sCD40L Is Increased and Associated with the Risk of Gestational Diabetes Mellitus in Pregnant Women with Isolated TPOAb Positivity by Xinxin Chen, Qingyao Wang, Xiangguo Cong, Shuyi Jiang, Shuxiang Li, Qiong Shen, Lei Chen

“…Soluble CD40 ligand (sCD40L) and soluble interleukin-2 receptor (sCD25) are abnormally expressed in autoimmune diseases and are reliable markers of inflammation. The purpose of this study was to evaluate sCD40L and sCD25 in early pregnancy and investigate their correlation with GDM and TPOAb. …”
Get full text

A Novel Nitronyl Nitroxide with Salicylic Acid Framework Attenuates Pain Hypersensitivity and Ectopic Neuronal Discharges in Radicular Low Back Pain by Wen-Juan Han, Lei Chen, Hai-Bo Wang, Xiang-Zeng Liu, San-Jue Hu, Xiao-Li Sun, Ceng Luo

“…Evidence has accumulated that reactive oxygen species and inflammation play crucial roles in the development of chronic pain, including radicular low back pain. …”
Get full text

GLIM criteria for definition of malnutrition in peritoneal dialysis: a new aspect of nutritional assessment by Dao Wang, Jun Yin, Wen Liao, Xiaoran Feng, Fengping Zhang

“…As a complex model for forecast the long-term mortality, the performance of adjusted factors combined with GLIM was poorer than combined malnutrition inflammation score (MIS) (IDI >0, p < 0.001), but fitter than combined geriatric nutritional risk index (GNRI) (IDI <0, p < 0.001).Conclusions The GLIM criteria provide a viable tool for nutritional assessment in patients with PD, and malnutrition defined according to the GLIM can predict prognosis with an acceptable performance.…”
Get full text

Health-related quality of life in patients with multiple sclerosis by Lázaro Aurelio Vázquez Gómez, Carlos Hidalgo Mesa, Benita Mabel Beltrán González, Yunier Broche Pérez, Ana María Mederos Herrera

“…<p><strong>Background:</strong> multiple sclerosis is a disease characterized by outbreaks of disability in any functional system that are produced by inflammation and demyelination of the central nervous system.…”
Get full text

The Role of the Gastrointestinal Microbiota in Parkinson’s Disease by Maurizio Gabrielli, Lorenzo Zileri Dal Verme, Maria Assunta Zocco, Enrico Celestino Nista, Veronica Ojetti, Antonio Gasbarrini

“…Dysbiosis has been strongly linked to PD and is associated with increased intestinal permeability, chronic inflammation, and the production of neurotoxic metabolites that may exacerbate neuronal damage. …”
Get full text

The research progress of biologics in elderly-onset rheumatoid arthritis (EORA) by Yujie Li, Yifan Liu, Yanhui Tian, Huimin Gu, Qingliang Meng, Jiakang Cui, Junfu Ma

“…Studies indicate that biologics, such as TNF-α inhibitors, IL-6 inhibitors, and JAK inhibitors, can significantly reduce inflammation and improve joint function in EORA patients. …”
Get full text

Modulation of Preactivation of PPAR-β on Memory and Learning Dysfunction and Inflammatory Response in the Hippocampus in Rats Exposed to Global Cerebral Ischemia/Reperfusion by Ge Kuang, Qin He, Yunmei Zhang, Ruichun Zhuang, Anling Xiang, Qingsong Jiang, Ying Luo, Junqing Yang

“…Our data suggests that the PPAR-β agonist GW0742 can exert significant neuroprotective effect against GCIRI in rats via PPAR-β activation and its anti-inflammation effect mediated by the inhibition of expression and activation of NF-κB in the hippocampus.…”
Get full text

Testosterone and Adipokines are Determinants of Physical Performance, Strength, and Aerobic Fitness in Frail, Obese, Older Adults by Lina E. Aguirre, Irum Zeb Jan, Kenneth Fowler, Debra L. Waters, Dennis T. Villareal, Reina Armamento-Villareal

“…In conclusion, in frail obese older adults, circulating levels of testosterone, adiponectin, and leptin appear to be important predictors of physical strength and fitness, while inflammation appears to be a major determinant of physical frailty.…”
Get full text

The Sequence of Prostaglandin-Endoperoxide Synthase 2 Gene in Women with Cervicitis by Maha A. Ahlial, Nazar Sh. Mohammed, Maysara S. Khalaf

“… Cervicitis is a clinical syndrome characterized by inflammation of primarily the columnar epithelium of the uterine endocervix. …”
Get full text

Discriminatory Value of Adiponectin to Leptin Ratio for COVID-19 Pneumonia by Federica Tonon, Stefano Di Bella, Fabiola Giudici, Verena Zerbato, Ludovica Segat, Raffaella Koncan, Andrea Misin, Barbara Toffoli, Pierlanfranco D’Agaro, Roberto Luzzati, Bruno Fabris, Stella Bernardi

