Altered expression profile of plasma exosomal microRNAs in exclusive electronic cigarette adult users by Dongmei Li, Zidian Xie, Sadiya Bi Shaikh, Irfan Rahman

“…Abstract Little is known about how exclusive e-cigarette use affects exosomal microRNA (miRNA) expression, which is crucial in inflammation and disease processes like cancer. We compared exosomal miRNA profiles between exclusive e-cigarette users and non-users. …”
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Critical pathomechanisms of NSAID-exacerbated respiratory disease (N-ERD) clarified by treatment with omalizumab, an anti-IgE antibody by Hiroaki Hayashi, Makoto Ishii, Yoshinori Hasegawa, Masami Taniguchi

“…Even when using standard treatments for respiratory and extra-respiratory symptoms, including systemic corticosteroids and aspirin desensitization, it is difficult to control the clinical symptoms and severe type 2 inflammation involved with mast cells, eosinophils, ILC2s, and platelet activation. …”
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Effect of non-surgical periodontal therapy on salivary and gingival crevicular fluid concentration of visfatin in periodontal health and disease by Hira Ismail, Anjani Kumar Pathak, Nand Lal, Pavitra Rastogi, Kaleem Ahmad, Mohd. Aamir Khan

“…Conclusion: The results of this investigation suggest a direct correlation between salivary and gingival crevicular fluid visfatin concentration and periodontal tissue inflammation and disease activity.…”
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Blimp-1 orchestrates macrophage polarization and metabolic homeostasis via purine biosynthesis in sepsis by Wenjuan Peng, Qiushi Qin, Rui Li, Yujia Liu, Lan Li, Yue Zhang, Liuluan Zhu

“…Abstract Sepsis is a life-threatening condition characterized by a dysregulated immune response to infection, leading to systemic inflammation and organ dysfunction. Macrophage polarization plays a critical role in pathogenesis of sepsis, and the influence of B lymphocyte-induced maturation protein-1 (Blimp-1) on this polarization is an underexplored yet pivotal aspect. …”
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Position-specific biomarker responses to match vs. VAMEVAL test modalities in elite female soccer players: a comparative analysis study by Manel Slimani, Hatem Ghouili, Wissem Dhahbi, Zouhaier Farhani, Mohamed Ben Aissa, Marouen Souaifi, Noomen Guelmami, Ismail Dergaa, Lamia Ben Ezzeddine

“…Significant effects (p<0.001–0.004; ƞ2p:0.36–0.59[large]) were observed in biomarkers reflecting energy metabolism (glucose), protein turnover (albumin), inflammation (tumor necrosis factor and C-reactive protein), and lipid profile (apolipoprotein-B) across conditions. …”
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Genomic characterization of chronic lymphocytic leukemia in patients of African ancestry by Cecilia Bonolo de Campos, Chantal E. McCabe, Laura A. Bruins, Daniel R. O’Brien, Sochilt Brown, Renee C. Tschumper, Cristine Allmer, Yuan Xiao Zhu, Kari G. Rabe, Sameer A. Parikh, Neil E. Kay, Huihuang Yan, James R. Cerhan, John N. Allan, Richard R. Furman, J. Brice Weinberg, Danielle M. Brander, Diane F. Jelinek, Marta Chesi, Susan L. Slager, Esteban Braggio

“…Furthermore, we found transcription enrichment of the Tumor Necrosis Factor-alpha (TNFα) Signaling via NF-κB pathway in AA CLL compared to EA CLL, suggesting that tumor promoting inflammation plays an important role in AA CLL. In summary, these results suggest that genomic instability and NF-kB activation is more prevalent in AA CLL than EA CLL.…”
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Evaluation of efficacy and safety of coenzyme Q10 in pediatric hemodialysis patients: a randomized controlled trial by Salma A. Rahman Sharaf, Sarah Farid Fahmy, Heba M. Adel Abou Zaghla, Ahmed Hussein Hassan, Sara Mahmoud Zaki

