Lymphocytic Esophagitis: Navigating an Uncharted Territory by Ahmad Jradi MD, Kaline Maya Khoury MD, Karam Karam MD, Dr. Ihab I. El Hajj MD, Elias Fiani MD

“…Lymphocytic esophagitis (LE) is an uncommon subtype of esophagitis defined by persistent esophageal inflammation characterized by a high count of intraepithelial lymphocytes with scarce granulocytes. …”
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L-Carnitine Improves Muscle Nutrient Metabolism and Intestinal Health in High-Fat-Fed Carp (Cyprinus carpio) by Xianglin Cao, Rongjie Yuan, Yi Guo, Mengtao Jia, Yinyin Wei, Jiameng zhou, Han Cui, Baohua Li, Jianjun Chen

“…L-Carnitine increased the expression of genes related to intestinal tight junction proteins (claudin-2, occludin, and zo-1), improved the expression of genes related to intestinal inflammation, and enhanced the physical barrier function and organization of the intestine. …”
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The role of the corticotropin-releasing hormone and its receptors in the regulation of stress response by E. V. Sukhareva

“…Disturbances of the CRH system regulation are directly related to such disorders: mental pathologies (depression, anxiety, addictions), deviations of neuroendocrinological functions, inflammation, as well as the onset and development of neurodegenerative diseases such as Alzheimer’s disease. …”
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Triptolide Inhibits Th17 Response by Upregulating microRNA-204-5p and Suppressing STAT3 Phosphorylation in Psoriasis by Qi He, Xingyue Wu, Quan Shi

“…Psoriasis is an immune and inflammation-related skin disease. Triptolide with immunosuppressive and anti-inflammatory properties has been utilized for psoriasis treatment. …”
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The Therapeutic Effect of Adipose-Derived Mesenchymal Stem Cells for Radiation-Induced Bladder Injury by Xuefeng Qiu, Shiwei Zhang, Xiaozhi Zhao, Kai Fu, Hongqian Guo

“…The histological and ELISA results indicated that the fibrosis and inflammation within the bladder were ameliorated by AdMSCs. …”
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A systematic in vitro study of the effect of normoglycaemic and hyperglycaemic conditions on the biochemical and cellular interactions of clinically-available wound dressings with... by Shirin Saberianpour, Gianluca Melotto, Rachel Forss, Lucy Redhead, Susan Sandeman, Nadia Terrazzini, Dipak Sarker, Matteo Santin

“…Dressings presenting absorbent layers made of synthetic, non-woven fibres supported the adhesion of monocytes macrophages and stimulate the release of factors known to play a role in the chronic inflammation. Non-woven absorbent layers based on carboxymethyl cellulose mainly stimulating the iNOS, an enzyme producing free radicals; in the case of Kerracel this was combined with a swelling of fibres preventing the penetration of cells. …”
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Recent Advances and Perspectives on the Use of Mineralocorticoid Receptor Antagonists for the Treatment of Hypertension and Chronic Kidney Disease: A Review by Kisho Miyasako, Yujiro Maeoka, Takao Masaki

“…Overactivation of MR triggers inflammation and fibrosis, which exacerbates kidney damage and accelerates disease progression. …”
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Impaired Fas-Fas Ligand Interactions Result in Greater Recurrent Herpetic Stromal Keratitis in Mice by Xiao-Tang Yin, Tammie L. Keadle, Jessicah Hard, John Herndon, Chloe A. Potter, Chelsea R. Del Rosso, Thomas A. Ferguson, Patrick M. Stuart

“…One of the key factors that limit inflammation of the cornea is the expression of Fas ligand (FasL). …”
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OK-432 Acts as Adjuvant to Modulate T Helper 2 Inflammatory Responses in a Murine Model of Asthma by Cheng-Jang Wu, Pin-Hsun Tseng, Cheng-Chi Chan, Sara Quon, Li-Chen Chen, Ming-Ling Kuo

“…Prior vaccination with OK-432 formulated against OVA attenuated lung eosinophilic inflammation and Th2 cytokine responses that were caused by challenging with OVA through the airway. …”
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Modulation of gut microbiota, up-regulation of ZO-1, and promotion of metabolism as therapeutic mechanisms of indole-3-carbinol against obesity in mice by XuWen Mao, Guliruoyi Paerhati, Yuche Wu, Lu Feng Cheng

“…We aim to ascertain whether I3C mediates the relations between mouse gut microbiota, intestinal barrier function, and metabolism to treat obesity in mice.MethodsThe experimental analyses focused on the changes in lipid distribution, inflammatory cytokines, glucose tolerance, gut microbiota composition, and serum metabolomics of 60 C57BL/6N mice.ResultsThe experimental results demonstrated that I3C reduced body weight, hepatic steatosis, and systemic inflammation and improved insulin resistance in mice on a high-fat diet (HFD). …”
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Outcome of Excision with Primary Midline Closure for Sacrococcygeal Pilonidal Sinus Disease by Bahzad Waso Hamad

