Anti-Inflammatory Effects of Protein Kinase Inhibitor Pyrrol Derivate by Halyna M. Kuznietsova, Maryna S. Yena, Iryna P. Kotlyar, Olexandr V. Ogloblya, Volodymyr K. Rybalchenko

“…MI-1 restored colon mucosa integrity and decreased mucosa inflammation down to GTI = 0.5 and leveled PCG and SOD. …”
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Mitigative Effect of Erythromycin on PMMA Challenged Preosteoblastic MC3T3-E1 Cells by Yi Shen, Weili Wang, Xiaomiao Li, David C. Markel, Weiping Ren

“…Recent approaches to limiting AL have focused on inhibiting periprosthetic inflammation and osteoclastogenesis. Questions/Purposes. …”
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Therapeutic Role of Protein Tyrosine Phosphatase 1B in Parkinson’s Disease via Antineuroinflammation and Neuroprotection In Vitro and In Vivo by Chien-Wei Feng, Nan-Fu Chen, Te-Fu Chan, Wu-Fu Chen

“…Several previous studies mentioned that protein tyrosine phosphatase 1B (PTP1B) acted as a negative regulator of the insulin signal pathway and played a significant role in the inflammation process. However, few studies have investigated the role of PTP1B in the central nervous system. …”
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Successful Treatment of Plasma Cell-Rich Acute Rejection Using Bortezomib: A Case Report by Sara Hashemi, Reut Hod-Dvorai, Rebecca Tong, Liye Suo

“…Following the treatment, the patient’s serum creatinine level trended down to 2 mg/dL, and a second repeat biopsy after 4 months showed a significant treatment effect with complete resolution of interstitial inflammation and decreased chronicity. Bortezomib is a proteasome inhibitor that prevents cell proliferation by inducing apoptosis in plasma cells and has shown great promise as a therapeutic agent for multiple myeloma. …”
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The The Evaluation of Clove oil Concentration on Physicochemical and Antimicrobial Activity in the Laponite Gel Delivery System by Dian Eka Ermawati, Susanti Putriana, Tri Setyowati, Tabita Putri Kuntari, Fitri Salsabila, M. Nur Dewi Kartikasari

“…Recurrent Aphthous Stomatitis (SAR) is inflammation in the oral mucosa. One of the factors that can cause SAR is bacterial and fungal infections of the oral mucosa. …”
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cGAS-STING targeting offers therapy choice in lung diseases by Yu Wang, Xuan Zhang, Weixue Wang, Yi Zhang, Joshua S. Fleishman, Hongquan Wang

“…However, chronic and aberrant activation of the cGAS-STING axis results in inflammatory and autoimmune diseases. cGAS-STING has emerged as a vital mechanism driving inflammation-related diseases, including lung diseases. …”
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Expression of the Receptor for Advanced Glycation End Products in Epicardial Fat: Link with Tissue Thickness and Local Insulin Resistance in Coronary Artery Disease by Elena Dozio, Elena Vianello, Silvia Briganti, John Lamont, Lorenza Tacchini, Gerd Schmitz, Massimiliano Marco Corsi Romanelli

“…Increased expression of receptor for advanced glycation end products (RAGE) in adipose tissue has been associated with inflammation, adipocyte hypertrophy, and impaired insulin signal. …”
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Management of patients with dry eye syndrome with systemic autoimmune and infectious diseases by G.M. Chernakova, E.A. Kleshcheva

“…Fyodorov Eye Microsurgery Federal State Institution, Moscow<br> ² Russian Medical Academy of Continuous Professional Education, Moscow<br> <br> It is known, that instability and hyperosmolarity of the tear film, inflammation and damage to the eye surface play a leading role in the pathogenesis of dry eye syndrome (DES), as well as neurosensory disorders. …”
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Comparative Analysis of Biomarkers in Type 2 Diabetes Patients With and Without Comorbidities: Insights Into the Role of Hypertension and Cardiovascular Disease by Symeon Savvopoulos, Haralampos Hatzikirou, Herbert F Jelinek

“…Objectives: Diabetes may have a common etiology based on inflammation and oxidative stress that may provide additional information about disease progression and treatment options. …”
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Enhancement of Anti-Inflammatory and Osteogenic Abilities of Mesenchymal Stem Cells via Cell-to-Cell Adhesion to Periodontal Ligament-Derived Fibroblasts by Keita Suzuki, Naoyuki Chosa, Shunsuke Sawada, Naoki Takizawa, Takashi Yaegashi, Akira Ishisaki

“…The subsequent adherence of MSCs to PDL-Fs plays an immunomodulatory role to terminate inflammation during wound healing and upregulates the expression stem cell markers to enhance the stemness of MSCs, thereby facilitating bone formation in damaged PDL tissue.…”
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Cardiovascular Risk in Systemic Autoimmune Diseases: Epigenetic Mechanisms of Immune Regulatory Functions by Chary López-Pedrera, Carlos Pérez-Sánchez, Manuel Ramos-Casals, Monica Santos-Gonzalez, Antonio Rodriguez-Ariza, Ma José Cuadrado

