A Gastroenterologist’s Perspective of The Medical Management of Patients with Crohn’s Disease and Ulcerative Colitis by ABR Thomson

“…Medical therapy in patients with inflammatory bowel disease (IBD) has specific objectives that need to be remembered when considering any form of intervention. …”
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Cholestasis in Crohn's Disease: A Diagnostic Challenge by Nir Hilzenrat, Esther Lamoureux, Averell Sherker, Albert Cohen

“…Because numerous potentially serious hepatobiliary complications have been associated with inflammatory bowel disease, prompt and aggressive investigation in these instances is recommended.…”
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Pitfalls in Labelled Leukocyte Scanning by H Hodgson, M Roddie

“…Radiolabelled leukocyte scanning is a valuable tool in the diagnosis and management of inflammatory bowel disease (IBO). As well as determining the presence or absence of disease and its complications, the degree of inflammation may be quantified either visually or numerically following four day fecal collection. …”
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Keeping an Eye on Crohn’s Disease: Orbital Myositis as the Presenting Symptom by Carol A Durno, Robert Ehrlich, Robert Taylor, J Raymond Buncic, Peter Hughes, Anne Marie Griffiths

“…Orbital myositis, a very rare extraintestinal manifestation of inflammatory bowel disease (IBD), likely represents a process of impaired immunoregulation related to the underlying intestinal inflammation. …”
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IL-1 stimulates ceramide accumulation without inducing apoptosis in intestinal epithelial cells by Fadia R. Homaidan, Marwan E. El-Sabban, Iman Chakroun, Mirvat El-Sibai, Ghassan S. Dbaibo

“…Background: In inflammatory bowel disease (IBD), cytokine levels (such as interleukin-1 (IL-1)) are elevated. …”
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Management of Primary Sclerosing Cholangitis: Conventions and Controversies by Natasha Chandok, Gideon M Hirschfield

“…PSC is uncommon, occurs predominantly in males and has a strong association with inflammatory bowel disease. While the pathogenesis of PSC has not been fully elucidated, emerging evidence supports roles for the innate and adaptive immune systems, and genome-wide analyses have identified several genetic associations. …”
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Intestinal Organoids in Colitis Research: Focusing on Variability and Cryopreservation by Talke F. zur Bruegge, Andrea Liese, Sören Donath, Stefan Kalies, Maike Kosanke, Oliver Dittrich-Breiholz, Sandra Czech, Verena N. Bauer, André Bleich, Manuela Buettner

“…Taken together, our findings demonstrate that organoid culture, if standardized, constitutes a good tool for reducing the need for animal experiments and might further improve our understanding of, for example, the role of epithelial cells in inflammatory bowel disease development.…”
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Enteral Nutrition in Crohn’s Disease: An Underused Therapy by S. Kansal, J. Wagner, C. D. Kirkwood, A. G. Catto-Smith

“…This paper reviews the literature on the history, efficacy, and putative mechanism of action of enteral nutrition for inflammatory bowel disease in both paediatric and adult patients. …”
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Crohn’s Disease – The Pathogenesis of a Granulomatous Vasculitis: A Hypothesis by Andrew J Wakefield

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Gastroduodenal Ulcerative Colitis in Association with Ulcerative Pancolitis by Khin San Aye, Lin Lin Htun, Thet Mar Win, Mya Thida Aye, Drmyothettin Tin, Than Than Aye

“…Ulcerative colitis (UC) is a chronic inflammatory bowel disease, traditionally regarded as being limited to the colorectum. …”
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Tirofiban-Induced Thrombocytopenia Occurring with Crohn’s Disease by Toni Ibrahim, Fady El Karak, Assem Araji, Elie El Rassy

“…This case report suggests a possible association between TIT and inflammatory bowel disease. Therefore, strict monitoring of the platelet count is required in patients who develop allergic reactions to tirofiban.…”
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Multiple Abscess Collections: Antibiotics or Steroids? by Philippe Raphael Dias, Levin Bolt, Christof Iking-Konert, Mattia Arrigo, Lars C. Huber

“…The combination of multiple abscess collections in different organs, negative microbiological studies, and the association with an inflammatory bowel disease is highly suggestive for an AAS. …”
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Does Smoking Reduce Infliximab’s Effectiveness against Crohn’s Disease? by Neeraj Narula, Richard N Fedorak

“…Crohn’s disease (CD) is an idiopathic inflammatory bowel disease and has no known cure. CD symptoms are treated using an array of medicines, including biological agents such as infliximab. …”
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Intestinal Immune Imbalance is an Alarm in the Development of IBD by Chunli Hu, Shengtao Liao, Lin Lv, Chuanfei Li, Zhechuan Mei

“…Immune regulation plays a crucial role in human health and disease. Inflammatory bowel disease (IBD) is a chronic relapse bowel disease with an increasing incidence worldwide. …”
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Colonic Squamous Cell Carcinoma in Ulcerative Colitis: Report of a Case and Review of the Literature by Huilan Cheng, Michael D Sitrin, Sateesh K Satchidanand, Jan M Novak

“…Related literature on colorectal SCC and squamous metaplasia, and their relationships with inflammatory bowel disease and human papilloma virus, is reviewed.…”
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Clinical Perspectives - Biologics in IBD: What's All the Fuss? by Hillary Steinhart

“…Up until the present time, agents with relatively nonspecific anti-inflammatory or immunomodulatory effects such as 5-acetylsalicylic acid, corticosteroids and azathioprine have been the mainstay of inflammatory bowel disease medical therapy. These drugs have been quite useful in one or more clinical settings, but they have been hampered by modest efficacy, significant toxicity or both. …”
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A Rare Case of New-Onset Ulcerative Colitis following Initiation of Secukinumab by Ted George Achufusi, Prateek S. Harnee, Sekou Rawlins

“…Recently, there has been increasing controversy regarding potential adverse effects of the drug especially in those with underlying inflammatory bowel disease. We present the case of a young male patient who developed severe new-onset ulcerative colitis following initiation of secukinumab for psoriasis, with excellent response and rapid resolution of symptoms with infliximab.…”
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Malpractice and Avascular Necrosis: Legal Outcomes by Rose M Carter

“…Avascular necrosis has been established as a possible serious complication of steroid treatment in inflammatory bowel disease. Two specific Canadian cases illustrating the sequence of medical history, time, expert testimony and legal outcomes are presented. …”
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Correlation of Patient-Reported Outcome (PRO-2) with Endoscopic and Histological Features in Ulcerative Colitis and Crohn’s Disease Patients by Sanja Dragasevic, Aleksandra Sokic-Milutinovic, Milica Stojkovic Lalosevic, Tamara Milovanovic, Srdjan Djuranovic, Ivan Jovanovic, Sanja Rajic, Mirjana Stojkovic, Biljana Milicic, Stefan Kmezic, Branislav Oluic, Marko Aleksic, Aleksandra Pavlovic Markovic, Dragan Popovic

“…Determination of inflammatory bowel disease activity determines further therapeutic approach and follow-up. …”
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QALYs: The Math Doesn’t Work by Tia G. Sawhney, Angela Dobes, Sirimon O'Charoen

“…Furthermore, our review of the mathematical properties of QALYs, including an analysis of quality-of-life utility (QOL utility) data recently collected from patients with inflammatory bowel disease (IBD), has led us to conclude that QALYs are an inappropriate metric of drug and treatment cost-effectiveness for all people, both disabled and nondisabled, and should not be the basis for US healthcare policy decisions.…”
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