In-Situ Electrospinning Dressings Loaded with Kaempferol for Reducing MMP9 to Promote Diabetic Ulcer Healing by Li J, Meng H, Guo W, Zhou L, Wu S, Gao G, Liu Q, You D, Qu W

“…Histological and immunofluorescence staining were performed to determine the status of epithelization, collagen deposition, MMP9 expression, macrophage polarization, inflammation response and angiogenesis.Results: Material science experiments have shown that the dressing has optimal fiber micromorphology and good water vapor transport properties (WVTR: 4.88 kg m− 2 24h− 1); in vivo, diabetic wound experiments have shown that the high porosity and pharmacological effects of PED4 can mutually promote the rapid healing of diabetic wounds (healed 95.9% on day 15), facilitate the transformation of macrophages from M1-type to M2-type and regulate the expression of MMP9.Conclusion: Portable electrospinning dressings equipped with kaempferol not only better fit irregular wounds, but also promote wound healing through MMP9 and macrophage polarization. …”
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Pyrrolizine-5-carboxamides: Exploring the impact of various substituents on anti-inflammatory and anticancer activities by Gouda Ahmed M., Abdelazeem Ahmed H., Abdalla Ashraf N., Ahmed Muhammad

“…Taken together, this study highlighted the significant impact of the substituents on the anti-inflammatory and anticancer activity of pyrrolizine-5-carboxamides, which could help in further optimization to discover good leads for the treatment of cancer and inflammation.…”
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Microplastics: A threat to Fetoplacental unit and Reproductive systems by Abass Toba Anifowoshe, Md Noor Akhtar, Abisola Majeed, Asem Sanjit Singh, Toyyibah Funmilayo Ismail, Upendra Nongthomba

“…They also bioaccumulate in testes, altering spermatogenesis, spermatozoa morphology, testosterone production, body weights, and inflammation as reported in mice. Such disruptions can increase the risk of developmental and reproductive disorders in the fetus, suggesting that exposure to plastic particles may carry long-term health implications. …”
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IOP-lowering therapy and ocular surface in glaucoma. Part 1. The effects of drug substances of glaucoma medications on the ocular surface by A.V. Antonova, V.P. Nikolaenko, V.V. Brzheskiy

“…</i> </p> <p> <i><b>Keywords</b>: glaucoma, IOP-lowering treatment, ocular surface, dry eye disease, Ocular Surface Disease Index, inflammation, preservatives, benzalkonium chloride, preservative-free medication.…”
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Antibiotic Prescription Practice and Resistance Patterns of Bacterial Isolates from a Neonatal Intensive Care Unit: A Retrospective Study from Jordan by Mariam Alameri, Lobna Gharaibeh, Mervat Alsous, Aseel Yaghi, Asma’a Tanash, Saqr Sa’id, Hanan Sartawi

“…<b>Background/Objectives</b>: Neonatal sepsis is a systemic inflammation in neonates caused by bacteria, viruses, or fungi that can progress into severe conditions. …”
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Secondary hyperoxaluria: Cause and consequence of chronic kidney disease by Loreto Mariscal de Gante, Laura Salanova, Mariel Valdivia Mazeyra, Rosario Serrano Pardo, Borja Quiroga

“…This transporter is active at both the intestinal and renal levels, and its mechanism of action is disrupted during systemic inflammation and metabolic syndrome, which could explain the rising incidence of secondary hyperoxaluria in recent decades. …”
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Exacerbation of diabetes due to F. Nucleatum LPS-induced SGLT2 overexpression in the renal proximal tubular epithelial cells by Aiko Seki, Koichiro Kajiwara, Jumpei Teramachi, Masahiko Egusa, Takuya Miyawaki, Yoshihiko Sawa

