Rosiglitazone Alleviates Mechanical Allodynia of Rats with Bone Cancer Pain through the Activation of PPAR-γ to Inhibit the NF-κB/NLRP3 Inflammatory Axis in Spinal Cord Neurons by Jie Fu, Baoxia Zhao, Chaobo Ni, Huadong Ni, Longsheng Xu, Qiuli He, Miao Xu, Chengfei Xu, Ge Luo, Jianjun Zhu, Jiachun Tao, Ming Yao

“…The results show that rosiglitazone inhibits the NF-κB/NLRP3 inflammation axis by activating PPAR-γ in spinal neurons, thereby alleviating BCP. …”
Get full text

Clinical Activity of Behcet’s Disease Associated with SARS-CoV-2 and Herpes Simplex Virus: Insights from Three Case Reports by Bakti FU, Sufiawati I

“…Herpes simplex virus type 1 (HSV-1) has long been recognized as a potential trigger for BD, as it can induce systemic inflammation and exacerbate symptoms. In contrast, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has recently emerged and may also initiate or worsen BD symptoms. …”
Get full text

Frequency of IL-1B Gene Polymorphisms in Patients with Gastroesophageal Cancer in the Hakkari Region by Derya Yaman, Selin Akad-Dinçer, Yusuf Karakaş, Gözde Ünsoy, Yunus Kasım Terzi, Feride İffet Şahin

“…Objective: Gastric cancer is a complex malignant tumor associated with chronic inflammation. In the present study, we aimed to investigate the frequency of interleukin 1B (IL-1B) gene polymorphisms affecting gene expression in patients with gastroesophageal cancer (GC) diagnosed in the Hakkari region. …”
Get full text

Role of Vitamin D and E as Antioxidants Against Cerebral Endothelial Dysfunction: An In Vivo Study in White Rats (Rattus norvegicus) Sepsis Model by Fauzan Fajri, Sukmawan Fajar, Denny Irmawati Hasan, Herlina Dimiati, Eka Yunita Amna, Nora Sovira, Anidar Anidar, Mulya Safri, Aris Gunawan

“…Based on the histopathological results of necrosis, inflammation, and hemorrhagic cell damage in sepsis rats reached over 50% of the field of view, significantly different from sepsis mice that had been given vitamin D and E. …”
Get full text

Circadian Rhythms Fluctuate the Treatment Effects of Intravesical Treatments on Rat Urinary Frequency Models by Tomofumi Watanabe, Takuya Sadahira, Yusuke Tominaga, Yuki Maruyama, Naoya Nagasaki, Takanori Sekito, Kohei Edamura, Toyohiko Watanabe, Motoo Araki, Masami Watanabe

“…Rats were then euthanized, and histopathologic examinations using a damage score validated the severity of bladder inflammation. We used nine additional rats to determine the treatment effect of various drugs against the urinary frequency. …”
Get full text

Extracellular Vesicles Released from Neprilysin Gene-Modified Human Umbilical Cord-Derived Mesenchymal Stem Cell Enhance Therapeutic Effects in an Alzheimer’s Disease Animal Model... by HyeJu Jeong, Ok Joon Kim, Seung-Hun Oh, Sanghoon Lee, Han A. Reum Lee, Kee Ook Lee, Boo-Yong Lee, Nam Keun Kim

“…Although there was no significant difference in cognitive function between the hUC-MSC groups, NEP-enhanced hUC-MSCs had superior neurogenesis and anti-inflammation properties compared to naïve hUC-MSCs due to increased NEP in the hippocampus by enriched NEP-possessing EVs. …”
Get full text

Profil Pasien Rinosinusitis Kronik di Poliklinik THT-KL RSUP DR.M.Djamil Padang by Hesty Trihastuti, Bestari Jaka Budiman, Edison

