Transcriptional profiles analysis of effects of Toxoplasma gondii rhoptry protein 16 on THP-1 macrophages by Ningai Yang, Ningai Yang, Ningai Yang, Mingyang Li, Hong Yang, Jiaming Li, Tiantian Dang, Guangqi Li, Zhijun Zhao, Zhijun Zhao, Zhijun Zhao

“…However, the precise mechanisms underlying the involvement of type II ROP16 proteins in infection, inflammation, and other processes remain unknown.MethodsTo investigate the mechanism of action of gonococcal ROP16 proteins in human macrophages, we constructed a lentivirus overexpressing ROP16 and established stably transfected cell lines. …”
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Branched-chain fatty acids from goat milk alleviate ulcerative colitis via the TLR4/NF-κB/NLRP3 pathway by Jiaxin Zhang, Jinjing Zhong, Zhengying Cui, Yu Shen, Yaping Zheng, Yu Zhang, Chaoxin Man, Yanmei Hou, Qianyu Zhao, Yujun Jiang

“…In conclusion, these results demonstrated that BCFAs in goat milk exerted effects on colitis-related inflammatory cytokines and inhibited inflammation by inducing the TLR4/NF-κB/NLRP3 pathway to alleviate DSS-induced ulcerative colitis. …”
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Immunometabolic alterations in type 2 diabetes mellitus revealed by single-cell RNA sequencing: insights into subtypes and therapeutic targets by Huahua Li, Lingling Zou, Zhaowei Long, Junkun Zhan, Junkun Zhan

“…Immune cells, including T cells and monocytes, play a pivotal role in driving systemic inflammation in T2DM; however, the underlying single-cell mechanisms remain inadequately defined.MethodsSingle-cell RNA sequencing of peripheral blood mononuclear cells (PBMCs) from 37 patients with T2DM and 11 healthy controls (HC) was conducted. …”
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Diagnostic value of interleukins 23 and 17 in the assessment of ulcerative colitis severity by M.V. Stoikevych, O.M. Tatarchuk, T.S. Tarasova

“…The purpose of the study was to investigate the state of cytokine regulation of inflammation depending on the severity of UC. Materials and methods. …”
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Acupoint catgut embedding alleviates experimental autoimmune encephalomyelitis by modulating neuroinflammation and potentially inhibiting glia activation through JNK and ERK pathwa... by Xiaofang Liu, Liansheng Yang, Zhumin Su, Xueying Ma, Yingying Liu, Lili Ma, Xiaomeng Ma, Mingxia Ma, Xiaoyun Liu, Kun Zhang, Kun Zhang, Xiaohong Chen

“…In ACE-treated mice, EAE disease severity was significantly ameliorated, along with improvements in anxiety-like behaviors and reduced inflammation and demyelination. The ACE treatment restored immune imbalance in the EAE mice by decreasing Th17 and Th1 cells, while increasing Treg cells in peripheral immune organs and reducing serum inflammatory cytokine levels. …”
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Argonaute2 and Argonaute4 Involved in the Pathogenesis of Kawasaki Disease via mRNA Expression Profiles by Zon-Min Lee, Hui-Chuan Chang, Shih-Feng Liu, Ying-Hsien Huang, Ho-Chang Kuo

“…(<i>p</i> > 0.05) Conclusion: Endothelial cell inflammation and injury, two basic pathological mechanisms, are thought to be involved in coronary endothelial dysfunction in KD. …”
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Methyl 3-Bromo-4,5-dihydroxybenzoate Attenuates Inflammatory Bowel Disease by Regulating TLR/NF-κB Pathways by Jing Huang, Lei Li, Liyan Xu, Lixin Feng, Yuxin Wang, Attila Gabor SIK, Meng Jin, Rongchun Wang, Kechun Liu, Xiaobin Li

“…Inflammatory bowel disease (IBD) is characterized by uncontrolled, chronic relapsing inflammation in the gastrointestinal tract and has become a global healthcare problem. …”
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An Attenuated Cytomegalovirus Vaccine with a Deletion of a Viral Chemokine Gene Is Protective against Congenital CMV Transmission in a Guinea Pig Model by Michael P. Leviton, Juan C. Lacayo, K. Yeon Choi, Nelmary Hernandez-Alvarado, Andrew Wey, Mark R. Schleiss

“…MIP deletion virus replicated with wild-type kinetics in cell culture but was attenuated in nonpregnant guinea pigs, demonstrating reduced viremia and reduced inflammation and histopathology (compared to a control virus with an intact GPCMV MIP gene) following footpad inoculation. …”
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A Nomogram Built on Clinical Factors and CT Attenuation Scores for Predicting Treatment Response of Acute Myeloid Leukemia Patients by Linna Liu, Wenzheng Lu, Li Xiong, Han Qi, Robert Peter Gale, Bin Yin

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Adipose-derived mesenchymal stem cells combined with platelet-rich plasma are superior options for the treatment of osteoarthritis by Weijie He, Jie Zhao, Jiafei Liu, Fangxing Wang, Zhenyu Xu

