Characteristics and multi-omics analysis of spontaneous spondyloarthritis in non-human primates: Case report by Lei Cai, Qing Lv, Ronghua Ma, Wei Liu, Yalun Guan, Zhongqiang Huang, Qingyu Liu, Yunfeng Li, Shuhua Liu, Ge Li, Yu Zhang

“…MRI imaging further confirmed inflammatory changes in the spine and facet joints of these monkeys, along with inflammation and bone destruction in peripheral joints. …”
Get full text

Genetic interaction between oxidative stress and body mass index in a Spanish population by Francisco Lara-Hernández, Rebeca Melero, María Elena Quiroz-Rodríguez, Celeste Moya-Valera, Mariana de Jesús Gallardo-Espinoza, Luis Álvarez, Ingrid Lizeth Valarezo-Torres, Laisa Briongos-Figuero, Jessica Abadía-Otero, Francisco Javier Mena-Martin, Guillermo Saez, Josep Redon, Juan-Carlos Martín-Escudero, Ana-Bárbara García-García, Guillermo Ayala, Felipe Javier Chaves

“…The genes selected regulate several key biological processes, including obesity, blood pressure, inflammation, lipid metabolism and redox homeostasis. …”
Get full text

Impact of endoplasmic reticulum aminopeptidases 1 (ERAP1) and 2 (ERAP2) on neutrophil cellular functions by Irma Saulle, Irma Saulle, Fiona Limanaqi, Micaela Garziano, Micaela Garziano, Maria Luisa Murno, Valentina Artusa, Valentina Artusa, Sergio Strizzi, Matteo Giovarelli, Carsten Schulte, Jacopo Aiello, Mario Clerici, Mario Clerici, Claudia Vanetti, Mara Biasin

“…In these cells following 3 h or 24 h rhERAP stimulation by Western Blot, RT-qPCR, Elisa, Confocal microscopy, transwell migration assay, Oxygraphy and Flow Cytometry we assessed: i) rhERAP internalization; ii) activation; iii) migration; iv) oxygen consumption rate; v) reactive oxygen species (ROS) accumulation; granule release; vi) phagocytosis; and vii) autophagy.ResultsWe observed that following stimulation rhERAPs: i) were internalized by neutrophils; ii) triggered their activation as witnessed by increased percentage of MAC-1+CD66b+ expressing neutrophils, cytokine expression/release (IL-1β, IL-8, CCL2, TNFα, IFNγ, MIP-1β) and granule enzyme secretion (myeloperoxidase, Elastase); iii) increased neutrophil migration capacity; iv) increased autophagy and phagocytosis activity; v) reduced ROS accumulation and did not influence oxygen consumption rate.ConclusionOur study provides novel insights into the biological role of ERAPs, and indicates that extracellular ERAPs, contribute to shaping neutrophil homeostasis by promoting survival and tolerance in response to stress-related inflammation. This information could contribute to a better understanding of the biological bases governing immune responses, and to designing ERAP-based therapeutic protocols to control neutrophil-associated human diseases.…”
Get full text

Phenotypes of primary sclerosing cholangitis in children by M.B. Dyba, V.S. Berezenko

“…Although immunosuppressive therapy is effective in controlling autoimmune inflammation, it does not inhibit the progression of fibrotic changes around the bile ducts, which, unfortunately, leads to the formation of biliary cirrhosis of the liver. …”
Get full text

Vaccarin suppresses diabetic nephropathy through <?A3B2 pi6?>inhibiting the EGFR/ERK1/2 signaling pathway by Zhu Xuexue, Meng Xinyu, Du Xinyao, Zhao Chenyang, Ma Xinyu, Wen Yuanyuan, Zhang Shijie, Hou Bao, Cai Weiwei, Du Bin, Han Zhijun, Xu Fei, Qiu Liying, Sun Haijian

“…RT-PCR is utilized to quantify the mRNA levels of renal fibrosis, oxidative stress and inflammation markers. The levels of malondialdehyde (MDA) and reactive oxygen species (ROS), as well as the content of glutathione peroxidase (GSH-Px), are measured. …”
Get full text

CSF3 promotes colorectal cancer progression by activating p65/NF-κB signaling pathway and inducing an immunosuppressive microenvironment by Junfeng Xu, Na Li, Hui Xie, Changwei Duan, Xingchen Liao, Ruoran Li, Heng Zhang, Yuanming Pan, Xianzong Ma, Shuwen Du, Jianqiu Sheng, Xin Wang, Lang Yang, Peng Jin

