Rare Case Studies of Bilateral and Symmetric Sacroiliac Disease by Stephen Soloway, Alyxandra M. Soloway, Tyler G. Chin, Timothy Lieske

“…Our goal is to point out the importance of proper evaluation, diagnosis, and importance of inflammatory SIJ disease and conditions that involve SIJ inflammation. Cases. We present three rare conditions presenting with bilateral and symmetric SIJ disease, none of which is ankylosing spondylitis, Crohn’s colitis, ulcerative colitis, psoriatic arthritis, and reactive arthritis (Reiter syndrome); there are reports of concurrent SIJ disease in rheumatoid arthritis and SLE. …”
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Helicobacter pylori and the microbiome in gastric cancer development and treatment: A year in review by P. Vieira, M. Barbedo-Tavares, C. Figueiredo

“…In the context of chronic inflammation mediated by H. pylori, some patients may develop intestinal metaplasia, a lesion that is associated with an increased risk of developing gastric cancer. …”
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Beneficial Effects of Resveratrol-Mediated Inhibition of the mTOR Pathway in Spinal Cord Injury by Jingying Zhou, Xue Huo, Benson O. A. Botchway, Luyao Xu, Xiaofang Meng, Songou Zhang, Xuehong Liu

“…The mammalian target of rapamycin (mTOR) signaling pathway plays an important role in cell death and inflammation in the acute phase and neuroregeneration in the subacute/chronic phases at different times. …”
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Unlocking the potential of antimicrobial peptides: Beta-defensins and the future of cancer diagnostics by Saranya Velmurugan, Gowtham Kumar Subbaraj

“…Studies have shown dysregulation of beta-defensins, particularly hBD-3, may contribute to oral squamous cell carcinoma progression via modulation of inflammation and immune responses. The Beta-defensin index (BDI), which measures hBD-3 and hBD-2 ratios, shows promise as a non-invasive test for early oral cancer detection. …”
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Aldosterone and Its Blockade: A Cardiovascular and Renal Perspective by V. Lahera, V. Cachofeiro, G. Balfagon, J.L. Rodicio

“…A pathophysiological action of aldosterone involves development of extracellular matrix and fibrosis, inflammation, stimulation of reactive oxygen species production, endothelial dysfunction, cell growth and proliferation. …”
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A Patient with Double-Negative VGKC, Peripheral Nerve Hyperexcitability, and Central Nervous System Symptoms: A Postinfectious Autoimmune Disease by Birte Eikeland

“…Research in the last few years has indicated that most voltage-gated potassium channel- (VGKC-) complex antibodies without leucine-rich glioma-inactivated protein 1 or contactin-associated protein-like 2 antibody specificity lack pathogenic potential and are not clear markers for autoimmune inflammation. Here we report on a patient with double-negative VGKC who developed severe peripheral nerve hyperexcitability, central nervous system symptoms with agitation and insomnia, dysautonomia, and systemic symptoms with weight loss, itch, and skin lesions. …”
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Nonalcoholic Fatty Liver Disease and Sarcopenia: Where Do We Stand? by Ivana Mikolasevic, Tajana Pavic, Tajana Filipec Kanizaj, Darija Vranesic Bender, Viktor Domislovic, Zeljko Krznaric

“…Crucial mechanisms involved in sarcopenia-nonalcoholic fatty liver disease (NAFLD) interplay are based on effects of insulin resistance, chronic inflammation, oxidative stress, and crosstalk between organs by secretion of cytokines (hepatokines, adipokines, and myokines). …”
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A Paraneoplastic Syndrome Characterized by Extremity Swelling with Associated Inflammatory Infiltrate Heralds Aggressive Transformation of Myelodysplastic Syndromes/Myeloproliferat... by James K. Mangan, Selina M. Luger

“…In each case, the transformation to AML was preceded by an inflammatory syndrome characterized by unilateral extremity swelling and an associated inflammatory skin infiltrate, as well as other signs of inflammation, including profound hyperferritinemia without evidence of a hemophagocytic syndrome. …”
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Supraventricular Arrhythmias after Thoracotomy: Is There a Role for Autonomic Imbalance? by George Vretzakis, Marina Simeoforidou, Konstantinos Stamoulis, Metaxia Bareka

“…Investigators believe that surgical factors (irritation of the atria per se or on the ground of chronic inflammation of aged atria), direct injury to the anatomic structure of the autonomic nervous system in the thoracic cavity, and postthoracotomy pain may contribute independently or in association with each other to the development of these arrhythmias. …”
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Outer Retinopathies Associated with COVID-19 Infection: Case Reports and Review of Literature by Naima Zaheer, Mohammad O. Tallouzi, N. Ajith Kumar, Sreekanth Sreekantam

