Dysfunction of G Protein-Coupled Receptor Kinases in Alzheimer's Disease by William Z. Suo, Longxuan Li

“…It also promotes an evil cycle to further increase Beta-amyloid accumulation and exaggerates brain inflammation, possibly even the basal forebrain cholinergic degeneration. …”
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ANTIBACTERIAL ACTIVITY OF MARIGOLD FLOWER (TAGETES ERECTA L.) ETHANOL EXTRACT CREAM AGAINST STAPHYLOCOCCUS AUREUS by Putu Lakustini Cahyaningrum, A.A A Sauca Sunia Widyantari

“…Background: Acne is caused by inflammation and obstruction of the skin pores, which traps excess oil (acne vulgaris). …”
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Sulfasalzine in the management of pure axial spondyloarthritis: Need to have a relook! by Subramanian Shankar, Arun Hegde

“…Cochrane metaanalysis reveals that ASAS 40 response (40% improvement in pain, function, and inflammation) is in the range of 25%-40% for various biologics over 24 weeks. …”
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Crossroads of Neurology and Virology: The Neurological Manifestations of COVID-19 by Kirolos Eskandar

“…Results: The review identifies multiple mechanisms by which SARS-CoV-2 invades the nervous system, including direct viral entry and systemic inflammation. Acute neurological manifestations include encephalitis, stroke, and Guillain-Barré syndrome, while long-term sequelae encompass cognitive impairment, neurodegeneration, and psychiatric disorders. …”
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Prepuce: Phimosis, Paraphimosis, and Circumcision by Yutaro Hayashi, Yoshiyuki Kojima, Kentaro Mizuno, Kenjiro Kohri

“…Balanoposthitisis a common inflammation occurring in 4–11% of uncircumcised boys. …”
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Dendritic Cells and Their Multiple Roles during Malaria Infection by Kelly N. S. Amorim, Daniele C. G. Chagas, Fernando B. Sulczewski, Silvia B. Boscardin

“…This ability relies on the presence of numerous surface and intracellular receptors capable of sensing microbial components as well as inflammation and on a very efficient machinery for antigen presentation. …”
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Epithelial mesenchymal transition and cancer stem cell markers in oral epithelial dysplasia and oral squamous cell carcinoma by Burcu Tokozlu, Özlem Özer Yücel, Sibel E. Gültekin, Leyla Arslan Bozdağ

“…OSCC cases showed significantly higher CD133 immunoreactivity and inflammation scores and significantly decreased E-cadherin expression compared to OED and OEH groups. …”
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Secondary endolymphatic hydrops: a clinical and literature overview by Aïna Venkatasamy, Aïna Venkatasamy, Aïna Venkatasamy, Aïna Venkatasamy, Anne R. J. Péporté

“…Secondary endolymphatic hydrops may result from cerebellopontine angle tumors, longstanding inner ear conditions, inner ear malformations, intracranial hypotension and recent investigations have highlighted the role of trauma and inflammation as key factors in SEH development.DiscussionDespite the diverse etiologies of SEH, the findings suggest that many of these conditions share a common final pathway in disrupting endolymphatic fluid balance. …”
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Increased Apoptosis and Proliferative Capacity are Early Events in Cyst Formation in Autosomal-Dominant, Polycystic Kidney Disease by Salwa Ibrahim

“…The development of heavy interstitial inflammation could contribute to progressive tubulointerstitial scarring, leading to progressive renal failure.…”
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Thymus and activation-regulated chemokine (CCL17) as a clinical biomarker in atopic dermatitis: significance and limitations in the new treatment era by Yoko Kataoka

“…The fallacy that eczema is always visible often hinders successful treatment, when there is subclinical inflammation which is inferable from the TARC level. …”
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Repetitive Noninvasive Monitoring of HSV1-tk-Expressing T Cells Intravenously Infused into Nonhuman Primates Using Positron Emission Tomography and Computed Tomography with F-FEAU by Gianpietro Dotti, Mei Tian, Barbara Savoldo, Amer Najjar, Laurence J.N. Cooper, James Jackson, Amanda Smith, Osama Mawlawi, Rajesh Uthamanthil, Agatha Borne, David Brammer, Vincenzo Paolillo, Mian Alauddin, Carlos Gonzalez, David Steiner, William K. Decker, Frank Marini, Steven Kornblau, Catherine M. Bollard, Elizabeth J. Shpall, Juri G. Gelovani