“…Background: Colony-stimulating factor 3 (CSF3) is a cytokine that promotes inflammation by stimulating the maturation, proliferation, and trafficking of myeloid progenitor cells. …”
Get full text

Identification of Three Significant Genes Associated with Immune Cells Infiltration in Dysfunctional Adipose Tissue-Induced Insulin-Resistance of Obese Patients via Comprehensive B... by Ming Zhai, Peipei Luan, Yefei Shi, Bo Li, Jianhua Kang, Fan Hu, Mingjie Li, Lei Du, Donglei Zhou, Weixia Jian, Wenhui Peng

“…Low-grade chronic inflammation in dysfunctional adipose tissue links obesity with insulin resistance through the activation of tissue-infiltrating immune cells. …”
Get full text

Profil Pasien Pneumonia Komunitas di Bagian Anak RSUP DR. M. Djamil Padang Sumatera Barat by Osharinanda Monita, Finny Fitry Yani, Yuniar Lestari

“…<br />Kata kunci: profil, pneumonia komunitas, anak</p><p>Abstract<br />Pneumonia is infection or inflammation of the lung and it is a major cause of morbidity and mortality in children aged under five years, especially in developing countries. …”
Get full text

Dihydroquercetin attenuated Prevotella copri-caused intestinal injury by modulating gut microbiota and bile acids in weaned piglets by Long Wang, Ruizhi Hu, Siqi Ma, Xizi Yang, Jiatai Gong, Hongkun Xiang, Mingkun Shi, Xupeng Yuan, Liang Chen, Hongfu Zhang, Bie Tan, Xi He, Jianhua He, Shusong Wu

“…Our previous studies have suggested that Prevotella may play a critical role in causing intestinal inflammation. This study aimed to clarify the impact of Prevotella copri on intestinal injury and the protecting effect by dihydroquercetin (DHQ) in weaned piglets. …”
Get full text

What Makes Umbilical Cord Tissue-Derived Mesenchymal Stromal Cells Superior Immunomodulators When Compared to Bone Marrow Derived Mesenchymal Stromal Cells? by R. N. Bárcia, J. M. Santos, M. Filipe, M. Teixeira, J. P. Martins, J. Almeida, A. Água-Doce, S. C. P. Almeida, A. Varela, S. Pohl, K. E. J. Dittmar, S. Calado, S. I. Simões, M. M. Gaspar, M. E. M. Cruz, W. Lindenmaier, L. Graça, H. Cruz, P. E. Cruz

“…This was further corroborated in vivo in a model of acute inflammation. To elucidate the potency differences observed between UCX and BM-MSCs, gene expression related to immune modulation was analysed in both cell types. …”
Get full text

Application of lacrimal gland ultrasonography in the evaluation of chronic ocular graft-versus-host-disease by Mingxia Zhong, Siyuan Liu, Jinghan Luo, Qin Zhang, Zhou Yang, Shanshan Zhang

“…These effects appear to be a common result of chemoradiotherapy-induced inflammation and rejection-associated responses. There were no significant differences in the morphology of lacrimal glands as revealed by ultrasonography. …”
Get full text

Dietary Solid-state-fermentation product of Bacillus velezensis T23 alleviate hepatic steatosis, oxidative stress, gut barrier damage, and microbiota dysbiosis in juvenile genetica... by Qiang Hao, Rolf Erik Olsen, Einar Ringø, Qianwen Ding, Tsegay Teame, Yuanyuan Yao, Chao Ran, Yalin Yang, Zhen Zhang, Zhigang Zhou

“…Fish groups fed with 0.2 g/kg and 0.3 g/kg T23 supplemented diet also exhibited significantly lower intestinal injury and intestinal inflammation via upregulating the expression of tight junction protein gene claudin, anti-inflammatory factor gene il-10 (p < 0.05). …”
Get full text

Association between red blood cell distribution width-to-albumin ratio and prognosis in post-cardiac arrest patients: data from the MIMIC-IV database by Yinhe Cai, Yinhe Cai, Yao Zhang, Yao Zhang, Ningzhi Zhou, Ningzhi Zhou, Yong Tang, Yong Tang, Haixia Zheng, Haixia Zheng, Hong Liu, Hong Liu, Jiahua Liang, Ruixiang Zeng, Shengqing Song, Yu Xia, Yu Xia

“…The red blood cell distribution width (RDW)-to-albumin ratio (RAR) has been widely explored in various inflammation-related diseases. However, the predictive value of RAR for the prognosis of CA remains unclear. …”
Get full text