“…<br />Kata kunci: rinosinusitis kronik, pemeriksaan rinoskopi anterior, pemeriksaan nasoendoskopi</p><p> </p><p>Abstract<br />Chronic rhinosinusitis is a common chronic inflammation of the nose and paranasal sinuses mucosa, but there  is no data about profile of chronic rhinosinusitis patients at ENT clinic Dr.M.Djamil general hospital Padang. …”
Get full text

Immunological pathogenesis and treatment progress of adenovirus pneumonia in children by Yaowen Liang, Jie Wei, Jianjun Shen, Zihao Liang, Xiuchang Ma, Yuchen Du, Wenxian Qian, Hui Dong, Ping Huang, Apeng Chen, Changhua Yi

“…Immunomodulatory therapy can reduce inflammation in children, while adjuvant therapy can improve respiratory function; however, it can also lead to complications. …”
Get full text

Mapping integral cell-type-specific interferon-induced gene regulatory networks (GRNs) involved in systemic lupus erythematosus using systems and computational analysis by Blessy Kiruba, Akshayata Naidu, Vino Sundararajan, Sajitha Lulu S

“…Systemic lupus erythematosus (SLE) is a systemic autoimmune disorder characterized by the production of autoantibodies, resulting in inflammation and organ damage. Although extensive research has been conducted on SLE pathogenesis, a comprehensive understanding of its molecular landscape in different cell types has not been achieved. …”
Get full text

Significance of single-nucleotide variants of anorexigenic hormone genes in childhood obesity by A.O. Nikulina

“…Genotypes of the GLP1R gene, such as CC rs10305421 determine insulin resistance (F=5.6); GA/AA rs3765468 – meta-inflammation (F=5.8); AA rs6918287 – basal hyperglycemia (F=6.3) and triglyceridemia (F=51.3), p<0.05. …”
Get full text

Diagnostic delay of myositis: protocol for an integrated systematic review by Christine Phillips, Matthew Cook, Anne Parkinson, Jane Desborough, Tergel Namsrai, Anita Chalmers, Christine Lowe

“…Introduction Idiopathic inflammatory myopathies (IIM). described as ‘inflammatory myositis’, are a heterogeneous group of rare muscular autoimmune diseases characterised by skeletal muscle inflammation. Its complex characteristics with lack of accurate diagnostic tests, unified classification system and comprehensive widely used diagnostic criteria could lead to diagnostic delay. …”
Get full text

The curvilinear relationship between Framingham Steatosis Index and depression: insights from a nationwide study by Chunqi Jiang, Bo Wang, Ning Wang, Jun Wang, Yinuo Qu, Guang Zhao, Xin Zhang, Xin Zhang

“…Subgroup analysis revealed statistically significant interactions between FSI and depression within the educational attainment groups.ConclusionOur study’s discovery is the curvilinear relationship between FSI and depression. Factors such as inflammation, hormonal levels, and metabolic disruptions could be the underlying mechanisms driving this relationship. …”
Get full text

Osteoblastic Differentiation and Mitigation of the Inflammatory Response in Titanium Alloys Decorated with Oligopeptides by Aroa Álvarez-López, Raquel Tabraue-Rubio, Rafael Daza, Luis Colchero, Gustavo V. Guinea, Martine Cohen-Solal, José Pérez-Rigueiro, Daniel González-Nieto

“…We find that the RGD-decoration remains stable for 1 week after the surgical procedure and reduces post-implantation macrophage-related inflammation. These results highlight the potential of peptide decoration on R-THAB^® functionalized surfaces to expedite the development of novel metallic biomaterials with enhanced biocompatibility properties, thereby advancing the field of regenerative medicine.…”
Get full text

Human adipose‐derived multipotent stromal cells enriched with IL‐10 modRNA improve diabetic wound healing: Trigger the macrophage phenotype shift by Yuxin Zhang, Wei Wang, Liang Chen, Heng Wang, Dong Dong, Jingjing Zhu, Yu Guo, Yiqun Zhou, Tianyi Liu, Wei Fu

“…Abstract Diabetic wounds present a significant challenge in regenerative medicine due to impaired healing, characterized by prolonged inflammation and deficient tissue repair, primarily caused by a skewed pro‐inflammatory macrophage phenotype. …”
Get full text

