The Impact of Chemotherapy and Body Mass Index on Cancer‐Related Fatigue in Colon Cancer Patients: A PROFILES‐Registry Study by Anneke Kastelein, Floortje Mols, Laura Kervezee, Niels H. Chavannes, Hans Gelderblom, Jacques Neefjes, Chris Hinnen

“…ABSTRACT Background Inflammation has been reported to drive cancer‐related fatigue (CRF). …”
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Sugemule-7 alleviates oxidative stress, neuroinflammation, and cell death, promoting synaptic plasticity recovery in mice with postpartum depression by Qiang Fu, Rui Qiu, Jiaquan Liang, Shuai Wu, Dezhi Huang, Yuxiang Qin, Qiaosheng Li, Xiaojie Shi, Xiyue Xiong, Zhongyong Jiang, Yuewen Chen, Yong Cheng

“…Overall, our study confirms the efficacy of Sugemule-7 in treating PPD at different concentrations, potentially alleviating depressive behaviors by enhancing synaptic plasticity, mitigating oxidative stress, reducing inflammation, and protecting neurons.…”
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Trimethylamine N-Oxide (TMAO) Plasma Levels in Patients with Different Stages of Chronic Kidney Disease by Marcia Ribeiro, Julie Ann Kemp, Ludmila Cardozo, Drielly Vargas, Marcelo Ribeiro-Alves, Peter Stenvinkel, Denise Mafra

“…Background: In patients with chronic kidney disease (CKD), trimethylamine n-oxide (TMAO) accumulation exacerbates inflammation and contributes to oxidative stress. These complications are putatively linked to the development of cardiovascular diseases. …”
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Development and validation of a risk prediction model related to inflammatory and nutritional indexes for postoperative pulmonary infection after radical colorectal cancer surgery by He Huang, Yanli Wang, Chengfei Liu, Jingxiang Han, Tian Yao, Linna Gao, Huiyang Gao, Yuhao Chen, Yinglei Cao, Fubin Qiu, Kai Jia

“…The contributions of inflammatory and nutritional indexes to the nomogram were evaluated through Net Reclassification Improvement and integrated discrimination improvement, while clinical practicability was assessed using decision curve analysis.Main outcome measures POI during hospitalisation.Results Independent factors identified from multivariable LR for prediction POI included age, respiratory disease, Systemic Inflammation Response Index, albumin-to-globulin ratio, operative method and operative duration. …”
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Thyroid hormone receptor- and stage-dependent transcriptome changes affect the initial period of Xenopus tropicalis tail regeneration by Shouhong Wang, Liezhen Fu, Bin Wang, Yanmei Cai, Jianping Jiang, Yun-Bo Shi

“…Specifically, T3 signaling via TRs inhibits the expression of ECM-related genes while promoting the expression of inflammation-related genes during the blastema formation period. …”
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GENI as an AMPK Activator Binds α and γ Subunits and Improves the Memory Dysfunction of Alzheimer’s Disease Mouse Models via Autophagy and Neuroprotection by Ying Wang, Lanjie Li, Danni Chen, Jiaheng Shan, Meijuan Yi, Hiroyuki Osada, Minoru Yoshida, Lan Xiang, Jianhua Qi

“…GENI exerts anti-AD efficacy in galactose-induced AD mice and naturally aging mice with AD through neuroprotection and modification of autophagy and neuron inflammation. Moreover, AMPK as the target protein of GENI to produce an anti-AD effect is identified and the ASP148, ASP157, and ASP166 of the AMPK α subunit and lysine (LYS)148, aspartic acid (ASP)156, LYS309, and ASP316 in the AMPK γ subunit as binding sites are confirmed. …”
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The activity of a herbal medicinal product of Phyllanthus niruri and Silybum marianum powdered extracts (Heptex®) in patients with apparent risk factors for nonalcoholic steatohepa... by Mohamed Kamal Shaker, Mohamed Hassany, Basem Eysa, AbdulMoneim Adel, Ahmed Zidan, Shahnaz Mohamed

“…Abstract Background Nonalcoholic steatohepatitis (NASH) is a severe form of nonalcoholic fatty liver disease (NAFLD) characterized by damage and inflammation of hepatocytes. Some medicinal plants have shown antioxidant and anti-inflammatory effects on liver cells. …”
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Moxibustion Regulates the BRG1/Nrf2/HO-1 Pathway by Inhibiting MicroRNA-222-3p to Prevent Oxidative Stress in Intestinal Epithelial Cells in Ulcerative Colitis and Colitis-Associat... by Xuejun Wang, Haiyang Ji, Yanting Yang, Dan Zhang, Xiehe Kong, Xiaoying Li, Hongna Li, Yunqiong Lu, Guang Yang, Jie Liu, Huangan Wu, Jue Hong, Xiaopeng Ma