An aggregation-induced emission-active lysosome hijacker: Sabotaging lysosomes to boost photodynamic therapy efficacy and conquer tumor therapeutic resistance by Hang Zou, Pingping Wang, Zhihao Bai, Liping Liu, Jingtong Wang, Yanfang Cheng, Bairong He, Zujin Zhao, Lei Zheng

“…The AIE-active QM-DMAC can specifically stain lysosomes in tumor cells, offering a high signal-to-noise ratio and enabling specific visualization of variations in lysosomal viscosity, such as those induced by inflammation or autophagy. Furthermore, QM-DMAC effectively generates reactive oxygen species (ROS) under white light irradiation, which precisely induces ROS-mediated lysosomal membrane permeabilization (LMP) and lysosome rupture. …”
Get full text

Enhanced protective effect of selenium-biofortified peptide RYNA(Se)MNDYT compared with its native peptide RYNAMNDYT in lipopolysaccharide-injured murine gut microbiota by Shujian Wu, Zhenjun Zhu, Mengfei Chen, Aohuan Huang, Yizhen Xie, Jiaming Chen, Liang Xue, Moutong Chen, Jumei Zhang, Juan Wang, Qingping Wu, Yu Ding

“…The results showed that Se-P2 exhibits a higher protective effect on lipopolysaccharide (LPS)-induced inflammation than P2, including pathology of the colon and liver, which suggested that the bioactivity of P2 was promoted by the organic combination of Se. …”
Get full text

Development of an innovative intravaginal model of probiotic inoculation in dairy ovine flocks: positive effects on the vaginal microbiota, vaginitis and fertility by M. Toquet, J. Gomis, E. Jiménez-Trigos, E. Bataller, M. Barba, A. Sánchez, P. González-Torres, Á. Gómez-Martín

“…The results of this study suggest that the use of probiotics via intravaginal inoculation as a strategy to positively modulate the microbiota and vaginal inflammation, derived from the use of intravaginal sponges, is also associated with improved fertility. …”
Get full text

Construction of a C-reactive protein-albumin-lymphocyte index-based prediction model for all-cause mortality in patients on maintenance hemodialysis by Junmin Huang, Junfeng Hao, Huasheng Luo, Lu Chen, Hongying Luo, Huafeng Liu, Yongzhi Xu, Peng Wang

“…The C-reactive protein-albumin-lymphocyte (CALLY) index is a novel biomarker that reflects inflammation, nutritional and immune status, all merged into one single derived parameter. …”
Get full text

Therapeutic effects of composite probiotics derived from fermented camel milk on metabolic dysregulation and intestinal barrier integrity in type 2 diabetes rats by Tabusi Manaer, Tabusi Manaer, Tabusi Manaer, Tabusi Manaer, Jialehasibieke Sailike, Xin Sun, Baheban Yeerjiang, Baheban Yeerjiang, Baheban Yeerjiang, Baheban Yeerjiang, Xinhua Nabi, Xinhua Nabi, Xinhua Nabi, Xinhua Nabi

“…Histological examinations revealed reduced pancreatic inflammation and hepatic steatosis, with restored colonic structure.ConclusionCPCM treatment significantly improved metabolic dysregulation in the T2DM rat model, reducing blood glucose and lipid levels, enhancing intestinal barrier function, and increasing insulin secretion. …”
Get full text

Dietary Tannic Acid Promotes Growth Performance and Resistance Against <i>Aeromonas hydrophila</i> Infection by Improving the Antioxidative Capacity and Intestinal Health in the Ch... by Liqin Ji, Yisen Shangguan, Chen Chen, Chengqing Wei, Junxian Zhu, Xiaoyou Hong, Xiaoli Liu, Xinping Zhu, Wei Li

“…Integrative analyses of two omics revealed that 2 g/kg of TA mitigated inflammation by activating the PPAR signaling pathway and regulating the lipid metabolism via multiple pathways, such as steroid biosynthesis and α-linolenic acid metabolism. …”
Get full text

GH inhibits ALV-J replication and restricts cell cycle by activating PI3K/Akt signaling pathway by Junliang Xia, Ling Lin, Rongyang Ju, Chengxun Xu, Guodong Mo, Xiquan Zhang

“…Previous studies have suggested that GH is involved in the regulation of innate immunity and inflammation. However, the specific role of GH in response to ALV-J remains unclear. …”
Get full text