“…Conclusions Repeated intra-articular injections of PRP and ADSCs alleviated inflammation and pain, promoted tissue repair, and modulated immune responses in rats with surgically induced OA. …”
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Square-Stepping HIIT Combined With 'Phyllanthus amarus' Supplementation Alleviates Fasting Blood Glucose and Oxidative Stress in Overweight and Obese Individuals by Surachat Buddhisa, Nattaphol Prakobkaew, Piyapong Prasertsri, Sudarat Boonpitak, Puttipong Poncumhak, Orachorn Boonla

“…Objectives: This study aimed to investigate the effects of square-stepping HIIT combined with PA supplementation on changes in blood glucose and insulin activity, lipid profile, inflammation, and oxidative stress in overweight and obese individuals. …”
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MiR-125b-5p ameliorates ox-LDL-induced vascular endothelial cell dysfunction by negatively regulating TNFSF4/TLR4/NF-κB signaling by Wenshuai He, Limin Zhao, Pengfei Wang, Maojia Ren, Yunfei Han

“…Ox-LDL exposure led to decreased cell viability and angiogenic capacity, along with increased apoptosis, inflammation, and oxidative stress in HUVECs. These effects were reversed by overexpressing miR-125b-5p or knocking down TNFSF4. …”
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Physically engineered extracellular vesicles targeted delivering miR-21-5p to promote renoprotection after renal ischemia-reperfusion injury by Di Wu, Wenjie Ma, Liucheng Wang, Chengcheng Long, Silin Chen, Jingyu Liu, Yiguan Qian, Jun Zhao, Changcheng Zhou, Ruipeng Jia

“…Additionally, N-EVs could restore damaged endothelial integrity, reduce cytokine release, and inhibit leukocyte infiltration, hence alleviating renal inflammation. In conclusion, our accessible engineering approach represents a promising strategy for treating renal IRI. …”
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Determining the mechanism of Shuxuening injection against liver cirrhosis through network pharmacology and animal experiments by Qiyao Liu, Tingyu Zhang, Yongan Ye, Xin Sun, Huan Xia, Xu Cao, Xiaoke Li, Wenying Qi, Yue Chen, Xiaobin Zao

“…In vivo experiments demonstrated that SXN treatment significantly improved liver function and pathology in CCl4-induced LC mice by reducing inflammation and collagen deposition. Furthermore, qRT-PCR demonstrated that SXN regulated the expression of MAPK8, AR and CASP3 in the livers of LC mice. …”
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Global Research Trends and Focus on the Link Between Heart Failure and NLRP3 Inflammasome: A Bibliometric Analysis From 2010 to 2024 by Lian Y, Zhang H, Xing W, Li S, Lai X, Jia S, Shang J, Liu H

“…This condition imposes a considerable medical burden and fiscal strain on society. Inflammation plays a crucial role in the inception, advancement, and outcome of HF. …”
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Inverse association between dietary flavonoid intake and nocturia in middle-aged and older adults from NHANES 2007–2010 by Yu Cai, Ying-Chao Liang, Xin-Yu Hu, Ling Li, De-Liang Liu, Shu-Fang Chu, Hui-Lin Li

“…The prevalence of nocturia exceeds 50% among older adults in the U.S. Inflammation and oxidative stress are considered potential factors affecting nocturia, according to prior research. …”
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Momordica Charantia Polysaccharides Attenuates MPP+-Induced Injury in Parkinson’s Disease Mice and Cell Models by Regulating TLR4/MyD88/NF-κB Pathway by Dengjun Guo, Jie Zhou, Meng Zhang, Reyisha Taximaimaiti, Xiaoping Wang, Hai Wang

“…Compared with the Control group, MPTP treatment can induce brain damage in mice (all P<0.05), change the metabolic state of neurotransmitters (all P<0.05), induce inflammation (all P<0.05), and induce apoptosis and the occurrence of oxidation reaction (all P<0.05); however, MCPs treatment can significantly reverse the above changes (all P<0.05). …”
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Association of Circulating Neprilysin with BMI, Cardiovascular Health, and Kidney Function in High-Risk Pregnancies: A Pilot Study by Kaltrina Kutllovci Hasani, Azra Kulovic-Sissawo, Adam Saloň, Christina Stern, Karoline Mayer-Pickel, Mila Cervar-Zivkovic, Nandu Goswami, Herbert Fluhr, Ursula Hiden

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Lysozyme-based spray for treatment of radiotherapy-induced oral mucositis by Zdenka Gojković, Jelena Rožić, Nataša Gašpar, Aziz Šukalo, Meliha Mehić, Amna Tanović Avdić, Una Glamočlija

“…Methods: A prospective, open-label study was conducted on patients with ulcerative inflammation of the oral cavity and pharynx mucous membranes clinically assessed for oral mucositis according to the World Health Organization (WHO) Oral Toxicity Scale. …”
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Mural cell dysfunction contributes to diastolic heart failure by promoting endothelial dysfunction and vessel remodelling by Mandy O. J. Grootaert, Alessandra Pasut, Jana Raman, Steven J. Simmonds, Bram Callewaert, Ümare Col, Mieke Dewerchin, Peter Carmeliet, Stephane Heymans, Elizabeth A. V. Jones

“…Conclusion Mural cell dysfunction contributes to HFpEF by inducing coronary vessel remodelling, at least in part by reducing EC proliferation and inducing EC inflammation through TNFα-dependent paracrine signalling. …”
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