miR663 Prevents Epo Inhibition Caused by TNF-Alpha in Normoxia and Hypoxia by Mete Ozkurt, Thomas Hellwig-Bürgel, Reinhard Depping, Selda Kadabere, Rumeysa Ozyurt, Abdullah Karadag, Nilüfer Erkasap

“…Objective. In chronic inflammatory diseases, proinflammatory cytokines such as TNF-α are present in high amounts in the circulation and are associated with anemia in most cases. …”
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Purine-Metabolizing Ectoenzymes Control IL-8 Production in Human Colon HT-29 Cells by Fariborz Bahrami, Filip Kukulski, Joanna Lecka, Alain Tremblay, Julie Pelletier, Liliana Rockenbach, Jean Sévigny

“…Interleukin-8 (IL-8) plays key roles in both chronic inflammatory diseases and tumor modulation. We previously observed that IL-8 secretion and function can be modulated by nucleotide (P2) receptors. …”
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Erbin Regulates Tissue Factors Through Ras/Raf Pathway in Coagulation Disorders in Sepsis by Yang C, Lei C, Jing G, Xia Y, Zhou H, Wu D, Zuo J, Gong H, Wang X, Dong Y, Aidebaike D, Wu X, Song X

“…It has been reported that ERBB2 Interacting Protein (Erbin) is involved in the development of various inflammatory diseases, and macrophages are involved in the regulation of coagulation disorders in sepsis. …”
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Theranostic nanoemulsions suppress macrophage-mediated acute inflammation in rats by Riddhi Vichare, Yalcin Kulahci, Rebecca McCallin, Fatih Zor, Fatma Nurefsan Selek, Lu Liu, Caitlin Crelli, Anneliese Troidle, Michele Herneisey, James M. Nichols, Andrew J. Shepherd, Vijay S. Gorantla, Jelena M. Janjic

“…Abstract In inflammatory diseases or following an injury, dysregulated inflammation is a common driver of pain and tissue damage. …”
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Chloroquine and Rapamycin Augment Interleukin-37 Expression via the LC3, ERK, and AP-1 Axis in the Presence of Lipopolysaccharides by Xiaoyi Shi, Chunhui Lai, Lianyu Zhao, Mingying Zhang, Xi Liu, Shanqin Peng, Weizhong Guo, Qiuying Xu, Song Chen, Guang-xing Chen

“…IL-37 is a cytokine that plays critical protective roles in many metabolic inflammatory diseases, and its therapeutic potential has been confirmed by exogenous IL-37 administration. …”
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Reduction of IL-17A Might Suppress the Th1 Response and Promote the Th2 Response by Boosting the Function of Treg Cells during Silica-Induced Inflammatory Response In Vitro by Wen Tang, Fangwei Liu, Ying Chen, Laiyu Song, Wujing Dai, Chao Li, Dong Weng, Jie Chen

“…IL-17A, the typical Th17 cytokine, is reported in some inflammatory diseases. However, the role of IL-17A in silica-induced inflammatory response is still not clear. …”
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Efficacy of umbilical cord-derived mesenchymal stem cells and exosomes in conjunction with standard IBD drug on immune responses in an IBD mouse model by Fatemeh Kheradmand, Seyedeh Fatemeh Yasaman Rahimzadeh, Seyed-Alireza Esmaeili, Sajad Sahab Negah, Najmeh Kaffash Farkhad, Seyedeh Elnaz Nazari, Mehrdad Hajinejad, Mohammad Ali Khodadoust, Afsane Fadaee, Jalil Tavakol Afshari, Majid Khazaei

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Alpha-1 Antitrypsin as a Regulatory Protease Inhibitor Modulating Inflammation and Shaping the Tumor Microenvironment in Cancer by Siyu Xiang, Liu Yang, Yun He, Feng Ding, Shuangying Qiao, Zonghua Su, Zheng Chen, Aiping Lu, Fangfei Li

“…This review seeks to bridge the gap in the understanding of AAT between inflammatory diseases and cancer, and to foster deeper investigations into its translational potential in cancer immunotherapy in the future.…”
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Neolithic introgression of IL23R-related protection against chronic inflammatory bowel diseases in modern EuropeansResearch in context by Ben Krause-Kyora, Nicolas Antonio da Silva, Elif Kaplan, Daniel Kolbe, Inken Wohlers, Hauke Busch, David Ellinghaus, Amke Caliebe, Efe Sezgin, Almut Nebel, Stefan Schreiber, Sabine Schade-Lindig, Joachim Wahl, Carola Berszin, Michael Francken, Irina Görner, Kerstin Schierhold, Joachim Pechtl, Gisela Grupe, Johannes Müller

“…The adaptively evolved function of the variant likely contributes to the high efficacy and low side-effects of modern IL-23 neutralisation therapies for chronic inflammatory diseases. Funding: German Research Foundation (EXC 2167 390884018 and EXC 2150 390870439).…”
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Omentin-1, a Protective Adipokine for Irritable Bowel Syndrome by Gao Y, Chen C, Huang X, Liu Y, Zhou Z, Pan Y

“…Adipokines have been reported to be critical immunoregulators in many clinical conditions, including gastrointestinal (GI) inflammatory diseases. Our study aimed to investigate associations of omentin-1 (a newly discovered adipokine) with IBS.Methods: In the current study, serum levels of omentin-1 were measured in 209 patients with IBS (including three subtypes) and 188 healthy controls by enzyme-linked immunosorbent assay (ELISA). …”
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Biosimilars in Focus: Evaluating Their Role Compared to Adalimumab in Clinical Practice by Dorota Waz, Michał Mazur, Jakub Szarłowicz, Zofia Goliszek, Karolina Łucja Sobek, Wiktoria Tabin-Barczak, Aldona Sokołowska, Klaudia Fikas, Kamil Chwaliszewski, Sebastian Samuła

