatory diseases. We describe a female patient with stage IIIA breast cancer in first complete remission with combination chemotherapy who developed nodular formations in the lung and axilla 12 years later. …”
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Systemic Role for Vitamin D in the Treatment of Psoriasis and Metabolic Syndrome by Lisa Wenyang Fu, Ronald Vender

“…The novel discovery of the systemic role of vitamin D in the modulation of the immune system especially the Type 1 helper T cell (Th1) pathway reveals its potential for treating Th1 inflammatory diseases. Psoriasis has been recently established to be a systemic disease centered on inflammation and involvement of cytokines of the Th1 pathway. …”
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Optic neuritis: relation between inflammatory genetic markers and occurrence of the disease by V. Punytė, R. Liutkevičienė

“…Typical ON is often related to multiple sclerosis while atypical ON can be caused by various infections, autoimmune disorders or different inflammatory diseases. Although the cause of ON is multifactorial, a lot of attention is given to inflammatory and immune processes which are considered to contribute to demyelination of axons. …”
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Angiotensin-(1-7) and Alamandine Promote Anti-inflammatory Response in Macrophages In Vitro and In Vivo by Melissa de Carvalho Santuchi, Miriane Fernandes Dutra, Juliana Priscila Vago, Kátia Maciel Lima, Izabela Galvão, Fernando Pedro de Souza-Neto, Mario Morais e Silva, Aline Cristina Oliveira, Flávia Carvalho Bittencourt de Oliveira, Ricardo Gonçalves, Mauro Martins Teixeira, Lirlândia Pires Sousa, Robson Augusto Souza dos Santos, Rafaela Fernandes da Silva

“…In conclusion, our work sheds light on the emerging proresolving properties of Ang-(1-7) and alamandine, opening new avenues for the treatment of inflammatory diseases.…”
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PEPITEM, its tripeptide pharmacophores and their peptidomimetic analogues regulate the inflammatory response through parenteral and topical dosing in models of peritonitis and psor... by Anella Saviano, Bonita Apta, Samantha Tull, Laleh Pezhman, Areeba Fatima, Mustafa Sevim, Antonio Mete, Myriam Chimen, Anna Schettino, Noemi Marigliano, Helen M. McGettrick, Asif J. Iqbal, Francesco Maione, G. Ed Rainger

“…PEPITEM is an immune-modulatory peptide that effectively regulates inflammation and mitigates immune-mediated inflammatory diseases (IMIDs). Here, we identify two independently active tripeptide pharmacophores within PEPITEM and engineered peptidomimetics with enhanced pharmacodynamic properties. …”
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NLRP3 inflammasome-modulated angiogenic function of EPC via PI3K/ Akt/mTOR pathway in diabetic myocardial infarction by Jia-Peng Li, Shu Qiu, Guang-Jie Tai, Yi-Ming Liu, Wei Wei, Meng-Meng Fu, Pan-Qi Fang, Joseph Nicolao Otieno, Tungalag Battulga, Xiao-Xue Li, Ming Xu

“…Abstract Background Inflammatory diseases impair the reparative properties of endothelial progenitor cells (EPC); however, the involvement of diabetes in EPC dysfunction associated with myocardial infarction (MI) remains unknown. …”
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New strategy for gastrointestinal protection based on gaseous mediators application by O. N. Sulaieva, J. L. Wallace

“…H2S-releasing anti-inflammatory drugs show considerable promise as a safer option for treating chronic inflammatory diseases.…”
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Functional Role of Milk Fat Globule-Epidermal Growth Factor VIII in Macrophage-Mediated Inflammatory Responses and Inflammatory/Autoimmune Diseases by Young-Su Yi

“…Chronic inflammation is considered to be one of the major causes of serious diseases, including a number of autoimmune/inflammatory diseases, cancers, cardiovascular diseases, and neurological diseases. …”
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Identification of O-glycosylation related genes and subtypes in ulcerative colitis based on machine learning. by Yue Lu, Yi Su, Nan Wang, Dongyue Li, Huichao Zhang, Hongyu Xu

“…O-GlcNAcylation plays a critical role in regulating immunity progression and the occurrence of inflammatory diseases and tumors. Yet, the mechanism of O-GlcNAc-associated colitis remains to be elucidated. …”
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CCL24 and Fibrosis: A Narrative Review of Existing Evidence and Mechanisms by Raanan Greenman, Chris J. Weston

“…Higher levels of CCL24 and CCR3 were found in the tissue and sera of patients with fibro-inflammatory diseases, including primary sclerosing cholangitis (PSC), systemic sclerosis (SSc), and metabolic dysfunction-associated steatohepatitis (MASH). …”
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Immune Optimization as a Preventive and Therapeutic Adjunct for the Management of Renin–Angiotensin–Aldosterone System Dysfunction Diseases: A Review by Michael T. Okafor, Queenet C. Onyebuchukwu, Germaine A. Okafor, Samuel C. Niteh, Chikere A. Anusiem

“…We reviewed articles with keywords, such as Renin Angiotensin Aldosterone System, Immune-Mediated Inflammatory Diseases, Immune Dysfunction, T lymphocyte activation/dysfunction, cytokines, RAAS Dysfunction, RAAS blockers, therapeutic adjunct, and prevention. …”
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S100 Calgranulin Proteins S100A8, S100A9 and S100A12 are Expressed in the Inflamed Gastric Mucosa of Helicobacter Pylori-Infected Children by Steven T Leach, Hazel M Mitchell, Carolyn L Geczy, Philip M Sherman, Andrew S Day

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Role of neuroimmunomodulation by vagus nerve stimulation in rheumatoid arthritis: Are we heading towards a drug-free era? by Prasan Deep Rath, Swetal Pandey, Rahul Bisaralli

“…Progressive clinical research in the field of neuroimmunomodulation has formed a base for the development of a new therapeutic paradigm for various inflammatory diseases, including rheumatoid arthritis (RA). …”
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