Combination of Metformin and Magnesium Citrate Reduces TNF-α, NF-κB p65, IL-6, CD4, and MMP-9 Expressions in Diabetic Model Rats by Rachmi Fauziah Rahayu, Adi Prayitno, Bambang Purwanto, Widiastuti Soewondo, Ida Nurwati, Eti Poncorini Pamungkasari, Paramasari Dirgahayu

“…KEYWORDS: diabetes mellitus, inflammation, cytokines, metformin, magnesium citrate…”
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Human placental extract improves liver cirrhosis in mice with regulation of macrophages and senescent cells by Natsuki Ishikawa, Yusuke Watanabe, Yuichirou Maeda, Tomoaki Yoshida, Naruhiro Kimura, Hiroyuki Abe, Akira Sakamaki, Hiroteru Kamimura, Takeshi Yokoo, Kenya Kamimura, Atsunori Tsuchiya, Shuji Terai

“…Gene expression pathway analysis using spatial transcriptomics also revealed the possibility of improving senescent cell-derived inflammation via mitochondrial function. Conclusions: HPE improves serum ALT levels via anti-inflammatory mechanisms in macrophages and senescent cells. …”
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Utilisation des Anti-Inflammatoires Non Stéroïdiens chez les personnes âgées en rhumatologie au CHR-Tsévié (Togo) by VES Koffi-Tessio, E Fianyo, ML Diallo, S Oniankitan, A Adjolou, KC Tagbor, KA Nouvedji, M Ngakui, A Tsowou, C Deghela, K Kakpovi, P Houzou, O Oniankitan, M Mijiyawa

“…Conclusion : La prise en charge de la douleur et de l’inflammation chez les personnes âgées est nécessaire et passe parfois par des anti-inflammatoires non stéroïdiens qui sont l’une des causes de morbidités liées aux médicaments. …”
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Clinical and morphological basis of two-step surgery for cataract and glaucoma by E.A. Ivachev, M.G. Fedorova

“…No cells typical of inflammation were detected. </p> <p> <b>Conclusion: </b>two-step surgery can be recommended for patients with cataract and uncontrolled glaucoma to control IOP and improve vision. …”
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A Shared Path: Co-occurrence and Clinical Implications of Celiac Disease and Type 1 Diabetes Mellitus by Wojciech Florczak, Joanna Śnieżna, Jakub Dziewic, Karol Dzwonnik, Wiktoria Domino, Urszula Zelik, Gabriela Trestka, Maria Przygoda, Jagienka Włodyka, Kamila Stępień, Sabina Adamczyk

“…CeD is a gluten-induced disease resulting in inflammation and impaired absorption of the nutrients, leading to malnutrition. …”
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Exploring the Mechanisms of Iron Overload-Induced Liver Injury in Rats Based on Transcriptomics and Proteomics by Yujia Shu, Xuanfu Wu, Dongxu Zhang, Shuxia Jiang, Wenqiang Ma

“…The results indicated that iron treatment with iron dextran significantly increased the scores of steatosis (<i>p</i> < 0.05) and inflammation (<i>p</i> < 0.05) in the NAS score. The integrated transcriptomic and proteomic analysis suggests that HO-1 and Lnc286.2 are potentially significant in iron overload-induced liver injury in rats. …”
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Effects of celastrol on the heart and liver galaninergic system expression in a mouse model of Western-type diet-induced obesity and metabolic dysfunction-associated steatotic live... by Nikolina Canová, Jana Šípková, Mahak Arora, Zuzana Pavlíková, Zuzana Pavlíková, Tomáš Kučera, Ondřej Šeda, Tijana Šopin, Tomáš Vacík, Ondřej Slanař

“…Celastrol influenced the gene expression of galanin receptors: it downregulated Galr1 in the heart and upregulated Galr2 in the liver and Galr3 in the heart ventricles, potentially affecting energy metabolism, oxidative stress, and inflammation. Fatostatin suppressed gene expression of all the detected members of the galaninergic system in the heart ventricles, depicting the role of SREBP in this process.ConclusionThese findings suggest that celastrol may beneficially modulate the galaninergic system under obesity and MASLD-to-MASH progression, indicating its potential as a therapeutic agent for disorders associated with metabolic dysfunction.…”
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Identification of novel clinical subtypes in patients with microscopic polyangiitis using cluster analysis: multicenter REVEAL cohort study by Ayana Okazaki, Shogo Matsuda, Takuya Kotani, Keisuke Fukui, Keisuke Fukui, Takaho Gon, Ryu Watanabe, Atsushi Manabe, Mikihito Shoji, Keiichiro Kadoba, Ryosuke Hiwa, Wataru Yamamoto, Motomu Hashimoto, Tohru Takeuchi

