TNF-α as a Therapeutic Target in Acute Pancreatitis — Lessons from Experimental Models by Giuseppe Malleo, Emanuela Mazzon, Ajith K. Siriwardena, Salvatore Cuzzocrea

“…A considerable body of experimental evidence suggests that tumor necrosis factor (TNF)-α plays a major role in several aspects of inflammation and shock. In particular, it is pivotal in many detrimental effects of acute pancreatitis, and it represents a major determinant of the systemic progression and end-organ damage (such as acute lung injury and liver failure) of this pathologic condition. …”
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A Giant Pseudoaneurysm of the Forearm as Unusual Complication of Bacterial Endocarditis by Michele Arcopinto, Teresa Russo, Antonio Ruvolo, Antonio Cittadini, Luigi Saccà, Raffaele Napoli

“…Two weeks after antibiotic therapy was started, he presented with red and painful swelling of the forearm without any sign of systemic inflammation. A giant hematoma connected to the radial artery was detected with ultrasound. …”
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Pylephlebitis Associated with Inferior Mesenteric Vein Thrombosis Treated Successfully with Anticoagulation and Antibiotics in a 37-Year-Old Male by Mohamed Abdallah, Ahmad Gohar, Smitha Naryana Gowda, Hafez M. Abdullah, Ali Al-hajjaj

“…It is a rare condition that usually arises as a complication of an intra-abdominal infection or inflammation. Being rare, it may be overlooked as a differential in cases of abdominal pain when the more common causes have been excluded. …”
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The Controversial C5a Receptor C5aR2: Its Role in Health and Disease by Ting Zhang, Malgorzata A. Garstka, Ke Li

“…Ramifications and controversies about C5aR2 are under debate since its identification, from putative ligands and cellular localization to intracellular signals and pathological roles in inflammation and immunity. The ruleless and even conflicting pro- or anti-inflammatory role of C5aR2 in animal models of diverse diseases makes one bewildered. …”
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Leptomeningeal Enhancement due to Neurosarcoidosis Mimicking Malignancy by Sahara N. Saltijeral, Horiana B. Grosu, Henriette De La Garza, Barbara O’Brien, Gloria Iliescu

“…Subsequently, image-guided fine-needle aspiration of the right upper paratracheal lymph node was performed, and biopsy studies showed noncaseating granulomatous inflammation. Based on the clinical picture, the diagnosis of neurosarcoidosis was made, and high-dose steroids were started and resulted in significant improvement.…”
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Pathogenesis of Helicobacter pylori-Related Gastroduodenal Diseases from Molecular Epidemiological Studies by Yoshio Yamaoka

“…Helicobacter pylori is a major human pathogen that infects the stomach and produces inflammation that is responsible for various gastroduodenal diseases. …”
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Progress on long non-coding RNAs in calcific aortic valve disease by Yan Shen, Jiahui Li, Zehao Zhao, Xiaomin Chen

“…The aortic valve, influenced by factors such as endothelial dysfunction, inflammation, oxidative stress, lipid metabolism disorders, calcium deposition, and extracellular matrix remodeling, undergoes fibrosis and calcification, ultimately leading to stenosis. …”
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A case report of idiopathic hypertrophic pachymeningitis by G. Makarevičius, J. Grigaitė, M. Jokubaitis, A. Klimašauskienė

“… Idiopathic hypertrophic pachymeningitis (IHP) is a condition characterised by diffuse or local thickening and fibrosis of dura matter caused by inflammation of unknown origin. It is a diagnosis of exclusion. …”
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Acute Acalculous Cholecystitis due to Viral Hepatitis A by Safak Kaya, Ahmet Emre Eskazan, Nurettin Ay, Birol Baysal, Mehmet Veysi Bahadir, Arzu Onur, Recai Duymus

“…Inflammation of the gallbladder without evidence of calculi is known as acute acalculous cholecystitis (AAC). …”
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Facial Swelling as a Primary Manifestation of Multiple Myeloma by Anju E. Thomas, Seema Kurup, Renju Jose, Cristalle Soman

“…Facial swellings can be classified into different groups which include acute swellings with inflammation, nonprogressive swellings, and slowly or rapidly progressive swellings. …”
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Extreme Procalcitonin Elevation without Proven Bacterial Infection Related to Amphetamine Abuse by András Lovas, Zsuzsanna Ágoston, Klára Késmárky, Péter Hankovszky, Zsolt Molnár

“…Although PCT has high sensitivity and specificity in differentiating bacterial sepsis from nonbacterial inflammation, our case report shows for the first time that it can be extremely elevated following serious amphetamine intoxication without bacterial infection.…”
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Stay Home: Role of Physical Exercise Training in Elderly Individuals’ Ability to Face the COVID-19 Infection by Walid Kamal Abdelbasset