“…Recently, many researchers suggested that the periodontal pathogenic bacteria Fusobacterium (F.) nucleatum has the TLR4-associated strong activator of the colorectal inflammation and cancer. The present study aimed to investigate the possibility of F. nucleatum as an exacerbation factor of diabetes through the renal SGLT2 induction. …”
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Human ACE2 transgenic pigs are susceptible to SARS-CoV-2 and develop COVID-19-like disease by Long Fung Chau, Simon Lillico, Tanja Opriessnig, Rosemary Blake, Luc Tardy, Chen-Hsuin Lee, Scott Maxwell, Claire Warren, Elizabeth Thornton, Catherine L. Mclaughlin, Gerry McLachlan, Christine Tait-Burkard, Sarah Fletcher, Stephen Anderson, Sharon Brown, Louise Gibbard, Thomas Tzelos, Dawn MacMillan-Christensen, J. Kenneth Baillie, David A. Dorward, David J. Griffiths, Finn Grey

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Definition of clinical immunology around the globe by José C. Crispín, José C. Crispín, José C. Crispín, Tineke Cantaert, Tineke Cantaert, Alberto Pinzon-Charry, Alberto Pinzon-Charry, Alberto Pinzon-Charry, Domenico Mavilio, Domenico Mavilio, Domenico Mavilio, Ahmed Seri, Ahmed Seri, Pierre Miossec, Pierre Miossec

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Effectiveness of rehabilitation interventions in patients with colorectal cancer: an overview of systematic reviews by Mengzhe Yang, Bhasker Amatya, Sana Malik, Krystal Song, Stefanie Marcella, Catherine Voutier, Fary Khan

“…The findings suggest: moderate-quality evidence for exercise interventions for improving physical fitness and quality of life; high-quality evidence for nutritional interventions in reducing postoperative infections; high-quality evidence for multimodal prehabilitation for improved preoperative functional capacity; moderate-quality evidence for nutritional interventions for improving humoral immunity, reducing inflammation, and length of stay; moderate-quality evidence for acupuncture in improving gastrointestinal functional recovery; psychosocial interventions in improving short-term quality of life and mental health, and lifestyle interventions for improved quality of life. …”
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Association between fibrinogen-to-albumin ratio and bone metabolism markers (β-CTX and P1NP) in Chinese individuals with osteoporotic fracture: a cross-sectional investigation by Li-long Feng, Ke Lu, Chong Li, Min-zhe Xu, Yao-wei Ye, Yi Yin, Hui-qiang Shan

“…The study may provide a novel clinical implication by introducing FAR as a potential reference indicator for assessing bone health, offering a cost-effective and conveniently obtainable biomarker to monitor inflammation to improve bone metabolism in the treatment of osteoporosis.…”
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The prevalence of optrA-carrying Enterococci in the vaginal micro-ecology of pregnant women in late pregnancy by Yanjun Xie, Fangyi Xu, Huali Dong, Jianfeng Mao, Chuanling Zhang

“…This study provides scientific support for controlling hospital infections and managing antibiotic-resistant bacteria, and provides a scientific basis for rational clinical medication.IMPORTANCEThe disruption of cervicovaginal microbiota homeostasis is considered a key factor in causing imbalance in the microenvironment, leading to inflammation, transmission of infections, and illness. …”
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The Antinociceptive and Anti-Inflammatory Activities of Aspidosperma tomentosum (Apocynaceae) by Anansa Bezerra de Aquino, Luiz Henrique Agra Cavalcante-Silva, Carolina Barbosa Brito da Matta, Willians Antônio do Nascimento Epifânio, Pedro Gregório Vieira Aquino, Antônio Euzébio Goulart Santana, Magna Suzana Alexandre-Moreira, João Xavier de Araújo-Júnior

“…We investigated the antinociceptive and anti-inflammatory activities of the crude ethanolic extract (CEE), its fractions, and the flavonoid isorhamnetin from Aspidosperma tomentosum using models of nociception and inflammation in mice. In the writhing test, the CEE and its fractions (except for soluble phase, CHCl3 100% and EtAcO 100%) at 100 mg/kg p.o. induced antinociceptive activity. …”
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miR-16-5p aggravates sepsis-associated acute kidney injury by inducing apoptosis by Han Li, Junyan Duan, Tongtong Zhang, Yingjie Fu, Yue Xu, Hongjun Miao, Xuhua Ge