“…With changes in reactive oxygen species (ROS), malondialdehyde (MDA), glutathione peroxidase (GSH-Px), and inflammatory cytokines interleukin (IL)-1β and tumor necrosis factor (TNF)-α), we verified that HPM protects against oxidative stress and inflammation in IECs of UC and CAC mice. The effect of HPM was inhibited in miR-222-3p overexpression mice, further demonstrating that the protective effect of HPM on UC and CAC mice was through inhibiting miR-222-3p. …”
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Human parietal epithelial cells as Trojan horses in albumin overload by Giovanna Priante, Monica Ceol, Lisa Gianesello, Claudia Maria Radu, Rachele Mantese, Lucia Federica Stefanelli, Martina Cacciapuoti, Francesca K. Martino, Lorenzo Arcangelo Calò, Franca Anglani, Federico Nalesso, Dorella Del Prete

“…The increase of pERK1/2, the upregulation of ROCK1, ROCK2, caspase -3, -6, and -7, and the morphological changes associated with loss of F-actin fibers indicated that inflammation, proliferation and apoptosis mechanisms had been activated. …”
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Neolithic introgression of IL23R-related protection against chronic inflammatory bowel diseases in modern EuropeansResearch in context by Ben Krause-Kyora, Nicolas Antonio da Silva, Elif Kaplan, Daniel Kolbe, Inken Wohlers, Hauke Busch, David Ellinghaus, Amke Caliebe, Efe Sezgin, Almut Nebel, Stefan Schreiber, Sabine Schade-Lindig, Joachim Wahl, Carola Berszin, Michael Francken, Irina Görner, Kerstin Schierhold, Joachim Pechtl, Gisela Grupe, Johannes Müller

“…Therefore, the protective A-allele may have increased survival by reducing intestinal inflammation and microbiome dysbiosis. The adaptively evolved function of the variant likely contributes to the high efficacy and low side-effects of modern IL-23 neutralisation therapies for chronic inflammatory diseases. …”
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A differentiated approach to complex treatment of radioiodine-induced salivary gland lesions by A. V. Kopchak, V. А. Makarenko

“…This treatment also outperformed traditional symptomatic correction in solving the problem of saliva retention (χ2 = 6.67; p < 0.05) and inflammation manifestations (χ2 = 6.20; p < 0.05). Clinical symptoms of the disease were fully resolved or reduced in 73.3 % of patients versus 33.3 % in control group and partially improved in 20.0 % versus 46.0 % of control group within 12 months after radiation exposure. …”
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Innovative Diagnostic Approaches and Treatment Strategies for Endometriosis: Current Trends and Future Direction - Review by Wiktoria Domino, Joanna Śnieżna, Wojciech Florczak, Karol Dzwonnik, Urszula Zelik, Jagienka Włodyka, Gabriela Trestka, Maria Przygoda, Jakub Dziewic, Kamila Stępień, Sabina Adamczyk

“…Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used to alleviate symptoms, while hormonal therapies, such as combined oral contraceptives, GnRH agonists, and progestogens, aim to inhibit ovulation and estrogen production to reduce inflammation and slow disease progression. Surgery, typically laparoscopic, is indicated for severe symptoms or advanced disease. …”
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Ameliorative effect of curcuminoids in liver fibrosis rat model via regulating GIPC1 gene and modulating MMP-8/TIMP-3 balance mediated by miR-483-5p by Rana Mostafa Adel, Sara Mostafa Kamal, Eman Adel Sherif, Sara Hatem El-shafiey

“…Conclusions This study concludes that CURC can modulate the novel miRNA-483-5p/MMP-8/TIMP-3 pathway and regulate GIPC1 expression, thus providing new perception of CURC as an effective therapeutic agent capable of lowering inflammation and remodeling liver damage. Graphical Abstract…”
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Changes in Serum Levels of Bone Morphogenic Protein 4 and Inflammatory Cytokines after Bariatric Surgery in Severely Obese Korean Patients with Type 2 Diabetes by Mee Kyoung Kim, Eun-Hee Jang, Oak-Kee Hong, Hyun-Ji Chun, Soon-Jib Yoo, Ki-Hyun Baek, Wook Kim, Eung Kook Kim, Ki-Ho Song, Hyuk-Sang Kwon