“…Cluster 2 comprised the elderly onset systemic inflammation group (N=75). Cluster 3 included patients in the younger-onset limited-organ disease group (N=45). …”
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Size effect-based improved antioxidant activity of selenium nanoparticles regulating Anti-PI3K-mTOR and Ras-MEK pathways for treating spinal cord injury to avoid hormone shock-indu... by Peixin Liu, Xiaodong Liu, Zihao Wu, Kui Shen, Zhaofeng Li, Xiaowei Li, Qifeng Wu, Leung Chan, Zhong Zhang, Yutong Wu, Liwen Liu, Tianfeng Chen, Yi Qin

“…Oxidative damage and inflammation are critical factors in secondary pathological processes. …”
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Depot-specific acetylation profiles of adipose tissues—therapeutic targets for metabolically unhealthy obesity by Haoyue Guo, Zhiyi Zhang, Juntao Yang, Jiangfeng Liu, Hongwei Lin, Ningbei Yin

“…The regulation of acetylated modifications in white adipose tissue (WAT), particularly for the differential Kac sites enriched in ECM remodeling and inflammation-related pathways, may serve as an effective intervention strategy for MUO, with NDST1 emerging as a promising therapeutic target. …”
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Retinal Neuropathy in IGT Stage of OLETF Rats: Another Characteristic Change of Diabetic Retinopathy by Zhenhong Guo, Xiaoyue Sun, Juhong Yang, Jinlan Xie, Feifei Zhong, Xinran Li, Yi Zhang, Fei Han, Xiaoyun Yang, Shaohua Yang, Wei Zhou, Baocheng Chang

“…Significant retinal neuropathy occurs in the IGT stage. Inflammation and hypoxia may damage the blood retina barrier (BRB), leading to diabetic retinopathy.…”
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Inflammatory changes in the choroid plexus following subarachnoid hemorrhage: the role of innate immune receptors and inflammatory molecules by Peter Solár, Peter Solár, Václav Brázda, Václav Brázda, Martin Bareš, Alemeh Zamani, Parisa EmamiAref, Andrea Joukal, Lucie Kubíčková, Erik Kročka, Klaudia Hašanová, Marek Joukal

“…Accumulation of macrophages positive for CCR2 and CX3CR1 was found in all periods after subarachnoid hemorrhage as well as after the application of artificial cerebrospinal fluid.DiscussionOur results suggest that the inflammation develops in the choroid plexus and blood-cerebrospinal fluid barrier in response to blood components as well as acutely increased intracranial pressure following subarachnoid hemorrhage. …”
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Unraveling the Role of Oxygen Pulse Variability in Endurance Exercise Training in Individuals with COPD: A Novel Approach to Response of Oxygen Pulse and Quality of Life in Pulmona... by Huang SY, Hsieh PC, Huang KL, Yang MC, Jao LY, Tzeng IS, Lan CC, Wu YK

“…Shiang-Yu Huang,1 Po-Chun Hsieh,2 Kuo-Liang Huang,3,4 Mei-Chen Yang,3,4 Lun-Yu Jao,3,4 I-Shiang Tzeng,5 Chou-Chin Lan,3,4,&ast; Yao-Kuang Wu3,4,&ast; 1Division of Respiratory Therapy, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan, Republic of China; 2Department of Chinese Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation; School of Post-Baccalaureate Chinese Medicine, Tzu Chi University, Hualien, Taiwan, Republic of China; 3Division of Pulmonary Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan, Republic of China; 4School of Medicine, Tzu-Chi University, Hualien, Taiwan; 5Department of Research, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan, Republic of China&ast;These authors contributed equally to this workCorrespondence: Yao-Kuang Wu, Division of Pulmonary Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, 289, Jianguo Road, Xindian City, New Taipei City, 23142, Taiwan, Republic of China, Tel +886-2-6628-9779 ext. 2259, Fax +886-2-6628-9009, Email drbfci@yahoo.com.twBackground: Chronic obstructive pulmonary disease (COPD) is characterized by airway inflammation, airflow limitation, reduced health-related quality of life (HRQL), and exercise intolerance. …”
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Endothelial and neuronal engagement by AAV-BR1 gene therapy alleviates neurological symptoms and lipid deposition in a mouse model of Niemann-Pick type C2 by Charlotte Laurfelt Munch Rasmussen, Signe Frost Frederiksen, Christian Würtz Heegaard, Maj Schneider Thomsen, Eva Hede, Bartosz Laczek, Jakob Körbelin, Daniel Wüstner, Louiza Bohn Thomsen, Markus Schwaninger, Ole N. Jensen, Torben Moos, Annette Burkhart