“…However, inhibition of miR-16-5p significantly mitigated LPS expose-mediated kidney injury and inflammation. Furthermore, LPS-exposed HK-2 cells increased more than 1.7-fold the expression levels of Bax and caspase-3, decreased 3.2-fold the expression level of B-cell lymphoma-2 (Bcl-2), and significantly promoted the occurrence of apoptosis. …”
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The Role of Advanced Cardiac Imaging in Monitoring Cardiovascular Complications in Patients with Extracardiac Tumors: A Descriptive Review by Annamaria Tavernese, Valeria Cammalleri, Rocco Mollace, Giorgio Antonelli, Mariagrazia Piscione, Nino Cocco, Myriam Carpenito, Carmelo Dominici, Massimo Federici, Gian Paolo Ussia

“…CMR’s mapping techniques allow for early detection of myocardial inflammation caused by cardiotoxicity. This review explores the applicability of echocardiography, cardiac CT, and CMR in cancer patients with extracardiac tumors.…”
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The relationship between non-HDL-C/HDL-C ratio and bone mineral density: an NHANES study by Shuo Qi, Biao Peng, Zhanwang Xu, Daodi Qiu, Guoqing Tan

“…Further analysis suggests that dyslipidemia may influence bone metabolism through pathways such as inflammation and oxidative stress.ConclusionThe effect of NHHR on bone mineral density (BMD) varies by BMI, gender, and age. …”
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Predictive biomarkers for cardiometabolic risk in postmenopausal women: insights into visfatin, adropin, and adiponectin by Anna Maria Cybulska, Daria Schneider-Matyka, Ireneusz Walaszek, Mariusz Panczyk, Dorota Ćwiek, Anna Lubkowska, Elżbieta Grochans, Kamila Rachubińska, Katarzyna Malewicz, Mariusz Chabowski, Mariusz Chabowski

“…The selection of visfatin, adropin, and adiponectin as biomarkers is based on their significant roles in metabolic regulation and inflammation, which are critical factors in cardiometabolic risk. …”
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Exploring and Verifying the Mechanism and Targets of Shenqi Pill in the Treatment of Nonalcoholic Steatohepatitis via Network Pharmacology and Experiments by Beihui He, Zheng Chen, Yunmeng Nie, Minmin Luo, Sumei Xu, Junbin Yan, Zhiyun Chen

“…The expression of inflammatory cytokines (IL-1β, IL-6, TNF-α) was reduced after SQP treatment, which confirmed that SQP could improve hepatic inflammation in rats. These results suggested that SQP could ameliorate NASH in rats, and that quercetin may be the critical active compound that exerts the therapeutic effect.…”
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Morphological features of autoimmune gastritis by Ye. A. Losik, L. S. Selivanova, M. Yu. Konkov, T. L. Lapina, A. S. Tertychnyi, V. T. Ivashkin

“…The signs of feeble inflammation in body of the stomach were found in 6 patients. …”
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Severe Hepatotoxicity in Mushroom Poisoning by Lepiota brunneoincarnata from Complete Recovery to Liver Transplantation: A Case Series with Review on Liver Function Tests and Liver... by Mohammad Hossein Anbardar, Neda Soleimani, Kourosh Kazemi, Zahra Jafarpour, Mahsa Hasani, Sahand Mohammadzadeh, Parnia Torfehnezhad, Sedighe Jafarian, Mahsa Farhadi, Mina Salari Sardari

“…Histopathologic examination of three explanted livers revealed massive necrosis with moderate to severe macrovesicular steatosis, significant ductular reaction, and parenchymal inflammation. Other patients followed a recovery process with a considerable drop in liver enzymes, especially ALT, during hospitalization utilizing conservative treatment. …”
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