“…Our data demonstrate a significant beneficial effect of bariatric surgery on established cardiovascular risk factors and a reduction in chronic nonspecific inflammation after surgery.…”
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Vincristine Regulates C/EBP-&beta;/TGF-&beta;1 to Promote A1 Astrocyte Polarization and Induce Neuropathic Pain by Chen Y, Tang G, Lu J, Tang S, Xiong X, Chen C, Pei L, Shi J

“…Moreover, silencing C/EBP-β reversed the enhanced expression of TGF-β 1 induced by Vincristine, attenuated astrocyte A1 polarization and proinflammatory factor release.Conclusion: Vincristine induced spinal cord inflammation by promoting A1 polarization of astrocytes via upregulating the C/EBP-β/TGF-β 1 signal pathway, thus leading to neuropathic pain. …”
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Efficacy of Antimicrobial Photodynamic Therapy for Treating Moderate to Deep Periodontal Pockets in Individuals with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis by João Victor Soares Rodrigues, Mariella Boaretti Deroide, Wilton Mitsunari Takeshita, Valdir Gouveia Garcia, Rafael Scaf de Molon, Leticia Helena Theodoro

“…Conversely, periodontal inflammation can disrupt glycemic control, further complicating this interlinked relationship. …”
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<i>Clostridium difficile</i>-associated disease by V. T. Ivashkin, O. S. Shifrin, A. S. Tertycnhy, Ye. A. Poluektova, T. L. Lapina, O. S. Lyashenko, K. V. Ivashkin

“…Influence of toxins induces damage and inflammation of intestinal wall due to impairment of intestinal epithelial barrier, stimulation of proinflammatory cytokine production, apoptosis and necrosis of epithelial cells. …”
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Design and application of synthetic 17B-HSD13 substrates reveals preserved catalytic activity of protective human variants by Michelle R. Garnsey, Yang Wang, David J. Edmonds, Matthew F. Sammons, Benjamin Reidich, Youngwook Ahn, Yotam Ashkenazi, Anthony Carlo, Matthew A. Cerny, Karen J. Coffman, Jeffrey A. Culver, Anne-Marie Dechert Schmitt, Heather Eng, Ethan L. Fisher, Jemy A. Gutierrez, Larry James, Samantha Jordan, Jeffrey T. Kohrt, Melissa Kramer, Erik A. LaChapelle, Jack C. Lee, Jisun Lee, Dongmei Li, Zhenhong Li, Shenping Liu, Jianhua Liu, Thomas V. Magee, Melissa R. Miller, Michael Moran, Deane M. Nason, Nicole L. Nedoma, Steven V. O’Neil, Mary A. Piotrowski, Jillian Racich, Ruth F. Sommese, Lucy M. Stevens, Ann S. Wright, Jun Xiao, Liying Zhang, Dahui Zhou, Ornella Barrandon, Michelle F. Clasquin

“…Abstract Several hydroxysteroid dehydrogenase 17-beta 13 variants have previously been identified as protective against metabolic dysfunction-associated steatohepatitis (MASH) fibrosis, ballooning and inflammation, and as such this target holds significant therapeutic potential. …”
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Characterization of a chemically induced osteoarthritis model in zebrafish by Gongyi Xiao, Jin Qin, Huiping Yang, Qizhi Song, Ruobin Zhang, Junlan Huang, Yuexi Mou, Wen Liu, Xianding Sun, Mao Nie

“…Our results effectively demonstrated the presence of synovial inflammation and cartilage damage within the zebrafish mandible, affirming the feasibility of inducing OA in zebrafish. …”
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Application and nursing of prone ventilation technique in ICU (俯卧位通气技术在ICU的应用及护理) by DAI Hongran (代洪然), WANG Huazhi (王华枝), LI Yuhua (李玉华), MA Haihong (马海红)

“…CT examination of 1 patient with atelectasis showed significant improvement in lung inflammation. Conclusion The application of prone ventilation in patients with ARDS and atelectasis in ICU can significantly improve the pulmonary ventilation function, promote the effective discharge of pulmonary secretions, increase the functional residual capacity, thus improve the cardiorespiratory fitness and promoting the recovery of patients. …”
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