“…Inclusion criteria was all patients with chronic midline located sinuses without evidence of acute inflammation. Exclusion criteria was all infected ,off midline located sinuses and recurrent sinuses. …”
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Examining the Effect of Consuming C8 Medium-Chain Triglyceride Oil for 14 Days on Markers of NLRP3 Activation in Healthy Humans by Helena Neudorf, Garett Jackson, Jonathan P. Little

“…Chronic, low-grade inflammation is associated with the development of numerous diseases and is mediated in part by overactivation of the NLRP3 inflammasome. …”
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Serum Glycoproteomics and Identification of Potential Mechanisms Underlying Alzheimer’s Disease by Naphatthakarn Kerdsaeng, Sittiruk Roytrakul, Suwannee Chanprasertyothin, Piangporn Charernwat, Sirintorn Chansirikarnjana, Piyamitr Sritara, Jintana Sirivarasai

“…Unique AD glycoproteins were associated with numerous pathways, including Alzheimer’s disease-presenilin pathway (16.6%), inflammation pathway mediated by chemokine and cytokine signaling (9.2%), Wnt signaling pathway (8.2%), and apoptosis signaling pathway (6.7%). …”
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The Effectiveness and Safety of Probiotic Supplements for Psoriasis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials and Preclinical Trials by Liuting Zeng, Ganpeng Yu, Yang Wu, Wensa Hao, Hua Chen

“…Two RCTs showed that probiotics can improve PASI and thereby improve the condition. For inflammation-related indicators, only one RCT showed that probiotics can improve the levels of CRP and TNF-α but have no obvious improvement effect on IL6. …”
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Androgenic Anabolic Steroids Cause Thiol Imbalance in the Vascular Endothelial Cells by Halszka Ponamarczuk, Maria Światkowska, Marcin Popielarski

“…Conclusions: These changes may be related to a thiol-disulfide imbalance and vascular endothelium dysfunction, that are often correlated with abnormal platelet aggregation, inflammation, increased vascular permeability, and vascular smooth muscle cell proliferation—all of which are observed in athletes who abuse AASs.…”
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Histopathological evaluation of green betel leaf extract ointment on incision wounds infected with Staphylococcus aureus in wistar rats by Winda Irawati Zebua, Linda Chiuman, Edy Fachrial

“…Incision wounds are particularly vulnerable to infections, with Staphylococcus aureus being a common causative agent of secondary complications, including prolonged inflammation and delayed healing. This study investigates the efficacy of green betel leaf extract ointment in accelerating the healing process of incision wounds in Wistar rats infected with Staphylococcus aureus. …”
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The modern use of hydroxyurea for children with sickle cell anemia by Charles T. Quinn, Russell E. Ware

“…Additional benefits of hydroxyurea beyond HbF induction include lower neutrophil and platelet counts, reduced inflammation, and improved rheology. Toxicities of hydroxyurea in SCA are typically mild and predictable; modest cytopenia is expected and actually therapeutic, while occasional gastrointestinal and cutaneous manifestations are well-tolerated. …”
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A Single 60 mg Dose of Denosumab Might Improve Hepatic Insulin Sensitivity in Postmenopausal Nondiabetic Severe Osteoporotic Women by Elena Passeri, Stefano Benedini, Elena Costa, Sabrina Corbetta

“…The pathway has been also suggested to influence glucose metabolism as observed in chronic low inflammation. Aim. To test whether systemic blockage of RANKL by the monoclonal antibody denosumab influences glucose metabolism in osteoporotic women. …”
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Network Pharmacology Analysis of the Therapeutic Potential of Colchicine in Acute Lung Injury by Fei Sun, Lijuan Zhang, Lulu Shen, Chunman Wang

“…Functional enrichment analysis highlighted several inflammation-related pathways, such as cytokine-mediated signaling pathway, CXCR chemokine receptor binding, NF-kappa B signaling pathway, TNF signaling pathway, and IL-17 signaling pathway. …”
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Quantitative Evaluation of Apically Extruded Debris During Root Canal Instrumentation with Self-Adjusting File, Reciprocating File, and Rotary Files: An In Vitro Study by Pratik A. Burad, Kushal U. Fuladi, Ankita D. Ramteke, Aishwarya M. Akotkar, Vidya A Mokhade, Anil Bhagat

“…Background: To prevent postoperative problems, successful debridement, disinfection, and obturation are essential components of endodontic therapy. Inflammation and flare ups may result from the apical ejection of bacteria, infected dentin, necrosed pulp tissue, and irrigants. …”
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