“…Traditional risk factors, as well as systemic inflammation mediators, including cytokines, chemokines, proteases, autoantibodies, adhesion receptors, and others, have been implicated in the development of these vascular pathologies. …”
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Vimentin-Rab7a Pathway Mediates the Migration of MSCs and Lead to Therapeutic Effects on ARDS by Kai Wang, Boxiang Du, Yan Zhang, Congyou Wu, Xiuli Wang, Xu Zhang, Liwei Wang

“…As a result, we found that MSCs from wild-type mice can significantly alleviate ARDS and reduce lung inflammation, while vimentin gene knockout reduced the therapeutic effect of MSCs in ARDS. …”
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Humoral and Cellular Immune Regulation in Albino Rat Exposed to Glyphosate and Aluminum Phosphide by Ujuamala Ezeani, Onyemaechi Afonne, Michael Ezeani

“…The chronic effects of these cytotoxic actions could potentially lead to tissue damage or trauma, resulting in subsequent chronic inflammation.…”
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Neutrophil-to-lymphocyte ratio as a novel predictor of sarcopenia in maintenance hemodialysis patients: a cross-sectional study exploring associations across body composition categ... by Yogesh M., Parth Anilbhai Parmar, Soumya Sharma, Jay Pareshbhai Kakadiya, Dhruv Lakkad

“…The neutrophil-to-lymphocyte ratio (NLR), an easily obtainable marker of inflammation, may predict sarcopenia risk. This study aimed to investigate the association between NLR and sarcopenia risk in maintenance hemodialysis patients, examining this association in the context of obesity. …”
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Rectal application of a highly osmolar personal lubricant in a macaque model induces acute cytotoxicity but does not increase risk of SHIV infection. by Sundaram A Vishwanathan, Monica R Morris, Richard J Wolitski, Wei Luo, Charles E Rose, Dianna M Blau, Theodros Tsegaye, Sherif R Zaki, David A Garber, Leecresia T Jenkins, Tara C Henning, Dorothy L Patton, R Michael Hendry, Janet M McNicholl, Ellen N Kersh

“…Thus neither the lubricant-induced type/extent of inflammation nor the presence of PQ15 affected infection risk. …”
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The protective effect of carnosic acid on dextran sulfate sodium-induced colitis based on metabolomics and gut microbiota analysis by Changhui Du, Zhenjie Li, Jing Zhang, Ni Yin, Lirong Tang, Jie Li, Jingyin Sun, Xiaoqing Yu, Wei Chen, Hang Xiao, Xian Wu, Xuexiang Chen

“…We found that CA effectively attenuated DSS-stimulated colitis in mice, as evidenced by reduced disease activity index (DAI), and systemic and colonic inflammation. Additionally, CA restored microbial diversity and improved the composition of gut microbiota in DSS-treated mice. …”
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Assessing the Comorbidity Cycle Between Psoriasis and Addiction Based on ICD Coding in the Stockholm Psoriasis Cohort by Hannah Wecker, Axel Svedbom, Fabio Sánchez Orrego, Stefanie Ziehfreund, Mona Ståhle, Alexander Zink

“…Nevertheless, both substance abuse triggering psoriasis and chronic psoriasis inflammation triggering addictions have to be considered. …”
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Real-world assessment of effectiveness and safety of filgotinib in 286 patients with ulcerative colitis in 9 UK centres by David Young, Sohail Rahmany, Deborah Taylor, Emma Davis, Michael Colwill, Sonia Kalyanji Mehta, Roisin Campbell, Karl Hazel, Karishma Sethi-Arora, Susan Ritchie, Ashley I Heinson, Helen Moyses, Keith Bodger, Emma Johnston, Lucy Hicks, Anjan Dhar, Jimmy Limdi, Rachel Cooney, John Paul Seenan, Kamal Patel, Alissa Walsh, Fraser Cummings

“…Effectiveness outcomes were assessed in patients with combined clinical disease activity and objective evidence of inflammation at filgotinib initiation. Results: Data were analysed for a total of 286 patients with a median follow-up time of 229 (IQR 113–324) days. …”
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Clinical outcomes and anti-inflammatory mechanisms predict maximum heart rate improvement after physical activity training in individuals with psychiatric disorders and comorbid ob... by Pau Soldevila-Matías, Joan Vicent Sánchez-Ortí, Patricia Correa-Ghisays, Vicent Balanzá-Martínez, Gabriel Selva-Vera, Roberto Sanchis-Sanchis, Néstor Iglesias-García, Manuel Monfort-Pañego, Pilar Tomás-Martínez, Víctor M Victor, Benedicto Crespo-Facorro, Constanza San Martin Valenzuela, José Antonio Climent-Sánchez, Rosana Corral-Márquez, Inmaculada Fuentes-Durá, Rafael Tabarés-Seisdedos

“…Peripheral blood biomarkers of inflammation, oxidative stress, vascular mechanisms, and metabolic activity, as well as neurocognitive and functional performance were assessed twice, before and after intervention. …”
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Adalimumab for endoscopic and histopathological mucosal healing in paediatric patients with moderate to severe Crohn’s disease by Edyta Szymanska, Maciej Dadalski, Wieslawa Grajkowska, Sylwia Szymanska, Maciej Pronicki, Jaroslaw Kierkus

“…Conclusions : Biological therapy with ADA has a positive impact on endoscopic mucosal healing in paediatric patients with CD, which is not associated with histological evidence of suppression of inflammation. Endoscopic MH correlates better than microscopic one with clinical remission.…”
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