“…Here we report the application of repetitive PET-CT imaging with [ 18 F]fluoro-5-ethyl-1-beta-D-arabinofuranosyluracil ( 18 F-FEAU) in two nonhuman primates demonstrating that autologous polyclonal macaque T lymphocytes activated and transduced with a retroviral vector encoding for the sr39 mutant herpes simplex virus 1 thymidine kinase ( sr39HSV1-tk ) reporter gene can be detected after intravenous infusion in discrete lymphoid organs and in sites of inflammation. This study represents a proof of principle and supports the application of 18 F-FEAU PET-CT imaging for monitoring the distribution of intravenously administered sr39HSV1-tk gene-transduced CTLs in humans.…”
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Evaluation of Tumour Necrosis Factor-Alpha and Interleukin-1beta in an Experimental Pyelonephritis Model Induced with Planktonic and Biofilms Cells of Pseudomonas aeruginosa by Rahul Mittal, Saroj Sharma, Sanjay Chhibber, Kusum Harjai

“…Urinary tract infections may induce severe inflammation, transient impairment in renal function and scar formation, ranging in severity from acute symptomatic pyelonephritis to chronic pyelonephritis, and have the potential to lead to renal failure and death. …”
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Antioxidant Vitamins in the Prevention of Atrial Fibrillation: What Is the Evidence? by Sonia Rasoli, Nicholaos Kakouros, Leanne Harling, Philemon Gukop, Manish Soni, Thanos Athanasiou, Antonios Kourliouros

“…Recently, increasing evidence implicates oxidative stress and inflammation in the pathogenesis of AF. We searched the literature for evidence to support the use of antioxidant vitamins C and E in the prevention of AF. …”
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Design and synthesis of amino-substituted N-arylpiperidinyl-based inhibitors of the (immuno)proteasome by Gobec Martina, Obreza Aleš, Jukič Marko, Baumgartner Ana, Mihelčič Nja, Potočnik Špela, Virant Julija, Mlinarič Irena, Stanislav Raščan, Sosič Gobec Izidor

“…The constitutive proteasome and the immunoproteasome represent validated targets for pharmacological intervention in the context of various diseases, such as cancer, inflammation, and autoimmune diseases. The development of novel chemical scaffolds of non-peptidic nature, capable of inhibiting different catalytically active subunits of both isoforms, is a viable approach against these diseases. …”
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Multifocal Multisystem Langerhans Cell Histiocytosis Involving Pituitary Masquerading as Crohn’s Disease: A Case Report and Review of the Literature by Mohd. Ashraf Ganie, Bhanu Malhotra, Manpreet Saini, Arshiya Dutta, Atul Sharma, Kim Vaiphie, Pinaki Dutta

“…Rectal ulcer biopsy showed nonspecific inflammation and necrosis. Hence, he was managed as inflammatory bowel disease (IBD). …”
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Human-Mimic Submuscular and Premuscular Irradiated Rat Model: Histologic Characteristics of the Capsule Tissue in Contact with the Breast Implant by Hyung Bae Kim, Se Young Han, Jin Sup Eom, Hyun Ho Han

“…Based on the tissue in contact with the silicone implant, ADM had a thinner capsule, less inflammation, less fibrosis, and less vascularization than the muscle and chest wall tissues. …”
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Tight junction proteins in glial tumors development and progression by Jakub Moskal, Slawomir Michalak, Slawomir Michalak

“…Several factors, such as neurotransmitters or cytokines, and processes like ischemia/hypoxia, inflammation, tumorigenesis, phosphorylation/dephosphorylation, ubiquitination, and palmitoylation, regulate tight junction proteins. …”
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Total Plasma Exchange for Hypertriglyceridaemia Complicated by Acute Pancreatitis: A Case Report by Dawlat Sany, Wael Ahmed Yousry, Wael Refai, Walid Hassan, Rami Qattan, Yasser Elsahawi

“…Conclusion: The authors suggest treatment with TPE for systemic inflammation and HTGP-induced multiorgan failure. However, further research is necessary.…”
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Mini Review: Anticholinergic Activity as a Behavioral Pathology of Lewy Body Disease and Proposal of the Concept of “Anticholinergic Spectrum Disorders” by Koji Hori, Kimiko Konishi, Misa Hosoi, Hiroi Tomioka, Masayuki Tani, Yuka Kitajima, Mitsugu Hachisu

“…Briefly, because acetylcholine (ACh) regulates not only cognitive function but also the inflammatory system, when ACh downregulation reaches a critical level, inflammation increases, triggering the appearance of cytokines with AA. …”
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The Liver X Receptor Promotes Immune Homeostasis via Controlled Activation of the Innate Immune System in the Liver by Hiroyuki Nakashima, Bradley M. Kearney, Manabu Kinoshita

“…Therefore, the primary role of LXRs is to accelerate efferocytosis without provoking inflammation and facilitate the transfer of free cholesterol from the intracellular space. …”
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