Case report: Non-linear evolution of oxytocin informs YBOCS changes post-DBS of the bed nucleus of the stria terminalis for treatment resistant OCD by Jean-Baptiste Belge, Jean-Baptiste Belge, Vincent Geenen, Anne L. Salado, Bruno Kaschten, Didier Martin, Gabrielle Scantamburlo, Gabrielle Scantamburlo

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Investigation of the association between circulating inflammatory proteins and encephalitis risk in Europeans by two-sample Mendelian randomization analysis by Yanwei Liu, Xilong Wang, Qiang Zhao, Jun Wei, Shiqiang Yang

“…BackgroundCytokines are powerful immune response factors that operate at inflammation sites and are also found in the blood. Nevertheless, research on encephalitis and these circulating inflammatory proteins is quite limited.MethodsThis study investigated the potential causal effects of 91 circulating inflammatory proteins on three different types of encephalitis using a two-sample Mendelian randomisation analysis. …”
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Investigation on the effectiveness of progranulin as a novel predictive biomarker for allergic disorders by Nisreen Waleed Mustafa, Zaid Nabeel Elia, Abeer Mansour Abdel Rasool, Sanaria Fawzi Jarjes, Salam Farid Nawara, Shakhawan Hamid

“…Additionally, C-reactive protein (CRP) levels were measured for the detection of inflammation. Serum PGRN level was estimated by the enzyme-linked immunosorbent assay (ELISA) technique, while interleukin-6 (IL-6) concentration was determined by the fluorescent immunoassay technique. …”
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Inhibition of high glucose-induced cardiac fibroblast activation: an effective treatment for diabetic cardiomyopathy using Chinese herbal medicine by Bin Wan, Jing Hu, Yue Luo, Yutong Han, Yaowen Zhang, Qinchuan Huang, Yulin Leng, Chunguang Xie, Chunguang Xie

“…In this review, we first introduced the physiology and function of CFs and discussed the conditions for the pathological activation of CFs in the process of diabetes, and then systematically summarized the effects of CHM on the activation of CFs by controlling the production of advanced glycosylation end products, oxidative stress and inflammation. This review will illustrate the potential of CHM to inhibit the activation of CFs and provide new ideas for the treatment of DCM.…”
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Strongyloides Colitis as a Harmful Mimicker of Inflammatory Bowel Disease by Julio Poveda, Farah El-Sharkawy, Leopoldo R. Arosemena, Monica T. Garcia-Buitrago, Claudia P. Rojas

“…Colonoscopy revealed diffuse inflammation suggestive of inflammatory bowel disease, which led to initiation of 5-aminosalicylic acid and intravenous methylprednisolone. …”
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An atypical case of infective endocarditis initially diagnosed as myopericarditis by Negin Ceraolo, Rachel Dietz, Spencer Prete, Erin L Simon

“…Background: Acute myopericarditis is inflammation of the pericardium, or the membrane surrounding the heart, and the myocardium, or the muscular myocardial layer of the heart. …”
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Promising Therapeutic Functions of Bone Marrow Mesenchymal Stem Cells Derived-Exosome in Asthma by Jia-Ying Yuan, Xiang-Yun Wang, Zhi-Ying Tong, Yu-Chao Dong, Jia-Yi Zhao, Yi Zhang, Yan Shang

“…Points also hold that BMMSC-Exo could interfere with airway inflammation and airway remolding in asthma via modulating the immune response, regulating gene expression, adjusting the phenotype of macrophage, etc. …”
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Neutropenic Sepsis in the ICU: Outcome Predictors in a Two-Phase Model and Microbiology Findings by Jan M. Kruse, Thomas Jenning, Sibylle Rademacher, Renate Arnold, Clemens A. Schmitt, Achim Jörres, Philipp Enghard, Michael Oppert

“…Infections with coagulase-negative staphylococci and enterococci were associated with a significantly higher mortality and a high degree of systemic inflammation. Conclusion. Patients with persistent organ dysfunction show an increased mortality in the further course of their ICU stay. …”
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The Fatty Acid Profile in Patients with Newly Diagnosed Diabetes: Why It Could Be Unsuspected by C. Castro-Correia, S. Sousa, S. Norberto, C. Matos, V. F. Domingues, M. Fontoura, C. Calhau

“…Several studies have shown a link between proinflammatory activity and the presence or deficit of some fatty acids. Inflammation is associated with several diseases including diabetes. …”
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Explore the Mechanism of Astragalus mongholicus Bunge against Nonalcoholic Fatty Liver Disease Based on Network Pharmacology and Experimental Verification by Lili Fu, Zhongming Wu, Yanjun Chu, Wenbin Chen, Ling Gao, Shumin Mu, Jiajun Zhao

“…Our results indicated that quercetin, as the main active component in AMB, exerts an anti-NAFLD effect by regulating the AMPK/MAPK/TNF-α and AMPK/ACC/CPT1α signaling pathways to inhibit inflammation and alleviate lipid accumulation.…”
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Potential Role of ANGPTL4 in the Cross Talk between Metabolism and Cancer through PPAR Signaling Pathway by Laura La Paglia, Angela Listì, Stefano Caruso, Valeria Amodeo, Francesco Passiglia, Viviana Bazan, Daniele Fanale

