Post-Genomics and Skin Inflammation by Daniela Braconi, Giulia Bernardini, Annalisa Santucci

“…Atopic dermatitis and psoriasis are two chronic skin inflammatory diseases that have so far received a greater attention within the scientific community through different post-genomic approaches; on the contrary, acne, which is undoubtedly one of the most common skin disorders involving inflammatory processes, seems to be still quite neglected under the post-genomic point of view. …”
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Anti-inflammatory treatment using alpha melanocyte stimulating hormone (α-MSH) does not alter osteoblasts differentiation and fracture healing by Johanna Graue, Melanie Timmen, Katharina Schmitz, Daniel Kronenberg, Markus Böhm, Kishor K. Sivaraj, M. Gabriele Bixel, Richard Stange

“…Abstract Background Alpha-melanocyte-stimulating-hormone (α-MSH) has been identified as a new anti-inflammatory treatment compound in rheumatoid arthritis (RA) and other inflammatory diseases. However, its direct effect on bone cell differentiation or on bone regeneration, which is an inflammatory process, too, has not been investigated, yet. …”
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Renewed Avenues through Exercise Muscle Contractility and Inflammatory Status by Nelo Eidy Zanchi, Felipe Natali Almeida, Fábio Santos Lira, José César Rosa Neto, Humberto Nicastro, Claudia Ribeiro da Luz, Mário Alves de Siqueira Filho, Vitor Felitti, Mariz Vainzof, Marilia Seelaender, Jacques R. Poortmans, Antonio Herbert Lancha

“…This paper aims to describe specific data from the literature regarding the effects of exercise on inflammatory diseases in order to promote a more sophisticated perspective on the anti-inflammatory effects of exercise.…”
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A Network Pharmacology-Based Strategy for Unveiling the Mechanisms of Tripterygium Wilfordii Hook F against Diabetic Kidney Disease by Yuyang Wang, Tongtong Liu, Fang Ma, Xiaoguang Lu, Huimin Mao, Weie Zhou, Liping Yang, Ping Li, Yongli Zhan

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Impact of Nutritional Factors on Colorectal Cancer: Implication the molecular mechanisms of Vitamins Supplementation by Hossna M. Ismail, Abdel-Aziz S. Shatat

“…Bad eating habits, smoking, intestinal inflammatory diseases, polyps, aging, and genetic factors all increase the risk of developing colorectal cancer. …”
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Peroxisome Proliferator-Activated Receptors and Acute Lung Injury by Rosanna Di Paola, Salvatore Cuzzocrea

“…Several studies have demonstrated that PPAR ligands possess anti-inflammatory properties and that these properties may prove helpful in the treatment of inflammatory diseases of the lung. This review will outline the anti-inflammatory effects of PPARs and PPAR ligands and discuss their potential therapeutic effects in animal models of inflammatory lung disease.…”
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Intravenous Immunoglobulins: Mode of Action and Indications in Autoimmune and Inflammatory Dermatoses by Lyubomir A. Dourmishev, Dimitrina V. Guleva, Ljubka G. Miteva

“…Today their indication has expanded, including the off-label therapy for a variety of autoimmune and inflammatory diseases. In dermatology, IVIGs are administered for treatment of different disorders at different therapeutic regimens, mostly with higher doses then those administered for treatment of infectious diseases. …”
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Severe Corticosteroid-Induced Ocular Hypertension Requiring Bilateral Trabeculectomies in a Patient with Takayasu’s Arteritis by Anna Maria Gruener, Pranev Sharma, Sally Ameen, Faisal Ahmed

“…It further emphasizes the need to raise awareness of the potential ocular side effects of steroids amongst physicians, in particular those looking after patients with autoimmune and inflammatory diseases.…”
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The Tumor Necrosis Factor Superfamily of Cytokines in the Inflammatory Myopathies: Potential Targets for Therapy by Boel De Paepe, Kim K. Creus, Jan L. De Bleecker

“…For each TNF family member, possibilities for treating inflammatory diseases in general and the IM in particular are explored.…”
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Bacterial Infections, DNA Virus Infections, and RNA Virus Infections Manifest Differently in Neutrophil Receptor Expression by Esa-Matti Lilius, Jari Nuutila

“…The analysis of the expression levels of FcγRI, CR1, and CR3, along with CRP and ESR data, provides a novel application to the diagnosis of infectious and inflammatory diseases. The best clinical benefit will be obtained when the individual variables are combined to generate the CIS point method for a bacterial infection marker, DNAVS point for differentiating between DNA and RNA virus infections, and CRP/CD11b ratio for a marker of Gram-positive sepsis.…”
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Serum levels of TNF-α, sIL-2R, IL-6, and IL-8 are increased and associated with elevated lipid peroxidation in patients with Behçet's disease by Cem Evereklioglu, Hamdi Er, Yusuf Türköz, Mustafa Çekmen

