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6661
Role of Vitamin D Status and Alterations in Gut Microbiota Metabolism in Fibromyalgia-Associated Chronic Inflammatory Pain
Published 2025-01-01“…We aimed to investigate the relationship between vitamin D status and gut dysbiosis markers in fibromyalgia (FM)-associated chronic inflammation. <b>Methods</b>: Blood samples were collected from sixty-eight female FM patients (49.9 ± 12.35 years). …”
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6662
Clinicopathological relationship between PM2.5 exposure and acute exacerbations of chronic obstructive pulmonary disease
Published 2025-02-01“…Conclusion: Elevated PM2.5 exposure significantly increases the risk of AECOPD, linked to heightened inflammation, pulmonary fibrosis, and diminished pulmonary function, and the majority of these patients are over 60 years old or are smokers. …”
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6663
Computer-guided identification of novel inhibitors of apoptosis-signaling kinase 1 from Spondia mombim bioactive compounds against colorectal cancer
Published 2025-01-01“…Abstract Background Apoptosis-signaling kinase 1 is a MAPKKK (mitogen-activated protein kinase) overexpressed in various types of human cancer including colorectal cancer. It mediates inflammation and apoptosis and promotes cell proliferation through the transcription of cyclin D1. 5-Fluorouracil remains one of the primary recommended drugs to manage colorectal cancer. …”
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6664
Helicobacter pylori reduces METTL14-mediated VAMP3 m6A modification and promotes the development of gastric cancer by regulating LC3C-mediated c-Met recycling
Published 2025-01-01“…Abstract Helicobacter pylori (H. pylori) plays an important role in the malignant transformation of the gastric mucosa from chronic inflammation to cancer. However, the mechanisms underlying the epigenetic regulation of gastric carcinogenesis mediated by H. pylori remain unclear. …”
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6665
Development of delayed pulmonary toxicities and transcriptional changes in pre-existing interstitial lung disease mice after partial thoracic irradiation
Published 2025-02-01“…DAD with progressive inflammation and fibrosis in bilateral lungs contributed to severe or even fatal complications after partial thoracic irradiation. …”
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6666
The association between periodontal disease and adverse pregnancy outcomes: a bibliometric analysis from 2000 to 2023
Published 2025-01-01“…BackgroundPeriodontal disease (PD) refers to a chronic inflammatory disorder affecting the supporting tissues of the teeth triggered by bacterial infection and is recognized to promote systemic inflammation, leading to dysfunction in specific organs. …”
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6667
Artificially Cultivated Ophiocordyceps sinensis Alleviates Diabetic Nephropathy and Its Podocyte Injury via Inhibiting P2X7R Expression and NLRP3 Inflammasome Activation
Published 2018-01-01“…It is known that chronic low-grade inflammation contributes to the initiation and development of both diabetes and diabetic nephropathy (DN), so we designed this study to investigate the role of P2X7R and NLRP3 inflammasome in DN pathogenesis and the antagonistic effects of artificially cultivated Ophiocordyceps sinensis (ACOS). …”
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6668
Secretion of S100A8, S100A9, and S100A12 by Neutrophils Involves Reactive Oxygen Species and Potassium Efflux
Published 2015-01-01“…These cytoplasmic proteins are secreted by neutrophils at sites of inflammation via alternative secretion pathways of which little is known. …”
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6669
A bibliometric analysis of exosomes in aging from 2007 to 2023
Published 2025-01-01“…The keyword analysis revealed that future research on exosomes in aging will possibly focus on “inflammation, cellular senescence, angiogenesis, insulin resistance, and Alzheimer's disease.”ConclusionWe identified the research trends of exosomes in the field of aging through this bibliometric analysis. …”
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6670
Multi-omics architecture of childhood obesity and metabolic dysfunction uncovers biological pathways and prenatal determinants
Published 2025-01-01“…This high-risk cluster exhibits a complex interplay across many biological pathways, predominantly underscored by inflammation-related cascades. Further, by incorporating comprehensive information from the environmental risk-scape of the critical pregnancy period, we identify pre-pregnancy body mass index and environmental pollutants like perfluorooctanoate and mercury as important determinants of the high-risk cluster. …”
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6671
Fermented sugarcane juice-derived probiotic Levilactobacillus brevis RAMULAB54 enhances lipid metabolism and glucose homeostasis through PPAR-γ activation
Published 2025-01-01“…Histopathology showed improved tissue structure, indicating LB13243's potential to reduce hyperglycemia and hyperlipidemia by modulating lipid metabolism and inflammation. LB13243's modulation of PPAR-γ suggests it as a promising natural option for managing diabetes and hyperlipidemia. …”
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6672
Extracellular vesicles from fifth-stage larval Angiostrongylus cantonensis upregulate cholesterol biosynthesis and suppress NLRP2-associated inflammatory responses in mouse astrocy...