“…Subsequently, ANGPTL4 has been shown to be involved in several nonmetabolic and metabolic conditions, both physiological and pathological, including angiogenesis and vascular permeability, cell differentiation, tumorigenesis, glucose homoeostasis, lipid metabolism, energy homeostasis, wound healing, inflammation, and redox regulation. The transcriptional regulation of ANGPTL4 can be modulated by several transcription factors, including PPARα, PPARβ/δ, PPARγ, and HIF-1α, and nutritional and hormonal conditions. …”
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BMP6, a potential biomarker of inflammatory fibrosis and promising protective factor for dilated cardiomyopathy by Feng Jiang, Jiayang Tang, Xiaoqi Wei, Hai Pan, Xinyi Fan, Peng Zhang, Shuzhen Guo

“…Abstract Background Dilated cardiomyopathy (DCM) stands as one of the most prevalent and severe causes of heart failure. Inflammation plays a pivotal role throughout the progression of DCM to heart failure, while age acts as a natural predisposing factor for all cardiovascular diseases. …”
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Insights into the binding selectivity of harzianoic acids A and B to tetraspanin CD81 by Gérard Vergoten, Christian Bailly

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Costus afer: A Systematic Review of Evidence-Based Data in support of Its Medicinal Relevance by Daniel Boison, Cynthia Ayefoumi Adinortey, Godwin Kweku Babanyinah, Olga Quasie, Rosemary Agbeko, Gilbert Kofi Wiabo-Asabil, Michael Buenor Adinortey

“…It is reportedly used in traditional medicine practice (TMP) to treat and manage many ailments including diabetes mellitus, stomach ache, arthritis, inflammation, and gout. These purported ethnomedicinal uses have triggered many research studies on the plant to amass scientific evidence. …”
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Cavernous Hemangioma-Like Kaposi Sarcoma: Histomorphologic Features and Differential Diagnosis by Nilüfer Onak Kandemir, Figen Barut, Banu Doğan Gün, Nilgün Solak Tekin, Sevinç Hallaç Keser, Şükrü Oğuz Özdamar

“…Typical histological findings of early-stage KS, consisting of mononuclear inflammation, extravasated erythrocytes, and a few immature vascular structures in superficial dermis, were observed. …”
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Anti-Inflammatory therapeutic potential of Bungur (Lagerstroemia speciosa L.) leaves ethanolic extract against LPS-activated macrophage through TLR4/MD2 signaling: A computational... by Rosyadah Nuraini, Dwijayanti Dinia Rizqi, Annisa Yuslinda, Kamila Fairuz Sarah, Widyananda Muhammad Hermawan, Ulfa Siti Mariyah, Widodo Nashi

“…Excessive inflammation, driven by macrophage activation and nitric oxide (NO) production, underlies various diseases. …”
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Adhesive polyelectrolyte coating through UV-triggered polymerization on PLGA particles for enhanced drug delivery to inflammatory intestinal mucosa by Jie Zhang, Yi-jing Yin, Xing-wang Wang, Wei-qi Lu, Zhao-yang Chen, Chao-hui Yu, Ke-feng Ren, Cheng-fu Xu

“…Abstract Administering medication precisely to the inflamed intestinal sites to treat ulcerative colitis (UC), with minimized side effects, is of urgent need. In UC, the inflammation damaged mucosa contains a large number of amino groups which are positively charged, providing new opportunities for drug delivery system design. …”
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Emerging PPARγ-Independent Role of PPARγ Ligands in Lung Diseases by Ajit A. Kulkarni, Collynn F. Woeller, Thomas H. Thatcher, Sesquile Ramon, Richard P. Phipps, Patricia J. Sime

“…PPARγ ligands show great promise in moderating lung inflammation, as antiproliferative agents in combination to enhance standard chemotherapy in lung cancer and as treatments for pulmonary fibrosis, a progressive fatal disease with no effective therapy. …”
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On the Dual Role of Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) in Human Malignancies by Andreea Calinescu, Gabriela Turcu, Roxana I. Nedelcu, Alice Brinzea, Anastasia Hodorogea, Mihaela Antohe, Carmen Diaconu, Coralia Bleotu, Daniel Pirici, Lucia B. Jilaveanu, Daniela A. Ion, Ioana A. Badarau

“…Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is a glycoprotein belonging to the carcinoembryonic antigen (CEA) family that is expressed on a wide variety of cells and holds a complex role in inflammation through its alternate splicing and generation of various isoforms, mediating intricate mechanisms of modulation and dysregulation. …”
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Integrative multiomics reveals common endotypes across PSEN1, PSEN2, and APP mutations in familial Alzheimer’s disease by Phoebe Valdes, Andrew B. Caldwell, Qing Liu, Michael Q. Fitzgerald, Srinivasan Ramachandran, Celeste M. Karch, Dominantly Inherited Alzheimer Network (DIAN), Douglas R. Galasko, Shauna H. Yuan, Steven L. Wagner, Shankar Subramaniam

“…Results We identified common disease endotypes, such as dedifferentiation, dysregulation of synaptic signaling, repression of mitochondrial function and metabolism, and inflammation. We ascertained the master transcriptional regulators associated with these endotypes, including REST, ASCL1, and ZIC family members (activation), and NRF1 (repression). …”
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