“…In conclusion, COVID-19-related thromboinflammatory response can result in localized vascular inflammation and hypoperfusion in any of the retinal capillary plexuses or choriocapillaris resulting in ischemia of the corresponding retinal or choroidal layers.…”
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A Case of Effective Mepolizumab Induction Therapy for Severe Eosinophilic Granulomatosis with Polyangiitis Diagnosed by Eosinophilic Cholecystitis and Interstitial Nephritis by Keita Hattori, Yuri Teramachi, Yoshinori Kobayashi, Takeshi Ito, Takatoshi Morinaga, Hirohumi Tamai, Yoshihiro Yamamoto

“…The histopathological findings of the gallbladder revealed necrotic vasculitis and granulomatous inflammation with marked eosinophilic infiltration. Kidney biopsy also showed marked eosinophilic infiltration in the tubulointerstitial area and eosinophilic tubulitis. …”
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T Helper 17 Cells in Autoimmune Liver Diseases by Masanori Abe, Yoichi Hiasa, Morikazu Onji

“…Because the liver is known to be an important source of transforming growth factor-β and IL-6, which are cytokines that are crucial for Th17 differentiation, it is very likely that Th17 cells contribute to liver inflammation and autoimmunity. In contrast, another distinct subset of T cells, regulatory T cells (Treg), downregulate immune responses and play an important role in maintaining self-tolerance. …”
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THE ROLE OF ANTIBIOTICS IN TREATING SALIVARY GLAND INFECTIONS by Irina Adriana Beuran, Simona Claudia Stefan, Elisabeta Maria Vasca, Robert Marius Grosu, Marius Petrea, Gabriel-Valeriu Popa, Bogdan Oprisan

“…For example, bacteria such as Staphylococcus aureus and Streptococcus, commonly involved in salivary gland infections, respond well to antibiotic therapy, which reduces inflammation and associated pain.…”
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Retinal Toxicity after Initial Administration of Nivolumab and Ipilimumab by Adnan Kilani, Efstathios Vounotrypidis, Susanna F. König, Armin Wolf

“…ICIs can induce significant ocular side effects. As ocular inflammation can be well controlled using systemic steroids, treatment with ICIs can be continued whenever possible, in particular, if there is a good treatment response of the systemic malignancy.…”
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Amyand’s Hernia, State of the Art and New Points of View by Guido Mantovani, Michela De Angelis, Francesco Di Lecce, Annalisa Pascariello, Domenico Risio, Luigi Boccia

“…Treatment of AH depends on grade of appendix inflammation and/or perforation. The technique utilized to repair hernia depends largely on surgeon’s preferences; the presence of inflamed or perforated appendix is not an absolute contraindication for using a prosthetic mesh.…”
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Anti-inflammatory and analgesic effects of Filipendula ulmaria extract by Lyubomir Marinov, Georgi Momekov, Yulian Voynikov, Dimitrina Zheleva-Dimitrova, Reneta Gevrenova, Vessela Balabanova, Iliya Mangarov, Irina Nikolova

“…The results revealed a dose-dependent moderate inhibition of the inflammation and pain induced by 3 days of oral pretreatment with methanolic extract of F. ulmaria extracts. …”
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Secondary Hemophagocytic Syndrome: The Importance of Clinical Suspicion by Cristina Oliveira, Sérgio Chacim, Isabel Ferreira, Nelson Domingues, José Mário Mariz

“…Clinically, patients present signs of severe inflammation, with unremitting fever, cytopenias, spleen enlargement, phagocytosis of bone marrow elements, hypertriglyceridemia, and hypofibrinogenemia. …”
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Positive and Negative Regulation of Cellular Immune Responses in Physiologic Conditions and Diseases by S. Viganò, M. Perreau, G. Pantaleo, A. Harari

“…After clearance or control of the pathogen, the effector immune response must be terminated in order to avoid tissue damage and chronic inflammation and this process involves coinhibitory molecules. …”
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Development of Two Types of Skin Cancer in a Patient with Systemic Sclerosis: a Case Report and Overview of the Literature by Firdevs Ulutaş, Erdem Çomut, Veli Çobankara

“…Fibrogenesis, chronic inflammation, and ulceration may eventually promote skin neoplasms. …”
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Erythrocyte and Reticulocyte Indices on the LH 750 as Potential Markers of Functional Iron Deficiency by Eloísa Urrechaga, Luís Borque, Jesús F. Escanero

“…The aims of the study were to investigate the correlation of Red cells size factor (RSf) and low Hemoglobin density (LHD%), reported by Beckman-Coulter analysers, with CHr and %Hypo in the assessment of iron status in the presence of inflammation. 381 samples were run on both LH 750 (Beckman-Coulter) and Advia 2120 (Siemens) analysers. …”
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