Glutamine-glutamate centered metabolism as the potential therapeutic target against Japanese encephalitis virus-induced encephalitis by Mengyuan Li, Hang Yuan, Xiaofei Yang, Yingfeng Lei, Jianqi Lian

“…Importantly, the supplementation of glutamine in vivo alleviated the intracranial inflammation and enhanced the survival of JEV-challenged mice. …”
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Morphological and molecular characterization of a Sarcocystis bovifelis-like sarcocyst in American beef by Aditya Gupta, Larissa S. de Araujo, Andrew Hemphill, Asis Khan, Benjamin M. Rosenthal, Jitender P. Dubey

“…Thick-walled sarcocysts often induce inflammation in striated muscles (causing bovine eosinophilic myositis), leading to condemnation of carcasses at slaughter. …”
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A Comparative Study of the Metabolic and Skeletal Response of C57BL/6J and C57BL/6N Mice in a Diet-Induced Model of Type 2 Diabetes by Elizabeth Rendina-Ruedy, Kelsey D. Hembree, Angela Sasaki, McKale R. Davis, Stan A. Lightfoot, Stephen L. Clarke, Edralin A. Lucas, Brenda J. Smith

“…The C57BL/6N mice exhibited more severe hepatic steatosis and inflammation. Only the C57BL/6N mice lost significant trabecular bone in response to the high fat diet. …”
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Post-Marketing Pharmacovigilance of Canakinumab from the FDA Adverse Event Reporting System (FAERS) by Weidong Zhang, Yunzhou Chen, Zeyu Yao, Mengling Ouyang, Minghui Sun, Shupeng Zou

“…<b>Background:</b> Canakinumab, a humanized anti-IL-1β monoclonal antibody, is known for its ability to suppress IL-1β-mediated inflammation. However, continuous monitoring of its safety remains essential. …”
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Role of Paricalcitol in Modulating the Immune Response in Patients with Renal Disease by Silvia Lucisano, Adriana Arena, Giovanna Stassi, Daniela Iannello, Gaetano Montalto, Adolfo Romeo, Giuseppe Costantino, Rosaria Lupica, Valeria Cernaro, Domenico Santoro, Michele Buemi

“…The aim was to highlight the existence of a relationship between vitamin D deficiency, chronic inflammation, and proteinuria, by measuring neutrophil gelatinase associated lipocalin (NGAL) and common inflammatory markers after administration of paricalcitol, a vitamin D analog, in vivo and in vitro. …”
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Skeletal muscle stem cells modulate niche function in Duchenne muscular dystrophy mouse through YY1-CCL5 axis by Yang Li, Chuhan Li, Qiang Sun, Xingyuan Liu, Fengyuan Chen, Yeelo Cheung, Yu Zhao, Ting Xie, Bénédicte Chazaud, Hao Sun, Huating Wang

“…Deregulated MuSC/MP/FAP interactions and the ensuing inflammation and fibrosis are hallmarks of dystrophic muscle. …”
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Optimising fatigue, abdominal pain and faecal incontinence in people with inflammatory bowel disease (IBD-BOOST Optimise): feasibility study of a checklist and algorithm for initia... by Thomas Hamborg, John McLaughlin, Ailsa Hart, Christine Norton, Sonia Bouri, Laura Miller, Jean-Frédéric LeBlanc, Asma Fikree, Imogen Stagg, Fionn Cléirigh Büttner

“…Five (3%) participants reported ‘red flags’ and 31/157 (20%) participants had a faecal calprotectin result ≥200 µg/g, of whom 12 (8%) were judged to have likely active inflammation when clinical symptoms and disease history were reviewed. …”
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An integrated investigation of mitochondrial genes in COPD reveals the causal effect of NDUFS2 by regulating pulmonary macrophages by Xiaoli Zou, Qiqing Huang, Tutu Kang, Shaoran Shen, Chenxi Cao, Jianqing Wu

“…Conclusions Our study established the causal linkage between mitochondrial malfunctions and COPD, providing a potential therapeutic avenue to alleviate pulmonary inflammation accounting for COPD by targeting mitochondria-related genes. …”
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Third or fourth branchial pouch sinus lesions: a case series and management algorithm by Yun Li, Kexing Lyu, Yihui Wen, Yang Xu, Fanqin Wei, Haocheng Tang, Siyu Chen, Zhangfeng Wang, Xiaolin Zhu, Weiping Wen, Wenbin Lei

“…Effective preoperative examination included administering contrast agent prior to a computed tomography (CT) scan and in-office laryngoscopy during the quiescent period of inflammation. Ultrasound was also very helpful in determining the presence of thyroiditis. …”
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The transcriptome of MHV‐infected RAW264.7 cells offers an alternative model for macrophage innate immunity research by Yun Liu, Ting‐Ting Feng, Wei Tong, Zhi Guo, Xia Li, Qi Kong, Zhi‐Guang Xiang

“…Results The transcriptome analysis showed the immediate (3 hpi.) up regulation of DEGs related to inflammation, like Il1b and Il6. DEGs related to M2 differential polarization, like Irf4 showed up regulation at 24 hpi., the late term after viral infection. …”
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A Body‐Temperature‐Triggered In Situ Softening Peripheral Nerve Electrode for Chronic Robust Neuromodulation by Xueyang Ren, Wenjie Tang, Yuehui Yuan, Shisheng Chen, Fangzhou Lu, Jinyang Mao, Jidan Fan, Xufeng Wei, Ming Chu, Benhui Hu