Published 2025-01-01“…Based on the transcriptomic data, we observed a downregulated trend of NOD-like receptors (NLRs) protein 2 (NLRP2), a key regulator of brain inflammation, in mouse astrocytes treated with L5 EVs. …”
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6673
Single‐cell landscape of the intrahepatic ecosystem in alcohol‐related liver disease
Published 2025-01-01“…In addition, our results also uncovered the important alterations of nonparenchymal cells, especially macrophages and T/NK populations that responsible for active inflammation responses in alcohol‐related hepatitis and immunosuppressive microenvironment in advanced cirrhosis livers, which likely facilitated the malignant progression of ALD. …”
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6674
Investigation of Novel Aronia Bioactive Fraction-Alginic Acid Nanocomplex on the Enhanced Modulation of Neuroinflammation and Inhibition of Aβ Aggregation
Published 2024-12-01“…The AANCP was administered to scopolamine-injected Balb/c mice, and to BV2 microglia treated with lipopolysaccharide (LPS) and amyloid beta (Aβ). Inflammation responses were measured via qPCR and ELISA in vitro, and cognitive functions were measured via behavior tests in vivo. …”
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6675
T cell related osteoimmunology in fracture healing: Potential targets for augmenting bone regeneration
Published 2025-03-01“…In this review, the role of T cell immunity in fracture healing has been summarized, and the modulatory effects of T cell immunity in inflammation, bone formation and remodeling have been highlighted. …”
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6676
Okra juice used for rapid wound healing through its bioadhesive and antioxidant capabilities
Published 2025-04-01“…Both in vitro and in vivo evaluations indicate that it can effectively accelerate the healing process by sealing the wound, improving epithelial regeneration and angiogenesis, and alleviating inflammation. In addition, it has improved biocompatibility compared to commercial medical glue. …”
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6677
Impact of Methotrexate and 7‐Hydroxymethotrexate Exposure on Renal Toxicity in Pediatric Non‐Hodgkin Lymphoma
Published 2025-01-01“…Moreover, 7‐OHMTX could produce crystalline‐like deposits within the renal tubules under acidic conditions or induce renal inflammation, oxidative stress, and cell apoptosis through various signaling pathways, ultimately leading to kidney damage. …”
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6678
Association of Serum Ferritin Levels With Obstructive Sleep Apnea in Overweight/Obese US Populations: A Population-Based Study From the NHANES
Published 2025-02-01“…In the future, further research is needed to explore the potential associations between ferritin, inflammation, obesity, and OSA.Keywords: ferritin, obstructive sleep apnea, overweight/obese, all-cause mortality, NHANES…”
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6679
uN2CpolyG-mediated p65 nuclear sequestration suppresses the NF-κB-NLRP3 pathway in neuronal intranuclear inclusion disease
Published 2025-02-01“…Emerging clinical evidence suggests that inflammation contributes to NIID pathogenesis, yet the underlying molecular mechanisms remain elusive. …”
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6680
Hydrogen-oxygen mixture inhalation as an adjunctive treatment to home-based exercise in older patients with knee osteoarthritis: an open-label, blinded-endpoint, randomized control...
Published 2025-01-01“…Secondary outcomes included inflammation levels (hs-CRP, NLR, PLR, LMR), Chair Stand Test (CST), Timed Up and Go (TUG), 36-item short-form health survey (SF-36), Exercise Adherence Rating Scale (EARS), and adverse events.ResultsA total of 121 subjects were enrolled, with an average age of 81.2 years, and 80.2% were female. …”
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