“…This study emphasized the potential efficacy of an average coenzyme Q10 dose of 4 mg/kg/day in pediatric hemodialysis patients; this gives the green light for other researchers to confidently evaluate larger doses as an attempt to control the systemic inflammation in this patient population. Further research is needed to determine whether coenzyme Q10 treatment improves clinical outcomes such as infection, hospitalization, cardiovascular events, and mortality in pediatric hemodialysis patients. …”
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Novel Mechanisms Modulating Palmitate-Induced Inflammatory Factors in Hypertrophied 3T3-L1 Adipocytes by AMPK by Naru Morita, Toshio Hosaka, Atsuko Kitahara, Toshitaka Murashima, Hirohisa Onuma, Yoshikazu Sumitani, Kazuto Takahashi, Toshiaki Tanaka, Takuma Kondo, Hitoshi Ishida

“…These findings provide evidence that AMPK plays a crucial role in ameliorating obesity-induced inflammation.…”
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Inhibition of miR-182-5p Targets FGF9 to Alleviate Osteoarthritis by Yang Sun, Sanmao Su, Mengjun Li, Ang Deng

“…Conclusions. miR-182-5p expression levels were increased in OA chondrocytes and regulated chondrocyte proliferation, apoptosis, and inflammation by targeting FGF9. miR-182-5p is a potential gene for OA treatment.…”
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Partial rejuvenation of the spermatogonial stem cell niche after gender-affirming hormone therapy in trans women by Emily Delgouffe, Samuel Madureira Silva, Frédéric Chalmel, Wilfried Cools, Camille Raets, Kelly Tilleman, Guy T'Sjoen, Yoni Baert, Ellen Goossens

“…The transcriptomic profile of transgender tissue confirmed a loss of mature characteristics - a partial rejuvenation - of the spermatogonial stem cell niche and, in addition, detected inflammation processes occurring in the samples. The present study shows that GAHT changes the spermatogonial stem cell niche by partially rejuvenating the somatic cells and inducing fibrotic processes. …”
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Syndecan-1: A Review on Its Role in Heart Failure and Chronic Liver Disease Patients’ Assessment by Radu-Stefan Miftode, Ionela-Lăcrămioara Şerban, Amalia-Stefana Timpau, Ionela-Larisa Miftode, Adriana Ion, Ana-Maria Buburuz, Alexandru-Dan Costache, Irina-Iuliana Costache

“…Multiple evidence revealed that syndecan-1 is also associated with tissue injury and may regulate inflammatory and regenerative responses, being considered a protective molecule that limits the inflammation and reduces cardiac remodelling and dysfunction after a myocardial infarction. …”
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Characterization of squash polysaccharide and the anti-diabetic effect on type 2 diabetic rat revealed by urine metabolomics analysis by Li Liang, Fuming Zhang, Quanhong Li, Baoguo Sun, Yuyu Zhang, Robert J. Linhardt

“…The regulation of nicotinamide N-oxide, histamine, cis-aconitate, citrate, L-malic acid, 3-(3-hydroxyphenyl) propanoic acid and N-acetyl-L-aspartic acid were mainly associated with energy metabolism, gut microbiota and inflammation. Study of surface plasmon resonance revealed the binding kinetics with galectin-3 (Gal-3) and fibroblast growth factor 2 (FGF2). …”
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Bedside hyperspectral imaging for the evaluation of microcirculatory alterations in perioperative intensive care medicine: a study protocol for an observational clinical pilot stud... by Thilo Hackert, Thomas Bruckner, Maximilian Dietrich, Sebastian Marx, Felix Nickel, Beat Peter Müller-Stich, Markus A Weigand, Florian Uhle, Thorsten Brenner, Karsten Schmidt

“…HSI data will be correlated with the Sequential Organ Failure Assessment score, global haemodynamics, inflammation and glycocalyx markers, surgical complications and 30-day outcome.Ethics and dissemination The protocol has been approved by the local ethics committee of the University of Heidelberg (S-148/2019). …”
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Chemical characterization of Siraitia grosvenorii granules and their efficacy and mechanism of action on PM2.5-induced acute lung injury by Qi Shao, Yan Zhao, YuYu Shi, Fafeng Cheng, ZeHan Zhang, Ying Liu, ChangXiang Li, ZiLin Ren, Hua Bai, Haojie Cheng, Rolando Maddela, Junqiang Tian, Xueqian Wang