“…Cytokines play a role in immune response and in many inflammatory diseases. The aim of this case-control study is to investigate serum pro-inflammatory cytokine tumour necrosis factor (TNF)-α, interleukin-1beta (IL-1β), soluble IL-2 receptor (sIL-2R), IL-6, and chemokine IL-8 levels in patients with BD. …”
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Interleukin-1, Tumour Necrosis Factor and Treatment of the Septic Shock Syndrome by Charles A Dinarello

“…The IL-1 receptor antagonist, a naturally occurring cytokine, blocks shock and death due to Escherichia coli as well as ameliorates a variety of inflammatory diseases. Soluble TNF and IL-1 surface receptors, which bind their respective cytokines. also ameliorate disease processes. …”
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Curbing Inflammation in Multiple Sclerosis and Endometriosis: Should Mast Cells Be Targeted? by David A. Hart

“…Inflammatory diseases and conditions can arise due to responses to a variety of external and internal stimuli. …”
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MicroRNAs in Postischemic Vascular Repair by Andrea Caporali, Costanza Emanueli

“…In adulthood, angiogenesis is activated as a reparative process during wound healing and following ischemia, and it plays a key role in tumor growth and metastasis as well as in inflammatory diseases and diabetic retinopathy. MicroRNAs (miRNAs) are endogenous, small, noncoding RNAs that negatively control gene expression of target mRNAs. …”
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Abnormal 18F-FDG Uptake Detected with Positron Emission Tomography in a Patient with Breast Cancer: A Case of Sarcoidosis and Review of the Literature by Selmin Ataergin, Nuri Arslan, Ahmet Ozet, Mehmet Ali Ozguven

“…18F-FDG PET is a useful and sensitive imaging method for a variety of malignancies, however, the specificity is low in active infections and inflammatory diseases. We describe a female patient with stage IIIA breast cancer in first complete remission with combination chemotherapy who developed nodular formations in the lung and axilla 12 years later. …”
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Systemic Role for Vitamin D in the Treatment of Psoriasis and Metabolic Syndrome by Lisa Wenyang Fu, Ronald Vender

“…The novel discovery of the systemic role of vitamin D in the modulation of the immune system especially the Type 1 helper T cell (Th1) pathway reveals its potential for treating Th1 inflammatory diseases. Psoriasis has been recently established to be a systemic disease centered on inflammation and involvement of cytokines of the Th1 pathway. …”
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Optic neuritis: relation between inflammatory genetic markers and occurrence of the disease by V. Punytė, R. Liutkevičienė

“…Typical ON is often related to multiple sclerosis while atypical ON can be caused by various infections, autoimmune disorders or different inflammatory diseases. Although the cause of ON is multifactorial, a lot of attention is given to inflammatory and immune processes which are considered to contribute to demyelination of axons. …”
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Angiotensin-(1-7) and Alamandine Promote Anti-inflammatory Response in Macrophages In Vitro and In Vivo by Melissa de Carvalho Santuchi, Miriane Fernandes Dutra, Juliana Priscila Vago, Kátia Maciel Lima, Izabela Galvão, Fernando Pedro de Souza-Neto, Mario Morais e Silva, Aline Cristina Oliveira, Flávia Carvalho Bittencourt de Oliveira, Ricardo Gonçalves, Mauro Martins Teixeira, Lirlândia Pires Sousa, Robson Augusto Souza dos Santos, Rafaela Fernandes da Silva

“…In conclusion, our work sheds light on the emerging proresolving properties of Ang-(1-7) and alamandine, opening new avenues for the treatment of inflammatory diseases.…”
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PEPITEM, its tripeptide pharmacophores and their peptidomimetic analogues regulate the inflammatory response through parenteral and topical dosing in models of peritonitis and psor... by Anella Saviano, Bonita Apta, Samantha Tull, Laleh Pezhman, Areeba Fatima, Mustafa Sevim, Antonio Mete, Myriam Chimen, Anna Schettino, Noemi Marigliano, Helen M. McGettrick, Asif J. Iqbal, Francesco Maione, G. Ed Rainger

“…PEPITEM is an immune-modulatory peptide that effectively regulates inflammation and mitigates immune-mediated inflammatory diseases (IMIDs). Here, we identify two independently active tripeptide pharmacophores within PEPITEM and engineered peptidomimetics with enhanced pharmacodynamic properties. …”
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New strategy for gastrointestinal protection based on gaseous mediators application by O. N. Sulaieva, J. L. Wallace

“…H2S-releasing anti-inflammatory drugs show considerable promise as a safer option for treating chronic inflammatory diseases.…”
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