“…From this point of view, this review suggests that physical exercise training plays a key role in promoting immune system regulation, delaying immunity dysfunction, reducing circulatory inflammation markers, and preventing sarcopenia and thus could prevent the risk of acquiring COVID-19 infection and reduce the complications of recommended self-isolation in older adults and elderly individuals. …”
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Anti-Inflammatory Activity and Free Radical Scavenging Activity of Tridax Procumbens Leaves-Based Chitosan Gel by R. Nandita, M. Jeevitha, Kaarthikeyan Gurumoorthy, Rajeshkumar Shanmugham, Sudarsan Ravichandran, Kethiswar Raj

“…Conclusion: The anti-inflammatory and antioxidant assay results demonstrate that the investigated compounds, notably TP leaves extract-based chitosan gel, have the potential to be effective agents in moderating oxidative stress and lowering inflammation.…”
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Antimetastatic and Anti-Inflammatory Potentials of Essential Oil from Edible Ocimum sanctum Leaves by Thamilvaani Manaharan, Ramaraj Thirugnanasampandan, Rajarajeswaran Jayakumar, Gunasekar Ramya, Gogul Ramnath, M. S. Kanthimathi

“…Our findings indicate that OSEO has both antimetastatic and anti-inflammatory potentials, advocating further investigation for clinical applications in the treatment of inflammation associated cancer.…”
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Study on the regulatory mechanisms of mitochondrial biosynthesis by polyoxometalates by Shan Lei, Bingnian Chen, Li Wang, Jian Li

“…In recent years, polyoxometalates (POMs) have been extensively researched for their potential in treating diabetes, tumors, cancer, inflammation, and other diseases, both in vitro and in vivo. …”
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Pengaruh Positifitas Leukosit Esterase dan Nitrit Urine Terhadap Nilai Neutrophil Lymphocyte Ratio (NLR) pada Pasien Infeksi Saluran Kemih by Citra Dian Kholisha, Siti Zaetun, Yudha Anggit Jiwantoro, Ersandhi Resnhaleksmana

“…Urinary tract infection (UTI) characterized by positivity of leukocyte esterase and nitrite can affect the Neutrophil Lymphocyte Ratio (NLR) value as a reflection of the degree of infection and inflammation by pathogenic microorganisms. Objective: To analyzed the effect of positivity leukocyte esterase and nitrite urine on NLR values in UTI patients. …”
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Selective Induced Altered Coccidians to Immunize and Prevent Enteritis by Helieh S. Oz

“…Coccidiosis causes gastrointestinal inflammation. Antibiotic additives contaminate animal products and enter food chain, consumed by humans with possible allergic, antibiotic resistance and enigmatic side effects. …”
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Deciphering the clinical profile and diagnostic framework of hemophagocytic lymphohistiocytosis in a tertiary care setting by Lipsa Priyadarshini, Meenakshi Mohapatro, Priyadarshini Biswal, Silla Alisha Patro, Devidutta Ramani Ranjan Rout, Simadri Swetapadma Roul

“…Background: Hemophagocytic lymphohistiocytosis (HLH) is a severe hyperinflammatory disorder marked by intense yet ineffective immune activation, resulting in hemophagocytosis, systemic inflammation, and multi-organ dysfunction. The diagnosis has traditionally depended on the 2004 HLH criteria, while the HScore, introduced in 2014, presents an alternative diagnostic approach. …”
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Cytokines and Myelination in the Central Nervous System by Thomas Schmitz, Li-Jin Chew

“…However, genetically altered animals, and models of CNS inflammation and demyelination, have offered great insight into the complexities of neuroimmune interactions that impact oligodendrocyte function. …”
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IL-22 and IDO1 affect immunity and tolerance to murine and human vaginal candidiasis. by Antonella De Luca, Agostinho Carvalho, Cristina Cunha, Rossana G Iannitti, Lucia Pitzurra, Gloria Giovannini, Antonella Mencacci, Lorenzo Bartolommei, Silvia Moretti, Cristina Massi-Benedetti, Dietmar Fuchs, Flavia De Bernardis, Paolo Puccetti, Luigina Romani

“…The ability to tolerate Candida albicans, a human commensal of the gastrointestinal tract and vagina, implicates that host defense mechanisms of resistance and tolerance cooperate to limit fungal burden and inflammation at the different body sites. We evaluated resistance and tolerance to the fungus in experimental and human vulvovaginal candidiasis (VVC) as well as in recurrent VVC (RVVC). …”
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