“…Our data indicate that high Adpn/Lep (>2.23) in lean patients is consistent with a state of good health, which decreases in case of inflammatory states, ranging from adipose tissue dysfunction with low-grade inflammation to COVID-19 pneumonia.…”
Get full text

Therapeutic Doses of Nonsteroidal Anti-Inflammatory Drugs Inhibit Osteosarcoma MG-63 Osteoblast-Like Cells Maturation, Viability, and Biomineralization Potential by E. De Luna-Bertos, J. Ramos-Torrecillas, O. García-Martínez, A. Guildford, M. Santin, C. Ruiz

“…Nonsteroidal anti-inflammatory drugs (NSAIDs) are frequently used to reduce pain and inflammation. However, their effect on bone metabolisms is not well known, and results in the literature are contradictory. …”
Get full text

A Rare Case of Acute Methotrexate Toxicity Leading to Bone Marrow Suppression by Samreen Khuwaja, Matthew Lyons, Beenish Zulfiqar

“…Peripheral blood smear showed signs of bone marrow suppression but no signs of hemolysis or inflammation. Serum methotrexate levels were minimally detectable at 0.05 umol/L. …”
Get full text

Ketamine-associated upper urinary tract dysfunction: What we know from current literature by Zhihuan Zheng, Zhongyi Li, Jiazhe Yuan, Feng Han, Li Huang, Zhao Wang

“…Conclusion: Ketamine abuse can lead to UUT impairment and dysfunction, with symptoms such as bladder dysfunction and contracted bladder with vesicoureteral reflux, direct damage and barrier dysfunction, inflammation, apoptosis, fibrosis and stricture, and papillary necrosis. …”
Get full text

Efficacy and Safety of Bicyclol Treatment for Non-Alcoholic Fatty Liver Disease: Results of a Cohort Study by I. Yu. Pirogova, S. V. Yakovleva, T. V. Neuymina, S. P. Sinitsyn, V. S. Chulkov, T. N. Shamaeva

“…Bicyclol therapy in NAFLD is accompanied by positive dynamics of inflammation activity markers, insulin resistance and lipid spectrum, which suggests a positive dynamics of the stages of liver fibrosis and steatosis.…”
Get full text

From Plasmacytoma to Rib Tuberculosis: The Case of A Breast Mass With An Unexpected Diagnosis by Hafedh Abbassi, Badra Bannour, Sarra Yacoub, Ekram Guerbej, Imen Bannour, Samir Hidar, Moncef Mokni

“…The mass was surgically excised, and histopathological analysis revealed granulomatous inflammation with caseous necrosis, suggesting TB. TB-polymerase chain reaction confirmed the diagnosis, despite negative Ziehl-Neelsen staining. …”
Get full text

Treatment of rheumatoid arthritis using dual-targeted and dual-response intelligent micelles: a “three birds with one stone” strategy by Rui-Bo Guo, Lu Zhang, Yang Liu, Liang Kong, Yang Yu, Bin Yang, Zuo-Jun Wang, Jing-Yi Zhang, Xue-Tao Li

“…Abstract Rheumatoid arthritis (RA) is an autoimmune disease whose pathophysiology is closely related to inflammation-associated cells and the microenvironment of inflamed joints. …”
Get full text

Molecular Mechanisms Linking Omega-3 Fatty Acids and the Gut–Brain Axis by Anna Zinkow, Wojciech Grodzicki, Malwina Czerwińska, Katarzyna Dziendzikowska

“…Additionally, n-3 fatty acids modulate inflammation by altering eicosanoid production, reducing proinflammatory cytokines, and promoting anti-inflammatory mediators. …”
Get full text

Utilization of an Intraoperative Grading Scale in Laparoscopic Cholecystectomy: A Nepalese Perspective by Suman Baral, Raj Kumar Chhetri, Neeraj Thapa

“…Various preoperative grading scales have been developed for predicting the difficulty of surgery in cholecystitis patients; however, intraoperative assessment of anatomical status and inflammation of the gall bladder has not been assessed till date except for some guidelines like the Parkland grading scale (PGS). …”
Get full text

Mechanism of hyperbaric oxygen therapy downregulating H-type angiogenesis in subchondral bone of knee osteoarthritis through the PHD2/HIF-1α pathway by Jianjian Wang, Wen Yu, Yuxin Zhang, Bo Chen, Zhaoxiang Meng

“…The effect of hyperbaric oxygen therapy on osteoarthritis was evaluated using Micro-CT, Safranin O-Fast Green staining, and detection of osteoarthritis inflammation markers (MMP-13, ADAMTS-5, Col2a1, and Aggrecan). …”
Get full text

Serum fatty acid-binding protein 3 levels differentiate active from inactive myositis and correlate with response to therapy by Latika Gupta, Sanjukta Majumder, Amita Aggarwal, Ramnath Misra, Able Lawrence

“…Background: Delay in the diagnosis of idiopathic inflammatory myopathies (IIMs) and resultant muscle wasting leads to a setting, wherein conventional biomarkers fail to identify inflammation amid damage. Fatty acid-binding protein 3 (FABP3) has a selective location and function lending unique potential as a specific biomarker in IIM. …”
Get full text