Granulomatous Lung Disease Requiring Mechanical Ventilation Induced by a Single Application of Oxaliplatin-Based Chemotherapy for Colorectal Cancer: A Case Report by Dane Wildner, Frank Boxberger, Axel Wein, Kerstin Wolff, Heinz Albrecht, Gudrun Männlein, Rolf Janka, Kerstin Amann, Jürgen Siebler, Werner Hohenberger, Markus F. Neurath, Richard Strauß

“…The histological workup revealed distinct granulomatous inflammation, but no microbial pathogens were to be found. …”
Get full text

The Role of Pyroptosis&#x2010;Related Gene Signature and Immune Infiltration in Juvenile Dermatomyositis by Qiao W, Zhu C, Huang D, Liu Y, Wang Z, Zhu T, Song Q, Yang X, Wang Y, Wang Y

“…GSVA and GSEA analyses demonstrated the involvement of PR-DEGs in multiple inflammation and immunity-related pathways, with the NOD-like receptor signaling pathway playing a central role.Conclusion: This study highlights the crucial role of pyroptosis in the pathogenesis of JDM, with the identified PR-DEGs potentially contributing to disease development and progression by regulating key inflammatory and immune-related pathways.Keywords: pyroptosis, JDM, immune infiltration analysis, machine learning, diagnostic…”
Get full text

Secondary prevention of preeclampsia by Muhammad Ilham Aldika Akbar, Muhammad Ilham Aldika Akbar, Roudhona Rosaudyn, Khanisyah Erza Gumilar, Khanisyah Erza Gumilar, Renuka Shanmugalingam, Gustaaf Dekker, Gustaaf Dekker

“…PE is a multifaceted illness characterized by syncytiotrophoblast (STB) stress, leading to endothelial dysfunction and systemic inflammation. Various subtypes of PE, in particular early-onset PE (EOP) and late-onset PE (LOP), have different pathophysiological pathways leading to STB stress and also different perinatal outcomes. …”
Get full text

The N‐terminal domain of gasdermin D induces liver fibrosis by reprogrammed lipid metabolism by Xue Wang, Chunyou Ning, Xingyi Cheng, Zhengzhong Wu, Dongbo Wu, Xuemei Ding, Cunxiang Ju, Zhihang Zhou, Lingfeng Wan, Wei Zhao, Peiliang Shi

“…Consequently, directing therapeutic efforts towards inhibiting pyroptosis could potentially serve as an innovative approach in managing inflammation related chronic hepatic disorders. Methods GSDMD‐NTki/wt mice and Alb‐creki/wt mice were generated using CRISPR/Cas9 technology. …”
Get full text

Altered expression of miRNA profile in peripheral blood mononuclear cells following the third dose of inactivated COVID-19 vaccine by Guanguan Qiu, Ruoyang Zhang, Huifeng Qian, Ruoqiong Huang, Jie Xia, Ruoxi Zang, Zhenkai Le, Qiang Shu, Jianguo Xu, Guoping Zheng, Jiangmei Wang

“…Bioinformatic analysis suggested that miR-25-5p, miR-34c-3p, and miR-206 may target multiple pathways involved in immune regulation and inflammation. Therefore, our study highlights miR-25-5p, miR-34c-3p, and miR-206 in PBMCs as promising biomarkers for assessing the immune response induced by the booster dose of the CoronaVac vaccine.…”
Get full text

Multi-Omics and Network-Based Drug Repurposing for Septic Cardiomyopathy by Pei-Pei Liu, Xin-Yue Yu, Qing-Qing Pan, Jia-Jun Ren, Yu-Xuan Han, Kai Zhang, Yan Wang, Yin Huang, Tao Ban

“…In vitro assays revealed that acetaminophen inhibited prostaglandin synthesis, reducing inflammation, while pyridoxal phosphate restored amino acid balance, supporting cellular function. …”
Get full text