“…Introduction and Purpose: Adalimumab, a TNF-α inhibitor, is a cornerstone treatment for autoimmune and inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease. …”
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Chemerin-9 is neuroprotective in APP/PS1 transgenic mice by inhibiting NLRP3 inflammasome and promoting microglial clearance of Aβ by Jiawei Zhang, Yaxuan Zhang, Lan Liu, Mengyuan Zhang, Xiaojie Zhang, Jiangshan Deng, Fei Zhao, Qing Lin, Xue Zheng, Bing Fu, Yuwu Zhao, Xiuzhe Wang

“…Chemerin, an adipokine, has been implicated in inflammatory diseases and central nervous system disorders, yet its precise function on microglial response in AD remains unknown. …”
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Radical Scavenging Activity-Based and AP-1-Targeted Anti-Inflammatory Effects of Lutein in Macrophage-Like and Skin Keratinocytic Cells by Jueun Oh, Ji Hye Kim, Jae Gwang Park, Young-Su Yi, Kye Won Park, Ho Sik Rho, Min-Seuk Lee, Jae Won Yoo, Seung-Hyun Kang, Yong Deog Hong, Song Seok Shin, Jae Youl Cho

“…These findings can be applied for the preparation of anti-inflammatory and cosmetic remedies for inflammatory diseases of the skin.…”
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Th9 Cells in Peripheral Blood Increased in Patients with Immune-Related Pancytopenia by Qing Shao, Yangyang Wang, Zhaoyun Liu, Hui Liu, Yihao Wang, Yang Zhao, Lijuan Li, Rong Fu

“…Th9 cells are associated with a variety of inflammatory diseases, but the role of Th9 cells in IRP remains unclear. …”
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The role of natural exosomes from SHED-MSC in immunoregulation of M0/M1 polarized macrophage cells by Ali Fallah, Abasalt Hosseinzadeh Colagar, Ayyoob Khosravi, Ayyoob Khosravi, Azadeh Mohammad-Hasani, Azadeh Mohammad-Hasani, Mohsen Saeidi, Mohsen Saeidi

“…IntroductionExosomes (EXOs) as a targeted cell-free therapy could offer a new therapeutic strategy for immune-mediated inflammatory diseases, due to their stability and ease of storage and handling. …”
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MCU complex: Exploring emerging targets and mechanisms of mitochondrial physiology and pathology by Jin Wang, Jinyong Jiang, Haoliang Hu, Linxi Chen

“…Regulation makes it a potential target for treating diseases, especially cardiovascular diseases, neurodegenerative diseases, inflammatory diseases, metabolic diseases, and tumors.…”
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Peripheral Blood NMLR Can Predict 5-Year All-Cause Mortality in Patients with Chronic Obstructive Pulmonary Disease by Li Y, Ge S, Liu J, Li R, Zhang R, Wang J, Pan J, Zhang Q, Zhang J, Zhang M

“…The peripheral blood (neutrophil + monocyte)/lymphocyte ratio (NMLR) can predict the clinical outcomes of several inflammatory diseases. However, its prognostic value in COPD remains unknown.Methods: This retrospective study included 870 patients with COPD due to acute exacerbation, and the 5-year all-cause mortality of these patients was recorded. …”
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Apoptotic Vesicles Attenuate Acute Lung Injury via CD73-Mediated Inhibition of Platelet Activation and NETosis by Tan L, Zhang C, Kou X, Zhao L, Wu D, Li J, Yu C, Xu T, Gao L, Mao X, Zhao C

“…Mesenchymal stem cell-derived apoptotic vesicles (apoVs) were recently found to have excellent therapeutic potential for inflammatory diseases. In this study, our aim was to investigate the therapeutic effects and underlying mechanisms of apoVs in ALI.Methods: ALI was induced in mice through intratracheal instillation of lipopolysaccharide (LPS). …”
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Exosomes Play an Important Role in the Progression of Plasma Cell Mastitis via the PI3K-Akt-mTOR Signaling Pathway by Xiaohong Wang, Yong Han, Jian Liu, Yingzhe Zhang, Kai Cheng, Jiwei Guo, Qingqun Guo, Song Liu, Hongguang Sun, Yitong Hua, Guoqiang Zhang, Shujian Xu, Fengli Guo, Zhenlin Yang

“…Plasma cell mastitis (PCM) is one of the most frequently encountered inflammatory diseases of the nonlactating breast. However, its pathogenesis has remained unknown. …”
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Unique pharmacological properties of etrasimod among S1P receptor modulators by Ibragim Gaidarov, H. Kiyomi Komori, Dariusz T. Stepniak, Karin Bruinsma, Huong Dang, Xiaohua Chen, Todd Anthony, Joel Gatlin, Lisa Karimi‐Naser, Anh‐Tuan Ton, Tim Indersmitten, Paul E. Miller, Andre Ghetti, Najah Abi‐Gerges, David Unett, Hussien Al‐Shamma, Christopher J. Rabbat, Catherine Crosby, John W. Adams

“…Etrasimod (ADP334) is an oral, once‐daily, selective sphingosine 1‐phosphate (S1P)1,4,5 receptor modulator for the treatment of moderately to severely active ulcerative colitis and in development for the treatment of immune‐mediated inflammatory diseases. Interaction between S1P and its five receptor subtypes (S1P1–S1P5) plays a role in several physiologic systems, including the cardiovascular and immune systems. …”
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