“…However, SGG reversed these changes, particularly tissue damage and oxidative stress, suggesting that lung protection is mediated by the antioxidant effect, which mitigates the release of alarmin and inflammation.…”
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Network Pharmacology Combined With Metabolomics Reveals the Mechanism of Yangxuerongjin Pill Against Type 2 Diabetic Peripheral Neuropathy in Rats by Jin R, Pei H, Yue F, Zhang X, Zhang Z, Xu Y, Li J

“…The effects are mainly related to reducing oxidative stress injury, promoting the expression of neuroprotection-related proteins, reducing the expression of inflammation-related proteins, and affecting amino acid metabolism, lipid metabolism, and nucleotide metabolism pathways. …”
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Lingguizhugan Decoction Protects against High-Fat-Diet-Induced Nonalcoholic Fatty Liver Disease by Alleviating Oxidative Stress and Activating Cholesterol Secretion by Lili Yang, Weili Lin, Colleen A. Nugent, Shijun Hao, Haiyan Song, Tao Liu, Peiyong Zheng

“…Increased expression of antioxidant OSIGN1 and decreased expression of genes (AHR, IRF2BP2, and RASGEF1B) that induce oxidative stress and inflammation were observed in NAFLD rats treated with LGZG. …”
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Supplementation with active vitamin D3 ameliorates experimental autoimmune thyroiditis in mice by modulating the differentiation and functionality of intrathyroidal T-cell subsets by Chun-Mei Wang, Ying-Jie Chen, Bo-Cheng Yang, Jia-Wen Yang, Wei Wang, Yang Zeng, Jun Jiang

“…Some research has suggested that vitamin D3 supplementation reduces thyroid inflammation, but this remains controversial.MethodsEAT was induced in female NOD/ShiLtJ mice by giving them water containing 0.05% sodium iodide, and 1μg/kg of 1α,25-(OH)2D3 was injected intraperitoneally every other day. …”
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SAA3 deficiency exacerbates intestinal fibrosis in DSS-induced IBD mouse model by Xiaodong Zou, Tong Wu, Jianjiao Lin, Tao Su, Hui Xiao, Chuyan Ni, Lijuan Hu, Wenchu Lin, Weilin Chen, Richard D. Ye, Li Xiang

“…SAA3, a highly conserved member of the serum amyloid A (SAA) apolipoprotein family in mice, is synthesized primarily as an acute phase reactant in response to infection, inflammation and trauma. An increasing number of evidence suggests that SAA3 exerts a vital role in the fibrotic process, even though the underlying mechanisms are not yet fully comprehended. …”
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Piezo1 aggravates ischemia/reperfusion-induced acute kidney injury by Ca2+-dependent calpain/HIF-1α/Notch signaling by Xiaoting Chen, Jintao Jiang, Bin He, Shangfei Luo, Qiaorui Tan, Youfen Yao, Rentao Wan, Honglin Xu, Silin Liu, Xianmei Pan, Xin Chen, Jing Li

“…Macrophages play a vital role in the inflammation and repair processes of ischemia/reperfusion-induced acute kidney injury (IR-AKI). …”
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Borneol, a Bicyclic Monoterpene Alcohol, Reduces Nociceptive Behavior and Inflammatory Response in Mice by Jackson Roberto Guedes da Silva Almeida, Grasielly Rocha Souza, Juliane Cabral Silva, Sarah Raquel Gomes de Lima Saraiva, Raimundo Gonçalves de Oliveira Júnior, Jullyana de Souza Siqueira Quintans, Rosana de Souza Siqueira Barreto, Leonardo Rigoldi Bonjardim, Sócrates Cabral de Holanda Cavalcanti, Lucindo José Quintans Junior

“…Antinociceptive and anti-inflammatory activities were studied by measuring nociception by acetic acid, formalin, hot plate, and grip strength tests, while inflammation was prompted by carrageenan-induced peritonitis. …”
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