“…Results Treatment with the AAV-BR1-NPC2 vector improved motor functions, reduced neocortical inflammation, and preserved Purkinje cells in most of the mice, referred to as high responders. …”
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Reduction of elevated Gli3 does not alter the progression of autosomal recessive polycystic kidney disease by Lauren G. Russell, Maria Kolatsi‐Joannou, Laura Wilson, Jennifer C. Chandler, Nuria Perretta Tejedor, Georgie Stagg, Karen L. Price, Christopher J. Rowan, Tessa Crompton, Norman D. Rosenblum, Paul J. D. Winyard, David A. Long

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A new Lactobacillus gasseri strain HMV18 inhibits the growth of pathogenic bacteria by Xiang Gao, Zixuan Wang, Xiang Li, Xiaoling Zhang, Shengqiang Du, Miaomiao Jia, Dailun Hu, Xianxian Jia, Bin Cong, Yan Zhang, Chunling Ma, Song Zhou, Jun Zhang

“…Pathological histology of the mice ileum showed that the mucosa, villi, lamina propria and crypt depth remained intact and there was no inflammation or hyperemia in the L. gasseri HMV18 gavaged group. …”
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Bone Defect Repair Using a Bone Substitute Supported by Mesenchymal Stem Cells Derived from the Umbilical Cord by Michal Kosinski, Anna Figiel-Dabrowska, Wioletta Lech, Lukasz Wieprzowski, Ryszard Strzalkowski, Damian Strzemecki, Lukasz Cheda, Jacek Lenart, Krystyna Domanska-Janik, Anna Sarnowska

“…Bone defects or atrophy may arise as a consequence of injury, inflammation of various etiologies, and neoplastic or traumatic processes or as a result of surgical procedures. …”
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Biochanin A Reduces Inflammatory Injury and Neuronal Apoptosis following Subarachnoid Hemorrhage via Suppression of the TLRs/TIRAP/MyD88/NF-κB Pathway by Ling-yun Wu, Zhen-nan Ye, Zong Zhuang, Yongyue Gao, Chao Tang, Chen-hui Zhou, Chun-xi Wang, Xiang-sheng Zhang, Guang-bin Xie, Jing-peng Liu, Meng-liang Zhou, Chun-hua Hang, Ji-xin Shi

“…Inflammatory injury and neuronal apoptosis participate in the period of early brain injury (EBI) after subarachnoid hemorrhage (SAH). Suppression of inflammation has recently been shown to reduce neuronal death and neurobehavioral dysfunction post SAH. …”
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RSK1 is an exploitable dependency in myeloproliferative neoplasms and secondary acute myeloid leukemia by Tim Kong, Angelo B. A. Laranjeira, Christopher T. Letson, LaYow Yu, Shuyang Lin, Jared S. Fowles, Daniel A. C. Fisher, Sherwin Ng, Wei Yang, Fan He, Minyoung Youn, Kailen Mark, Ana San Jose, Jingxian Liu, Alexander B. Kim, Maggie J. Cox, Mary C. Fulbright, Aarthi Jayanthan, Gerrit Los, Stacey L. Rentschler, Li Ding, Kathleen M. Sakamoto, Sandra E. Dunn, Grant A. Challen, Stephen T. Oh

“…Supported by mass cytometry (CyTOF) profiling, we reveal aberrant networks of PI3K/AKT/mTOR signalling and NFκB-mediated hyper-inflammation. Combining ATAC-Seq, CUT&Tag, RNA-seq, and CyTOF, we demonstrate that targeting of ribosomal protein S6 kinase A1 (RSK1) suppresses NFκB activation and diminishes pro-inflammatory mediators including tumor necrosis factor (TNF) associated with MPN disease severity and transformation. …”
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Cannabinoid receptor 2 selective agonist ameliorates adjuvant-induced arthritis by modulating the balance between Treg and Th17 cells by Na Tian, Cui Yang, Yu Du, Miao Chen, Bin Li, Bin Li, Bin Li, Bin Li, Bin Li, Dan Li, Sheng-Ming Dai

“…This study explores the therapeutic efficacy of HU-308, a CB2 receptor-specific agonist, on inflammation and immune balance in AIA.MethodsAIA was induced in mice by CFA injection. …”
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