“…The electrodes are readily wrapped around nerves and applied for long‐term stimulation in vivo with minimal inflammation. Neuromodulation experiments demonstrate their potential clinical utility, including vagus nerve stimulation in rats to suppress seizures and alleviation of cardiac remodeling in a canine model of myocardial infarction.…”
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Association of The MCP-1 rs1024611 Polymorphism with Polycystic Ovary Syndrome in A Population of Indian Women: A Case-Control Study by Jijo Francis, Honey Sebastian, Saley Daniel, Leyon Varghese, Sareena Gilvaz, Ragitha Thenkattil Sankarankutty, Siji Susan George, Pulikkottil Raphael Varghese, Suresh Kumar Raveendran

“…In the Indian population, its prevalence varies from 3.7 to 22.5%depending on ethnicity and diagnostic criteria. Chronic inflammation plays a pivotal role in PCOS pathogenesis.The monocyte chemoattractant protein-1 (MCP-1) is an important chemotactic factor for inflammatory response ofmonocytes. …”
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Separate Evaluation of the Effects of Hydroalcoholic Extracts of Eryngium Caucasicum L. and Zataria Multiflora L. on Gastric Ulcers in an Animal Model by mahdi Jalahi, Mohammad Azadbakht, Jafar Akbari, Fereshteh Talebpuor, Fatemeh Akbari

“…The histopathological results showed that Zataria multiflora and Eryngium caucasicum played an effective role in reducing inflammation, bleeding in stomach tissue, and congestion. …”
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Evaluation of the immunological functions of placental alkaline phosphatase in vivo using ALPP transgenic mice by Tse-Ching Chen, Kwai-Fong Ng, Ning Chen, Yi-Ling Pan, Chun-An Cheng, Hsiao-Chun Wu, Yi-Jen Hsueh, Nien-Yi Chiang, Hsi-Hsien Lin, Hsi-Hsien Lin, Hsi-Hsien Lin, Hsi-Hsien Lin

“…ALP is also considered as an anti-inflammatory protein due to its ability to dephosphorylate and inactivate inflammation-triggering molecules such as lipopolysaccharide (LPS). …”
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Uterus didelphys: the first case report on molecular profiling of endometrial tissue from both uterine cavities by Alberto Sola-Leyva, Bárbara Romero, Analuce Canha-Gouveia, Inmaculada Pérez-Prieto, Nerea M. Molina, Eva Vargas, Juan Mozas-Moreno, Clara Chamorro, Merli Saare, Andres Salumets, Signe Altmäe

“…Methods This case report aims to study the physical separation in uterine didelphys and its impact on endometrial microbiome and inflammation, and the patterns of endometrial receptivity observed. …”
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Molecular Mechanisms Underlying Neuroinflammation Intervention with Medicinal Plants: A Critical and Narrative Review of the Current Literature by Sandra Maria Barbalho, Beatriz Leme Boaro, Jéssica da Silva Camarinha Oliveira, Jiří Patočka, Caroline Barbalho Lamas, Masaru Tanaka, Lucas Fornari Laurindo

“…Neuroinflammation is a key factor in the progression of neurodegenerative diseases, driven by the dysregulation of molecular pathways and activation of the brain’s immune system, resulting in the release of pro-inflammatory and oxidative molecules. This chronic inflammation is exacerbated by peripheral leukocyte infiltration into the central nervous system. …”
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Surgical Outcomes of Trabeculectomy in Uveitic Glaucoma: A Long-Term, Single-Center, Retrospective Case-Control Study by Rina Kanaya, Riki Kijima, Yasuhiro Shinmei, Akihiro Shinkai, Takeshi Ohguchi, Kenichi Namba, Shinki Chin, Susumu Ishida

“…Following sufficient inflammation suppression, surgical outcomes of UG may be comparable with those of POAG.…”
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Serum vitamin C levels and their correlation with chronic kidney disease in adults: a nationwide study by Chunli Wang, Jili Zhao, Qiaoqiao Zhou, Jing Li

“…Introduction Inflammation and oxidative stress play significant roles in the development of chronic kidney disease (CKD). …”
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Peripheral nerves modulate the peri-implant osteogenesis under type 2 diabetes through exosomes derived from schwann cells via miR-15b-5p/Txnip signaling axis by Yingying Wang, Fang Qu, Yaqin Wu, Kengliang Lan, Yingyi Shen, Ziang Wu, Qi Zhong, Ximeng Cao, Zhen Fan, Chun Xu

“…Luciferase assays and Western blotting confirmed TXNIP as a direct miR-15b-5p target, implicating its involvement in ROS signaling and inflammation-related osteogenesis suppression. Furthermore, normal SCs exosomes improved bone parameters around dental implants in T2DM rats. …”
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Is Lung Disease a Risk Factor for Sudden Cardiac Death? A Comparative Case–Control Histopathological Study by Ioana Radu, Anca Otilia Farcas, Septimiu Voidazan, Carmen Corina Radu, Klara Brinzaniuc

“…Conclusions: A close association exists between SCD and the histopathological alterations observed in the pulmonary parenchyma, including inflammation, fibrosis, emphysema, blood extravasation, stasis, intimal lesions, and vascular media thickening in intraparenchymal vessels. …”
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